11042016 mutasi
TRANSCRIPT
MUTASI
Priyambodo, M.Sc.
DNA Structure
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CONTOH SOAL
1. DNA sel kulit katak memiliki kandungan Basa Nitrogen Adenin sebanyak 28%. Hitung berapa persentase Guanin dalam seutas rantai DNA sel kulit katak tersebut!
2. Isolasi RNA dari jaringan palisade Musa paradisiaca yang dilakukan pada siang hari menunjukkan adanya Guanin sebanyak 30% dari total basa nitrogen. Hitung persentase basa Nitrogen Timin yang bisa diisolasi!
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Jawaban
1. Diket: DNA sel kulit katak
Adenin= 28%
Ditanya: Guanin dalam seutas DNA
Jawab:
Adenin = Timin = 28%
Guanin + Sitosin = 100% - (2x28%)
= 44%
Guanin = 44% : 2 = 22%
DNA dalam seutas rantai = 22% : 2 = 11%
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Jawaban
2. Diket: Isolasi RNA Musa paradisiaca
Guanin 30%
Ditanya: Timin hasil isolasi
Jawab: 0%
Tidak ada timin di dalam RNA
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DNA to Chromosome
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Cell Cycle of Plant
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DNA Replication
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Transisi
Transversi
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Point Mutation
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Chromosome Rearrangements
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The Bar phenotype in Drosophila melanogaster results from an X-linked duplication
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Chromosomal Rearrangements in Human Beings
• Cri du Chat Syndrome, 46,XX or XY,5p–
– The syndrome known as cri du chat
(French: cry of the cat) is so called because of the catlike cry that about half the affected infants make.
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Cri-du-Chat Results
from Deletion of the
Terminus of
Chromosome 5
The deletion is carried
in heterozygous form.
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Cri-du-chat syndrome (Del 5p)
Wolf-Hirschhorn syndrome (Del 4p16)
Wiiliams-Bauren syndrome (Del 7q11.23)
Rubinstein-Taybi syndrome (Del 16p13.3)
Velocardiofacial syndrome (Del 22q11)
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Perubahan Jumlah
Kromosom
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Variasi pada euploid
Tipe euploidi Jumlah genom Komplemen
kromosom
Diploid 2n AA BB CC
Triploid 3n AAA BBB CCC
Tetraploid 4n AAAA BBBB
CCCC
Pentaploid 5n AAAAA
BBBBB
CCCCC staff.unila.ac.id/priyambodo
Variation in Chromosome Number
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Diploid plant
A tetraploid plant
Treat with colchicine.
Allow to grow.
Take a cutting of the tetraploid portion.
Root the cutting in soil.
Tetraploid portion of plant (note the larger leaves)
Plant Geneticists Can Induce Polyploidization
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JUMLAH KROMOSOM BAWANG PUTIH KULTIVAR SANGGA
sel-sel diploid
sel diploid dan autotetraploid
sel autotetraploid
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Polyploid Formation is a Major Force in Plant Evolution
Roughly 35% of flowering plant species arose through polyploidization. staff.unila.ac.id/priyambodo
Polyploids, like the octaploid on the left, often are larger than
their diploid progenitors (strawberry on right).
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tetraploid
diploid
Polyploid Formation in Animals Is Rare
One possible explanation is the
operation of the dosage compensation
mechanism for sex chromosomes. staff.unila.ac.id/priyambodo
Berbagai kemungkinan variasi dalam aneuploidi
Tipe aneuploid Formula Komplemen
Kromosom
Disomi (normal) 2n (ABC) (ABC)
Monosomi 2n – 1 (ABC) (AB)
Nullisomi 2n – 2 (AB) (AB)
Trisomi 2n + 1 (ABC) (ABC) (C)
Dobel Trisomi 2n + 1 + 1 (ABC) (ABC) (B) (C)
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Variation in Chromosome Number
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100% 150% 100%
Trisomy 2 individual
100%
1
100% 100%
Normal individual
2 3
100% 50% 100%
Monosomy 2 individual
Aneuploidy
Aneuploidy is almost always
harmful.
Imbalanced gene dosage is
believed to cause the negative
effects of aneupoidy.
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Human Aneuploid Conditions
Aneuploidy for all
chromosomes
occurs frequently.
The reason only
trisomy 13, 18 or 21
is seen in live births
is because other
autosomal
aneuploides are
embryonic lethal
conditions.
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Monosomi pd manusia (Sindrom Turner = 45,X0)
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Trisomi (sindrom Klinefelter = 47,XXY)
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Trisomi-21 (sindrome down=47,+21)
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Trisomi-13 (sindrom Patau)
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Trisomi -18 (sindrome edwadrs)
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Aneuploidi pada manusia
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