3.b

Absolute Bioavaibility (F)

F=¿¿

F= 528ng .h /ml1289ng .h /ml

x500ng500ng

F= 528ng .h /ml1289ng .h /ml

F=0. 4

Klirens total (Cl)

Cl=D0 IV¿¿

Cl= 500ng1289ng .h /ml

Cl=0.38ml /h

Obat dalam plasma pada saat diserap pada 92%

k=0.6933.9h

k=0.17h−1

92% obat diabsorbsi

D0= 92% x 500 ng

D0= 460 ng

C0=D0

V

C0=460ng234 L

C0=1.96ng /L

logCp= k .t2.303

+logC0

logCp=(0.17h−1)(24h)

2.303+ log 1.96ng/L

logCp=1.77+0.2 9

logCp=2.06

Cp=10(2.06)

Cp=2.06 ng/L