Reactions 1487, p32 - 8 Feb 2014

STelaprevir

DRESS syndrome in an elderly patient: case reportA 66-year-old man experienced DRESS syndrome while

receiving telaprevir for hepatitis C virus.The man presented with a progressively worsening rash for

3 weeks. He also exhibited chills, fever and pruritus, and wasunable to open his eyes due to facial oedema. Anerythematous, maculopapular rash with areas of confluenceand desquamation was evident on his arms, anterior chest andface. He had started treatment for hepatitis C virus 2 monthspreviously, with pegylated interferon, ribavirin and telaprevir[route and dosage not stated]. On admission, eosinophilia wasobserved, with an eosinophil count of 800/µL, peaking at1000/µL on day 2, and decreasing to 500/µL at discharge. Askin biopsy showed spongiotic and purpuric perivasculardermatitis with eosinophils, and he was diagnosed with DRESSsyndrome secondary to telaprevir treatment.

The man was treated with antihistamines and steroids, anddischarged to close outpatient follow up with an allergist oncehis symptoms improved.

Author comment: "He was given the diagnosis of drug-related eosinophilia with systemic symptoms (DRESSsyndrome) secondary to telaprevir."Ciampa B. A man and his itchy dress Journal of General Internal Medicine 28(Suppl. 1): S268-S269, Jun 2013. Available from: URL: http://doi.org/10.1007/s11606-013-2436-y [Abstract]. - USA 803099308

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Reactions 8 Feb 2014 No. 14870114-9954/14/1487-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved