dr. eiffel - anemia defisiensi besi
TRANSCRIPT
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Pre#alensi Anemia ) negara asia tenggara
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Distri"usi "esi
*omponen penting
+eta"olisme dan transfer elektron
1 mcg( 1 ml sel dara! mera! ,eritin -!emosiderin
+ioglo"in-enim
♂ Deasa : /5$05 mcg(kg"" ♂ le"i! sedikit
Total "ody iron of / 0g
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Iron transport pat!ay
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Distribution of Iron in Adults
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Etiologi
Pregnancy(lactation 2ormal grot! Blood loss 3astric "ypass +ala"sorption
4eliac disease-IBD
*eganasan Parasit Diet
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Kebutuhan Besi
Pria dan anita :.5 dan 1 mg 6anita +enstruasi dan !amil : 7 mg and 7.5
mg. 5% $ 1% dari 1 to 7 mg "esi dalam diet
deasa di a"sor"si.
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Defisiensi "esi → / stadium perkem"angan
Deplesi cadangan "esi
Defisiensi "esi eritropoisis
Anemia defisiensi "esi
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8tiologi defisiensi "esi
Deplesi besi Defisiensi besi Anemia def besi
Diet inadekuat
Pertum"u!an cepat
$ "ayi
$ rema9a
&aid normal
Donor dara!
&aid
&amil
Perdara!an akut
+ala"sor"si
3astrectomy
;egional enteritis
Peradangan kronik
Terapi ple"otomi
Diet
Perdara!an kronik
Peptic Ulcer
Tumor kolon
Di#erticulitis
Parasit
+ala"sor"si "erat
+yoma uteri
Diet
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Diagnosis
Anamnesis
;iayat penyakit pasien Pemeriksaan fisik
la"oratorium
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Gambaran Klinik
,atigue
koilonyc!ia
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*on9ungti#a anemis
3e9ala penyakit penyerta
;am"ut rontok Papil lida! atropi
Pallor
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koilonyc!ia
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>a"oratorium Anemia Defisiensi Besi
?erum Iron LOW
?erum Iron
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?erum ,erritin LOW
4an "e @falselynormal in inflammatory
states
?aturasi Transferin : ?I
TIB4
$ 7$/%
$ ' 7 % : kurang
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>a"oratorium defisiensi "esi
Deplesi ,e Defisiensi ,e An. Def ,e
Hb 2ormal ↓ ringan +ikrositer!ipokrom
Iron store (mg ' 1 !I(ug"dl 2ormal ' ' 0
#IB$(ug"dl /$/C /C 01
% saturasi 7$/ ' 15 ' 1
&erritin ' 0 ' 7 ' 1
% sideroblast 0$ 1 7
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Blood film:
Hypochromic microcytic Picture. Occasional Target cells.
Pencil shaped poikilocytes.
Normal reticulocyte count. Bone marrow iron:
Normal to hypercellular.
B! precursors are increased in num"er. #ron stain negati$e.
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Iron Deficiency Anemia
cigar cell
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+ikrositer &ipokrom
Anemia defisiensi "esi
Anemia penyakit kronik
T!allasemia
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'erbedaan antara thalasemia dan anemiadefisiensi besi
>a" Def "esi t!alasemia?I >o 2ormal
,eritin >o 2ormal(!ig!TIB4 &ig!
,e ??T >o 2ormal(!ig!
;D6 &ig! 2ormal
+4E ÷ ;B4 1/ ' 1/
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'erbedaan antara anemia penakit kronik dananemia defisiensi besi
Hematology 2000
l ! f d f
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Diagnostic algorit!m for iron deficiency anemia
American Family Physician, Volume 75, Number 5 March 1, 2007
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#atalaksana Anemia Defisiensi &e
Koreksi defisiensibesi→ restorehemoglobin level.
Cadangan besi .
Parenteral ironmungkin dibutuhkan
Terapi penyakitdasar
Terapi lini pertama
$ oral iron t!erapy
1 g(d>: 7$/ mgg
Iron sulfate / mg: mg elemental iron
/75 mg iron gluconate/ mg elemental iron
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Te!- "ran- cereal-atau pengo"atan ↑ p& lam"ung
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Peningkatan &" yang diinginkan
BB
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Total defisit "esi :
BB
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Algorit!m for e#aluation and treatment of irondeficiency anemia.
American Family Physician, Volume 75, Number 5 March 1, 2007
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