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INTISARI

FIFIANA, L, I., FORMULASI KAPTOPRIL DALAM SEDIAAN TABLET

LEPAS LAMBAT DENGAN MATRIKS KOMBINASI HIDROKSIPROPIL

METILSELULOSA DAN METIL SELULOSA, SKRIPSI, FAKULTAS

FARMASI, UNIVERSITAS SETIA BUDI, SURAKARTA.

Kaptopril adalah obat hipertensi yang memiliki waktu paruh 2-3 jam.Pemberian obat berulang dinilai tidak praktis, karena itu kaptopril diformulasikan

dalam bentuk sediaan tablet lepas lambat menggunakan matriks HPMC dan Metil

selulosa. Tujuan dari penelitian ini untuk mengetahui pengaruh kombinasi matriks

HPMC dan Metil selulosa dalam sediaan tablet lepas lambat kaptopril terhadap

sifat fisik dan kecepatan pelepasan obat yang memenuhi persyaratan.

Tablet lepas lambat kaptopril dibuat dalam 5 formula berdasarkan variasi

kadar : 100%HPMC : 0% Metil selulosa (FI), 75%HPMC : 25%Metil selulosa

(FII), 75%HPMC : 25% Metil selulosa (FIII), 0%HPMC :100%metil selulosa

(FIV) dan kontrol negatif (FV). Tablet dibuat dengan metode granulasi basah,

granul yang diperoleh diayak dengan ukuran 16/18 mesh. Granul yang diperoleh

diuji kualitas meliputi waktu alir dan sudut diam. Granul dicetak menjadi tablet

menggunakan mesin dengan tekanan maksimal. Tablet diuji kualitas mutu fisik

meliputi keseragaman bobot, kekerasan, kerapuhan tablet dan disolusi. Uji

disolusi dilakukan selama 8 jam dalam medium HCL 0,01 N menggunakan alat

tipe dayung dengan kecepatan 75rpm. Data dianalisis secara statistik dengananova satu jalan, LSD menggunakan SPSS 12.0 for windows dengan taraf

kepercayaan 95 %.

Hasil penelitian menunjukkan bahwa Penambahan HPMC mempercepat

waktu alir, memperkecil sudut diam granul dan kekerasan tablet. Hasil uji disolusi

menunjukkan bahwa pola pelepasan kaptopril dari tablet lepas lambat mengikuti

kinetika orde nol. Mekanisme pelepasan kaptopril pada formula I-IV mengikuti

mekanisme transport anomalous diffusionyaitu kombinasi erosi dan difusi dimana

mekanisme difusi lebih dominan, sedangkan pada formula V mengikuti

mekanisme difusi fick. Kecepatan pelepasan kaptopril : 0,0627mg/menit (FI);

0,0694mg/menit (FII); 0,0716 mg/menit (FIII); 0,0686mg/menit FIV);

0,0502mg/menit (FV).

Kata kunci: kaptopril, metil selulosa, HPMC

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ABSTRACT

FIFIANA, L, I.,CAPTOPRIL FORMULATION IN SUSTAINED RELEASE

TABLET BY COMBINATION MATRIX OF HYDROXYPROPYL

METHYL CELLULOSE AND METHYL CELLULOSE, THESIS,

FACULTY OF PHARMACY, SETIA BUDI UNIVERSITY, SURAKARTA.

Captopril is hypertensive drug which half life 2-3 hours. Repeated drug

administration considered impractical, because captopril formulated in a

preparation of sustained release tablet using HPMC and methyl cellulose matrix.

The purpose of this study was to findnot the effect of combinated HPMC and

methyl cellulose matrix in preparation of sustained release tablet of captopril to

the physical properties and release rate that meets the requirements.

Sustained release tablet of captopril was made in 5 formula based on

variations in levels : 100%HPMC : 0% methyl cellusosa (FI), 75%HPMC : 25%

methyl cellusosa (FII), 75%HPMC : 25% methyl cellusosa (FIII), 0%HPMC

:100%methyl cellusosa (FIV) and negative control(FV). Tablets was made by wet

granulation method, granules which obtained sieved by 16/18 mesh. The granules

which obtained teste in quality include flow rate and angle of repose. The granules

was molded into tablets using machine with a maximum pressure. Tablet was

tested for the physical quality included weight uniformity, hardness, friability and

dissolution. Dissolution testing conducted for 8 hour in 0,01 N HCL medium

using a paddle type device by speed of 75 rpm. Data were statistically analyzed byone way ANOVA, LSD using SPSS 12.0 for windows with 95% confidence.

The results showed that the addition of HPMC the flow rate, minimize the

angle of repose of granules and tablet hardness. The results of dissolution showed

that pattern of captopril release from sustained release tablet follows zero order

kinetic. Mechanism of captopril release on the formula I-IV follows transport

mechanism of Anomalous diffusion i.e combination of erosion and diffusion

wheres the diffusion mechanism was dominant, while in the formula V follows

the fick diffusion mechanism. Release rate of captopril : 0,0627mg/min (FI);

0,0694mg/min (FII); 0,0716 mg/min (FIII); 0,0686mg/min(FIV);

0,0502mg/min(FV).

Keywords : sustained release, captopril, methyl cellulose, HPMC