full makalah
TRANSCRIPT
-
7/24/2019 Full Makalah
1/64
LAPORAN KASUS PENGGANTI CPC
SEORANG LAKI-LAKI 62 TAHUN MENDERITA SINDROMA GERIATRI,
TIROIDITIS KRONIS HASHIMOTO, DM TIPE 1, CHF NYHA III,
AUTOIMMUNE HEMOLYTIC ANEMIA, DAN VITILIGO
Disusun Oleh:
Nanindita Fauzia Maharani
BAGIAN ILMU PENYAKIT DALAM
FAKULTAS KEDOKTEAN UNI!ESITAS DIPONEGOO
SUP Dr KAIADI SEMAANG
"#$%
1
-
7/24/2019 Full Makalah
2/64
DAFTAR MASALAH
No Tanggal Maala! A"#$% No Tanggal Maala! Pa$%
1 23/10/201528/10/2015 HipotiroidismTiroiditis H!s"imoto
213/10/201503/12/2015
#$ Tip 2#$ Tip 1
3 23/10/2015 CH% N&HA III
' 13/10/2015 Hiprt(si st!) 1
5 23/10/2015 Autoimune hemolytic anemia
* 13/10/2015 +iti,i)o d()!( ritrodrm! 2 25/10/2015 Eritrodrm!
- 13/10/2015 E..si P,r! #p,s
8 13/10/2015 Hmip!rs dtr!
13/10/2015 Aotmi!
10 13/10/2015 Hipo!,4mi(mi!
11 15/10/2015 #is,ipidmi!
12 13/10/2015 I(o(ti((si! A,i
13 23/10/2015 #prsi ri()!(
1' 23/10/2015 Frailty
15 23/10/2015 #p(d(
1* 13/10/2015 Hipo(!trmi! 1 23/10/2015 Hipo(!trmi!
1-0*/11/2015
1-/11/2015
Piri6"m!tri
ISK
18 30/10/2015Hospitalized Acquired
Pneumonia 7HAP3 1'/102015 HAP
1 0/11/2015 U,s d4its )r!d 1 R9 ),t!
20 2*/11/2015 A4ss m!(s dtr!
2
-
7/24/2019 Full Makalah
3/64
LAPORAN KASUS
I& IDENTITAS PENDERITA
N!m! : T(9 $
Umr : *2 t!"(
A,!m!t : Pdri!( Lor; Sm!r!()
Pr
R!() : Gri!tri Lt 1
Nomor C$ : C55'80
$!s RS :1'61062015
#i!ss!( : 2261062015
#P>P : dr9 =!m4!() >o(i K; Sp9P#; K6Gr
II& 1& DATA DASAR
ANAMNESIS 'a(#oana)n*$+ #anggal 2O"#o*. 2/10 a) /&// 3$
K*l(!an (#a)a 4*a" na%a
R$3a5a# *n5a"$# *"a.ang 4
? 5 "!ri p!si( m()," ss! (!.!s; dir!s!!( "!mpir sp!(
? 1 4,!( p!si( m()," ,m!s s,r" t4"; sri() @p!t ,,!" 4i,! 4r!ti.it!s d!( s4!)i!(
4s!r !t(B! di"!4is!( (t 4ristir!"!t di tmp!t tidr9 Tid! !d! m!, m!p( m(t!";
tid! !d! p(r(!( 4r!t 4!d!(; d! !i !)! 4)!; tid! dm!m; tid! !d! 4rri()!t
m!,!m; s!r! sr!; 4!() !ir 4s!r sri() di4!(t d()!( o4!t p(@!"!r; 4!() !ir @i, !r(!
4i!s!;
di mp!t !())ot! )r!; disrt!i r!m4t ro(to9
R$3a5a# *n5a"$# 7a!(l( 4
? 1 t!"( B!() ,!, p!si( pr(!" dir!!t !i4!t stro; "i())! p!si( m()!,!mi
,m!"!( !())ot! )r! !(!(; d!( dir!!t "!mpir 1 4,!(9 St,!" m(d!p!t!(
3
-
7/24/2019 Full Makalah
4/64
pr!!t!( .isiotr!pi; p!si( m()!t!!( d!p!t 4r!ti.it!s sprti 4i!s!9
? 4,!( B!() ,!, p!si( m(
4rp! ,! B!() s,it sm4"; ,!m! ,!m!!( ,! sm!i( m,!s d!( "!rs di,!!(
opr!si
? ' 4,!( B!() ,!, st,!" di,!!( opr!si; ,it p!si( tr!s! )!t!, d!( ,!r 4r@!6
4r@! mr!"!( "!mpir di s,r" t4"; ,!, 4rsisi; d!( tr!s! )!t!,9 P!si( sd!"
3 dir!!t !r(! ,"!( B!() s!m!
Ri!B!t d!r!" ti())i 7? dit!"i s
Ri!B!t (@i() m!(is 7? dit!"i s
p!si( 4!r mi(m o4!t s
s(ti!( i(s,i(
Ri!B!t tr!(s.si 76
Ri!B!t s!it tmor/ )!(!s!( 76
Ri!B!t s!it )o(do 76
Ri!B!t
R$3a5a# $"oo$al *"ono)$ 7an l$ng"(ngan 4
6 P(drit! mrp!!( p(si(!( PNS; sd!" - t!"(; )i!t!( s"!ri6"!ri s!!t i(i
m()r
prm!"!((B!; sprti m(
p(drit! d!ri !() p(si(!(; d!( p()o4!t!( p(drit! dit!())() =P>S9
6 P(drit! mmi,ii 3 or!() !(!:
19 L!i6,!i; si! 31 t!"(; 4r
m(i!"; d()!( )!
-
7/24/2019 Full Makalah
5/64
39 L!i6,!i; si! 2* t!"(; 4r
G!200 mtr9 >!,!(!( di d!r!" rm!" !sp!, d!( d!t!r9
6 #i 4,!!() rm!" p!si( mmi,ii !m!r B!() dis!!( (t os6os!( ptri s4!(B!
- !m!r
6 Ri!B!t mroo s
6 P!si( mm,i"!r! 4r() prtt 5 or
6 Lo!si rm!"
S"o. P$"olog$ 7an F(ng$ 4
GCS : E'$*+5 %()si dprsi : -/15 7dprsi ri()!( Sor mi(i m(t!, : 22/30 7)!())!( o)(iti. sd!() Sor Norto( : 1'/20 7m()i(!( @i, tr
Ko(ti((si 76 =rp!!i!( 7?
II& 2 PEMERIKSAAN FISIK '2 O"#o*. 2/10 a) /&// 8I9+
K!d!!( Umm : s!it sd!(); 4!d!( tr,i"!t 4()!; trp!s!() (!s!, !(,
Ks!d!r!( : ompos m(tis; GCS:E' +5 $* 15
T!(d! it!, : t!(!( d!r!" :130/0 mmH) 74r4!ri()
5
-
7/24/2019 Full Makalah
6/64
(!di : -- /m(it; r),r6r),r; isi d!( t)!()!( @p
s" : 3*;5oC 7!i,,r
,!
-
7/24/2019 Full Makalah
7/64
A7o)*n:
I(spsi : !)! mm4(@it; (t!si 76
As,t!si : =U 7? N
Prsi : timp!(i; PS 7? N; PA 76; !r! tr!4 timp!(i; (Bri to C+A 6/6
P!,p!si : sp,; "p!r d!( ,i( tid! tr!4!; (Bri t!( pi)!strim 76
E"#.*)$#a : Sprior I(.rior
- Edm! ?/? ?/?
6 Ar!, di()i( 6/6 6/6
6 C,44i() .i()r ?/? 6/6
6 Gr! ?/? ?/?
6 K!t!( otot '''/555 '''/3''
6 To(s ?N/?N ?N/?N
KONDISI PASIEN
:1 t!"( s4,m dir!!t
-
? ' 4,!( s4,m m!s RS#K
-
7/24/2019 Full Makalah
8/64
P*.a3a#an 7$ RSDK
In7*= D$agno#$" )*n(.(# 9$ll*3$>?
Daa. P*n$la$anN $ l a $
A7a N$!$l
G*ala-g*ala
K,m!"!( T4" 0 ?2
Piir!( ,!m4!t 63 ?1
Kr!() ri()!t ?* 62K,it ri() ?3 6*
Tid! t!"!( di()i( ?' 65
R!m4t ri() 62 ?2
=r!t 4!d!( (!i ?1 61
Ko(stip!si ?2 61
S!r! sr! ?5 6*
P!r!stsi ?5 6'
Kt,i!( ?2 0
Tan7a-#an7a
Pr)r!!( ,!m4!t ?11 63
K,it !s!r ?- 6-K,it tr!4! di()i( ?3 62
D!
-
7/24/2019 Full Makalah
9/64
II& PEMERIKSAAN PENUN
-
7/24/2019 Full Makalah
10/64
Lim.osit * 20 '0 J
$o(osit 1 2 10 J
L!i(6,!i( A$C 2J
Eritrosit =ri(ti : 1/100 ,osit
Trom4osit '3'000 '10000 150 '00 ri4/ mm
Rti,osit 89'2 095 195 J
PPT/K 1292/109 9' 1193 dti
!PTT/K ''9'/339* 239' 3*98 dti
%i4ri(o)( 2009' 180 350 m)/d,
K I M I A K L I N I K
NILAI NORMAL
1;1/;2/10 10;1/;2/10 1;1/;2/10 21;1/;2/10
G#S 1*3 '* 150 -' 10* m)/ d,
Urm 55 81 15 3 m)/ d,
Cr!ti(i( 19* 19 0;* 1;3 m)/d,
N!trim 131 131 13' 13- 13* 1'5 mmo,/ L
10
-
7/24/2019 Full Makalah
11/64
K!,im '9* '9- '95 '9* 3;5 5;1 mmo,/ L
C,orid! 5 102 101 8 10- mmo,/ L
C!,@im 291 291 2912 2952 mmo,/L
$!)(sim 09-- 190 09-' 09 mmo,/L
SGOT '1 22 15 3' U/L
SGPT 32 23 15 *0 U/L
=i,ir4i( tot!, 191 090 190 m)/d,
=i,ir4i( dir 0931 090 093 m)/d,
Proti( tot!, -9- *9' 892 )/dL
A,4mi( 290 391 39' 590 )/dL
As!m r!t -90 395 -92 m)/d,
Ko,stro, Tot!, 222
120 2'* m)/d,
Tri),isrid 12 200 m)/d,
H#L 51 150 m)/d,
11
-
7/24/2019 Full Makalah
12/64
L#L 150 '0 *0 m)/d,
Ga)a.an Da.a! T*$ '1@;1/;2/10+
Eritrosit A(isositosis ri()!( 7(ormositi; m!rositi; Poii,ositosis sd!() 7o!,osit;
,iptosit; t!r drop @,,; @i)!r @,,; r(!si; Eritrosit md! 7?
