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BAB I
PENDAHULUAN
1.1 Latar belakang
Spina bifida merupakan suatu anomali perkembangan yang ditandai dengan defek
penutupan selubung tulang pada medulla spinalis sehingga medulla spinalis dan
selaput meningen dapat menonjol keluar (spina bifida cystica), atau tidak menonjol
(spina bifida occulta).
Penonjolan dari korda spinalis dan meningens menyebabkan kerusakan pada korda
spinalis dan saraf, sehingga terjadi penurunan atau gangguan fungsi pada bagian
tubuh yang dipersarafi oleh saraf tersebut atau di bagian bawahnya. Gejalanya
tergantung kepada letak anatomis dari spina bifida. Kebanyakan terjadi di punggung
bagian bawah, yaitu daerah lumbal atau sakrum, karena penutupan vertebra di bagian
ini terjadi paling akhir.
Spina bifida kira-kira muncul pada 1-2 dari 1000 kelahiran hidup, tetapi bila satu anak
telah menderita maka resiko untuk anak yang lain menderita spina bifida meningkat
2-3%. Seorang ibu yang memiliki bayi menderita spina bifida , maka resiko hal ini
terulang lagi pada kehamilan berikutnya akan meningkat.
Spina bifida ditemukan terutama pada ras Hispanik dan beberapa kulit putih di Eropa,
dan dalam jumlah yang kecil pada ras Asia dan Afrika-Amerika. Spina bifida tipe
okulta terjadi pada 10 – 15 % dari populasi. Sedangkan spina bifida tipe cystica
terjadi pada 0,1 % kehamilan. Terjadi lebih banyak pada wanita daripada pria (3 : 2)
dan insidennya meningkat pada orang China.
Kelainan ini seringkali muncul pada daerah lumbal atau lumbo-sacral junction. Tetapi
juga dapat terjadi pada regio servikal dan torakal meskipun dalam skala yang kecil.
1.2 Identifikasi Masalah
Laporan ini membahas tentang risiko terkena rabies antara wisatawan asing secara khusus
berbicara di daerah endemis rabies, strategi pencegahan rabies termasuk profilaksis pra-
eksposur dan pasca pajanan dan kemajuan dalam tes diagnostik untuk mendiagnosa rabies.
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1.3 Tujuan dan Manfaat
Laporan ini diharapkan dapat memperluas pengetahuan tentang pencegahan rabies dan
tindakan promotif bagi tenaga medis untuk dapat memberikan pra-perjalanan saran untuk
wisatawan ke daerah endemis rabies dan untuk wisatawan sendiri untuk menyadari resiko
rabies saat bepergian ke rabies endemik daerah.
BAB II
KAJIAN PUSTAKA
2.1 Ringkasan Jurnal ke 1
Judul :
Ringkasan :
Rabies remains a problem in most countries of Southeast Asia, where stray dogs and
cats are common. Local people and travelers in this area are inevitably at risk of
exposure to the rabies virus. Pre-exposure prophylaxis is an excellent preventive
measure against rabies but in other hand the cost-benefit relationship of pre-exposure
vaccination is still debatable.
Data were collected from 870 foreign backpackers using questionnaire. The
questionnaire was comprised four parts that was general information about the
travelers, rabies pre-exposure preparations, knowledge about rabies, and the details of
any animal exposure.
Although 80.7% had sought travel health information before travel, only 55.6% had
received information about rabies. 70.9% had not been vaccinated for rabies at all and
among those 61,8% cited the cost of the vaccine; 11,8% did not of or were unaware of
the risk of rabies and 9,3% thought that unnecessary. 95,7% backpackers knew that
they could get rabies if bitten by infected animals but only 59% of them who knew
that being licked on an open wound could also transmit rabies virus. 98% knew that
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dogs could carry rabies virus, but only about half of them aware that other mammals
could also carry the virus. Moreover 40% thought the bite of healthy-looking dog
posed no risk of rabies.
On an average stay of a month, 3.6% had been licked, whereas 6 of 870 backpackers
(0.69%) had been bitten. 54% of exposures took place within the first 10 days after
arrival in Southeast Asia. The animals most commonly encountered were dogs,
followed by cats and monkeys. Among those who were bitten, only 67% sought
medical care, and only 50% received post-exposure treatment.
Kesimpulan :
Only 55.6% of the travelers had received information about rabies, 70.9% had not
been vaccinated for rabies at all, 59% of them who knew that rabies could be
transmitted aside from via bite, half of travelers didn’t know mammals beside dogs
can carry the virus and 40% thought a healthy looking dog poses no risk of rabies. It
is clear that travelers are at risk of rabies exposure and the disease is virtually fatal
once symptoms develop. Therefore, many international guidelines recommend pre-
exposure rabies vaccination for travelers in rabies-endemic areas. Health education is
also important to prevent misconceptions, misunderstandings and lack of awareness.
