7. penyebab virus - rhabdiviridae (rabies) & rotavirus
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7/21/2019 7. Penyebab Virus - Rhabdiviridae (RABIES) & RotaVirus
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RHABDOVIRUSRHABDOVIRUS
Disease : RabiesDisease : Rabies CNS inflammationCNS inflammation
Spread by infected animal-bite.Spread by infected animal-bite.
Viral characteristicViral characteristic
A.A. Virus structure :Virus structure :
•Rhabdovirus : rode /roundRhabdovirus : rode /round∅
! " #$% nm.! " #$% nm.•&lycoproteins cover p ' #% nm.&lycoproteins cover p ' #% nm.
•&enome : sin(le stranded RNA ) *+ , " #%&enome : sin(le stranded RNA ) *+ , " #%
•ave RNA polymeraseave RNA polymerase
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B.B. Reaction against physical & chemical substance :Reaction against physical & chemical substance :
Resistant in t !Resistant in t ! ""°
## in se$eral %ees.in se$eral %ees.
Inacti$ation by Inacti$ation by #O#O''..
( : ( : UV) in t *+UV) in t *+°
# an hour# an hour) lipi, sol$ent) lipi, sol$ent
-ether) +)/ So,ium ,eo0ycholic1) trypsin)-ether) +)/ So,ium ,eo0ycholic1) trypsin)
,etergent & e0treme pH,etergent & e0treme pH#. #. Antigen characteristic:Antigen characteristic:
Only serotype but the strain can ,i22erent)Only serotype but the strain can ,i22erent)
base, on : base, on :
Species Species 3eographic 3eographic
4he ,i22erentiation on nucleoprotein & 4he ,i22erentiation on nucleoprotein &
glycoprotein glycoprotein
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D. Animal susceptibility & Virus gro%ing :D. Animal susceptibility & Virus gro%ing :
5i,e susceptibility host 5i,e susceptibility host→
all animalall animalpoiilothermic & human coul, be in2ecte,. poiilothermic & human coul, be in2ecte,.
Virus : #6S) sali$a) urine) lymph) mil & bloo,. Virus : #6S) sali$a) urine) lymph) mil & bloo,.
Strain : Strain :
. 7ong incubation perio, strain -'8+ ,ays1. 7ong incubation perio, strain -'8+ ,ays1
inclusion bo,ies in cytoplasminclusion bo,ies in cytoplasm
'. Short incubation perio, strain -"8 ,ays1'. Short incubation perio, strain -"8 ,ays1
hasn9t inclusion bo,ies. hasn9t inclusion bo,ies.
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7/21/2019 7. Penyebab Virus - Rhabdiviridae (RABIES) & RotaVirus
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#linical appearance
Rabies primary animal ,iseaseRabies primary animal ,isease human) throughhuman) through
. In2ecte,animal bite. In2ecte,animal bite
'. #ontact %ith in2ecte,sali$ary animal'. #ontact %ith in2ecte,sali$ary animal
Incubation perio, 8 %eesIncubation perio, 8 %ees
4he sign ,i$i,e, into " phases4he si
gn ,i$i,e, into " phases ::
. ro,ormal phase: 2e$er) malaise) anore0ia) hea,ache). ro,ormal phase: 2e$er) malaise) anore0ia) hea,ache)
nausea & $omitingnausea & $omiting
'. Sensory phase : 7acrimation) hallucination) muscle rigi,ity.'. Sensory phase : 7acrimation) hallucination) muscle rigi,ity.
;. <0citement phase : photophobia ) soun,) & %ater.;. <0citement phase : photophobia ) soun,) & %ater.
". aralytic phase : ascen,ing muscle paralytic". aralytic phase : ascen,ing muscle paralytic
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7aboratory Diagnosis
A.A. =icroscopic:=icroscopic:
• Immuno2luorescensi : rabies hamster antiseraImmuno2luorescensi : rabies hamster antisera
• Brain or cornea impression.Brain or cornea impression.
• athognomonicathognomonic : negri bo,ies->1 in muscle ?=S: negri bo,ies->1 in muscle ?=SB.B. Virus isolation:Virus isolation:
• In2ecte, tissue -sali$a1In2ecte, tissue -sali$a1 inoculate to mouse intrainoculate to mouse intracerebral.cerebral.
• ->1 : 7eg 2lacci, paraly@e,) encephalytic & ,eath.->1 : 7eg 2lacci, paraly@e,) encephalytic & ,eath.
• #6S9s mouse e0amination#6S9s mouse e0amination 6egri bo,ies & rabies Ag6egri bo,ies & rabies Ag
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#. Serology :#. Serology :
Ab test against rabies : I) # or 6t test. Ab test against rabies : I) # or 6t test. Ab : ->1 in human ? animal along sic. Ab : ->1 in human ? animal along sic.
D.D. Animal obser$ation:Animal obser$ation:
. Suspecte, animal rabies. Suspecte, animal rabies ille,ille, tissuetissue
e0amination.