Trom4osit Estim!si
-
7/24/2019 Full Makalah
13/64
9&
EKG
Ir!m! : Si(s
%r(si : -0 /m(it; 6r),r
Ais : LA#G, P : 0;10 dti; P mitr!, 76; P p,mo(!, 76
PR i(tr!, : 0;1' dti
RS @omp, : 0;08 dti
o(! tr!(sisi : +'
S)m9 ST : Iso,tri
G, T : i(rtd 7? +36*; T!,, 76R/S di +1 1 mm
S +1 ? R +5 35 mm
Ks!( : $n( .$#)*, LAH9, non *$%$> ST-T >!ang* V-6 '(*" $"*)$ an#*.ola#*.al+
C& B FOTO THORAKS AP-LATERAL '1;1/;2/10+
13
H*)a#olog$ '1;1/;2/10+ Ha$l
Coom4s Tst #ir 1?/pos 1
Coom4s Tst I(dir 6/()
Co,d A),ti(i( ?/pos
D!rm A),ti(i( ?/pos
I)(no*.olog$ '2;1/;2/10+ Ha$l Sa#(an R(("an
TSHs 539*
IU/mL
HBpot"Broid : F -
Et"Broid : 0925 5
HBprt"Broid : 0915
%T' 1900 pmo,/L 109* 19'
-
7/24/2019 Full Makalah
14/64
KESAN 4
C!rdiom)!,B 7L.t +(tri@, disrt!i ,o()!tio !ort!
G!m4!r!( dm! p,mo(mE..si p,r! dp,s
D& CT SCAN KEPALA POLOS '1;1/;2/10+
KESAN 4
I(.!r p!d! @oro(! r!di!t! !(!(; (@,s ,(ti.orms !(!(; t"!,!ms !(!(; pri6(tri,!r @or( !(trior (tri, ,!tr!,is iri
T! t!mp! prd!r!"!( i(tr!r!(i!, Si(sitis m!si,!ris !(!( iri; .ro(t!,is !(!( sp"(oiditis d!( tmoiditis !(!( iri G!m4!r!( !)i() !tro.i sr4ri
III& HASIL KONSULTASI ANTAR 9AGIAN DIVISI KULIT '10 OKTO9ER 2/10+
St!ts drm!to,o)i : Lo!si : s,r" t4"
1'
-
7/24/2019 Full Makalah
15/64
UKK : m!,! ritm; s!m!
Lo!si : !i; t()!i; ,()!(; t!()!(
UKK : m!,! "ipopi)m(t!si; .isr!
Assssm( : Eritrodrm! d()!( iti,i)o
IV& DAFTAR A9NORMALITAS
19 Lm!s
29 Ss! (!.!s 4i,! 4r!ti.it!s
39 =()! "!mpir di s,r" 4!d!(
'9 K,it )!t!,; ri(); 4r@! pti"!(
59 Ko(stip!si
*9 Ri!B!t stro
-9 Ri!B!t opr!si .ist, !i4!t ,! B!() s,it sm4"
89 K,!i(!( ,it dir!s!!( s
159 Ati.it!s "!mpir sm! di4!(tAKS %
1*9 =r@! "ipopi)m(t!si di d! ,()!(; t!()!(; !i; t()!i
1-9 T!ip(!
189 Hiprt(si st!) 1
19 Ko(229 Kd! 4!s!, p!r : R=H 7?; S#
239 Kmp!t strmit!s dm
2'9 Hmip!rs dtr! !(!(
259 A(mi! 7H4 -;35
2*9 Rti,ositosis
15
-
7/24/2019 Full Makalah
16/64
2-9 Hipr4i,ir4i(mi! i(dir@t
289 Coom4s tst ?/positi.
29 Ts !),ti(!si !rm !(d @o,d : ?/pos
309 Lositosis 71'500
319 Aotmi!
329 Ri!B!t "ipo(!trmi!
339 Hipo!,4mi(mi! 7391
3'9 Hipr),imi!
359 Hipr!)r)!si trom4osit
3*9 EKG : LAH=; ST6T @"!()s (o( spsi.i
3-9 6T"or!s : !rdiom)!,i 7L+; )!m4!r!( dm! p,mo(m; ..si p,r! dp,s
389 CT S@!( Kp!,! : I(.!r p!d! @oro(! r!di!t! !(!(; (@,s ,(ti.ormis !(!(;
t"!,!ms !(!(; pri(tri,!r @or( !(trior (tri, ,!tr!,is iri
V& MASALAH
A& S$n7.o)a G*.$a#.$"
si(drom! sr4r!, 76; o(.sio 76; )!())!( oto(om 76; i(o(ti((si! 7?;
1@ I: I))o$l$#5713 Iso,!tio(Imp!@tio( Impot(@
In#a$l$#5 I))(no-7*%$>$*n>5
I!tro)(i@ In%*>#$on
In#*l*>#(al $)a$.)*n#712 I(!(itio(
I(som(i! I)a$.)*n# o% $$onM "!ri();sm,,
In>on#$n*n>* Imp@(itB
Kaa$#a %(ng$onal
%r!i,tB 71'#p(d( 715
9& Maala! M*7$
19 Hipotiroidism 71; 3; '; 5; 8; 11; 12; 20; 23
29 #i!4ts $,its 7-; ; 3'; 35
39 CH% N&HA III 72; 1-; 21; 3*; 3-
'9 Hiprt(si st!) 1 710; 1859 Autoimmune hemolytic anemia71; 25; 2*; 2-; 28; 2
*9 E..si p,r! dp,s 722; 30
1*
-
7/24/2019 Full Makalah
17/64
-9 Eritrodrm! d()!( iti,i)o 7'; 1*
89 Hmip!rs dtr! 7*; 2'; 38
9 Aotmi! 731109 Hipo!,4mi(mi! 733
119 Hipo(!trmi!pr4!i!( 732
VI& RENCANA PEMECAHAN MASALAH
19 Hipotiroidism
Assssm(t : Etio,o)i : Atoim( : Tiroiditis H!s"imoto
I(.si
K)!(!s!(
S(dr : )!())!( "ipo.isis d!( "ipot!,!ms
K)!!t!( : @om! midm!
Ip# : A(ti TPO
IpR : Lot"Broi( 100 m@)/2'
Ip$ : %T'; TSHs ti!p 4,!(; KUT+/8
IpE : $(
-
7/24/2019 Full Makalah
18/64
I(s,i( !(!,o) ),!r)i( 20 (it 7SC s4,m tidr
Ip$ : G#S I6II ti!p mi())
IpE : P(B!it di!4ts B!() didrit! p!si( d!p!t m(im4,!(
4o@or!( )i(
.()si )i(
39 CH% N&HA III
Assssm( : #E : HH#; IH#
#A : L+H
%()si sisto,i d!( di!sto,i
Ip# : E@"o@!rdio)r!.i
IpR : Posisi dd
O2 3 ' LP$
N!C, 09J 1* tpm
%rosmid '0 m)/2'
C!ptopri, *;25 m)/12
N6!sti, sisti( 200 m)/8
L!@t,os! sBrp 15 @@/8
N4,isr /'
tid! m()
'9 Hiprt(si st!) 1
Asssm( : %!tor rsio: HH#
Komp,i!si : rti(op!ti; (.rop!ti
Ip# : E@"o@!rdio)r!.i; .(dsopi; (ti( rti(
IpR : #it r(d!" )!r!m
C!ptopri, *;25 m)/8
18
-
7/24/2019 Full Makalah
19/64
Ip$ : KUT+/8
IpE : Istir!"!t @p; r!()i m!!( !si(
59 Mied type autoimmune hemolytic anemia7AIHA
Asssm( : 6
Ip# : 6
IpR : Tr!(s.si DE 1 !(to()/"!ri
CB@,ospori( 50 m)/12
As!m .o,!t '00 m@)/8
Ip$ : H4 post orsi
IpE : A!( di,!!( tr!(s.si d!r!" (t mmpr4!ii H4
*9 Eritrodrm! d()!( +iti,i)o
Asssm( : Atoim(: s(dr pro4,m 1
Ip# : =iopsi ,it
IpR : $tB,prd(iso,o( 1* m) 71 0 1 H2 po
CT$ ' m)/ 8
#osBmt"!so( oi(t o,s/ 12
Ur! @r!m 10J o,s/12
Komprs N!C, 09J/12
B!() ,@t
Ip$ : 6
IpE : $(
-
7/24/2019 Full Makalah
20/64
Ip$ : RR; ro(t)( t"or! ,!()
IpE : A!( di,!!( pmris!!( @!ir!( p!r
89 Hmip!rs dtr!
Asssm( : Etio,o)i : SNH s,
Rsio : Immo4i,it!sd!( omp,i!si(B!
I(st!4i,itB
6 G(r!, RO$ r@is
6 Strt@"i()
6 $o4i,is!si 4rt!"!p
Ip$ : KUT+/8
109 Hipo!,4mi(mi!
Assssm( : P(B!it ro(is
$!,(trisi
Ip# : 6
IpR : #it str! pti" t,r
Ip$ : C !,4mi( ,!()
20
-
7/24/2019 Full Makalah
21/64
IpE : Kr!()!( proti( di!i4!t!( p(B!it ro(is
119 #is,ipidmi!
Assssm( : S(dr pro4,m 1 d!( 2
Ip# : 6
IpR : #it r(d!" ,m!
