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waktu (jam) C (mcg/mL) ln C AUC0-12

0 4.302085908 1.4591 2.922032

0.75 3.49 1.2499017362 0.8425

1 3.25 1.1786549963 2.855

2 2.46 0.9001613499 2.163 1.86 0.6205764877 1.63

4 1.4 0.3364722366 1.23

5 1.06 0.0582689081 0.93

6 0.8 -0.2231435513 0.705

7 0.61 -0.4942963218 0.535

8 0.46 -0.7765287895 0.72 12.0175

10 0.26 -1.347073648 0.41

12 0.15 -1.8971199849 0.535427AUC12- C!12/"l#!$ 3tt%k t&ak

AUC t#tal 15.47496

nt$&c$!t 1.459126981"l#!$ -0.27990678 k$l

1. $l 0.279907 --* 'a&u" n+a 3 t%t%k t$&ak'%&, ka

t1/2 2.475824

#"%"/C!0 4.648908

AUC t#tal 15.47496

"l#!$ 3 t%t%k t$&ak'%& -0.280148

Cl$a&anc$ $l 1.301261

2. !$&"amaan ln C!(t) -0,2799t ln 4,302

C!(t) 4,302 . $-0,28.t

3. 0,3 4,3.$-0,28.t

t 9,511 jam

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%&

  &$na 3 t%t%k t$&ak'%& m$nunjukan !"$" $l%m%na"% --* 0,28015

0 2 4 6 8 10 12 14

-2.5

-2

-1.5

-1

-0.5

0

0.5

1

1.5

2

() - 0.27990596 1.4591207141

0.9999898726

C#lumn C

L%n$a& (C#lumn C)

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t (jam) C! ln C

0.5 19.29 2.959587

1 17.56 2.865624

1.8 15.1 2.714695

4 9.98 2.300583

5.8 7.1 1.9600958 4.7 1.547563

12 2.21 0.792993

18 0.71 -0.34249

24 0.23 -1.469676

%nt$&c$!t 3.054332

"l#!$ -0.188556 $l.

C! (0) 21.20701

Cp (t) = 21,21.e^(-0,18856t)

0

-2

-1

0

1

2

3

4

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10 15 20 25 30

C#lumn C