aplikasi obat imunosupresi 97.kuliah (01) b6m3.ppt

7/26/2019 APLIKASI OBAT IMUNOSUPRESI 97.kuliah (01) b6m3.ppt

1/19

APLIKASI OBATIMUNOSUPRESI& ANTI ALERGI

(=IMMUNE INTERVENTION)

Harijono KariosentonoDermato-venerolog!t"

S#ra$arta%


2/19

TUUAN INTER'ENSI IMUN

)% Mem*er$#at re!*on! m#n ter+a,a*t#mor ,an *atogen

% Mene$an (!#*re!. re!*on! m#nole+ $arena *en/a$t otom#n ,angraft rejection

0% Mer#1a+(deviation. re!*on! m#n/ang misled (men/e!at$an. *a,a*en/a$t alerg


3/19

PENGOBATAN PEN2AKIT AKIBATGANGGUAN RESPONS IMUN

)%Tera* $a#!atv (agen *en/e1a1.

elmna! agen ant1ot$" antvral"

ant 3am#r" ant *ara!t & antt#mor%

m#no*ro4la5! (= m#n!a!.

*a!6 -nat#ral ( tran!*la7ental"

a1 tran!6er.

- art4!al (m!% T5 I'IG.


4/19

A$t6 - nat#ral (*a!7a n6e$! 1a$ter"

vr#! 3am#r" *ara!t ,!1.

- art4!al (va$!na!.

% Im#notera* (*engg#naan o1at .

- m#no!#*re! ( $ort$o!tero,"a8at+o*rn" !$lo6o!6am, ,!1.

-ant alerg (ant +!tamn.%


5/19

KORTIKOSTEROID

9:ormon" ,!nte!a $orte$ A,renal

9E6e$ Mneralo$ort$o, - Al,o!teron

Gl#$o$ort$o, - :,ro$ort!on (Kort!ol.

9Ant In;ama!9Im#no!#*re!!

9Meta1ol!me 9Gl#$oneogene!!9L*ol!!9Proten 1rea$,o


6/19

Kortikosteroid

(KS)

Sintesa Protein :

Tran!$r*! DNA

Tran!la! mRNA

KS+Reseptor=Komplek Reseptor Kortikosler

Int !el DNA GRE (Glco!orticoid Res"onElement)

GRE GRE (-.

Tran!$r*! Tran!$r*!


7/19

Mekanisme Kerja Kortikosteroid :


8/19


9/19

ANTI INFLAMASI STR!I":ANTI INFLAMASI STR!I":

)%Men#r#n$an> Men7ega+ re!*on3arngan ter+a,a* *ro!e! n;ama!

%Meng+am1at A$#m#la! !el-!el

In;ama!

0%Meng#rang ,lata! ,an *ermea1lta!$a*ler

?%Penng$atan Snte!a L*o$ortn ) Meng+am1at en8m 6o!6ol*a!e A Me,ator L*, @ ter1ent#$


10/19

E6e$ Im#no!#*re! Stero,

)% Gangg#an *a,a *ro!e!tran!$r*! men#r#n$an

mole$#l *ro-In;ama!% Mene$an Re*l$a! &

Pergera$an !el

Mono!to*ena" eo!no*ena"lm6o!to*ena


11/19

ANTI :ISTAMIN

ADALA: OBAT 2ANG BEKERA ANTAGONISTER:ADAP :ISTAMIN ata# 1e$er3a !e7ara$om*ett6 ,g +!tamn t+, re!e*tor +!tamn*a,a !el7ega+ $er3a +!t *a,a organ

target% :ISTAMIN

-me,ator *atogenet$ *a,a 1er1aga*en/a$t alerg

-,$el#ar$an ole+ !el MAST>Ba!o4l!etela+ !tm#l#! ,egran#la!

-1era!al ,ar a! amno +!t,n !e$alterle*a! ma!#$ $e *em1 ,ara+ (%- mnt.


12/19

Pele*a!an +!tamn a$1at

- rea$!>ntera$! antgen ant1o,

- $onta$ ,g o1at" $em$al" ma$anan"

al$olo, ,an venom % :!tamn /ang le*a! ntera$! ,g

re!e*tor /g ter!e1ar , 3arngan%

Ant+!tamn t,a$ meng+lang$an e6e$+!t /ang tela+ tm1#l" !+g 1erg#na#t$ *en7ega+an ,* *engo1atan ge3alao$ +!t%


13/19

Re!e*tor +!tamn

:ISTAMIN

re!e*tor +!tamn :) *a,a3arngan t#1#+" / !el otot *olo!

, 1ron$#!" #!#! +al#! ,an *em1%,ara+%

re!e*tor : *eran C" *ro,#$!

a!am lam1#ng re!e*tor :0 1er+#1#ngan ,g

!!tem !ara6" 6#ng! ma!+


14/19

KLASIIKASI ANTI:ISTAMIN

A:) -genera! lama>*ertama

-genera! 1ar# ($e,#a. non#sedating

#genera! $etga

A: o1at *ene$an *ro,#$!

a!am lam1#ng A:0 1el#m ter!e,a #t$ *engg#naan

$ln!%


15/19

A:) genera! *ertama

Ma7am -,6en+,ramn" $lor6enramnmaleat"

-*rlamn maleat"+,ro$!8n:Fl" -*rometa8n :Fl"!*ro+e*ta,n%

E6e$ 6arma$olog!

-!e,atve lar#t ,lm lema$" !a


16/19

E6e$ !am*ng

Se,a! & e6e$ lan *, SSP di$$iness%n$oor,na!" ,*lo*a ,an $ele!#an%

E6e$ rang!angan SSP e#6ora" gel!a+n!omna ,an tremor (ter#tama or t#a,an ana$.

Kon!t*a!" ,!#r" 1at#$" na#!ea

vomtng" gla#$oma"*al*ta! +am1atan *, re!e*tor $olnerg$" ,ana,renerg$%


17/19

Dam*a$ $ln! ntera$!+!tamn *, re!e*tor :)

&'eal are (e,em & $emera+an.a$1at *ermea1lta! *em1 ,ara+menng$at ,an va!o,lata!%

*rrits (gatal. a$tva! !ara6!en!or$

Mcosal oedem

R'inorr'ea ole+ $arena !e$re! !elgo1let ,an $elen3ar m#$#! menng$at


18/19

A:) genera! $e,#a>non!e,a!

Ma7am a$rva!tn" a!tem8ol"lorata,n" ter6ena,n" !etr8n

T,a$ le


19/19

Ana4la$!! ,an alerg

Rea$! ana4la$!! ,an 1e1era*area$! alerg re6ra$ter ,engan*em1eran A:-)" $arena 1#$an

+an/a +!tamn /ang 1er*eran" ta*1an/a$ me,ator lan /g ,le*a!%

O1at *ertama /ang ,g#na$an #t$

rea$! ana4la$!! ($+#!,#! !+o$. A,renaln n3%

aplikasi obat imunosupresi 97.kuliah (01) b6m3.ppt

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