Ip# : 6
IpR : 6 Psiotr!pi
6 At!si pro4,m mdis B!() didrit!
Ip$ : K!d!!( mm; dr!
IpE : $m4ri!( moti!si sm!()!t "idp p!d! p!si( (t
p(Bm4"!(; d!( pr4!i!( o(disi mm p!si(
1'9Frailty
Assssm( : S(dr d!ri pro4,m mdis B!() m,tip,
Komp,i!si :!ailure to thri"e
21
-
7/24/2019 Full Makalah
22/64
Ip# : #!r!" rti(; !,4mi(
IpR : $mpr4!ii s,r" pro4,m mdis
I(.s RL 12 tts/m(it
#it (!si tim #$; RG 2100 !,ori
R"!4i,it!si mdis: ,!ti"!( otot d()!( .isiotr!pi; mo4i,is!si
Ip$ : Ko(disi mm; 4!,!(@ @!ir!(; !sp!( diit
IpE : p((t mmpr4!ii o(disi i(i s"i())! tid! m(
IpR : $mpr4!ii s,r" pro4,m mdis
R"!4i,it!si mdis: ,!ti"!( otot d()!( .isiotr!pi; mo4i,is!si
Ip$ : Ko(disi mm
IpE : P(
-
7/24/2019 Full Makalah
23/64
S : ,m!s
O : K!d!!( mm : ,m!"; !)! p@!t
Ks!d!r!( : omposm(tis T!(!( #!r!" : 130/0 mmH) 74r4!ri()
N!di : -8/m(it 7r),r; !t !()!t
S" : 3*9-0
C RR : 1* /m(it
Mon$#o.$ng F(ng$ T$.o$7
E
:Hipotiroidism dis4!4!( !r(! !toim(Tiroiditis H!s"imoto
Rsio )!!t!( : @om! midm!
Komp,i!si : ..si p,r!; ..si pri@!rd
P :
# : E@"o@!rdio)r!.i
R : Lot"Broi( 200 m@)/2'
$ : KUT+/8
16;11 %T' 11931 pmo,/L 109* 19'
2;11 TSHs 1595* IU/mLHBpot"Broid : F - Et"Broid : 0925 5
HBprt"Broid : 0915
-
7/24/2019 Full Makalah
24/64
O : HA1C 4 *;2 J 7N: * 8 J
Mon$#o.$ng GD I;II
U.$n R(#$n
D!r(! : K(i(); !)! r" Krist!,C! o!,!t
Uri@ !@id
::
:
() /L?/pos
?/pos
=> : 19025 Si,i(dr P!to,o)i
Si,9 ,i,i( : 1 2 /LPK
pH : 595 Si,9Hi!,i( : 2 3 /LPK
Proti( : //m)/d, Si,9 Gr!(,!r
K!s!r
: 8 10 /LPK
Rdsi : 0//m)/d,Si,9 Gr!(,!r H!,s
: ' * /LPK
Uro4i,i(o)( : 190 m)/d, Si,9Epit, : 6/() LPK
=i,ir4i( : 6/() m)/d, Si,9Eritrosit : 6/() LPK
Asto( : 6/() m)/d, Si,9Losit : 0 1 /LPK
Nitrit : 6/() m)/d, $@s : ?/pos
Epit, : 3 5 /LPK =!tri : ?? /pos
Epit, T4,s : 0 1 /LP=O!, .!t 4odis
?/pos
&!st @,, : 6/()
Losit : 10 2//LP= Sprm! : 6/()
Eritrosit : / //LP= Kp!t!( : 6
2'
P*)*.$"aan ')g;7l+ 26;1/ 2;1/ /2;11 /0;11 16;11 1;11 2;11 /;12
G# P!s! 30 11 13' 38 11- *3 53 22
G# PP 2
-
7/24/2019 Full Makalah
25/64
F(n7("o$ 4 '2 No 2/10+
Tid! did!p!t!( t!(d! rti(op!ti di!4ts d!( "iprt(si
S!!t i(i !mi tm!( t!(d! O# ssp@t G,!om!; OS !t!r! s(i,is m!tr
Ha$l EMG 4 '#gl 2@ No 2/10+
$otori : N9 $di!(s !(!(: tid! m(@, ),om4!()
N9 U,(!ris !(!( : L!t(si d4(; !mp,itdo r(d!"; NC+ r(d!"
N9 Ti4i!,is iri : L!t(si d4(; !mp,itdo r(d!"; NC+ r(d!"
N9 pro(!, iri : tid! m(@,
S(sori: N9 $di!(s d!( N9 U,(!ris !(!(: tid! m(@,
% ! : N9 $di!(s !(!(: r!() prodti.
N9 U,(!ris !(!( : m!si" prodti.
H R.,s : N9 Ti4i!,is iri : r!() prodti.
Ks!( : #!p!t ss!i d()!( )!m4!r!( po,i(rop!ti s(sorimotor N9 $di!(s; N9 U,(!ris
!(!(; N9 Ti4i!,is; d!( N9 Pro(!, iri ,si dmB,i(!si !so(!,; disrt!i
po,ir!di,op!ti C5 C* !(!( d!( L5 S1 iri
E :6 #$ Tip 1; m!si" m()i( LA#A 7Latent Autoimune Diabetes in Adultsd()!( did!p!t!( po,i(rop!ti B!() m!si" m()i( !i4!t di!4ts
6 Rsio KA#
6 Piri!6Hm!tri! ##/ ISK P.ol*) 1
25
-
7/24/2019 Full Makalah
26/64
P :
# : K,tr ri(
R : #it #$ 100 !,/ '5 ) proti(; 25J Lm!; *0J KH
I(s,i( Asp!rt * * * (it 7SC
I(s,i( )!r),i( 10 (it 7SC p, 23900
=i,! G#S *0 m)/d, : =o,s 2 .,s #'0J; I+%# #10J 1* tpm
$ : G# I/II ti!p mi()); KUT+/8
Pmris!!( %isi
L"r : >+P p(" 7?
P,mo dp!( d!( 4,!!(): 6 rdp di d! 4!s!, p!r
6 sti())i SIC III 4!!" : R=H ?/?; R=K ?/? ;
"i() ?/?
>!(t() : 6 o(.i)r!si
6 s!r!
Kmp!t trmit!s : dm! ?/? 7pitti()
=!,!(@ @!ir!( : 6-00 @@/2'
2*
-
7/24/2019 Full Makalah
27/64
Pmris!!( P((
9GA '2;1/;2/10+
Tmpr!tr : 3*98 0C TCO2 : 239'
%iO2 : 5290 J =!s E@ss : 6395 mmo,/,pH : -93' =E E..@ti : 639-
pCO2 : '1 mmH) O2 S!tr!si : - J
pO2 : 2 mmH) A6A#O2 : 225
HCO3 : 2291 mmo,/, RI : 295
Ks!( : P% r!tioAR#S 7Acute #espiratory Distress $yndrome
B FOTO THORAKS AP-LATERAL '/;1/;2/10+
KESAN 4
=!t!s !(!(
E : Pro4,m 19 Tiroiditis ro(is H!s"imoto d()!( )!!t!( @om! midm!
Pro4,m 29 #i!4ts d()!( rsio KA#
Pro4,m 39 CH% N&HA I+ d()!( )!!t!( dm! p,mo !t; AR#S
Pro4,m 59E..si P,r! @(dr() 4rt!m4!" !i4!t or"idr!si; d!( m!si"
m()i( trd!p!t i(.si : HAPP.ol*) 1
P :
# : E@"o@!rdio)r!.i p()@!t!( sptm =TA; Gr!m ,tr sptm
R : 6 Posisi dd
6 O2 s()p 8 LP$
2-
-
7/24/2019 Full Makalah
28/64
6 Ko(s, ICUtmp!t d!( (ti,!tor 76
6 N!C, 09 J 12 tpm
6 %rosmid '0 m) 7I+ 4o,s di,!( 6 IS#N 3 m)/
6 I(s,i( Asp!rt d()!( SBri() Pmp dosis Q G#S 7d()!(
t!r)t G#S 1006200 m)/d,
G#S 7m)/d,#osis I(s,i( Asp!rt
7(it /'
100 6 #5J101 150 0;5 #5J
151 200 1 #5J
201 250 2 N!C, 09J
251 300 3 N!C, 09J
301 350 ' N!C, 09J351 '00 5 N!C, 09J
'01 '50 * N!C, 09JF '50 - N!C, 09J
6 C.tri!so( 2 )r!m/2'
6 $t"B,prd(iso,o( 125 m)/12
6 N6!sti, sisti( 200 m)/8
6 N4,isr /'
mo(itori() t!t d!( pr, 4!@p (ti,!tor 4i,! !d!!( mm
p!si( mm4!i !!( di,!!( 4r4!)!i pmris!!(
s,!(
P.ol*) & CHF NYHA IV
S : ss! (!.!s 4rr!()
28
-
7/24/2019 Full Makalah
29/64
O :
Mon$#o.$ng K*a7aan U)() 7an Tan7a-#an7a V$#al
1;1/ /2;11 /;11 11;11 13/11 15/11 1*/11 1-/11 18/11
KU ss! ? ss! ; ,m!" ,m!s ss! ss! ? ss! ss! ss! ss! 6K*a7a.an C$ C$ C$ C$ C$ C$ C$ C$ C$TD '))Hg+ 1'0/80 1*0/100 1*0/100 1*0/80 1'0/-0 1'0/80 1*0/100 130/80 1*0/-0
HR '=;)n#+ 80 80 -' * 100 -8 8' 8* 88
RR'=;)n#+ 22 20 22 2' 22 20 20 20 18
# 'oC+ 3*9* 3- 3*95 3892 3-9* 3*98 3*98 3*95 3-
SO2 100 100 - 8
9C ')l+ 6-00 6'00 6250 6800 6200 62000 63000 62*00 61'00
9GA '/6;11;2/10+
Tmpr!tr : 3*9' 0C TCO2 : 21
%iO2 : 3290 J =!s E@ss : 6'92 mmo,/,
pH : -9' =E E..@ti : 65pCO2 : 32 mmH) O2 S!tr!si : - J
pO2 : 1 mmH) A6A#O2 : -
HCO3 : 20 mmo,/, RI : 191
E>!o>a.7$og.a%$4 '1;11;2/10+
2
-
7/24/2019 Full Makalah
30/64
Ksimp,!( : 6 L+H Ko(s(stris
6 E.si P,r! Si(istr!
6 %()si sisto,i d! (tri, 4!i; L+E% *5J
6 #is.()si di!sto,i 4r!t 7rstriti.
