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USULAN PENELITIAN SKIRPSI
PENGARUH PEMBERIAN COENZYME Q10 SECARA ORALTERHADAP
KADAR KOLESTEROL TOTAL DAN LDL DALAM DARAH MODEL
TIKUS PERIODONTITIS
Diajukan guna melengkapi tugas akhir dan memenuhi salah satu syarat untuk menyelesaikan S1 Kedokteran Gigi dan mencapai gelar Sarjana Kedokteran gigi
Oleh:
Hesti Devinta
G1G012031
KEMENTERIAN RISET, TEKNOLOGI DAN PENDIDIKAN TINGGI
UNIVERSITAS JENDERAL SOEDIRMAN
FAKULTAS KEDOKTERAN
JURUSAN KEDOKTERAN GIGI
PURWOKERTO
2015
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USULAN PENELITIAN SKRIPSI
PENGARUH PEMBERIAN COENZYME Q10 SECARA ORALTERHADAP KADAR KOLESTEROL TOTAL DAN LDL DALAM DARAH MODEL
TIKUS PERIODONTITIS
Oleh:HESTI DEVINTA
G1G012031
Diajukan sebagai pedoman pelaksanaan penelitian studi akhir pada Jurusan Kedokteran Gigi Fakultas Kedokteran Universitas Jenderal Soedirman
DisetujuiPada tanggal:
Pembimbing I Pembimbing II
Dr. Drg. A. Haris Budi Widodo, M.Kes., A.P., S.IP drg. Rinawati SatrioNIP. 197005031999031001 NIP. 19630602 198803 2 001
MengetahuiWakil Dekan Bidang Akademik Fakultas Kedokteran
Universitas Jenderal Soedirman
Dr. dr. VM Wahyu Siswandari, Sp. PK., M.Si, Med.NIP. 19710122 199903 2 001
DAFTAR ISI
Halamanii
HALAMAN JUDUL............................................................................. i
HALAMAN PENGESAHAN............................................................... ii
DAFTAR ISI.......................................................................................... iii
DAFTAR GAMBAR ............................................................................ vi
DAFTAR TABEL.................................................................................. vii
BAB I PENDAHULUAN...................................................................... 1
A. Latar Belakang......................................................................... 1
B. Rumusan Masalah..................................................................... 4
C. Tujuan Penelitian...................................................................... 4
D. Manfaat Penelitian.................................................................... 5
E. Keaslian Penelitian................................................................... 6
BAB II TINJAUAN PUSTAKA .......................................................... 7
A. Landasan Teori......................................................................... 7
1. Periodontitis.............................................................................. 7
a. Gambaran Umum.................................................................. 7
b. Mekanisme............................................................................ 8
2. Profil Lipid................................................................................ 9
a. Kadar Kolesterol Total.......................................................... 7
b. Kadar LDL............................................................................ 7
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3. Hubungan Profil Lipid dengan Periodontitis.......................... . . 12
4. Hubungan Antiokasidan dengan Periodontitis.......................... 14
5. Peranan Antioksidan pada Penyakit Periodontal....................... 18
6. Coenzyme q10............................................................................ 19
B. Kerangka Teori......................................................................... 26
BAB III METODE PENELITIAN...................................................... 27
A. Kerangka Konsep ..................................................................... 27
B. Hipotesis.................................................................................... 27
C. Jenis dan Rancangan Penelitian................................................ 28
D. Lokasi dan Waktu Penelitian.................................................... 28
E. Variabel Penelitian.................................................................... 28
F. Definis Operasional................................................................... 29
G. Populasi dan Sampel Penelitian................................................ 30
H. Sumber Data.............................................................................. 31
I. Instrumen Penelitian.................................................................. 31
J. Cara Pengumpulan Data............................................................ 32
K. Alur Kerja.................................................................................. 33
L. Analisis Data............................................................................ 33
M.Jadwal Penelitian....................................................................... 34
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DAFTAR PUSTAKA ........................................................................... 35
DAFTAR GAMBARv
Halaman
Gambar 2.1 Abnormalitas Inti.......................................................................18
Gambar 2.2 Kerangka Teori..........................................................................19
Gambar 3.1 Kerangka Konsep.......................................................................20
Gambar 3.2 Alur Penelitian...........................................................................28
DAFTAR TABEL
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Halaman
Tabel 1.1 Keaslian Penelitian....................................................................... 6
Tabel 3.1 Definisi Operasional..................................................................... 22
Tabel 3.2 Jadwal penelitian........................................................................... 29
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