hormon kelenjar adrenal - · pdf filehormon kelenjar adrenal dr. syazili mustofa, m.biomed...
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Hormon kelenjar adrenal
Dr. Syazili Mustofa, M.BiomedLektor mata kuliah ilmu biomedik
Departemen Biokimia, Biologi Molekuler, danFisiologi
Fakultas Kedokteran Unila
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Adrenal Gland
A. KORTEKS ADRENAL1. Zona glomerulosa
• Mineralocorticoids: Aldosterone2. Zona fasciculata
• Glucocorticoids: Cortisol3. Zona reticularis
• Androgens : Estrogen; progesteron; testosteron
B. MEDULLA ADRENAL Norepinephrine Epinephrine
ADRENAL gland
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Adrenal Gland
A. zona glomerulosa• mineralocorticoids- aldosterone
B. zona fasciculata• glucocorticoids- cortisol
C. zona reticularis• androgens- estrogen, progesterone,
testosterone
KORTEKSADRENAL
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SINTESIS Mineralokortikoid, Glukokortikoid & Androgen
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Zona Glomerulosa
Mineralokortikoid: ALDOSTERON
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Aldosteron
• Sintesis di zona glomerulosa• Prekursor: kolesterol• Sintesis diinduksi oleh:
- angiotensin II- perubahan kadar K+ & Na+
• Peran: - Keseimbangan air & Na
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Hormon yg mengatur Keseimbangan Na & Air (Mark, tabel 46.1)
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PERAN ANGIOTENSIN- ALDOSTERON
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Sistem-Renin-Angiotensin-Aldosteron
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Zona Fasikulata
Glukokortikoid:KORTISOL
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Kortisol
• Sintesis di zona fasikulata• Prekursor: kolesterol• Regulasi (gambar Mark 45.2):• Peran pd metabolisme bahan bakar:
- Merangsang lipolisis di jar adiposa & pengeluaran as amino dr prot otot
- Di hati, merangsang glukoneogenesis & glikogenesis
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Sintesis kortisol di dalam sel
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Regulasi sekresi kortisol
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Efek Kortisol pd metabolisme bahan bakar
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Efek fisiologis non metabolik normal Kortisol
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Mekanisme imuno supresi &respon inflamasi
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Zona Retikularis
Androgen:TESTOSTERON,
ESTROGEN & PROGESTERON
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Testosteron• Sintesis di zona retikularis• Prekursor: kolesterol DHEA • Peran:
- Perkembangan seks pria yi, maskulinisasi genetalia eks & int, seks sekunder, kesuburan & karakter anabolik jaringan somatik (btk kerangka, ukuran & berat otot
• > 95% testosteron dlm darah disintesis di testis pd pria & ovarium pd wanita. Sisa diproduksi kel Adrenal
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Sintesis Testosteron
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Sintesis Estrogen
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Sintesis Progesteron
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MEDULAADRENAL
EpinefrinNor epinefrin
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Struktur EPINEFRIN
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SINTESIS NOR EPINEFRIN & EPINEFRIN
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Mekanisme kerjaH. steroid
Androgen:TESTOSTERON,
ESTROGEN & PROGESTERON
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