6 G,o4!, (ormoi(ti
6 $R mi,d6modr!t
E : Pro4,m 39 CH% N&HA II d()!( dm! p,mo !t 7pr4!i!(
CH% B!() didrit! dis4!4!( !r(! "iprt(si ,!m!; di4ti!( d!ri
@"o@!rdio)r!.i B!() m((
6 IS#N 7I+ @o(ti(osIS#N 5 m)/8
6 C!ptopri, 12;5 m)/8
6 Spiro(o,!to( 100 m)/2'
E : K!d!!( p!si( mm4!i; d!( )!)!,
30
-
7/24/2019 Full Makalah
31/64
P.ol*) 0&Mixed type AIHA
S : 6
O : $!t! : o(
-
7/24/2019 Full Makalah
32/64
6 Si,ospori( 50 m)/12
6 As!m .o,!t '00 m@)/8
$ : K,i(is !(mi!; d!r!" rti(
E : P!si( !!( di,!!( tr!(s.si; d!( pr, dipr"!ti!( m()i(!( tr
r!si tr!(s.si sprti !,r)i; dm!m; sBo
P.ol*) 6& E.$#.o7*.)a 7*ngan V$#$l$go
St!ts #rm!to,o)is : Lo!si 1 : s,r" t4"
UKK : rosis
Lo!si 2 : ,()!(; t!()!(; t()!i; !i
UKK : m!,! "ipopi)m(t!si; rst!
Lo!si 3 : 4oo()
UKK : ,s; d!s!r pidrmis; 4rsi"
R9 m!(s dtr! : s,,i() 7?; "iprmis 7?; tr!4! "!()!t; .,t!si 7?; (Bri t!( 7?
E :6 +iti,i)o d()!( Eritrodrm! 7pr4!i!(
6 U,s d4its R9 G,t! dr!
- A4ss R9 $!(s dtr!P.ol*) 2/
32
-
7/24/2019 Full Makalah
33/64
P :
# : P()@!t!( ps; ,tr ps
R : 6 $tB,prd(iso,o( 1* m) 71 0 1 stop
6 Ci(d!mi@i( 300 m)/8
6 Ur! @r!m 10J o,s/12
6 Komprs N!C, 09J/12
6 I(sisi dr!i(!s !4ss
6 %isiotr!pi
$ : E.,ors(si ,it ti!p "!ri
E : $(
-
7/24/2019 Full Makalah
34/64
A(!,isis C!ir!( P,r! :
Ca$.an Pl*(.a S*.()
LDH *51 U/,
8a.na (i(); E..si B!() tr
P :
# : 6
3'
-
7/24/2019 Full Makalah
35/64
R : 6 O2 3 LP$ 7(!s!, !(,
6 N!C, 09 J 12 tpm
6 N6!sti, sisti( 200 m)/8
6 N4,is!si d()!( %,ti@!so( propio(!t 0;5 m) ? =rom"si(
1 @@ ti!p 8
$ : KUT+/
E : A!( di,!!( pmris!!( d!"!
P.ol*) & A?o#*)$a
Mon$#o.$ng U.*() 7an C.*a#$n$n
P*)*.$"aan /;11 2/;11 26;11 R(("anU.*()
898 -0 '315 3 m)/ d,
C.*a#$n$n195 19' 191'
0;* 1;3 m)/d,
E : Aotmi! tr
Aotmi! d()!( proti(ri! m!si" m()i( !r(! (.rop!ti di!4ts
P :
# :
R :At!si p(B!it d!s!r
RL 1* tpm
$ : KUT+/8
E : =4r!p! o(disi d!p!t m(
P :
35
-
7/24/2019 Full Makalah
36/64
# : 6
R : #it str! pti" t,r
Korsi "ipo!,4mi( Q pr"it()!(
$ : C !,4mi( post orsi
E : P!si( dm!m !r(! i(.si B!() m()i( !r(! i(.si s!,r!(
(@i()
P.ol*) 10& H$ona#.*)$a
Tanggal /;11 26;11
S4 Ss! (!.!s 4i,! tidr tr,(t!(); d! !i4()!; 4!t 76 Ss! 76; ,m!s 7?
O4 P*)*.$"aa
n/;11 26;11
R(("an
Na#.$() 13' 12* 13* 1'5 mmo,/
L
Kal$() '95 '9*3;5 5;1 mmo,/ L
C!lo.$7a - 58 10- mmo,/ L
A4
Hipo(!trmi!
P4
#: N!trim ri(
R:
At!si p(B!it d!s!r 7CH% N!C, @!ps 500 m)/8
N!C, 09J 12 tpm
$: E,tro,it/mi()) =!,!(@ @!ir!(/2'
E: $i(m @p
TANGGAL 1 No*)*. 2/10
P.ol*) 16& P$(.$a - !*)a#(.$a
S : p!si( dm!m; m())i)i,
3*
-
7/24/2019 Full Makalah
37/64
O : K!d!!( mm : s!it 4r!t; ),is!"
Ks!d!r!( : omposm(tis
T!(!( #!r!" : 1*0/80 mmH) 74r4!ri()
N!di : 8* /m(it 7r),r; !t !()!t
S" : 389-0C
RR : 22 /m(it 7tid! ssm!,
SpO2 : -J 7(!s!, !(,
P,mo dp!( d!( 4,!!(): 6 rdp di d! 4!s!, p!r
6 sti())i SIC + 4!!" : R=H ?/?
H!si, K,tr Uri(
Km!( : E(tro@o@@s .!@!,is; S(siti. tr"!d!p : Ampi@i,i(6s,4!@t!m
Pipr!@i,i(6t!o4!@t!m
E : %4ris At d!p!t di!i4!t!( !r(! I(.si S!,r!( Kmi"
Km()i(!( ,!i( !d!,!" !r(! d"idr!si
P :
# : 6
R : 6 O2 3 LP$ 7(!s!, !(,
6 N!C, 09 J 200 @@ )Br di,!(6 P!r!@t!mo, 500 m)/8
6 G!(ti #C ti!p 5 "!ri
$ : KUT+/*
N!di : -* /m(it 7r),r; !t !()!t
S" : 3*9-0C
RR : 1* /m(it 7tid! ssm!,
3-
-
7/24/2019 Full Makalah
38/64
SpO2 : J
P,mo dp!( d!( 4,!!(): S# si,r ?/? s!r! t!m4!"!( 6/6
/1 D**)*. 2/10 '*.a3a#an !a.$ "*-@+
/@ D**)*. 2/10 '*.a3a#an !a.$ "*-01+
E : 19 Tiroiditis H!s"imoto
29 #$ Tip 1
38
-
7/24/2019 Full Makalah
39/64
##/ LA#A
39 CH% N&HA II
'9 Hiprt(si st!) 1
59 AIHA
*9 +iti,i)o
89 Hmip!rs dtr! @ SNH
119 #is,ipidmi!
P :
# : 6
R : 6 Lot"Broi( 200 m@)/2'
6 I(s,i( !(!,o) !sp!rt * * * (it 7SC s4,m m!!(
6 I(s,i( !(!,o) ),!r)i( 10 (it 7SC s4,m tidr
6 C!ptopri, 12;5 m)/8
6 IS#N 5 m)/8
6 Spiro(o,!to( 50 m)/2'
6 Sim!st!ti( 10 m)/8
6 As!m .o,!t 1 m)/2'
6 Si,ospori( 50 m)/12
$ : 1 4,!(/s!!t o(tro,; @ : 6 %T' d!( TSHs 1 4,!( ,!)i
6 #!r!" rti(
6 Pro.i, ,ipid
E : m(
o(tro, di dotr spsi!,is p(B!it d!,!m
KUN
-
7/24/2019 Full Makalah
40/64
R()a! #a)a" 7*an
S*)*n#a.a a$*n #$7(. 7$ .(ang "*l(a.ga aga. l*$! )(7a! 7$*ng("
'0
-
7/24/2019 Full Makalah
41/64
VIII& PEM9AHASAN
Sor!() ,!i6,!i *2 t!"( d!t!() d()!( ,"!(ss! (!.!s; 4rt!m4!" 4r!t 4i,!