'. Other animal rabies possibility'. Other animal rabies possibility stalle,stalle,
& obser$e, about + ,ays. & obser$e, about + ,ays.
;. I2 sign ->1;. I2 sign ->1 ille,ille, & tissue e0am.& tissue e0am.
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Immunity & re$entingImmunity & re$enting
Rabies pre$enting pathophysiology through $accine:Rabies pre$enting pathophysiology through $accine:
. Virus replication in muscle close, 2rom inoculation. Virus replication in muscle close, 2rom inoculation
sitesite $irus$irus
enough to cause in2ection o2 #6S.enough to cause in2ection o2 #6S.
'. 3i$ing $accine ? immunogenic substance promptly'. 3i$ing $accine ? immunogenic substance promptly
,epress $irus replication & prohibit in$asion to #6S. ,epress $irus replication & prohibit in$asion to #6S.
;. Action o2 passi$e ab :;. Action o2 passi$e ab :
a. inoculate, in2ecte, $irus & $irus ,ecreasea. inoculate, in2ecte, $irus & $irus ,ecrease
b. to gi$e enough time to $accine to stimulate acti$e ABb. to gi$e enough time to $accine to stimulate acti$e AB
pro,uction to prohibit $irus entering to #6S. pro,uction to prohibit $irus entering to #6S.
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Vaccine type :Vaccine type :
. Human ,iploi, cell $accine-HD#V1. Human ,iploi, cell $accine-HD#V1
'. Rabies $accine absorption -RVA1'. Rabies $accine absorption -RVA1
;. 6eural tissue $accine -64V1;. 6eural tissue $accine -64V1
". Doc embryo $accine -D<V1". Doc embryo $accine -D<V1
*. Attenuate, li$ing $accine*. Attenuate, li$ing $accine
7/21/2019 7. Penyebab Virus - Rhabdiviridae (RABIES) & RotaVirus
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REOVIRIDAE
ROTA VIRUS
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6 genus :- Reovirus- Orbivirus
- Rotavirus3 genus pada pertumbuhan
REOVIRIDAE
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-en!ebab pen!" sa#" $erna% sa#" na&aspada manusia ' he(an
- Sindroma )#ini) : be#um *e#as
- +udah diiso#asi dari tin*a dari padadari hidung , tenggoro)an
- Tumbuh subur pada bia)an gin*a# )era $pe
Reo . Respirator! Enteri) Orphan
REOVIRIDAE REOVIRUS
7/21/2019 7. Penyebab Virus - Rhabdiviridae (RABIES) & RotaVirus
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/ Orbi . $in$in , #ing)aran
/ ertama)a#i ditemu)an o#eh 0arden d))
121/ 0er)embangbia) da#am : serangga%
Vertebrata% Tumbuhan
/ ada manusia : demam ringan% sa)it)epa#a
/ 4ang pa#ing patogen men!ebab 50#ueton ue #idah biru ada )ambin
REOVIRIDAE OR0IVIRUS
7/21/2019 7. Penyebab Virus - Rhabdiviridae (RABIES) & RotaVirus
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• / 0entu) virus men!erupai roda 7rota . roda8
• / ertama)a#i ditemu)an o#eh 0ishop d)) 123
pd pend" diare non-ba)teria# di Austra#ia• / 0ersi&at invasi&
/ enu#aran . oro-&e$a#
•
/ Terutama men!erang ana)-ana) 6 b# - 9 th• / ama #ain :
– - Duovirus
– - I;V . In&anti#e ;astroenteritis Virus
– - <RV= . <uman Rotavirus =i)e Agent
REOVIRIDAE ROTAVIRUS
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/ 0ervariasi : Diare ringan - berat Dehidrasi S!o) >
/ Se#& #imiting disease Sembuh da#ambeberapa hari
/ ?has : Sebe#um diare ter*adi +untah-muntah @ suhu tinggi
;ambaran ?#ini)
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• / Re#ati& stabi#
• / Resisten terhadap pe#arut-pe#arut #ipid
• / Susah dibia) pada bia)an *aringan
Si&at RotavirusSi&at Rotavirus
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• / +i)ros)op e#e)tron :- maha#
- tenaga te)nisi )husus
- sangat )omp#e)s
• / 0erdasar)an intera)si Antigen-antibodi :- =ate) ag#utinatin test
- Radio Immuni Assa! 7RIA8
- Reverse assive <aemog#utination 7R<A8- o#!a$r!#amide ;e# E#e$trophorese 7A;E8
- u$#ei$ A$id <!bridisation 7A<8
- E#isa 7En!m =in)ed Imuno Sorbent Assa!8
/ Diagnosis $epat
Diagnosis Rotavirus
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/ Supporti&/ +en$egah dehidrasimenga)ibat)an s!o)
Terapi RotavirusTerapi Rotavirus