antasida, dll(1)

7/23/2019 Antasida, dll(1)

1/40

ANTASIDA

ANTAGONIS H2PENGHAMBAT POMPA

PROTONPROKINETIKdr. IKA KOMALA

BAGIAN FARMAKOLOGIUNIV. SWADAYA GUNUNG JATI


2/40

OBAT YANG DIGUNAKAN UNTUKPENYAKIT ASAM PEPTIK

Penya!" a#a$ %e%"! $en&a'% '('#%e%"!'$ )(a$*'n+ dan d',den'$-re/'# +a#"r,e#,0a+'# )%en+e('aran

e$*a(! &a!ran dar! (a$*'n+ $e(a('!e#,0a+'#- dan eadaan1eadaan!%er#ere#! %a",(,+!# #e%er"! #!ndr,$

3,((!n+er1E((!#,n. Pa",+ene#!# '('# %e%"!'$ "!da

#e%en'nya d!%aa$!

dr Ia K,$a(a


3/40

A#a$ (a$*'n+ dan #ere#! %e%#!nd!%er('an 'n"' "er4ad!nya '('#

%e%"!'$. Fa",r (a!n 5 e"aanan $',#a "erada%

a#a$ '#'#nya %r,d'#! dar! $''#+a#"r,d',den'$ dan #ere#! *!ar*,na",(e #e(1#e( e%!"e(.

Peran %en"!n+ dar! *a"er! Helicobacterpylori "erada% %a",+ene#!# '('# #earan+

!n! #e&ara ('a# d!"er!$a. Pen++'naan Salicylatedan ,*a"

an"!!n/a$a#! n,n#"er,!d "erada% $',#a(a$*'n+

dr Ia K,$a(a


4/40

Searan+ !n! "er#ed!a ,*a" yan+$ene"ra(!#!r a#a$ (a$*'n+ $en+'ran+!#ere#! a#a$ (a$*'n+ a"a' $en!n+a"ane"aanan $',#a $e(a('! a"!6!"a#

7#!",%r,"e"!08 a"a' an"!$!r,*a. Ke*anyaan d,"er $en+,*a"! #e$'a

'('# %e%"!'$ yan+ a$*' dan $ereayan+ d!ya!n! "er!n0e#! H %y(,r! d+ ,*a"

an"!$!r,*a d!,$*!na#! d+ ,*a"an"!#ere#!

dr Ia K,$a(a


5/40

ANTASIDA

An"a#!da ada(a *a#a (e$a yan+*erea#! den+an a#a$ !dr,(,r!da(a$*'n+ 'n"' $e$*en"' +ara$ dan

a!r. Man0aa" an"a#!da %ada '('# %e%"!'$

*erda#aran e$a$%'an $en+'ran+!

a#a$ (a$*'n+ dan arena %e%#!n "!daa"!0 da(a$ (ar'"an den+an %H 9 :$aa *!#a $en+'ran+! a"!6!"a# %e%"!.

dr Ia K,$a(a


6/40

Dar! %ene(!"!an $en'n4'an *a;a%e$*er!an an"a#!da d,#!# renda#e"!a% ar! $e$*er!an %er(!nd'n+an

$',#a (a$*'n+ (e;a" ran+#an+an%r,d'#! %r,#"a+(and!n dan%en+!a"an #'*#"an#! %e$*'a" ('a.

dr Ia K,$a(a


7/40

Ke*anyaan an"a#!da yan+ d!+'naan#aa" !n! $en+and'n+ $a+ne#!'$

!dr,#!da dan a('$!n!'$ !dr,#!da*a! #end!r! $a'%'n *en"' ,$*!na#!dan adan+ da(a$ ,$*!na#! den+an

na"r!'$ *!ar*,na" a"a' +ara$ a(#!'$. K,$*!na#!1,$*!na#! #ed!aan "e(a

d!e$*an+an 'n"' $e$a#!$a(ane0e"!6!"a# dan $e$!n!$a(!#a#!e"!danya$anan.

