acetazolamide
TRANSCRIPT
Deskripsi umum: FI4Sifat pisikokoimia: fi 4, USP 30
Gol. Obat, PIO n AHFS 2004Indikasi: AHFs 2005, hal 855 n PIO Mek. Kerja a to Z drug fact 2003Farmakokinetik: ahfs 2004 hal 885Dosis: ahfs 2004 hal 855, pioKontraindikasi: BNF 57, 2009, hal 592, mayler hal 654ES & toksisitas: ES (BNF 57, 2009, hal 592-593)Interaksi Obat: A to Z Drug Facts, 2003
Contoh sediaan yg beredar dipasaran: AHFS 2004, hal 8553.2. Pra formulasiFormula umum: sediaan : Zat aktif Pengisotonis Pelarut: NaOH (dibuat terpisah)
WFI
3.3. FormulasiFormula sediaan: Fornas hal.5Usulan Formula: sediaan: acetazolamidum 500 mg Pelarut: NaOH
3.4. Metode dan Pembuatan Sediaan
A. PerhitunganBuat table: Nama zat aktif, delta TF, dan C (%), delta TF.C
- TonisitasAcetazolamidePenurunan titik beku:W: o,52-∆Tb x C/ 0,576= 0,52-0,13x10%/0,576= 0,900
NaOH pH 9.2; POH=4,8__[OH]=10-4.8__[NaOH]= 1/1 x [OH-]___M NaOH=0,0000158___mol NaOH=0,0000158 M x 5 ml=0,0000792 mmol__ massa NaOH= 7,924x10-5 mol x 40 = 0,0032
B. PenimbanganAkan dibuat sediaan injeksi acetalomide dengan kekuatan sediaan 500 mg sebanyak 500 vial
DAFTAR PUSTAKADitjen POM Departemen Kesehatan RI. 1995. Farmakope Indonesia. Edisi ke empat. Jakarta: Departemen Kesehatan RI.
Uni
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Medication Safety Issues
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AcetaZOLAMIDE may be confused with acetoHEXAMIDE
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