4r
4r@!64r@! pti"9 P!si( mmi,ii ri!B!t stro; p(drit! di!4ts dit!"i s
,!,; "iprt(si; d!( pr(!" opr!si .ist, di d!r!" ),t! sit!r 4,!( ,!,9
#!ri sor psio,o)i d!( .()si; did!p!t!( dprsi ri()!(; )!())!( o)(iti. sd!();
p!si( tr)o,o() .r!i, d()!( AKS %9 P!d! pmris!!( .isi did!p!t!( !d!!( mm s!it
sd!(); d()!( 4!d!( t!mp! mm4()!; 4r!t 4!d!( tr)o,o() ori)"t; o(+P m(i()!t; d()!( ro(i 4!s!" "!,s
di d! 4!s!, p!r9
#!ri "!si, sor m(rt =i,,i@; sor "ipotiroid did!p!t!( (i,!i 3'; B!()
m()i(di!si!( ,i(is "ipotiroid9 P!si( ,!, di,!!( pmris!!( .()si tiroid; d!(
did!p!t!( p(i()!t!( TSHs 7539* IU/mL d!( p(r(!( ti()!t %T' 71900 pmo,/L9
S"i())! did!p!t!( simp,!( p!si( m(drit! "ipotiroid9
=r4!)!i p(B4!4 d!ri "ipotiroid 1
'1
-
7/24/2019 Full Makalah
42/64
P.$)a.5 !5o#!5.o$7$)
C"ro(i@ !toimm( t"Broiditis
I!tro)(i@
T"Broid@tomB
R!dioiodi( t"r!pB or tr(!, irr!di!tio(
Iodi( d.i@i(@B or @ss#r)s 6 t"io(!mids; ,it"im; !miod!ro(; i(tr.ro(6!,.!; i(tr,i(62; pr@",or!t; tBrosi(
i(!s i("i4itors
I(.i,tr!ti dis!ss 6 .i4ros t"Broiditis; "mo@"rom!tosis; s!r@oidosis
Tr!(si(t "Bpot"Broidism
P!i(,ss 7si,(t; ,Bmp"o@Bti@ t"Broiditis
S4!@t )r!(,om!tos t"Broiditis
Postp!rtm t"Broiditis
S4tot!, t"Broid@tomB
%o,,oi() r!dioiodi( t"r!pB .or Gr!s "Bprt"Broidism
%o,,oi() it"dr!!, o. spprssi doss o. t"Broid "ormo( i( t"Broid p!ti(tsCo()(it!, t"Broid !)(sis; dBs)(sis; or d.@ts i( "ormo( sB(t"sis
C*n#.al !5o#!5.o$7$)
TSH d.i@i(@B
TRH d.i@i(@B
G*n*.al$?*7 #!5.o$7 !o.)on* .*$#an>*
P!d! p!si( i(i; d()!( tid! !d! ri!B!t s!it tiroid d!( tr!pi "iprtiroid s4,m(B!;
srt! p(B4!4 !r(! tr!pi; i!tro)(i !r(! opr!si tiroid; d!p!t disi()ir!(9 P())(!!(
o4!t6o4!t!( sprti B!() dis4t!(
pmris!!( !(ti6TPO 7T"Broid Proid!s; d!( "!si,(B! positi.9 P!si( di(B!t!!( s!it
"ipotiroid !i4!t !toim(; B!() dis4t Tioiditis H!s"imoto9 Tiroiditis H!s"imoto mrp!!(
p(B4!4 "ipotiroidism primr !i4!t tr
A,)oritm! 19 E!,!si Hipotiroism3
'2
-
7/24/2019 Full Makalah
43/64
#is.()si ,(
d()!( mor4idit!s B!() si)(i.i!( d!( tid! dit!()!(i9 Hipotiroidism tr
prmp!( d!( 2J ,!i6,!i p!d! p!si( B!() ,4i" t! d!ri *0 t!"(9G
p!d! or!() ,!(
K!r!tristi p!to,o)i p!d! p!si( "ipotiroidism !d!,!"dm! non pitting msi(os! 7misdm! B!() tr
,!i( di
dors!, d!( !i; srt! .os! spr!,!i,!r9 Srsi ,(
'3
-
7/24/2019 Full Makalah
44/64
ri() d!( !s!r9 R!m4t p!,! d!( t4" tr!4! ri(); r!p"; tid! m()i,!t; srrt! md!"
ro(to92
A,ir!( d!r!" )i(
.r!si .i,tr!si 4i!s!(B! (orm!,9 Esrsi @!ir!( m,!,i ri( 4rr!(); !r(! 4rr!()(B!
@!ir!( 4!)i!( dist!, (.ro( s4!)!i !i4!t 4rr!()(B! pr.si )i(
p!d! "ipotiroidism; !!( tt!pi (!trim tot!, t4" m(i()!t d!( s4!)i!( 4s!r tri!t d()!(
mopo,is!!rid! str!s,,r9 Pr4!"!( p!d! )i(
o(stip!si9 $sip( (!.s m!!( p!si( 4rr!(); (!m( 4r!t 4d!( 4rt!m4!" !r(!
rt(si @!ir!( o," dposit ),ioproti( "idro.i,i92
Hipotiroidism m(B4!4!( r(d!"(B! mt!4o,i 4!s!, s"i())! tr
p(),!r!( (r)i 4!s!,; o(smsi osi)( d!( p())(!!( s4str!t9 P(r(!( trmo)(sis
di!it!( d()!( )
tri),isrid!9 Rspo(s i(s,i( tr"!d!p ),os! tr,!m4!t o," !r(! !4sor4si di ss 4rr!()92
T
(orm!,is!si srsi TSH d!( %T'; srt! m(@)!" pro)rsi.it!s p(B!it m(
P!d! p(drit! "ipotiroidism s@!r! ,!si di4ri!( tr!pi or!, d()!( si(tti L6t"Broi(
7T'9 L6t"Broi( !!( m()o(rsi m(
mrom(d!si!( dosis B!() ,4i" r(d!" d!ri dosis 4i!s! p!d! p!si( ,!(si!; t!pi m!si" sdiit
4ti t(t!() iss i(i9*Hipotiroidism primr !r(! tiroiditis !toim( ro(is di!it!( d()!(
i(s.isi(si !dr(oorti!, primr !i4!t !dr(!,itis !toim(9 Tr!pi p!d! p!si( "ipotiroidism
d()!( d.isi(si ),ioortioid d!p!t mmi@ risis !dr(!, !r( !dr(!, tid! m!mp
m(i()!t!( 4t"!( ortiso, B!() dis4!4!( !r(! m(i()!t(B! mt!4o,ism9 P!si(
d()!( )!!t!( om! misdm!; di4ri!( "idroortiso( 2006'00 m) pr "!ri (t
m()!t!si "ipoortiso,mi!9-
P!si( B!() dio4!ti d()!( T' 4i!s!(B! m,!i mm4!i d!,!m d! mi()); t!pi
pm,i"!( ,()!p d!p!t tr
-
7/24/2019 Full Makalah
45/64
$sip( )
m(i()!t prt!m!; d!( mdi!( srsi TSH m,!i
)!())!( .()si di!sto,i B!() m()i(di!si!( 4!"! p(B4!4 )!)!,
"iprt(si9 T!r)t or)!( t!m! d!ri omp,i!si "iprt(si ro(is !d!,!"
@r4ro!s,!r; !ort! d!( sistm pri.r !s,!r; )i(
"iprt(si B!it p(i()!t!( !.tr,o!d dim!(!
di(di() (tri, iri; B!() !!( 4romp(s!si m(
tr
p(i()!t!( rsist(si !s,!r9 $sip( m!(ism prsis(B! m!si" 4,m m((
-
7/24/2019 Full Makalah
46/64
d!( p(r(!( mod,!si p!r!simp!tis
dtrmi(!( o(tr!ti,it!s sisto,i !d!,!" @p!t!( m!simm d!ri pm(d!( sr!4t otot;
dim!(! 4r"4()!( d()!( !tiit!s mo,, miosi(9 Trd!p!t d! miosi( r!(t!i 4r!t 7$Bosi(
H!B C"!i($HC B!(i $HCd!( $HC9 T3 did!p!t!( mr!()s!() sprsi )( $HC
(!m( m(r(!( sprsi )( $HC9 P!d! m!(si!; p()!r" T3 tr"!d!p sprsi $HC
,4i" m(o(
)( pomp! !,sim di rti,m s!rop,!sm! 4rsi.!t rspo(si. tr"!d!p T3913;1'
P!d! p!si( d()!( "ipotiroidism; trd!p!t p(r(!( @r!"
4rr!()(B! d(Bt
i(otropi d!( ro(otropi "ormo( tiroid9 H!, i(i t(t d!p!t mmpr4r o(disi )!)!,
p!d! p!si(9 P!d! "ipotiroidism B!() ,!(s!!t !!( di,!!( tr!(s.si; tr(B!t! "!si,(B! I(omp!ti4, $!Bor/$i(or9 L!()!" s,!(
-
7/24/2019 Full Makalah
47/64
7p!,i() sri() I)$;
s, d!r!" B!() m()!i4!t!( !),ti(!si s, d!r!" mr!" p!d! s" r(d!"915A(mi! "mo,iti
!toim( 7AIHA !r(! !d!(B! %arm agglutinin "!mpir s,!, dis4!4!( o," !d!(B!
!(ti4odi I)G B!() 4r!si d()!( !(ti)( proti( p!d! s, d!r!" mr!" 7R=C prm!!( p!d!
s" t4"9 U(t !,!s!( i(i; mr! dis4t %arm agglutininmsip( mr!
m())mp!,!( s, d!r!" mr!"91-;18K!d!()6!d!(); p!si( m()i( mmi,ii tip @!mpr!(
!(ti4odi di()i( d!( "!()!t; B!() s!()!t m())!()) ,i(is !r(! mr! 4i!s!(B!
m(B4!4!( rs!!( R=C p!r!" d!( sri() mmi,ii rspo( B!() 4r tr"!d!p tr!pi915
T!4, 29 K,!si.i!si AIHA1'
'-
-
7/24/2019 Full Makalah
48/64
P!d! p!si( i(i trd!p!t tip @!mpr!( !),ti(!si %arm d!( cold9 =4r!p! p!si(
d()!( tip "!()!t AIHA
-
7/24/2019 Full Makalah
49/64
S!,!" s!t is B!() s,it !d!,!" !t tr!(s.si9 P!si( d()!( AIHA !r(! 4rsio
tr
mr! d()!( p(B!it
m()i( pr, m(B!ri() !,,o!(ti4odis (t 44r!p! !t; i(i ,4i" 4!i (t tr!(s.si
p!si( d()!( !(mi! 4r!t d!( di!m!ti s@!r! "!ti6"!ti918G,oortioid !d!,!" tr!pi !!,
pi,i"!( (t "!()!t AIHA; 4i!s!(B! p!d! rt!( 1;061;5 m)/)/ "!ri prd(iso( !t! st!r!9
#osis "!ri!( B!() ,4i" ti())i !t! tr!pipulse high dosem()i( dipr,!(9 Rspo( m()i(
4,m tr,i"!t s,!m! 3 ' "!ri t!pi "!rs tr,i"!t p!d! - "!ri9 >m,!" rti,osit d!p!t
m(i()!t; d!( "mo),o4i( "!rs (!i 2 3 )/ d, pr mi())9 St,!" "mo),o4i( m(@!p!i 10
)/d,; tapperingd!ri stroid d!p!t dim,!i9 Si,ospori( A t,!" d!p!t 4r"!si,; t!pi 4is!