The combination of these two is a good strategy to prevent rabies in travelers since
standard post-exposure treatment might be not available especially in rural areas.
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2.2 Ringkasan Jurnal ke 2
Judul : Rabies Prevention in Traveler
Ringkasan :
Rabies is an acute, almost invariably fatal, progressive encephalomyelitis caused by
neurotropic lyssaviruses of the Rhabdoviridae family. Rabies virus present in the
saliva of an infected animal. It most commonly transmitted via animal bite and rarely
via scratches to skin, licks to open wounds or mucous membranes. The virus travels to
the brain along the nerve. The density of nerve endings in the bitten area, the
proximity of the bite site to the central nervous system (CNS), and the severity of the
bite, determines how quickly the virus cause rabies encephalitis. The incubation
period can range from 1–12 weeks to several years. Prodromal symptoms are
nonspecific only showing common mild symptom. Most commonly the disease will
progress to ‘furious’ encephalitic rabies with symptoms such as aerophobia,
hydrophobia and hyper salivation.
Rabies viruses are present in most parts of the world, although it is mainly a problem
in developing countries. Over 50.000 people die of rabies each year and 95% victims
resides in Asia and Africa. 80% of the cases occur in rural areas. Countries at greatest
risk are India, Nepal, Sri Lanka, El Salvador, Guatemala, Peru, Colombia, Ecuador
and some Shouth-East Asia Nations. As for in Indonesia Rabies has been reported in
Bali, Islands of Flores, Sulawesi, Sumatra, Ambon and Kalimantan.
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High level of contact to animal and extensive outdoor exposure can increase risk to be
exposed to rabies virus. All travelers should avoid approaching stray animals, stay
aware to avoid surprising stray dogs or bats and avoid carrying or eating food in
presence of monkeys.
People at high risk and long term travelers to rabies endemic or isolated areas should
be offered with pre-exposure vaccination. There are several kinds of vaccines exist
such as HDCV, PCECV, PVRV, RVA and Lyssavac. The vaccines must be given via
the deltoid region in adults and via the anterolateral aspect of the thigh in children
under 12 months. Individual with anaphylactic sensitivity to eggs or egg proteins
should be given HDCV instead of PCECV. More than 200 cases of successful
maternal vaccination during pregnancy without adverse fetal outcomes have been
reported.
Post-Exposure Prophylaxis (PEP) is needed to prevent clinical rabies after exposure
has occurred. It includes thorough wound cleansing and disinfection, passive
immunization by installation of rabies neutralizing antibodies into the wound and
stimulation of an active immune response with rabies vaccine. Recommended PEP
depends on the category of risk of
All wounds must be thoroughly cleaned with copious soap or detergent and water,
followed by poviodone iodine. Suturing only should be delayed, and if is unavoidable,
the wound should be infiltrated with rabies immune globulin (RIG) then suturing can
be performed after at least several hours later.
All category III and category II should receive RIG. Due to global shortage of HRIG
unlike most of developed country, many developing countries use ERIG instead. This
is preferable to not administering RIG at all, and the incidence of adverse reactions,
mainly serum sickness (which commonly occurs a week later), is low (0.8–6.0%). A
recent study suggests that the mandatory skin test recommended before ERIG
administration does not necessarily predict serum sickness. Post-exposure prophylaxis
may be ceased if the animal is definitely found to be negative for rabies after testing
in a reputable laboratory, or if the animal has remained well after 10 days.
Kesimpulan :
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All travelers require education regarding rabies prevention if travelling to a rabies
endemic area. Those at high risk of exposure should be offered pre-exposure
vaccination. Modern cell culture vaccines are well tolerated, although cost and time
taken to complete the course can be of concern to travelers. Post-exposure prophylaxis
should always be commenced where indicated, as no contraindications exist.
2.3 Ringkasan Jurnal ke 3
Judul : Advances in Diagnosis of Rabies
Ringkasan :
Rabies virus is a neurotropic virus of the genus Lyssavirus of the family
Rhabdoviridae and transmissible to human by inoculation or inhalation of infectious
virus. There are seven distinct genetic lineages can be distinguished within the genus
Lyssavirus classical rabies virus itself (RABV genotype 1, serotype 1), Lagos bat
virus (LBV, genotype 2, serotype 2), Mokola virus (MOKV, genotype 3, serotype 3),
and Duvenhage virus (DUUV, genotype 4, serotype 4). The European bat lyssaviruses
(EBLV) subdivided into two biotypes (EBLV1, genotype 5 and EBLV2, genotype 6)
and the Australian bat lyssavirus (ABLV, genotype 7).
