efek antipiretik phylantus

7/22/2019 efek antipiretik phylantus

1/13

LEMBAR PERSETUJUAN

JUDUL : EFEK ANTIPIRETIK INFUSA MENIRAN

(Phyllanthus niruriLinn.) TERHADAP MENCIT

JANTAN GALUR SWISS WEBSTER

PENYUSUN : FENTY D. BARUS

NRP : 07101!

BANDUNG" JANUARI 011

MENYETUJUI"

PEMBIMBING UTAMA PEMBIMBING PENDAMPING

R#$n%&ni" '%."A* D+,$&nn%"'."AIF

ii


2/13

SURAT PERNYATAAN

Y%n- &*%n'% *%n-%n 'i%/% ini :

N%% : F&n*2 D. B%,$

NRP : 07101!

M&n2%*%3%n %/% K%2% T,4i$ I4i% ini %'%4% %$i4 3%2% $&n'ii" ,3%n

',4i3%$i '%i 3%2% #%n- 4%in.

A%i4% 'i3&,'i%n %i 'i3&*%,i ini *i'%3 &n%" %3% $%2% &$&'i%

&n&i% $%n3$i $&$,%i %*,%n 2%n- &4%3,.

D&i3i%n &n2%*%%n $%2%

B%n',n-" F&,%i 01

F&n*2 D.B%,$

iii


3/13

ABSTRAK

EFEK ANTIPIRETIK INFUSA MENIRAN (Phyllanthus niruriLinn.)TERHADAP MENCIT JANTAN GALUR SWISS WEBSTER

F&n*2 D. B%,$" 0115 P&iin- I : R#$n%&ni" '%."A*

P&iin- II : D+,$&n%" '."AIF

D&% %'%4% -&+%4% 2%n- %4in- $&in- 'i%4%i #4& $&*i% #%n-. P%'%

,,n2% '&% 'i#%*i '&n-%n &&i%n %n*ii&*i3 ($&&*i: Acetaminofen /

Paracetamol). Di$%in- &n--,n%%n #%* %n*ii&*i3" '%%* 'i-,n%3%n #%*

*%'i$i#n%4 2%n- &%$%4 '%i *%n%%n" 6#n*#n2% &ni%n.

T,+,%n &n&4i*i%n ini ,n*,3 &n-&*%,i &&3 %n*ii&*i3 in,$% &%

&ni%n.P&n&4i*i%n ini 'i4%3,3%n *&%'% 80 &3# &n6i* +%n*%n -%4, Swiss

Webster '&n-%n &%* %'%n $&3i*% 9 -%. M&n6i* 'i3&4##33%n $&6%% %6%3

'%4% 4i% 3&4##3 %$in-%$in- *&'ii '%i &n% &3# &n6i* $&&4, 'i

in',3$i '&n-%n ;%3$in 6%%3 2%n- &&i &&3 '&% *&%'% &n6i*.

S&*&4% < +% 'i in',3$i $,, 'i ,3, 3&%4i. K&4##3 I" II" '%n III %'%4%

3&4##3 %%n ,+i in,$% &% &ni%n (IHM) '#$i$ !"9=" 18=" '%n !=.

S&'%n-3%n 3&4##3 I> %'%4% 3&4##3 3#n*#4 n&-%*i &n--,n%3% %?,%'&$*

'%n 3&4##3 I> $&%-%i 3#n*#4 #$i*i '&n-%n %%$&*%#4.

D%*% 2%n- 'i ,3, %'%4% &n,,n%n $,, *,, &n6i* $&$,'% 'i

in',3$i ;%3$in 6%%3. An%4i$i$ '%*% &n--,n%3%n ANA>A $%*, %%" 2%n-

%%i4% *&'%%* &&'%%n 'i4%n+,*3%n '&n-%n ,+i T,3&2 HSD '&n-%n @ 0"09"

3&%3n%%n '&n-%n ni4%i 0"09.

H%$i4 &n&4i*i%n &n,n+,33%n %*%%*% &n,,n%n $,, *,, &n6i* %'%

3&4##3 IHM !"9=" IHM 18=" '%n IHM != &i4i3i &&3 %n*ii&*i3.

K&$i,4%n %'%4% &&i%n in,$% &% &ni%n &&&3 $&6%%

$i-nii3%n %'% &n,,n%n $,, *,, &n6i* -%4, S/i$$ W&$*& +%n*%n.

K%*% 3,n6i : An*ii&*i3" M&ni%n

iv


4/13

ABSTRACT

ANTIPYRETIC EFFECT OF MENIRAN (Phyllanthus niruri Linn.)INFUSION TO MALE MICE STRAIN SWISS WEBSTER

F&n*2 D. B%,$" 01 T,*# I : R#$n%&ni" '%." A*

T,*# II : D+,$&n%" '."AIF

Fever is the most common symptoms experienced by each people.

In most cases fever were treated with the provision of antipyretics (such as

Acetaminophen / Paracetamol!. "esides the use of antipyretic dru#s$ can be used

traditional medicine derived from plants$ for example meniran.