An"a#!da 4'+a *er6ar!a#! da(a$ ra#a danar+a

dr Ia K,$a(a


8/40

Kand'n+an '"a$a dar! an"a#!da

Kandungan

Kapasitas

netralisasi

Bentukgaramdalam

lambung

Kelarutan

garam

Efek samping

NaH


9/40

Pen++'naan (!n!# an"a#!da

La4' %r,d'#! a#a$ (a$*'n+ #e#'da$aan :> $e?@4a$

Pe$*er!an d,#!# "'n++a( an"a#!da >$e? 4a$ #e"e(a $aan e0e"!0$ene"ra(an a#a$ (a$*'n+ #e(a$a 24a$

D,#!# ed'a yan+ d!*er!an = 4a$#e"e(a $aan $e$%er"aanan e0e#e(a$a 9 : 4a$

dr Ia K,$a(a


10/40

H'*'n+an d,#!#1re#%,n an"a#!da *er6ar!a#!"er+an"'n+ a%a#!"a# #ere#! (a$*'n+

)!%,@!%er#ere",r- dan e&e%a"an%en+,#,n+an an"a#!da dar! (a$*'n+.

An"a#!da e0e"!0 da(a$ $en!n+a"an%enye$*'an '('# d',den'$.

Ke'n"'n+an %d %enye$*'an '('#%e%"!'$ 'ran+ 4e(a#.

Pada '4! ,n"r,( "era%! "er*a! an"a#!da

'n"' '('# d',den! ada(a :C $e?an"a#!da d!*er!an dan = 4a$ #e#'da$aan dan #aa" "!d'r.

dr Ia K,$a(a


11/40

An"a#!da "a*(e" '$'$nya (e$a $ene"ra(!#!ra#a$ dan %er(' #e4'$(a *e#ar "a*(e".

An"a#!d "a*(e" "!da d!re,$enda#!an 'n"'%en+,*a"an '('# %e%"!'$ yan+ a"!0.

Senya;a1#enya;a a('$!n!'$ *eer4a$e(a('! a#! #!",%r,"e"!0 (an+#'n+ a"a'

den+an $en+!a" #'*#"an#!1#'*#"an#! yan+*!#a $e('a!.

Rea#! yan+ "!da d!!n+!nan $e(!%'"!%er'*aan da(a$ 0'n+#! n,r$a( '#'#.

Gara$ $a+ne#!'$ #er!n+ %'nya e0e%en&aar dan a('$!n!'$ !dr,#!da *!#a$enye*a*an #e$*e(!".

dr Ia K,$a(a


12/40

Ma#a(a !n! da%a" d!"an+an! den+an$en+,$*!na#!an a"a' $e$*er!an

#e&ara *er+an"!an. Ma#a(a (a!n $'n+!n *erenaan den+an

a*#,r%#! a"!,n )#,d!'$ $a+ne#!'$a('$!n!'$ a(#!'$- dan a(a(,#!##!#"e$a"!. Un"'n+nya a( !n! anya$en4ad! $a#a(a (!n!# %ada %a#!enden+an +an++'an +!n4a(.

Da(a$ d,#!# *e#ar and'n+an na"r!'$dar! *e*era%a an"a#!da da%a" $en4ad!#e*'a 0a",r %en"!n+ %ada %a#!en%ender!"a +a+a( 4an"'n+ ,n+e#"!0.

dr Ia K,$a(a


13/40

An"a#!da "e(a d!+'naan 'n"' $eredaanra#a #a!" dar! e#,0a+!"!# '('# %e%"!'$ dan

'('# d',den'$ na$'n '4! "er,n"r,( d+%(a#e*, $en'n4'an "a ada e0e dar! d,#!#7e0e"!08 "'n++a( '" $eredaan ra#a #a!"%ada ,nd!#! !n!.

In"era#! ,*a" An"a&!d da%a" $en+ad#,r*#! ,*a" d! #a('ran

+a#"r,!n"e#"!na( dan $en+'ran+! ad#,r*#!nya.

An"a&!d da%a" $en'r'nan a*#,r#! 5 d!+,!n

0e '!n,(,n "e"ra&y&(!n

Men!adaan a*#,r%#! 5 !"ra,na,(ee",,na,(

dr Ia K,$a(a


14/40

OBAT ANTISEKRESILAMBUNG

Sere#! a#a$ (a$*'n+ *erada %ada,n"r,( "!+a a+,n!# %,, 5 !#"a$!na&e"y(&,(!ne dan +a#"r!n.

A('r '$'$ a!r ada(a $e(a('!%,$%a %r,",n yan! K@HATPa#e.

