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DR.EFRIYAN IMANTIKA

BAGIAN FISIOLOGI

PSPD UNILA

ORG N REPRODUKSI W NIT


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ORGAN REPRODUKSI WANITA

OVARIUM (KEL. GONAD): OVUM (n)

1. FUNGSI GAMETOGENIK

FASE PROLIFERASI

FASE PERTUMBUHAN FASE PEMBELAHAN (MEOTIK)

FASE PEMATANGAN

SATU JENIS OVUM ADALAH 23 KROMOSOM + X

2. FUNGSI HORMONAL

ESTROGEN

PROGESTERON


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TUBA FALOPII: TRANSFER OVUMATAU SEBAGAI TEMPAT FERTILISASI

UTERUS: TEMPAT IMPLANTASIBLASTOKISTA/ PERKEMBANGANEMBRIO - FETUS

VAGINA: PROSES PENGELUARANSPERMA PADA SAAT COITUS


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Siklus ovum:

Oocyte MaturationFollicle DevelopmentThe Effect of LH on Theca Cells

The Effect of FSH on Granulosa CellsFollicular Microenvironment

Inhibin

Follicle-Regulatory ProteinProstaglandinsMelatoninSteroids, Gonadotropins, anda Prolactin


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SIKLUS HIDUP WANITA

1. Intrauterine

2. Childhood

3. Puberty4. Adulthood

5. Pre menopause

6. Peri menopause7. Post menopause


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1. Intrauterin

Tergantung TDF dan MIS


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Perkembangan seks

intrauterin:1. Jaringan embrionik indifferen

Tuberkel genital

Lipatan uretra2. Saluran reproduksi2 sistem duktus primitif

Wolfii testosteron

Mulleri MIF3. Genitalia eksterna--DHT


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2. Childhood

0 10 15300.000- menarche 300-400 ovulasi

400.000

folikelprimordial

fetus childhood pubertas menopause


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Oogenesis:

SESAAT SEBELUM OVULASI--MEIOSIS

Oogonium

Oosit

primer

Oositsekunder(23)

BadanPolar

Ovum


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3. Pubertas (Menstruasi)


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Siklus Menstruasi (28

hari/21-35 hari)1. HIPOTALAMUSGnRH (Gonadotropin releasing hormon)

2. ADENOHIPOFISE

FSH: BEKERJA PADA SEL TEKA

LH: BEKERJA PADA SEL GRANULOSA

3. OVARIUM

FASE FOLIKULER = ESTROGEN

OVULASI FASE LUTERAL = PROGES TERON

4. UTERUS

FASE PROLIFERASI FASE SEKRESI

FASE MENSTRUASI

5. VAGINA

6. KELOMPOK MAMMA


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Siklus Menstruasi Rutin:

Cyclic hormonal stimulation of endometrial

growth

Average length 28 days (21-35 days)

Divided into two phases :

Follicular phase

Lutheal phase


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Fase folikular

The first part of the menstrual cycle whichextends from day 1 to ovulation

Characteristic :

A variable length. A low basal temperature. Development of the ovarian follicles.

Increase in the number of glandular andstoma cells of the endometrium. Vascular growth of the endometrium. Secretion of osterogen from the ovary.


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Fase luteal

The second part of the menstrual cycle, whichextends from ovulation to the onset ofmenses.

Characteristic : A fairly constant duration of 12 to 16 days

(usually 12 days). A basal body temperature that is elevated

above 98oF.

Tortuosity of endometrial glands. Marked edema of the endometrial stroma. Increased secretion of progesterone by the

ovary.


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5 & 6:Pre dan perimenopause

Final menstrual bleeding

The disruption of the ovulatory mechanism

The imbalance between progesterone andestrogen

Establish a characteristic syndrome of premenopause: sweating ,hot flushes, dizzinesstingling sensation the in the extremities,headaches, sleeplessness and anxiety


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7. Postmenopause

The remaining follicles in both ovariesbecome less sensitive to gonadotropinstimulation. There is a resultant:

Increase in follicle stimulating hormone(FSH)Endometrial disease

The relative estrogen dominance at premenopausal age -- unscheduled bleeding

The estrogen's stimulations withoutprogesterone develops endometrialhyperplasia -- continuous stimulationdevelops atypical hyperplasia --endometrial carcinoma


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Fungsi Estrogen:

PROLIFERASI DAN PERTUMBUHAN JARINGAN DARI ORGAN SEX.

1. UTERUS : PEMBESARAN ENDOMETRIUM : PROLIFERASIDAN PERKEMBANGAN KELENJAR UNTUK NUTRISI DARIOVUM YANG MENGALAMI IMPLAMTASI.

