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NH 2

S S S S

S S S S

NH 2 NH2

NH 2

S

S

S SS S

S S

S S

S S

S SHOOC COOH

CHO CHO

Variableregion

Heavy chain Constant region

Light chain

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Antibody

Antigen

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a

b

c

d

e

f

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150

120

90

60

30 60 90 120 150 180

Primary response Secondaryresponse

0

30

Days

Primaryimmunization

Booster doseof antigen

(secondary immunization)

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Hapten

Antigen

Macrophage

T Cellreceptor

TCell

BCell

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B Cell

Ag

Induction byantigen

Nucleus

Cytplasm

1st day

Ribosomes

2nd day

Endoplasmicreticulum

3rd day

Antibody

4th day

Plasma cell

NucleusAntibody

Antibody

molecules

5th day

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