lampiran 1. surat keterangan determinasi daun …eprints.ums.ac.id/31186/8/7._lampiran.pdf49...
TRANSCRIPT
44
Lampiran 1. Surat keterangan determinasi daun pepaya
45
Lanjutan lampiran 1
46
Lampiran 2. Gambar pohon pepaya yang digunakan untuk penelitian
47
Lampiran 3. Hasil uji saponin pada serbuk daun pepaya
48
Lampiran 4. Gambar tablet pada berbagai formula
49
Lampiran 5. Perhitungan bobot setiap eksipien
a. Gelatin
0,416% =
x 800 = 3,33 mg
0,832% =
x 800 = 6,66 mg
b. Explotab
2% =
x 800 = 16 mg
8% =
x 800 = 64 mg
c. Talk
6% =
x 800 = 48 mg
d. Avicel 101
F1 = 800 - (327+3,33+16+48)mg = 405,67 mg
F2 = 800 - (327+6,66+16+48)mg = 402,34 mg
F3 = 800 - (327+3,33+64+48)mg = 357,67 mg
F4 = 800 - (327+6,66+64+48)mg = 354,34 mg
50
Lampiran 6. Hasil uji sifat fisik granul
a. Kecepatan alir
Replikasi F 1
(g/detik)
F 2
(g/detik)
F 3
(g/detik)
F 4
(g/detik)
1 12,75 10,88 12,66 12,37
2 12,82 10,99 13,03 11,8
3 12,78 11,42 12,75 11,9
Rata-rata 12,78333 11,09667 12,81333 12,02333
SD 0,035119 0,285365 0,192959 0,304357
b. Sudut diam
Replikasi F 1 (0) F 2 (
0) F 3 (
0) F 4 (
0)
1 33,15 31,83 34,1 32,57
2 32,65 33,49 34,23 33,57
3 33,07 33,31 34,48 33,7
Rata-rata 32,95667 32,87667 34,27 33,28
SD 0,268576 0,910897 0,193132 0,618304
c. Pengetapan
Replikasi F 1 (%) F 2 (%) F 3 (%) F 4 (%)
1 7 7 9 6
2 8 10 8 7
3 6 8 6 7
Rata-rata 7 8,333333 7,666667 6,666667
SD 1 1,527525 1,527525 0,57735
d. Kadar air
F 1 (%) F 2 (%) F 3 (%) F 4 (%)
2,50 6,00 3,00 3,50
51
Lampiran 7. Hasil uji sifat fisik tablet
a. Keseragaman bobot
Nomor F 1 F 2 F 3 F 4
1 794,7 772 781 797,8
2 799,3 764,8 792,4 798,4
3 797,3 771,2 796,3 780,7
4 795,3 771,4 782,3 786,8
5 798,8 777,2 796,4 792,8
6 795 775 791,9 796,8
7 797,8 776,5 797,4 779,1
8 799,2 767,5 796,4 792,6
9 793,4 764,1 798 796,8
10 794 776,5 790,5 785
11 794 771,1 794,7 787,2
12 796,9 766,9 791,1 785,4
13 795,9 767,9 796 796
14 794,4 763 794,8 778,5
15 796,7 778 794,3 790,8
16 791 778,2 799,9 799,7
17 797 767,2 784 797,6
18 795,1 768,3 788,8 789,5
19 794,2 771,2 791,2 785,2
20 797,8 776,1 791,2 799,8
Rata-rata 795,89 771,205 792,43 790,825
SD 2,161359 4,880948 5,187749 7,013061
CV 0,27 0,63 0,65 0,89
b. Kekerasan
Nomor F 1 (kg) F 2 (kg) F 3 (kg) F 4 (kg)
1 6,91 3,77 8,35 7,5
2 7,57 3,69 8,17 7,96
3 7,57 3,52 8,15 7,44
4 7,5 3,85 7,62 6,99
5 7,51 3,35 8,24 7,63
Rata-rata 7,412 3,636 8,106 7,504
SD 0,282524 0,201196 0,282719 0,350756
52
Lanjutan lampiran 7
c. Kerapuhan
Replikasi F 1 (%) F 2 (%) F 3 (%) F 4 (%)
1 0,19 0,36 0,24 0,19
2 0,22 0,4 0,16 0,21
3 0,18 0,41 0,17 0,23
Rata-rata 0,196667 0,39 0,19 0,21
SD 0,020817 0,026458 0,043589 0,02
d. Waktu hancur
Replikasi F 1
(menit)
F 2
(menit)
F 3
(menit)
F 4
(menit)
1 15 12 19 15
2 14 10 20 16
3 12 11 18 15
Rata-rata 1,527525 1 1 0,57735
SD 13,66667 11 19 15,33333
53
Lampiran 8. Hasil pemeriksaan sifat fisik granul dengan metode factorial
design
a. Kecepatan alir
Factor Coefficient
Estimate
df Standard
Error
95% Cl
Low
95% Cl
High
VIF
Intercept 12.18 1
A-gelatin -0.62 1 1.00
B-explotab 0.24 1 1.00
AB0.22 1 1.00
Final Equation in Terms of Coded Factors:
kecepatan alir = +12.18
-0.62 * A
+0.24 * B
+0.22 * A * B
Final Equation in Terms of Actual Factors:
kecepatan alir = +14.74667
-0.59359 * gelatin
-0.017917 * explotab
+5.56807E-003 * gelatin * explotab
b. Sudut diam
Factor Coefficient
Estimate
df Standard
Error