O*a"1,*a" yan+ *er%eran ada(a 5

an"a+,n!# Re#e%",r H2 a+enan"!$'#ar!n! %en+a$*a" %,$%a%r,",n dan ,&"re,"!de

dr Ia K,$a(a


15/40

Ga$*aran #e$a"!(a$*'n+

dr Ia K,$a(a


16/40

ANTAGONIS RESEPTOR H2

E$%a" ,*a" yan+ d!+'naan 5 cimetidine,ranitidine, famotidine, dannizatidine.

Pada %e$*er!an d,#!# "'n++a( a+en1a+en

!n! $a$%' $en+'ran+! 9 C #ere#!a#a$ (a$*'n+ *a#a( dan #ere#! a#a$(a$*'n+ yan+ d!#"!$'(a#! ,(e $aanan.

Pada *anya %en+'4!an "e(a "er*'"!e0e"!6!"a# da(a$ $en!n+a"an%enye$*'an '('# d',den'$ dan (a$*'n+dan $en&e+a ea$*'an.

dr Ia K,$a(a


17/40

Se(a!n !"' a+en !n! 4'+a d!+'naan da(a$%enan+anan $ed!# #!ndr,$a 3,((!n+er1

E((!#,n dan eadaan !%er#ere#!(a$*'n+ %ada mastocytosis#!#"e$!.

DOSIS

Peneanan #ere#! a#a$ %ada $a(a$ar! $er'%aan %enen"' %en"!n+%enye$*'an '('# d',den'$.

D,#!# &!$e"!d!n 5 :CC1CC$+ 2@r a"a'CC $+ %ada 4a$ "!d'r.

D,#!# ran!"!d!n dan n!a"!d!n 5 >C $+2@r a"a' =CC $+ #aa" 4a$ "!d'r.

dr Ia K,$a(a


18/40

D,#!# 0a$,"!d!n 5 2C $+ 2@r a"a':C $+ %ada 4a$ "!d'r.

Un"' $en&e+a ea$*'an 5

d,#!# 4a$ "!d'r d!*er!an #e"!a% ar!#aa" 4a$ "!d'r.

Se$'a an"a+,n!# H2 '$'$nya

d!",(eran#! den+an *a! den+an#ed!!" e0e #a$%!n+.

dr Ia K,$a(a


19/40

E0e #a$%!n+

,*a" 5 ;ar0ar!n "e,%!((!n d!ae%a$ dan%en!",!n.

Ran!"!d!n dan 0a$,"!d!n 5 #a!" e%a(a)=:-.

dr Ia K,$a(a


20/40

TERAPI KOMBINASI

K,$*!na#! an"ara an"a+,n!# re#e%",r H2

dan an"a#!da #e&ara ('a# d!re#e%an;a(a'%'n anya #ed!!" da#ar ra#!,na('n"' a( !n!.

T!da ada e'n"'n+an da(a$ #e+!%er&e%a"an e#e$*'an a"a' %er*a!an%en+'ran+an ra#a nyer!.

K,$*!na#! an"a+,n!# re#e%",r H2 den+an

#e*'a %en+a$*a" %,$%a %r,",n)$!#5,$e%ra,(- "a$%anya$en+a$*a" e0e"!6!"a# ,$e%ra,(.

dr Ia K,$a(a


21/40

PENYAKIT REFRAKTER

U('# %e%"! yan+ "!da *ere#%,n"erada% %en+a$*a" H2 a"a'an"a#!da $a#! $er'%aan #e*'a$a#a(a '#'#nya %ada ,ran+ '#!(adan %er,,.

Se*anya 2C '('# aan +a+a( 'n"'#e$*' den+an "era%! ,n6en#!,na(#e(a$a : $++.

dr Ia K,$a(a


22/40

A("erna"!0 %en+,*a"an 'n"' e+a+a(an%en+a$*a" re#e%",r H2 ya!"' den+an

%en++'naan d,#!# "!n++! a"a'%er%an4an+an %en+,*a"an den+an$er'*a e %en+a$*a" %,$%a%r,",n.

Pada %a#!en yan+ $en'n4'an !n0e#!H.%y(,r! d!%er('an ,$*!na#! an"!*!,"!dan *!#$'".

