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KALSIUM

Simbol : Ca

Nomor Atom dan Nomor Massa : 20/40

Konfgurasi elektron : s22s22!"#s2#!"4s2 #d 4!

Struktur : Kubus !usat muka

Sen$a%a kalsium : CaC' Ca0()&4*"(&+*2

(tulang*

,- !m"0 !m

Ukuran atom

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4s

3d

4p

Ca

Ca2

.

4

s

3

d

4

p

4s

3d

4p

Kalsium da!at membentuk kom!leks koordinasi dengan bilangankoordinasi: " 0

)enggambaran orbital alensi atom kalsium

Conto1 !enggambaran orbital alensi atom Ca dengan bilangankoordinasi -

Struktur bipiramida

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#

)emea1an orbital d bergantungligan !ada kom!leks okta1edral

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4

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3

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entuk ikatan Cakalmodulin

4s

H2

3d

As Glu As AsGlu O*

&rbita

lLigan

4p

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almodulin is an 56 1and !rotein t1at

seres as a alium sensor7Calmodulin

Multi8untionalalium ree!tor

member o8 t1e 561and 8amil$ o8!roteins7

onsists o8 t%oglobular lobes 9oined

b$ a long al!1a 1eli7 5a1 lobe ontains

t%o 56 1ands7 ;1ereare 4 alium bindingsites (s1o%n as ' 2' #'

and 47*

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Structure of calmodulin, a cytosolic protein of 148 amino acids that binds Ca2+ions.(a)

The bacbone of the calmodulin molecule, deduced from crystallo!raphic analysis of theCa2+"calmodulin comple#. The four bound Ca2+ions are represented by blue spheres. (b)

$mino acid se%uence of one of the four Ca2+"bindin! sites in calmodulin. &ach site

contains aspartate ('), !lutamate (&), and aspara!ine ()residues (purple) hose side

chains establish ionic bonds ith a Ca2+ion, formin! a loop in the bacbone. *n other

Ca2+"bindin! sites in calmodulin, o#y!en atoms on the side chains of threonine and serineresidues also artici ate in Ca2+ bindin