2. VAGINA : SEL KUBOID STRATIFIED (KUAT THDPTRAUMA/INFEKSI, PEMBESARAN

3. TUBA FALOPII : PEMBESARAN KELENJAR, CILIA

4. PEMBESARAN GENETALIA EKSTERNA : DEPOSISI LEMAK :MONS PUBIS, LABIA MAYORA, LABIA MINORA.

5. KELENJAR SUSU : JARINGAN STROMA, SISTEM DUKTUS,

DEPOSISI LEMAK, AREOLA.6. TULANG : AKTIVITAS OSTEBLAST, MATRIX TULANG, DEPOSISI

GARAM TULANG, PENUTUPAN EPIFISE.


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7. DEPOSISI PROTEIN

8. DEPOSISI LEMAK : LEMAK--- SUBKUTAN, KEL. MAMMA,PANTAT DAN PAHA -- FIGURE WANITA

9. RAMBUT TUBUH : ESTROGEN TAK BERPENGARUH

10. KULIT : HALUS LEMBUT , VASKULARISASI HANGAT

11. AIR DAN ELETROLIT SEPERTI ALDOSTERON : RETENSI

NATRIUM DAN AIR

12. BEHAVIOUR : LEBIH EMOSIONAL


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Fungsi Progesteron:

1. UTERUS :

- FASE SEKRESI DARI ENDOMETRIUM PERSIAPAN

IMPLANTASI

- RELAKSASI MIOMETRIUM

2. TUBA FALOPII : SEKRESI MUKUS UNTUK NUTRISI OVUM YANG DI

BUAHI SEBELUM IMPLAMTASI

3. KEL. MAMMA : PERKEMBANGAN LOBULUS, ALVEOLI DAN

SEKRETORISPERSIAPAN EFEK PROLAKTIN

4. AIR DAN ELEKTROLIT : RETENSI NATRIUM, AIR DAN CHLORIDA

5. PROTEIN : KATABOLIK SEPERTI GLUKOKORTIKOID


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ORGAN REPRODUKSI PRIA


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PERJALANAN SPERMA

TESTIS (TUBULUS SEMINIFERUS)

EPIDIDIMIS

DUKTUS DEFERENS (VASDEFERENS) VESICA SEMINALIS

DUKTUS EJAKULATORIUS

URETRADIBANTU OLEH:-KEL.PROSTAT

-KEL. BULBOURETRA


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Spermatogenesis:

Spermatogonium

Spermatogonia

Spermatositprimer(4)

Spermatositsekunder (16)

spermatid

spermatozoa


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Siklus hidup pria:

1. Intrauterin: Proses Maskulinisasi

2. Lahir: Sekresi testosteron terhenti

3. Pubertas

Sel leydig pertama kali aktif kembali

Sekresi testosteron terus menerus

- feedback sekresi GnRH o/ hipofisis

anterior4. Menopause PriaEfisiensi testis --

Degeneratif


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Sexual Respon:

Kaplan three stage : desire,excitement, orgasm

Master and Johnson four phase model : Excitement phase : penisflaccid, semi

erect, fully erect penis, tetstes elevate,scrotum thicken, sex flush

Plateu phase : cowperssecretion,tetstes elevate further and rotate

Orgasm : emission phase, expulsion

phase, rectal sphincter contact Resolution phase ; loss of erection,

testes descend, scroum thins


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Spermache: Beginning of

ejaculationPituitary-Testicular axis of SpermatogenicRegulation

Structure and Function of Leydig Cells---

Testosterone Transport andMetabolism(mol. Prekursor kol.) Pituitary-Leydig Cell Axis: Hormonal

Control

Pituitary-Seminiferous Tubule Axis Sertoli Cells FSH & Testosterone Inhibin: Produced by sertoli cells


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Kontrol fungsi testis:

- feedback

Inhibin Testosteron

Spermatogenesis

Hipotalamus

GnRH

Hipofisisanterior

FSH LH

Sel sertoli Sel leydig


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Histology of Spermatogenesis

Spermatocytogenesis

Meiosis Spermiogenesis

Sperm Maturation in the Epididymis

Sperm Capacitation and Acrosome Reaction


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ORGAN SEKS PRIMER(TESTIS)

TESTOSTERON SPERMATOZOA

ORGAN SEKSSEKUNDER

KARAKTERISTIK SEKSSEKUNDER


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KONGENITAL

Klinefelterssyndrome (47.XXYand variants)

Cryptocrcidism

Congenital anorchia (vanisningtestis synarome)

Noonansssyndrome

Motonic muscular dystrophy

Sickle cell disease

ACQUIRED

Orchtis (mumps, pyogenic,traumatic)

Malignacy (germ cell,leukemia, lmphoma)

Torsion

Varicocele

Spinal cord injury

Systemic illness (liver disease,renal filure)

Drug

X-irradiatin

Aging


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TERIM K SIH

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