7LA#A; m()i()!t p!d! p(B!it p!si( i(i trd!p!t 4!(B! m!(i.st!si d!ri !toim(9 LA#A
!d!,!" 4(t pro)rsi. ,!m4!t d!ri di!4ts m,,its !toim( B!() dit!(d!i d()!( si! B!()
,4i" t! p!d! s!!t di!)(osis; !d!(B! !to!(ti4odi p!(r!s; d!( 4rr!()(B! i(s,i( !4so,t
p!d! s!!t di!)(osis9 $sip( p!si( d()!( LA#A mmi,iim!mp!( mmprt!"!(!(
'
-
7/24/2019 Full Makalah
50/64
.()si s, 4t! di4!(di()!( di!4ts tip 1; LA#A @(dr() mmi,ii pro)rsi.it!s rs!!(
.()si s, 4t! B!() @p!t d!( 4r s"i())! mmr,!( i(tr(si i(s,i( i(t(si.91
Ta*l @&C,i(i@!, %!trs o. TBp 2 #i!4ts; TBp 1 #i!4ts; !(d L!t(t Atoimm( #i!4ts
o. Ad,t"ood
FEATURES TYPE 2 DIABETES TYPE 1 DIABETES
[CORRECTED]
LATENT
AUTOIMMUNE
DIABETES IN
ADULTS
[CORRECTED]
Kto!@idosis Us!,,B !4s(t Di,, d,op r!pid,B (,ssp!ti(t r@is i(s,i(
rp,!@m(t t"r!pB
A4s(t !tdi!)(osis; 4t m!B
4 prs(t "(
p!ti(t 4@oms
sr,Bi(s,i(op(i@
C!rdio!s@,!r@omp,i@!tio(s
Ris 2' tims "i)"rt"!( i(diid!,s "o !r
),B@mi@
I(@r!sd ris o.@!rdio!s@,!r mor4iditB
!(d mort!,itB r,!td to
stros; !@t @oro(!rB(ts; !(d @oro(!rB
r!s@,!ri!tio(s "i)"
i(@id(@ r!ts @omp!rdit" ),B@mi@
i(diid!,s; sp@i!,,B i(om(
S!m ris !sp!ti(ts it"
T2#$
$i@ro!s@,!r
@omp,i@!tio(s
7rti(op!t"B;
(p"rop!t"B;(rop!t"B
I(@r!sd I(@r!sd I(@r!sd
P!t"op"Bsio,o)B Prip"r!, i(s,i(rsist!(@ rd@d
p!(@r!ti@ 4t!6@,, m!ss
!(d .(@tio( rd@di(s,i( s@rtio(
Atoimm( dstr@tio( o.p!(@r!ti@ 4t!6@,,s
L!t(t!toimm(
dstr@tio( o.
p!(@r!ti@ 4t!6@,,s
Ato!(ti4odis N)!ti GA#6*5
!to!(ti4odis
GA#6*5
!to!(ti4odB is
50
http://www.aafp.org/afp/2013/0301/p310http://www.aafp.org/afp/2013/0301/p310 -
7/24/2019 Full Makalah
51/64
FEATURES TYPE 2 DIABETES TYPE 1 DIABETES
[CORRECTED]
LATENT
AUTOIMMUNE
DIABETES IN
ADULTS
[CORRECTED]
Is,t6@,, !(ti)(62
I(s,i(
!to!(ti4odis
NOTE: U(,i
LA#A; T1#$ p!ti(tstBpi@!,,B !r positi .or !,,
t"r !to!(ti4odis
tBpi@!,,B t" o(,Bo( dt@td
Is,t6@,,
!(ti4odis
I(s,i(
rirm(ts .or
tr!tm(t
Us!,,B ,!t i( t" dis!s
"( t" rm!i(i() 4t!6
@,, m!ss !(d .(@tio( @!((o ,o()r spport!@@pt!4, ),B@mi@
@o(tro, !@"id 4B or!,
!)(ts or i(@rti(mimti@s
I(s,i( is rird .rom t"
tim o. di!)(osis
I(s,i( s"o,d 4
i(iti!td !s soo( !s
t" p!ti(td,ops!to!(ti4odis
DM indicates type diabetes mellitus* +AD-, indicates glutamic acid decarboylase* LADAindicates latent autoimmune diabetes in adults* .DM indicates type . diabetes mellitus9
#eprinted %ith permission !rom /nger 01 Diagnosing and managing latent autoimmune diabetes in
adults9 Pr!@ti@!, #i!4to,o)B9 223*.(.)455
Tid! sprti #i!4ts tip 2; LA#A @(dr() m(
or!, d!( !)( p!r(tr!,9 Ad!(B! !to!(ti4odi tr"!d!p !(ti)( p!(r!ti is,t @,, B!()
mrp!!( ,m( B!() B!() mm(B! trd!p!t p!d! LA#A d!( di!4ts tip 19 Sit!r 10
30 prs( or!() d!s! d()!( di!4ts tip 2 ts positi. (t !to!(ti4odi; tr)!(t() p!d!
si! d!( t(is d!ri psrt! d!,!m ,ompo stdi; d!( 4rpot(si LA#A9 #i I())ris;Prospecti"e
Diabetes $tudB; !(ti4odi !s!m ),t!m!t d!r4osi,!s ditm!( p!d! 10 prs( d!ri 59000
p!si( d()!( di!4ts tip 29 Pr!,(si !(ti4odi ),t!m!t d!r4osi,!s !s!m ,4i" ti())i
p!d! p!si( B!() ,4i" md! 3' prs( p!si( 25 s!mp!i 3' t!"( B!() positi. (t !(ti4odi9
P!si( d()!( LA#A 4i!s!(B! positi. (t s!t !to!(ti4odi; sd!()!( or!()6or!() d()!(
di!4ts tip 1 sri() mmi,ii mi(im!, d! !to!(ti4odi trdtsi p!d! di!)(osis91
#!,!m !(!,isis )(otip; LA#A mmi,ii .itr )(ti d!ri d! di!4ts tip 1 d!( tip
29 S4!)!i @o(to"; d!,!m s!t !(!,isis; p!si( d()!( LA#A mmi,ii p(i()!t!( rsio p!d!
)(otip HLA6#=1 s!m! d()!( p!si( d()!( di!4ts tip 1 d!( (t !ri!( d!,!m .!tor
51
http://www.aafp.org/afp/2013/0301/p310http://www.aafp.org/afp/2013/0301/p310 -
7/24/2019 Full Makalah
52/64
tr!(sripsi -6sprti 2 7TC%-L2 )( d()!( p!si( d()!( tip 2 di!4ts9 +!ri!( di TC%-L2
t,!" tr4ti m(i()!t!( risio di!4ts tip 2 p!d! 44r!p! pop,!si; d!( r!( . s!m!
(t LA#A d!( di!4ts tip 29 #()!( dmii!(; LA#A t!mp!(B! 4r!d! di sptrm
r!()!( i(s,i( !(t!r! tip 1 d!( di!4ts tip 2920
$sip( p!to)(sis B!() tp!t d!ri LA#A 4,m
-
7/24/2019 Full Makalah
53/64
s() tr!(sportr (T8 d!,!m srm m()i( 4r)(! d()!( !d!(B! d.isi(si i(s,i( ,()!p; d!( it 4!( mrp!!( .itr "!s di!4ts tip 2;
44r!p! p!si( d()!( di!4ts tip 2 4rm4!() KA# d!,!m !d!!( trt(t 7i(.si
4i!s!(B! p!r!" !t! p(B!it ,!i( 9#()!( dmii!(; to!sidosis tid! 4is! di!(d!,!( s4!)!i
i(di!si mt,! 4!"! p!si( mmi,ii di!4ts 1 !t! 4!"! tr!pi i(s,i(
di4t"!(920
Pmris!!( !to!(ti4odi di4t"!( s!!t di!)(osis di!4ts tip 1 !t! tip 2 tid!
-
7/24/2019 Full Makalah
54/64
"ipo),imi or!, 9 S,!i( it; p!d! t!"!p !!, d!,!m pr
i(t(si. mmprp!(
P!si( i(i i(s,i( !4so,t di mdi!( "!ri922 A(ti GA# !d!,!" !to!(ti)( p!d! p!si( #$ tip 19
S(sitiit!s d!ri !(ti GA# p!d! #$ tip 1 !d!,!" 82J d!( spsi.isit!s 100J9 A(ti GA# positi.
s4,m 10 t!"( tr
-
7/24/2019 Full Makalah
55/64
di!4ts m,,its s!r!() p(B4!4 t!m! 4t!!( p!d! or!() 4!r 206-' t!"( d!( p(B4!4
t!m! st!dim !"ir p(B!it )i(
+iti,i)o mrp!!( p(B!it dpi)m(t!si ,it B!() did!p!t d!( tr
p(dd d(i!9 P(B!it i(i dis4!4!( !i4!t pross !toim( B!() m()(!i m,!(osit9
P!to)(sis P(B4!4 d!ri iti,i)o tid! dit!"i s@!r! p!sti9 %!tor )(ti 4i!s!(B!
mm!i(!( pr!( @p 4s!r 20630J p!si( mmp(B!i ri!B!t ,!r)! d()!( p(B!it
i(i92*P!to)(sis(B! m,i4!t!( pross !toim( p!d! m,!(osit9 =ti d!ri tori i(i !d!,!"
p!d! pmris!!( "isto,o)is tid! did!p!t!( !d!(B! m,!(osit p!d! ,it B!() tr(!9 Pross
!toim( i(i Im(it!s s,,r =ti tr,i4!t!( im(it!s s,,r d!,!m p!to)(sis iti,i)o !(t!r! ,!i(
tr
sitotosi disit!r m,!(osit B!() m()"i,!()9 $,!(osit spsi.i B!() 4rsir,!si;
sitotosi C#8? ,im.osit T ditm!( p!d! d!r!" tpi p!si( d()!( iti,i)o; (!m(
tid! dp!t dip!sti!( !p!!" s, T i(i 4r"4()!( d()!(B!() ditm!( p!d! ,it928
Im(it!s "mor!, $,tip, !(ti4odi tr"!d!p !(ti)( m,!(osit trm!s tirosi(!s;
tirosi(!s r,!td proti( 1 d!( 2; Pm,1-; SO tr!(s@riptio( .!@tors; d!( m,!(i(6
@(@tr!ti() "ormo( r@ptor 1 7$CHR1 ditm!( p!d! p!si( p!si( d()!(
iti,i)o928
Sitoi( Sitoi( mm!i(!( pr!( p(ti() d!,!m p!to)(sis iti,i)o9 Co(to" 44r!p!