Pada %a#!en #yndr,$a 3,((!n+er1E((!#,nd!*'"'an d,#!# an"a+!n!# H2 yan+(e*! "!n++! )$!#5 &!$e"!d!n 2:CC $+@r-

dr Ia K,$a(a


23/40

PENGHAMBAT POMPA PROTON

Ada(a #enya;a1#enya;a #'*#"!"'#!*en!$!da,( y+ #e&ara n,nre6er#!*e($en+a$*a" %,$%a %r,",n #e( %ar!e"a(

(a$*'n+ yan! K

@H

ATPa#e. O*a" !n! $er'%aan %r,dr'+ yan+

$e$*'"'an a"!6a#! d! (!n+'n+an a#a$dar! ana(!'('# #ere",r! #e( %ar!e"a(.

D,#!# "'n++a( %er ar! da%a" #e&ara e0e"!0$en+a$*a" CC #ere#! a#a$ (a$*'n+

dr Ia K,$a(a


24/40

O*a" yan+ d!%aa! #aa" !n! ada(a 5omeprazole, lansoprazole, rabeprazol

danpantoprazole. Se$'anya e0e"!0 'n"' %en+,*a"an 4an+a

%ende ):1 $++- %ada '('# %e%"!'$ '('#d',den'$ dan %enya!" +a#"r,0a+'# yan+

*era". J'+a e0e"!0 'n"' %en&e+aan ea$*'an

'('# d',den'$ dan e#,0a+!"!# %ada d,#!#yan+ e&!(.

Pen+a$*a" %,$%a %r,",n (e*! *a!d!*and!n+ an"a+,n!# H2dan $!#,%r,#",(da(a$ %enye$*'an '('# %e%"!'$ a!*a"AINS.

dr Ia K,$a(a


25/40

O*a" !n! 4'+a d!+'naan 'n"' #!ndr,$1#!ndr,$ !%er#ere#! %a",(,+!# #e%er"!

#!ndr,$a 3,((!n+er1E((!#,n ne,%(a#!aend,r!n $'("!%e( dan mastocytosis#!#"e$!.

O*a" !n! 4'+a d!#e"'4'! #e*a+a! *a+!an "era%!,$*!na#! %ada !n0e#! H. pylori ya!"' 5

: r &(ar!"r,$y&!n%en+a$*a" %,$%a%r,",n a"a'

C r

&(ar!"r,$y&!na$%!&!((!n%en+a$*a"%,$%a %r,",n

dr Ia K,$a(a


26/40

Pen+a$*a"1%en+a$*a" %,$%a %r,",n"e(a $enda%a"an %er#e"'4'an 'n"'*er*a+a! !nd!a#! yan+ *er'*'n+anden+an %enya!"1%enya!" a#a$ %e%"!.

Pera"!an "en"an+ ea$anan%en++'naan %en+a$*a" %,$%a %r,",n*er'*'n+an den+an e0e #'%re#!#e$%'rna yan+ (a$a dar! *ar!er a#a$"erada% $a#'nya *a"er! e "'*'dan !%er+a#"r!ne$!a.

dr Ia K,$a(a


27/40

Pada "!'# %e$*er!an r,n!# d,#!#*e#ar ,$e%ra,( $enye*a*an"er4ad!nya "'$,r ar#!n,!d (a$*'n+.

Te"a%! a( !n! *e('$ d!(a%,ran"er4ad! %ada $an'#!a. O*a"1,*a" !n!#e%er"!nya a$an da(a$ '4!1'4! (!n!#

!n++a #aa" !n!.

dr Ia K,$a(a


28/40

PROKINETIK

Mean!#$e ,(!ner+! *er"an++'n+ 4a;a*'n"' $e$,d'(a#! 0en,$ena $,",r! d!'#'# #e!nn+a a+en ,(!n,$!$e"! e0e"!0

da(a$ $en!n+a"an $,"!(!"a#+a#"r,!n"e#"!na(.

A+en %r,!ne"! #e(e"!0 5 $e",&(,%ra$!ded,$%er!d,n dan &!#a%r!de.

