regenerasi sel dan penyembuhan luka

8/10/2019 Regenerasi Sel Dan Penyembuhan Luka

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Regenerasi Sel dan

Penyembuhan Lukadr. Sari Eka Pratiwi

Departemen Patologi Anatomi

Program Studi Pendidikan DokterFakultas Kedokteran Universitas Tanjungpura

2014


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Sebelum Mulai, kita senam dulu
http://localhost/var/www/apps/conversion/tmp/scratch_3/Senam%20Otak-atik%20(%20otak%20tengah%20)%20by%20Angga.mp4http://localhost/var/www/apps/conversion/tmp/scratch_3/Senam%20Otak-atik%20(%20otak%20tengah%20)%20by%20Angga.mp4


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Inflammation

Stimulus

Tissue

Reaction

Repair

Cell

ChemicalVascular


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Causes

Physical agentsMechanical

Thermal

Chemicals & drugs

Microbiologic agents

Immunologic reactions Radiation


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Repair & Regeneration

Repair : process of recovering the damagedtissue :

Initial tissue cells

Other cells

Regeneration : process of recovering by

initial tissue cells


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Regeneration

Two processes :

Proliferation of surviving cells

Migration of surviving cells


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Three groups of cells

Labile cells

Stable cells

Permanent cells


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Role of the extracellularmatrix in regenerationand repair. Liverregeneration with

restoration of normaltissue after injuryrequires an intact cellularmatrix. If the matrix is

damaged the injury isrepaired by fibrous tissuedeposition and scarformation.


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Mechanisms

regulating cell

populations


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Signaling Cell Growth


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Healing Processes

Induction of an inflammatory process

Proliferation and migration of parenchymaland connective tissue cells

Angiogenesis and granulation tissue Synthesis of ECM proteins and collagen

deposition

Tissue remodelling Wound contraction

Acquisition of wound strength


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Wound healing

Superficial regeneration

Deep repair


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Healing Processes

The main components :

- ANGIOGENESIS

- SCAR FORMATION


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ANGIOGENESIS

Definition :The process of blood vessel formation in adultor NEOVASCULARIZATION

Mechanisms :- Angiogenesis from Endothelial Precursor Cells- Angiogenesis from Pre-Existing Vessels

- Growth Factors and Receptors Involved inAngiogenesis

- ECM Proteins as Regulators of Angiogenesis


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Angiogenesis by mobilization of endothelial precursor cells

(EPCs) from the bone marrow and from preexisting vessels

(capillary growth).


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Two patterns of healing

Healing by first intention

(primary union = repair perprimam)

Healing by second intention

(secondary union = repair persekundam)


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Healing of skin ulcers. A, Pressure ulcer of the skin, commonly found in diabetic patients. The

histologic slides show: B, a skin ulcer with a large gap between the edges of the lesion; C, a

thin layer of epidermal re-epithelialization and extensive granulation tissue formation in thedermis; and D, continuing re-epithelialization of the epidermis and wound contraction


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A, Granulation tissue showing numerous blood vessels, edema, and a loose ECM containingoccasional inflammatory cells. Collagen is stained blue by the trichrome stain; minimal mature

collagen can be seen at this point. B, Trichrome stain of mature scar, showing dense collagen,

with only scattered vascular channels.


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Multiple roles of macrophages in wound healing. Macrophages participate in wound

debridement, have antimicrobial activity, stimulate chemotaxis and the activation of

inflammatory cells and fibroblasts, promote angiogenesis, and stimulate matrix remodelingand synthesis. ROS, reactive oxygen species


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SCAR FORMATION

Processes of Scar Formation :

1. Emigration and Proliferation of

Fibroblast in the site of injury

2. Deposition of ECM

3. Tissue Remodeling


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Scar Formation

Net collagen depends on increasedcollagen synthesis and decreaseddegradation

Scar compossed of spindle-shapedfibroblasts, dense collagen, fragmentsof elastic tissue and ECM components

Vascular regression --- pale, avascularscar


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Tissue Remodeling

Granulation tissue to Scar --- involvestransitions in the composition of TheECM

The Balance between ECM synthesis anddegradation results in remodeling ofthe connective tissue framework


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Keloid. A, Excess collagen deposition in the skin forming a raised scar known as keloid. B,

Note the thick connective tissue deposition in the dermis


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Development of fibrosis in chronic inflammation. The persistent stimulus of chronic

inflammation activates macrophages and lymphocytes, leading to the production of growth

factors and cytokines, which increase the synthesis of collagen. Deposition of collagen isenhanced by decreased activity of metalloproteinases.


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THANK YOU


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Tugas

Kelainan melanosit

Benign epithelial tumor

Premalignant and Malignant Epidermal

Tumors

Chronic Inflammatory Dermatoses

Infeksi virus dan jamur

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