%he purpose of this research is to find out the effect of antipyretic of

meniran infusion.%his research was conducted to &' male mice strain Swiss Webster with

avera#e wei#ht ) #ram. %he mice were divided by five #roups randomly with

containin# six mice each #roup. %he #roupin# was done before inducted by

*easles vaccine that #ave fever effect to the mice. After + hours induction$ the

temperature was measured a#ain. ,roup I$ II$ and III is the tested #roups that

were #iven I-* $)$ 0&$ and +. While #roup I1 is the ne#ative control

usin# a2uadest$ and #roup 1 is the positif control usin# paracetamol.

%he data measured is the reduction of body temperature of mice after the

induction of measles vaccine. 3ata analysis usin# one way A451A$ that if there

are differences continued by %u6ey -S3 test with 7 8 '.')$ si#nificance with p

value 9 '.').

%he results show an avera#e reduction body temperature of mice at the

I-* #roup $)$ 0& I-* and I-* has antipiretyc effect.

%he conclusion is the provision of meniran infusion has si#nificant effect

to reduction body temperature of Swiss Webster strain male mice.

:eyword Antipyretic$ *eniran

v


5/13

KATA PENGANTAR

P,+i '%n $2,3, 3&%'% T,%n Y&$,$ Ki$*,$" 2%n- *&4% &&3%*i '%n

&iin- &n,4i$ '&n-%n 3%$iN2% 2%n- &$% $&in--% &n,4i$ '%%*

&n2&4&$%i3%n K%2% T,4i$ I4i% ini.

K%2% T,4i$ I4i% ini '%%* *&/,+,' %*%$ %n*,%n '%n ',3,n-%n '%i

&%-%i i%3. Un*,3 i*, &n,4i$ &n-,6%3%n %n2%3 *&i% 3%$i 3&%'% :

1. R#$n%&ni" '%" A* $&4%3, &iin- I 2%n- *&4% &$&'i% &4,%n-3%n

/%3*," *&n%-%" '%n i3i%n $&4%% &iin- &n,4i$ '%4%

&n2&4&$%i%n K%2% T,4i$ I4i% ini.

. D+,$&n%" '" AIF $&4%3, &iin- II 2%n- *&4% &$&'i% &4,%n-3%n

/%3*," *&n%-%" '%n i3i%n $&4%% &iin- &n,4i$ '%4%

&n2&4&$%i%n K%2% T,4i$ I4i% ini.

8. B%%3 N%n% C%2%n% $&4%3, $*% L%#%*#i, F%%3#4#-i Uni;&$i*%$

Ki$*&n M%%n%*% '%n $*% 4%inn2% 2%n- *&4% %n2%3 &%n*, &n,4i$

'%4% &n%*%4%3$%n%%n &n&4i*i%n.


6/13

. S&,% i%3 2%n- *i'%3 '%%* 'i$&,*3%n $%*, & $%*, 2%n- *&4% %n2%3

&%n*, '%4% &n2&4&$%i%n K%2% T,4i$ I4i% ini.

A3i 3%*%" $-% K%2% T,4i$ I4i% ini '%%* &%n%%* %-i 3i*% $&,%.

B%n',n-" F&,%i 01

P&n,4i$

vii


7/13

DAFTAR ISI

H%4%%n

JUDUL............................................................................................................ i

LEMBAR PERSETUJUAN........................................................................... ii

SURAT PERNYATAAN...............................................................................

ABSTRAK......................................................................................................

A"S%;A


8/13

..8 D%%3 D&%...........................................................................

.8 An%4-&$i3 '%n

An*ii&*i3..........................................

.8.1 A$&*%in#&n..........................................................................

.8.1.1 F%%3#3in&*i3..............................................................

.8.1. In'i3%$i......................................

.8.1.8 E&3 S%in-.............................................................................

.8.1.< D#$i$...................................

.8 >%3$in C%%3..........................................................................................

.8. D&$3i$i.

.8.8 In'i3%$i

.8.< 3#n*% In'i3%$i

.8.9 E&3 S%in-.

.8.! P&n2i%n%n '%n K&%$%n

.< M&ni%n..

.


9/13

8.< M&*#'& An%4i$i$..................................................................................... 7

8.9 Hi#*&$i$ S*%*i$*i3..................................................................................... 7

8.! A$&3 P&n&4i*i%n........................................................................................

BAB I> HASIL DAN PEMBAHASAN.......................................................


10/13

T%&4


11/13

G%% . >%3$in C%%3..........................................................

G%% .10 M&ni%n (Phyllanthus niruri L)................................................

G%% .1 S&n2%/% F4%;#n#i'..........

1!

1

DAFTAR GRAFIK

G%i3


12/13

DAFTAR LAMPIRAN

L%i%n 1 P&i*,n-%n D#$i$..............................

L%i%n P#$&', P&,%*%n In,$% ....................................................

L%i%n 8 H%$i4 U+i * T&$*................................

L%i%n < H%$i4 ,+iA451A$%*, %% '%n ,+i HSD ....................................


13/13

xiv

efek antipiretik phylantus

Documents