Me",&(,%ra$!de $er'%aan an"a+,n!#d,%a$!n yan+ 'a" $e$a#'! SSP

$e$%'nya! #!0a" an"!$'n"a.

dr Ia K,$a(a


29/40

en"er! dar! %(e'# $!en"er!'#. O*a"1,*a" !n! $e$%er&e%a" (!ren#

e#,0a+'# $en!n+a"an ",n'# #n+"er

e#,0a+'# *a+!an *a;a $e$%er&e%a"%en+,#,na+n (a$*'n+ dan$e$e%er%ende ;a"' "ran#!" %ada'#'# a('#.

dr Ia K,$a(a


30/40

A%(!a#! (!n!# 5 d!+'naan 'n"' $eredaan+e4a(a %ada %a#!en %ender!"a e+a+a(an+eraan $,",r! (a$*'n+ '#'#nya+a#"r,%are#!# d!a*e"!a %a#!en 6a+,",$!a"a' +an++'an %en+,#,n+an (a$*'n+(a!nnya. J'+a d!+'naan 'n"' $en'r'nane4ad!an ear"*'rn %ada %a#!en %ender!"are/'# +a#"r,0a+'# r,n!#.

Pen++'naan &!#a%r!de #'da d!*a"a#! arenae0e #a$%!n+ ar!"$!a 6en"r!'(er yan+ 0a"a(dan !n"era#! ,*a" yan+ "!da d!!n+!nan.

dr Ia K,$a(a


31/40

O*a" d!a*#,r%#! d+ &e%a"d+ ,n#en"ra#!%'n&a :C12C $en!" ;a"' %ar' %(a#$a 21:

4a$. D,#!# $e",&(,%ra$!de 5 C $+ :@r *er#a$a

;a"' $aan dan "!d'r.

Un"' e$,"era%! aner d,#!# 5 12 $+@+

E0e #a$%!n+ 5 $en+an"' +e(!#a rea#!1rea#! d!#",n! %ar!n#,n dan d!#!ne#!a "ard!6e)%ada (an#!a- %en!n+a"an r!(!# %r,(a"!ne(en4ar !%,#a +a(a",re dan $en#"r'a#!.

D,#!# &!#a%r!de 5 C $+ :@r

%ada %a#!en +a#"r,%are#!# d!a*e"!a >1C$+.

dr Ia K,$a(a


32/40

D,$%er!d,n

$er'%aan an"a+,n!# d,%a$!n yan+

#e&ara%er!0era( *eer4a #e(e"!0 %ada re#e%",r D2.

D,$%er!d,ne $e$%'nya! a#!a"an"!e$e"! yan+ #a$a den+an

$e",&(,%ra$!de. E0e an"!e$e"! da%a" d!#e*a*an ,(e

,$*!na#! e0e %er!6era( )+a#"r,!ne"!-

den+an an"a+,n!# "erada% re#e%",rd,%a$!n d! &e$,re&e%",r "r!++er ,neyan+ "er(e"a d!('ar Sa;ar dara ,"a d!area %,#"re$a.

dr Ia K,$a(a


33/40

Pe$*er!an d,$%er!d,ne %er ,ra( da%a"$ena$*a (a$anya ,n"ra#! U an"ra( dan

d',den'$ $en!n+a"an %en+,#,n+an(a$*'n+ dan $ena$*a "eanan %ada#n+"er e#,0a+'# *a+!an *a;a %ada ,ran+#ea".

Ind!a#! 5 #!ndr,$a d!#%e%#!a 0'n+#!,na()"!da d!an4'ran 'n"' %e$*er!an 4an+a%an4an+-. M'a( dan $'n"a yan+d!#e*a*an ,(e %e$*er!an (e6,d,%a dan

*r,$,r!%"!n (e*! dar! 2 $!n++'. M'a( dan$'n"a a'" )"!da d!an4'ran %en&e+aanr'"!n %ada $'n"a #e"e(a ,%era#!-.

dr Ia K,$a(a


34/40

Pe$aa!an %ada ana1ana "!dad!an4'ran e&'a(! 'n"' $'a( dan

$'n"a %ada e$,"era%! aner danrad!,"era%!.

D,#!# 5 C $+ ) "a*(e"- =@r > 1 =C$en!"Se*e('$ $aan dan 4!a %er(' #e*e('$"!d'r $a(a$.

D,#!# ana ) Se'*'n+an e$,"era%!

aner dan rad!,"era%!-5 C21C: $+@+ BB= :@r. O*a" d!$!n'$ > 1 =C $en!"#e*e('$ $aan dan #e*e('$ "!d'r$a(a$.

dr Ia K,$a(a


35/40

Ha"!1a"! %en++'naan %ada %ender!"a den+an+an++'an n+#! a"! dan +!n4a(.

