3 (1)v.doc
Post on 31-Jan-2016
213 Views
Preview:
DESCRIPTION
v.doc
TRANSCRIPT
3.b
Absolute Bioavaibility (F)
F=¿¿
F= 528ng .h /ml1289ng .h /ml
x500ng500ng
F= 528ng .h /ml1289ng .h /ml
F=0. 4
Klirens total (Cl)
Cl=D0 IV¿¿
Cl= 500ng1289ng .h /ml
Cl=0.38ml /h
Obat dalam plasma pada saat diserap pada 92%
k=0.6933.9h
k=0.17h−1
92% obat diabsorbsi
D0= 92% x 500 ng
D0= 460 ng
C0=D0
V
C0=460ng234 L
C0=1.96ng /L
logCp= k .t2.303
+logC0
logCp=(0.17h−1)(24h)
2.303+ log 1.96ng/L
logCp=1.77+0.2 9
logCp=2.06
Cp=10(2.06)
Cp=2.06 ng/L
top related