sitoi( B!() !4(orm!, ditm!( p!d! p!si( iti,i)o !(t!r! ,!i(:
W I(tr,i( 7IL6* 7I("i4itor pro,i.r!si m,!(osit; i(tr.ro( 7I%N6)!mm! 7i(isi!tor
!poptosis; d!( tmor (@rosis .!@tor 7TN%6!,p"! 7i("i4itor pro,i.r!si m,!(osit
d!( i(isi!tor !poptosis m(i()!t p!d! ,it iti,i)o di4!(di() d()!( ,it
(orm!,928
W Esprsi )r!(,o@Bt6mo(o@Bt @o,o(B stim,!ti() .!@tor 7G$6CS%; stm @,,
.!@tor 7SC%; d!( 4!si@ .i4ro4,!sti@ )rot" .!@tor 74%G%; B!() 4rpr!( d!,!m
stim,!si s, pi)m(; did!p!t!( r(d!" p!d! ,it iti,i)o di4!(di() ,it (orm!,928
55
-
7/24/2019 Full Makalah
56/64
W $(r((B! !d!r tr!(s.ormi() )rot" .!@tor 7TG%64t! did!p!t!( p!d! p!si(
d()!( iti,i)o9 H!, i(i 4r"4()!( d()!( p(i()!t!( C#8? ,im.osit d!(
p(r(!( m!tr!si s, T r),!tor B!() m())!()) i("i4isi i(.,!m!si p!d!
iti,i)o928
+iti,i)o did!p!t!( 4r"4()!( d()!( p(B!it !toim(9 %r(si tr
m(i()!t p!d! p(B!it !toim( sprti p(B!it tiroid !toim(; !(mi! pr(isios!; SLE;
d!( p(B!it Addiso(9 +iti,i)o mrp!!( s!,!" s!t ompo(( d!ri po,B),!(d,!r !toimm(
sB(drom tip II; B!() mmp(B!i !r!tristi !d!(B! p(B!it tiroid !toim( 74i!s!(B!
!toim( tiroiditis ro(i !t! p(B!it Gr!sX; #$ tip 1; i(s.isi(si !dr(!, primr; d!(
"ipopitit!ri9
$(@,(B! p(B!it !toim( p!d! p!si( i(i m(@, s!!t si! t!9 Usi! mrp!!(
.!tor rsio B!() p(ti() tr
p!d! si! p!r" 4!B! !t!s st,!" !d!!( im(oompt( m!i( ,!m! m!i( 4rr!() d!(
pm4(t!( s, T 4rr!()9 P(B!it !toim( tr
tr"!d!p s,.6!(ti)( tr
m(B4!4!( pr4!"!( s, T pri.r s"i())! tr
r@ptor i@io( @ir@, 7TREC s, positi. mrp!!( d!s!r d!ri !tiit!s timi9 S4r!p! ,!m!
TREC d!p!t 4rt!"!( p!d! sor!() i(diid tid! d!p!t dit!"i9 %r(si d!ri TREC s@!r!
4rt!"!p tr( s!mp!i m!sim!, p!d! si! *0!( B!() m((
di!4ts m,its p!d! tis pr@o4!!(9 H!, i(i did!p!t!( d!ri pross sp!(si "omost!ti
B!() 4rd!s!r!( p!d! IL621 p!d! s, T spsi.i is,t9 C!,!s@i! t !, m((
-
7/24/2019 Full Makalah
57/64
C#' T s,.6r!@ti 4t! is,t tid!,!" @p d!( pro,i.r!si "omost!ti@ 4rd!s!r!( IL6-
d!p!t m(@ts!( #$9
S,r" "!, i(i !"ir(B! mmi@ tr4(t(B! s, T .tor end-di!!erentiated; s, i(i
d!p!t m(mp p!d!
di..r(ti!td mmp(B!i moi( d!( "omi() r@ptor pro.i, B!() d!p!t m(B4!4!(
i(.i,tr!si
H4()!( !(t!r! dis,ipidmi!; "ipotiroid; d!( p(B!it
s4!)!i 4rit:30
W Tip II! 7Hipro,stro,mi! 5* prs(
W Tip II4 7Hipro,stro,mi! d!( "iprtri),isridmi! 3' prs(
W Tip I+ 7Hiprtri),isridmi! 195 prs(
W Tid! !d! ,!i(!( 895 prs(
P(B4!4 t!m! d!ri "!, i(i dis4!4!( !r(! !m,!si L#L !i4!t p(r(!( "ipotiroid932
E. tr!pi T' p!d! p!si( "ipotiroid d()!( dis,ipidmi! @p 4!i9 P!d! !(!,isis d!ri
1 stdi B!() trp4,i!si did!p!t!( p!si( d()!( !d!r o,stro, !!, s4,m tr!pi T' 310
m)/dL d!( rr!t! p(r(!( st,!" ditr!pi !d!,!" '* m)/dL; sd!()!( mr! B!()
mmp(B!i !d!r o,stro, !!, ,4i" d!ri 310 m)/dL mmp(B!i rr!t! p(r(!( B!()
t,!" di,!por!( p!d! p!si( d()!( om! mBdm! d!( "ipotiroidism 4r!t B!() tid!
dio4!ti9Hipotiroidism; i(s.isi(si !dr(!,; si(drom inappropriate "ormo( !(tidirti
7SIA#H; d!( po,idipsi! primr; di)o,o()!( d!( m!s d!,!mdi!)(osis di.r(si!, d!ri
"ipo(!trmi! o,mi9 L!por!( m(B!t!!( 4!"! p!to)(sis Y"ipo(!trmi! "ipotiroidY
5-
-
7/24/2019 Full Makalah
58/64
!d!,!" s(dr !r(! tid!m!mp!( d!,!m m()srsi!( !ir 44!s; B!() dis4!4!(
o," p(r(!( !,ir!( !ir (.ro( dist!,; srt! srsi !soprsi( ,4i"!(9 P!d! p(,iti!(
A,,o( d; m,!por!( p!si( d()!( "ipotiroid d!( p(B!it )i(
srp! d!,!m ,!
p!d! "ipotiroidism m()i( o(s(si d!ri p(r(!( tr!it di ,!
Tr!(sd!t "!si, d!ri tid!sim4!()!( d!,!m t!(!( "idrost!ti d!( o(oti; sprti p!d!
p!si( d()!( CH% d!( (p"rosis; !t! o(disi str(!, B!() m!s r!() p,r!93' P!d!
!ss i(i m()i(!( ..si !i4!t
Polyglandular autoimmune syndrome7PAS trdiri d!ri s,ompo )!())!( !toim(
d!ri ,(
-
7/24/2019 Full Makalah
59/64
T!4, -9 A4(orm!,it!s Kompo(( d!ri PAS3-
5
-
7/24/2019 Full Makalah
60/64
Atoim(it!s; .!tor ,i()()!(; d!( .!tor )(ti !d!,!" 3 .!tor t!m! B!() "!rs
diprtim4!()!( d!,!m p!to.isio,o)i PAS III9P(B!it !toim( B!() mmp()!r"i ,(
(dori( t())!, sri() diiti d()!( p(r(!( ,(
dim!(! p!si( d()!( p(B!it o,!)( !!( m(si(tsis im(o),o4,i( B!() !!( m()(!,i
t!r)t s,,r or)!( (o(6spsi.i; sprti 4,oproti( d!( !s!m (,!t9 Atoim( !!(
m(Br!() t!r)t or)!( p!d! i(diid B!() mmi,ii prdisposisi )(ti st,!" m(d!p!t
.!tor prsipit!si B!() tid! dit!"i9 Pro)rsi.it!s p(B!it 4r"4()!( d()!( rspo(
s(dr B!() m(Br!() !(ti)( B!() di"!si,!( o,"
m(B4t!( .!tor ,i()()!( m(
!toim(it!s po,i),!(d,!; sprti irs93*
PAS III; sprti PAS II; tr!it d()!( )( HLA ,!s II d()!( !,, HLA B!() t!mp!
"!s (t sti!p9 G( (o(6HLA m(d!s!ri PAS III tt!p III sri() di!m!ti p!d! i(diid d!,!m ,!r)! B!() s!m!9 HLA6#R=1Z0'/#A1Z0301/
#=1Z0302 !d!,!" HLA "!p,otBp tr!it domi(!( d()!( r(t!(!( di immune-mediated
diabetes 7I$#9 $(!ri(B!; HLA6#=1Z0*02 !,, m,i(d()i tr"!d!p I$#; 4!"!(
m(i()!t p!d!p!si( d()!( !,op@i! tot!,is93*
=4r!p! !ri!si )( tr,i"!t p!d! d! !d!!( tiroiditis !toim( d!( I$# t,!"