Ha"!1a"! %en++'naan %ada ;an!"a a$!( dan$eny'#'!.

Td d!an4'ran 'n"' %e$*er!an 4an+a%an4an+.

E0e Sa$%!n+ 5 E0e e#"ra%!ra$!da( 4aran+"er4ad! a( !n! #e+era !(an+ #e&ara$enye('r' #e+era #e"e(a %e$*er!an ,*a"d!en"!an.

D,$%er!d,ne da%a" $eran+#an+ %en!n+a"anadar %r,(a"!n %(a#$a )y%er%r,(a&"!ne$!a-yan+ da(a$ 4an+a %an4an+ da%a"$enye*a*an +a(a",rea dan +!ne,$a#"!a.

dr Ia K,$a(a


36/40

Rea#! a(er+! yan+ 4aran+ "er4ad!#e%er"! ra# dan 'r"!ar!a.

Kontraindikasi : Pender!"a yan+!%er#en#!"!0 "erada% d,$%er!d,ne.Pender!"a den+an %r,(a"!n,$a "'$,r

!%,#e yan+ $en+e('aran %r,(a"!n. T!da *,(e d!+'naan 4!a #eran+an

$,"!(!"a# (a$*'n+ da%a"$e$*aayaan #e%er"! adanya%endaraan ,*#"r'#! $ean!a"a'%er0,ra#! +a#"r,!n"e#"!na(.

dr Ia K,$a(a


37/40

In"era#! ,*a" 5 Pe$*er!an ,*a"ana(+e#! ,%!,!d dan an"! ,(!ner+!

$'#ar!n! #e&ara *er#a$aan da%a"$en+an"a+,n!# a"!6!"a# e0ed,$%er!d,ne.

Pe$*er!an an"a#!da #e&ara *er#a$aanda%a" $en'r'nan *!,a6a!(a*!(!"a#d,$%er!d,ne.

E0e *!,a6a!(a*!(!"a# da%a" *er"a$*adar! = $en4ad! 2= *!(a d!$!n'$ >

4a$ #e"e(a $aan.

dr Ia K,$a(a


38/40

A+en yan+ $e(!nd'n+! $',#a

sucralfate

S'&ra(0a"e a"a' a('$!n!'$ #'&r,#e #'(0a"eada(a #e*'a d!#aar!da yan+ d!#'(0a#!yan+ d!e$*an+an 'n"' %en++'naan

%ada %enya!" '('# %e%"!'$. Mean!#$e er4a 5 $e(!*a"an %,(!$er!#a#!

dan %en+!a"an #e(e"!0 "erada% 4ar!n+an'('# yan+ ner,#!# d!$ana *aan !n!*er"!nda #e*a+a! %en+a(an+ "erada%a#a$ %e%#!n dan &a!ran e$%ed'.

dr Ia K,$a(a


39/40

S'&ra(0a" da%a" #e&ara (an+#'n+$enyera% +ara$1+ara$ &a!ran e$%ed'

dan $en#"!$'(a#! #!n"e#!# %r,#"a+(and!nend,+en.

D,#!# 5 + :@r %ada #aa" %er'"

,#,n+ )#e"!danya 4a$ #e*e('$$aan-.

S'&ra(0a" $e$*'"'an %H a#a$ 'n"'a"!6a#! #e*a!nya "!da d!*er!an

*er#a$a an"a#!da an"a+,n!# re#e%",rH2a"a' %en+a$*a" %,$%a %r,",n.

dr Ia K,$a(a


40/40

senyawa bismuth koloid

Se%er"! #'&ra(0a" #enya;a *!#$'" 4'+a

*eer4a den+an %en+!a"an #e&ara #e(e"!0%ada #*'a '('# $e(a%!#!nya dan$e(!nd'n+!nya dar! a#a$ dan %e%#!n.

Mean!#$e er4a (a!n 5 %en+a$*a"an

a"!6!"a# %e%#!n #"!$'(a#! %r,d'#! (end!rdan %en!n+a"an #!n"e#!# %r,#"a+(and!n.

B!(a ,*a" !n! d!,$*!na#!an den+an

an"!*!,"! #e$!#a( $e"r,n!da,( dan"e"ra#!(!n "!n+a" %enye$*'an '('#$en!n+a" !n++a

E0e #a$%!n+ $!n!$a(.

d I K (

antasida, dll(1)

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