Conserved antigenic sites on the nucleocapsid proteins permit recognition of all
lyssaviruses with modern commercial preparations of anti-rabies antibody conjugates
used for diagnostic tests on brain tissue. Humans working with suspect material must
be vaccinated against lyssaviruses or other pathogens that may be present in
diagnostic samples. As no clinical sign or gross post-mortem lesion can be considered
pathognomonic in domestic or wild animals, the diagnosis of rabies has to rely on
laboratory testing. Serological evidence of infection is rarely useful because of late
seroconversion and the high mortality rate of host species, although such data may be
used in some epidemiological surveys.
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The only way to perform a reliable diagnosis of rabies is to identify the virus or some
of its specific components using laboratory tests. Several laboratory techniques may
be used; the methods vary in their efficiency, specificity and reliability. They are
preferable conducted in CNS tissue and the virus is particularly abundant in the
thalamus, pons and medulla. Removing the entire organ is necessary to collect and
test the brain tissues needed, but under some circumstances a simplified method of
sampling through the occipital foramen, or through the orbital cavity can be used.
During the shipment of suspect material for diagnosis no risk of human contamination
should arise. When it is not possible to send refrigerated samples, other preservation
techniques may be used. The choice of the preservative is closely linked to the tests to
be used for diagnosis.
The most widely used test for rabies diagnosis is the fluorescent antibody test (FAT).
The sensitivity of the FAT depends on the degree of autolysis and how
comprehensively the brain is sampled, on the type of lyssavirus and on the proficiency
of the diagnostic staff.
The antibody may be conjugated to an enzyme such as peroxidase instead of
fluorescein isothiocyanate (FITC). This conjugate may be used for direct diagnosis
with the same sensitivity as FAT, but attention should be paid to the risk of
nonspecific false-positive results. This risk is considerably reduced by the thorough
training of the technicians. It must also be emphasised that this technique needs one
incubation step more than the FAT.
In case that FAT gives an uncertain result or when the FAT is negative in the case of
known human exposure, detection of the replication of rabies virus must be done.
There are some tests to detect the infectivity of a tissue suspension in cell cultures or
in laboratory animals, such as:
Mouse inoculation test: Five-to-ten mice, 3-4 weeks old (12-14 g), or a litter of 2-
day-old newborn mice, are inoculated intracerebrally. The young adult mice are
observed daily for 28 days, and every dead mouse is examined for rabies using the
FAT
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Cell culture test: Neuroblastoma cell lines, e.g. CCL-131 in the American Type
Culture Collection are used for routine diagnosis of rabies. The cells are grown in
Dulbecco’s modified Eagle’s medium (DMEM) with 5% fetal calf serum (FCS),
incubated at 36°C with 5% CO2. Its sensitivity has been compared with that of baby
hamster kidney (BHK-21) cells. Presence of rabies virus in the cells is revealed by the
FAT. The result of the test is obtained after at least 18 hour.
Serological tests are rarely used in epidemiological surveys, due to late
seroconversion and the low percentage of animals surviving the disease and therefore
having post-infection antibodies. There are some types of serological test, such as:
a. fluorescent antibody virus neutralisation test
The principle of the fluorescent antibody virus neutralisation (FAVN) test is the
neutralisation in vitro of a constant amount of rabies virus (‘challenge virus
standard’ [CVS] strain adapted to cell culture) before inoculating cells susceptible
to rabies virus
b. The rapid fluorescent focus inhibition test (RFFIT)
A serological test based on the ability of neutralising antibodies to inhibit the
growth, in cell culture, of challenge virus.
c. Virus neutralisation in mice (no longer recommended)
d. Enzyme-linked immunosorbent assay (ELISA)
Commercial kits are available for indirect ELISA that allow a qualitative
detection of rabies antibodies in individual dog and cat serum samples following
vaccination. ELISA methods are useful for monitoring of vaccination campaigns
in wildlife populations
For follow-up investigations in oral vaccination campaigns, virus neutralisation (VN)
tests in cell culture are preferred. However, if poor quality sera are submitted, the VN
tests in cell culture are sensitive to cytotoxicity, which could lead to false-positive
results. For such samples, the use of an indirect ELISA with rabies glycoprotein-
coated plates has been shown to be as sensitive and specific as the VN test on cells.
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Kesimpulan :
BAB III
KESIMPULAN
3.1 Kesimpulan
All travelers travelling from developed country to developing country especially those
who travel off the usual tourist routes are more likely at higher risk of exposure to
rabies. Moreover the travelers’ preparations and knowledge regarding rabies are
usually low. This may lead to misconception and misunderstanding and increase the
risk to rabies exposure. Therefore travelers are advised to see physician before going
to rabies endemic area especially to rural area. Although the cost might become a
concern for travelers, a complete course of pre-exposure vaccination, three shots, is
highly recommended. Post-exposure prophylaxis should always be commenced where
indicated. Laboratory testing is the only way to perform reliable diagnosis of rabies
conducted in CNS tissues. The most widely used diagnostic test for rabies is FAT.
The FAT can provides a reliable diagnosis in 98-100% of cases for all genotypes if a
potent conjugate is used.