prak.kimor iii (aspirin)

7/24/2019 PRAK.kimoR III (Aspirin)

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Praktikum Kimia Organik/Kelompok VIII/S.Genap/2015

Lembar Pengesahan Laporan Praktikum

Kimia Organik

Reaksi Asetilasi Pembuatan Aspirin

Dosen pengampu praktikum kimia organik dengan ini menyatakan bahwa :

Kelompok VIII

!rie" Pratama !#isha 1$0%122&%'

(rika)ul 1$0%11*+12

,abib -aulana asminto 1$0%112'1'

Kar"ika !inil ,aa 1$0%112&'0

-. Gheral (rlangga P. 1$0%11$'0+

1. Telah melakukan perbaikan-perbaikan yang disarankan oleh Dosen Pengampu

Asisten Praktikum

!. Telah menyelesaikan laporan lengkap praktikum Asetilasi dari praktikum kimia

organik yang disetu"ui oleh Dosen Pengampu Asisten Praktikum.

atatan ambahan

3osen Pengampu

Pekanbaru# $ April !%1&

3rs. (ar ,S4 -.Si

ABSTRAK

eaksi !setilasi 6Pembuatan !spirin7


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Reaksi asetilasi adalah reaksi pemasukkan gugus asetil kedalam substrat yang sesuai.Aspirin memiliki banyak manfaat seperti dalam bidang kesehatan yaitu sebagai obat-

obatan dan kebesihan kulit. Oleh karena itu pembuat aspirin sangat penting. Tujuan

dalam praktikum ini adalah membuat aspirin dalam skala labor, memahami dan

mempelajari proses reaksi yang terjadi, dan menghitung presentase aspirin yang

dihasilkan. Bahan yang kita gunakan dalam percobaan ini yaitu 5 gram asam salisilat

sebagai bahan utama, ! ml asam asetat glasial, dan katalis asam kuat "#!$O%&

sebanyak ' tetes, dilakukan pemanasan dengan suhu 5(-'( ) *, didinginkan dengan batu

es selama ! jam. +ristal yang dihasilkan di saring menggunakan pompa akum. ada

proses uji kemurnian aspirin, aspirin yang telah direkristalisasi tambahkan ml alcohol

dan tetes ferri klorida didalam tabung reaksi begitu juga pada asam salisilat. ada

percobaan ini didapatkan berat aspirin yang telah di rekristalisasi adalah 5 gr dengan

rendemen //0. 1adi aspirin dapat disintesis dari reaksi acetylasi.

+ata +unci2 asetilasi, asam salisilat,aspirin, kristal

ABSTRACT

Acetylation reaction is the reaction to put an acetyl group into the appropriate substrate.

Aspirin has many benefits such as health sector, namely drugs and skin hygene. 3t is ery

important to make an aspirin. The goal in this e4periment is to make an aspirin in

laboratory scale, to understand and learn the process of the reaction, and calculate the

percentage of aspirin produced. The materials e use in this e4periment is 5 gr of

salicylic acid as the main ingredient, ! ml of glacial acetic acid, and a strong acidcatalyst "#$O& as ' drops, carried heating ith temperature 5(-'()*, cooled ith ice

cubes for ! hours . The resulting crystals filtered using a acuum pump. 3n the process of

testing the purity of aspirin, aspirin has recrystalli6ed add ml of alcohol and drops of

ferric chloride in a test tube as ell as the salicylic acid. 3n these e4periments hae found

that aspirin eight in recrystalli6ation is 5 gr to yield //0. $o aspirin can be synthesi6ed

from the reaction of acetylation.

+eyords2 acetylation, aspirin, crystal, salicylic acid

3!8! ISI



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Lembar Pengesahan..........................................................................................................i

!9S!K........................................................................................................................ii3!8! ISI ...................................................................................................................iii

3!8! G!-9!........................................................................................................#

3!8! !9(L............................................................................................................#i

9!9 I. P(:3!,;L;!:..............................................................................................1

1.1 'atar (elakang.............................................................................................1

1.! Tu"uan Praktikum.........................................................................................!

9!9 II. I:

!.1 Asam )alisilat...........................................................................................*!.1.1 Pembuatan Asam )alisilat.........................................................................$

!.! Asetat Anhidrat.........................................................................................&

!.!.1 Pembuatan Asetat Anhidrat......................................................................+

!.* ,tanol........................................................................................................

!.*.1 )iat dan /egunaan ,tanol........................................................................

!.$ 0erri /lorida.............................................................................................

!.$.1 Pembuatan 0erri /lorida...........................................................................

!.$.! /egunaan 0erri /lorida...........................................................................1%

!.& A2uades..................................................................................................11

!.+ Asam )ulat............................................................................................1!

!.3 )intesa4solasi Produk.............................................................................1!

!.3.1 Reaksi Asetilasi.......................................................................................1!

!.3.! Rekristalisasi...........................................................................................1*

!.3.* Reaksi Pengu"ian Aspirin........................................................................1&

!. Produk.....................................................................................................1+

!..1 Aspirin.....................................................................................................1+

!..1 5anaat Aspirin.......................................................................................13

9!9 III. -(O3OLOGI P(O9!!:....................................................................1+

*.1 Alat-Alat.................................................................................................1

*.! (ahan-(ahan...........................................................................................1

*.* Prosedur Per6obaan................................................................................. 1

*.*.1 Pembuatan Aspirin..................................................................................1

*.*.! Rekristalisasi Aspirin...............................................................................1

*.*.* 7"i /emurnian Aspirin............................................................................ 1



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*.$ Rangkaian Alat........................................................................................ !%

9!9 IV. ,!SIL 3!: P(-9!,!S!:........................................................................21$.1 8asil Praktikum......................................................................................!1

$.$.1 Pembuatan Aspirin..................................................................................!1

$.$.! Rekristalisasi Aspirin...............................................................................!!

$.$.* 7"i /emurnian Aspirin............................................................................ !!

$.$.$ Reaksi /imia Pembuatan Aspirin............................................................!!

$.! Pembahasan............................................................................................!!

9!9 V. K(SI-P;L!: 3!: S!!:.........................................................................25

&.1 /esimpulan.............................................................................................!&&.! )aran.......................................................................................................!&

3!8! P;S!K!......................................................................................................2'

L!-PI!: !. L!PO!: S(-(:!!

L!-PI!: 9. P(,I;:G!:

L!-PI!: . 3OK;-(:!SI P(L!KS!:!!: P!KIK;-

3!8! G!-9!



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Gambar 2.1)truktur Asam )alisilat..................................................................................*

Gambar 2.2)truktur Asetat Anhidrat................................................................................+

Gambar *.1 Rangkain Alat Proses pemanasan Aspirin..............................................!%

Gambar *.2 Rangkaian Alat Proses Penyaringan Aspirin................................................!%

3!8! !9(L



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abel 2.1 )iat-siat 0isika dan /imia Asam )alisilat........................................................$

abel 2.2 )iat-)iat 0isika dan /imia Asetat Anhidrat.....................................................&

abel 2.*Sifat Fisika dan Kimia Air.........................................................................11

abel $.18asil Pengamatan Pembuatan Aspirin........................................................!1

abel $.28asil Pengamatan Rekristalisasi Aspirin....................................................!!

abel $.*8asil 7"i /emurnian Aspirin........................................................................!!


prak.kimor iii (aspirin)

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