diid(ti.i!si o," s,r" )(om d!( p(d!t!()(9 G( B!() p!,i() p(ti() !d!,!" human
leucocyte antigen 7romosom *; sitotosi T6,im.osit tr!it !(ti)( ' 7romosom 2; proti(
tirosi( .os.!t!s
-
7/24/2019 Full Makalah
61/64
!toim( (o( (dori( ,!i((B!; d!( !(ti4odi !(titiroid sri() di!m!ti d!,!m si(drom E!(s
7osist(si AIHA d!( ITP9 Ti)! p(B!it !toim( 7AIHA; ITP; d!( tiroiditis H!s"imoto
m()i( 4r4!)i
P!d! !ss i(i; !mi tm!( 4r4!)!i p(B!it !toim(; d!(
-
7/24/2019 Full Makalah
62/64
DAFTAR PUSTAKA
19 Ross #S; Coopr #S; $,dr >E9 #isordrs t"!t @!s "Bpot"Broidism9 Do,tr K,r9 Spt
1*; 201'9 A!i,!4, o( : 9ptod!t9@om
29 Sm!, AR; L!()i &9 Hipotiroidism9 #!,!m: #tiroido,o)i ,i(i9 Sm!r!(): =!d!( P(r4it U(irsit!s #ipo()oro9 200 25 315
39 >!mso( >L; $!(d, S>; Dtm!( AP9 #isordrs o. t" t"Broid ),!(d9 I(: I(: K!spr #L;
H!sr SL; >!mso( >L; %!@i AS; Lo()o #L; Los@!,o >9; ditors9 H!rriso(s pri(@ip,s o.i(tr(!, mdi@i( 1t" ditio(9 U(itd St!t: $@Gr!6Hi,, Ed@!tio(9 2015: 2283 2308
'9 R"m!( SU; Cop #D; S(s(B A#; =ri(si D9 T"Broid disordrs i( ,dr,B p!ti(ts9
Sot" $d >9 2005875:5'365'
59 Gsi() A; Li(si A; Li(s! $K9 T" t"Broid ),!(d !(d t" pro@ss o. !)i() "!t is
( T"Broid Rs!r@" 2012; 5:1*9 A!i,!4, !t:"ttp://9t"Broidrs!r@"; =@6P@@o P; C"rosos G;
#()!( K; Grossm!( A; Hrs"m!( >$; Ko@" C; $@L!@",!( R; N $; R4!r R; Si()r %;+i(i A; Di@rt $O; ditors9 Sor@E(dott I(tr(t9 Sot" #!rtmot" 7$A:
$#Tt9@om; I(@9 20006201' $!r 28
89 Ross #S9 Tr!tm(t o. "Bpot"Broidsm9 I(: Coopr #S; $,dr >E; ditors9 Uptod!t9 Do,tr
K,r9 >!( 21; 20159 A!i,!4, !t: 9ptod!t9@om
9 !m!(i P; Di,,i!ms GH; Li,,B LS9 HBprt(sio(9 I(: Li,,B LS; ditor9 P!t"op"Bsio,o)B o.
"!rt dis!s9 't"Eds9 P"i,!d,p"i!: Lippi(@ott Di,,i!ms !(d Di,i(s9 200- 311 333
109 S"!" R+; %i.r $A9 H!rt .!i,r9 I(: Li,,B LS; ditor9 P!t"op"Bsio,o)B o. H!rt #is!s9 't"
Eds9 P"i,!d,p"i!: Lippi(@ott Di,,i!ms !(d Di,i(s9 200- 225 251
119 K,i( I; #!(i S9 T"Broid dis!ss !(d t" "!rt9 Cir@,!tio( 200-11*1-25635
129 =io(di =; P!,miri EA; Lom4!rdi G; %!io S9 E..@ts o. t"Broid "ormo( o( @!rdi!@.(@tio(: t" r,!ti import!(@ o. "!rt r!t; ,o!di() @o(ditio(s; !(d mBo@!rdi!,
*2
http://www.uptodate.com/http://www.thyroidresearchjournal.com/content/5/1/16http://www.uptodate.com/http://www.thyroidresearchjournal.com/content/5/1/16 -
7/24/2019 Full Makalah
63/64
@o(tr!@ti,itB i( t" r),!tio( o. @!rdi!@ pr.orm!(@ i( "m!( "Bprt"Broidism9 > C,i(
E(do@ri(o, $t!49 2002; 8-73:*8-
139 "!() &; Post DS; C"() A; =,!s@o CE; Tom!s,,i G%; t !,9 T"Broid "ormo(s !(d,@tro@!rdio)r!p"i@ p!r!mtrs: .i(di()s .rom t" t"ird (!tio(!, "!,t" !(d (tritio(
!mi(!tio( srB9 P,os O(9 201387':16-
1'9 K,i( I; O
1*9 G"rs =C; %rid4r) RC9 Atoimm( "mo,Bti@ !(mi!9 Am > Hm!to, 2002 *:2589
1-9 Pt L#9 Tr!tm(t o. !toimm( "mo,Bti@ !(mi!s9 Crr Opi( Hm!to, 2001 8:'119
189 #Lo)"rB TG9 Atoimm( "mo,Bti@ !(mi!9 I(: Lit@"o.si R; ditor9 Hospit!,
P"Bsi@i!( Hm!to,o)B =o!rdRi $!(!,9 2013 871
19 U()r >9 L!t(t !toimm( di!4ts i( !d,ts9 Am Fam Physician12010 Apr 1817-:8'36
8'-
209 $@C,,o@" #K9 C,!ssi.i@!tio( o. di!4ts m,,its !(d )(ti@ di!4ti@ sB(droms9 I(:
N!t"!( #$; Do,.sdor. >I; ditors9 Uptod!t9 Do,tr K,r9 O@t 0*; 201'9 A!i,!4, !t:9ptod!t9@om
219 Eis(4!rt" GS; Po,o(sB KS; =s >=9 TBp 1 di!4ts m,,its9 I(: L!rs( PR; Kro((4r)
H$; $,md S; Po,o(sB KS; ditors9 L!rs(: Di,,i!ms Tt4oo o. E(do@ri(o,o)B; 10t"
d9P((sB,!(i!: A( Impri(t o. E,sir S@i(@9 2003
229 >o(s AG; H!ttrs,B AT9 T" @,i(i@!, ti,itB o. C6pptid m!srm(t i( t" @!r o.
p!ti(ts it" di!4ts9 #i!4ti@ $di@i(9 2013 80361-239 Tomi,"to >; immt P; $!@!B IR; Kos,! P; +id)r( Gt !,9 A(ti4odis to ),t!mi@ !@id
d@!r4oB,!s !s prdi@tors o. i(s,i(6dp(d(t di!4ts m,,its 4.or @,i(i@!, o(st o.
dis!s9 L!(@t9 1' >( ' 3'37810: 138365
2'9 %!r"!( >; A,)"!s"!m A; !.!r U; $i AR$A; R!s"d 9 Imp!@t o. !(ti6),t!mi@ !@idd@!r4oB,!s6*5; !(ti i(s,i( !(d !(ti6tBrosi( p"osp"!t !to!(ti4odis o( dis!s !@tiitB
i( tBp 1 di!4ts p!ti(ts9 >or(!, o. #i!4ts Rs!r@" M C,i(i@!, $t!4o,ism9 2013 168
259 =ro(, $;Ai,,o LP; %ridm!( E; +i(i AI; Nsto RD; =o,to( A>$9 Comp,i@!tio(s o.
di!4ts m,,its9 I(: I(: L!rs( PR; Kro((4r) H$; $,md S; Po,o(sB KS; ditors9L!rs(: Di,,i!ms tt4oo o. (do@ri(o,o)B; 10t" d9P((sB,!(i!: A( Impri(t o. E,sir
S@i(@9 2003
2*9 H!(d! S; K!r I9 +iti,i)o: @,i(i@!, .i(di()s i( 1'3* p!ti(ts9 > #rm!to, 1 2*:*53
2-9 +!( d( Di
-
7/24/2019 Full Makalah
64/64
29 Goro(B >>; DB!(d C$9 Imm( !)i() !(d !toimm(itB9 C,,9 $o,9 Li. S@i9 20129
*:1*151*23
309 O=ri( T; #i((( S%; O=ri( PC; P!,m4o P>9 HBpr,ipidmi! i( p!ti(ts it" prim!rB!(d s@o(d!rB "Bpot"Broidism9 $!Bo C,i( Pro@ 13 *8:8*0
319 Hoo)r4r)) N; >!(s( H; St!,s =; t !,9 Grot" "ormo( (orm!,is ,o6d(sitB,ipoproti( r@ptor )( prssio( i( "Bpot"Broid r!ts9 $t!4o,ism 1* '5:*80
329 Lit",, H; =o4r) >; H,,si() K; t !,9 Srm ,ipoproti( !(d !po,ipoproti( @o(@(tr!tio(s
!(d tiss ,ipoproti(6,ip!s !@tiitB i( ort !(d s4@,i(i@!, "Bpot"Broidism: t" ..@t o.s4stittio( t"r!pB9 Er > C,i( I(st 181 11:3
339 P!(t!,o( K$; H!tipo), =A9 HBpo(!trmi! !(d t" t"Broid: @!s!,itB or !sso@i!tio( >9
C,i(9 $d9 2015; '; 3263*
3'9 H..(r >E9 #i!)(osti@ !,!tio( o. ! p,r!, ..sio( i( !d,ts: I(iti!, tsti()9 I( : Ki()
TE; %i(,!B G; ditors9 Uptod!t9 Do,tr K,r9 O@t 0*; 201'9 A!i,!4, !t:9ptod!t9@om
359 K!"!,B G>9 Po,B),!(d,!r !toimm( sB(droms9 7ur 0 7ndocrinol9 200 >,91*171:11620
3*9 Koo A9 TBp III Po,B),!(d,!r Atoimm( SB(drom9 I(: K"!rdori R; ditor9
$ds@!p9 A) 28; 201'9 A!i,!4, !t : mdi@i(9mds@!p9@om
3-9 Eis(4!rt" GS; Gott,i4 PA9 T" imm(o(do@ri(op!t"B sB(droms9 I(: L!rs( PR;
Kro((4r) H$; $,md S; Po,o(sB KS; ditors9 L!rs(: Di,,i!ms tt4oo o.
(do@ri(o,o)B; 10t" d9 P((sB,!(i!: A( Impri(t o. E,sir S@i(@9 2003
389 #ittm!r $; K!"!,B G>9 G(ti@s o. t" !toimm( po,B),!(d,!r sB(drom tBp 3!ri!(t9 T"Broid9 2010 >,9 207-:-3-6'3
39 K!() $&; H!"m >R; >() TS; L GD; Kim #K; P!r $H9 A 206B!r6o,d om!( it"
H!s"imotos t"Broiditis !(d E!(s sB(drom9 &o(si $di@!, >or(!,9 200*:'-73:'32 '3*
http://www.uptodate.com/http://www.uptodate.com/