95% Cl
Low
95% Cl
High
VIF
Intercept 33.35 1
A-gelatin -0.27 1 1.00
B-explotab 0.43 1 1.00
AB0.22 1 1.00
Final Equation in Terms of Coded Factors:
sudut diam = +33.35
-0.27 * A
+0.43 * B
-0.23 * A * B
Final Equation in Terms of Actual Factors:
sudut diam = +32.30000
+0.067067 * gelatin
+0.046250 * explotab
-5.69319E-003 * gelatin * explotab
54
Lanjutan lampiran 8
c. Pengetapan
Factor Coefficient
Estimate
df Standard
Error
95% Cl
Low
95% Cl
High
VIF
Intercept 7.42 1
A-gelatin 0.083 1 1.00
B-explotab -0.25 1 1.00
AB0.22 1 1.00
Final Equation in Terms of Coded Factors:
pengetapan = +7.42
+0.083 * A
-0.25 * B
-0.58 * A * B
Final Equation in Terms of Actual Factors:
pengetapan = +4.67000
+0.63263 * gelatin
+0.062500 * explotab
-0.014577 * gelatin * explotab
d. Kadar air
Factor Coefficient
Estimate
df Standard
Error
95% Cl
Low
95% Cl
High
VIF
Intercept 3.75 1
A-gelatin 1.00 1 1.00
B-explotab -0.50 1 1.00
AB0.22 1 1.00
Final Equation in Terms of Coded Factors:
kadar air = +3.75
+1.00 * A
-0.50 * B
-0.75 * A * B
Final Equation in Terms of Actual Factors:
kadar air = -2.16667
+1.35135 * gelatin
+0.072917 * explotab
-0.018769 * gelatin * explotab
55
Lampiran 9. Hasil pemeriksaan sifat fisik tablet dengan metode factorial
design
a. Keseragaman bobot
Factor Coefficient
Estimate
df Standard
Error
95% Cl
Low
95% Cl
High
VIF
Intercept 0.61 1
A-gelatin 0.15 1 1.00
B-explotab 0.16 1 1.00
AB0.22 1 1.00
Final Equation in Terms of Coded Factors:
keseragaman bobot = +0.61
+0.15 * A
+0.16 * B
-0.030 * A * B
Final Equation in Terms of Actual Factors:
keseragaman bobot = -0.25667
+0.12012 * gelatin
+0.010417 * explotab
-7.50751E-004 * gelatin * explotab
b. Kekerasan
Factor Coefficient
Estimate
df Standard
Error
95% Cl
Low
95% Cl
High
VIF
Intercept 6.67 1
A-gelatin -1.09 1 1.00
B-explotab 1.14 1 1.00
AB0.22 1 1.00
Final Equation in Terms of Coded Factors:
kekerasan = +6.67
-1.09 * A
+1.14 * B
+0.79 * A * B
Final Equation in Terms of Actual Factors:
kekerasan = +12.00000
-1.44845 * gelatin
-0.051250 * explotab
+0.019770 * gelatin * explotab
56
Lanjutan lampiran 9
c. Kerapuhan
Factor Coefficient
Estimate
df Standard
Error
95% Cl
Low
95% Cl
High
VIF
Intercept 0.25 1
A-gelatin 0.052 1 1.00
B-explotab -0.048 1 1.00
AB0.22 1 1.00
Final Equation in Terms of Coded Factors:
kerapuhan = +0.25
+0.052 * A
-0.048 * B
-0.042 * A * B
Final Equation in Terms of Actual Factors:
kerapuhan = -0.043333
+0.074074 * gelatin
+3.33333E-003 * explotab
-1.06356E-003 * gelatin * explotab
d. Waktu hancur
Factor Coefficient
Estimate
df Standard
Error
95% Cl
Low
95% Cl
High
VIF
Intercept 14.75 1
A-gelatin -1.58 1 1.00
B-explotab 2.42 1 1.00
AB0.22 1 1.00
Final Equation in Terms of Coded Factors:
waktu hancur = +14.75
-1.58 * A
+2.42 * B
-0.25 * A * B
Final Equation in Terms of Actual Factors:
waktu hancur = +14.23000
-0.70170 * gelatin
+0.13188 * explotab
-6.25626E-003 * gelatin * explotab
57
Lampiran 10. Hasil statisitik uji antara formula 1 dengan formula optimum
One-Sample Statistics
N Mean Std. Deviation Std. Error Mean
FORMULA1 8 9.6100 10.75277 3.80168
FORMULAOPTIMUM 8 9.5963 10.75220 3.80148
One-Sample Test
Test Value = 2
95% Confidence Interval of the
Difference
t df Sig. (2-tailed)
Mean Difference Lower Upper
FORMULA1 2.002 7 .085 7.61000 -1.3795 16.5995
FORMULAOPTIMUM 1.998 7 .086 7.59625 -1.3928 16.5853