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KELENJAR TIROIDMAHESA RAMADHIANTO

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ANATOMISalah satu kelenjar

endokrin manusiayan terdiri dari !lo"us yanterhu"un sehina"er"entuk se#erti

dasi ku#u$ku#u%

 Terletak di &' ( ) &t*

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HIST+LO,I

• -olikel

• .ara/olikel

• Koloid

•

Ka#ilersinusoidal

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-ISIOLO,I

Sel /olikel  selsekretorikutama tiroid

Kum#ulan /olikel

menelilinikoloid

Koloid  storaehormon tiroid

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Koloid  tirolo"ulin

Sel /olikel  ! hormon0

 Tetraiodotironin1tiroksin 2T34

 Triiodotironin 2T54

 Tirolo"ulin 6 T5 6 T3  sintesis hormo

 T5 6 T3  /unsi 7MR 27asal Meta"oli'

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7AHAN DASAR HORMON TIROID

 Tirosin  suatu as% Amino esensidalam tu"uh kita8 "ukan "erasal makanan

Iodium  harus di#eroleh dari m

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MUST KNOW

 T3 and T5 are #rodu'ed in thyroid land "ut T5 is the a't

'om#onent%

 T5 'an also 'ome /orm T3%

 T3$to$T5 'on&ersion is sto##ed "y li&er disease and 'ertadrus 2#ro#ylthioura'il8 #ro#ranolol8 #rednisone4

 T3 and T5 are 'ir'ulatin as "ound #roteins$T7, 2thyroid"indin lo"ulin4

I/ T7, oes u#$T3 and T5 9ould o u#% I/ T7, oes do9n$T

and T5 9ould o do9n%

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.ATOLO,I TIROID

*% Kelenjar 2anatomis4

!% Hormonal 2:siolois4

Major diseases 0

5% Hi#otiroid3% Hi#ertiroid

 Terantun kadar T5 dan T3

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H;.ERTIROID

Kelainan tiroid yan ditandai menink

hormon T5 dan T3

ETIOLO,I 0

 Tumor hi#o:sis  sekresi TSH meninkat

Autoimune disease

 ra&e disease

  TSH2stim4a"s  most 'ommon 'auses

Multinoduler oiter

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•   Hyperthyroidism is a 'ondition 'aused "y the<e'ts o/ too mu'h thyroid hormone%

  Hyperthyroidism0 usu% e='ess synthesis andse'retion o/ thyroid hormone "y the thyroid laalso kno9n as thyrotoxicosis%

   /ree thyro=ine 2T348 /ree triiodothyronine 2T548 o

Most 'ommon o/ thyroto=i'osis0

di<use to=i' oiter 2Graves disease8 >(+$?+@4

to=i' multinodular oiter 2.lummer disease8 *($!+@

to=i' adenoma 25$(@4%

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SIGNS AND SYMPTOMS

  Skin: In'reased S9eatin and heat intoleran'e8 ony'holysis8

hy#er#imentation8 #ruritus and thinnin o/ the hair%

  Eyes: e=o#htalmos i/ ra&es disease

  !rdi!"0 .al#itations8 e=ertional dys#nea8 aninal$like 'hest #ain8ta'hy'ardia8 atrial :"rillation8 H-

  GI: Beiht loss8 diarrhea

  Ne#ro$psy"h: An=iety8 restlessness8 irrita"ility8 emotional la"ility8#sy'hosis8 aitation8 and de#ression

  Met!%o&i"'Endo"rine: Hy#erly'emia8 lo9 serum total and hih$densitli#o#rotein 2HDL4 'holesterol

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