pertemuan_3_sistem imun seluler.pptx

8/19/2019 pertemuan_3_sistem imun seluler.pptx

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IMUNOLOGISISTEM IMUN

:SELULAR

HARIYANTO IH., M.SI., APT. (hariyant [email protected] .i dPHARMA!Y ST"#YPRO$RAMM%&A!"'TY O& M%#I!IN%"NI %RSITY O&TAN)"N$P"RA*+ - *+ /

mailto:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]


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PENDAHULUA

NSISTEM IMUN I

PERTAHANAN TUBUH


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FUNGSI SISTEM

IMUN1. Pengenalan (self-nonself)

. Efe!"o# ($engel%$%nas%)

&. Reg'las%(!ese%$ angan)

. Me$o#% (#e-%nfe!s%)


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SIST%M

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Immune System

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2 0 line of defenseP r olects.!re-e )(posure

Innate(Nons

pecific )1 line o f defe nse

Cellu lar C Oli4JOnentsumoral COl t "I#nents um o

Phys ical Barrier


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.u cdon .. prateln classes Inco..........ent~l.m

Bindin to an tl _ n!antl"ody and patho _n surla ces

Bindin to rnan nose on" a~a

COn# p

&cti)a tin en*yme s

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tim e et eene5posure and

responseNota nti ge n -spec ific

Ant igen-specnic

65posure r esuts in me m 65po results in

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PAMPs PRRs*""+:,,l+%.o#egons"a"e.e ',$% ,$% #on'"#%en"s-*eal"*,%$$'n%"2

pat4o7en-assc588 iated molecular pattern 9: acter ium

reco7n ition receptor

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.... p4a7olysosome

matory cyto


10/28

MO'%0"'3MO'%0"'

P%RM"0AAN L%gan 3s Rese+"o#

PAMP ( Pathogen-Associated Molecular Pattern ) Pa"ogen

PRR ( Pattern-RecognitionReceptor )

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Inn.e Immunerecolnltlon

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13/28

PHAS%S O& PHA$O!YTOSIShttp4 mad3physio.51o6spot.co.id *+ + +7 8hat3is3in92ction3physica135arri2rs3and.htm1

o ,4emot a 5is anda d4eren ce

of micro e to p4a7 oc yte .

e In7est ion o fmic r o e

y p4a7 ocyte .

o or m at ion of ap4a7 os ome .

o us ion 01t4 ep4a7oso me

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o

o

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orm a tion of r es lduelody

conta inin7Ind i7esti le mat er ia l.

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14/28

SITO0IN,0%MO0IN

#ANR%SPON

IN&'AMASI

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n

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15/28

SITO6IN DAN6EMO6IN

SITO6IN PROTEIN 6E4IL TERLARUT 7ANG MEREGULASI FUNGSI IMUN SELINFLAMASI

7ANG DISE6RESI6AN OLEH SEL-SEL IMUN TERTENTU DAN MEMILI6I EFE6 PADA SEL-SEL SITO6IN

SITO6IN

DIHASIL6AN SE5AGAI RESPON TERHADAP STIMULUS SISTEM IMU

MENGI6AT RESEPTOR SPESIFI6 6EMUDIAN MEM5A8A SIN7ALMELALUI nMESSENGER UNTU6 MEGU5AH A6TI9ITAS SEL 7ANG

DIPENGARUHI

6EMO6IN PROTEIN 6E4IL TERLARUT 7ANG 5ERPERAN SE5AGAI6EMOATRA6TAN

FAGOSIT DAN SEL T

6ERUSA6AN SEL, ARINGAN A6I5AT INFE6SI 5A6TERI 9IRUS DAN LU6AMEN7E5A56AN


16/28

H":"N$AN SIST%M IM"N:A;AAN dan

IM"N #APATAN S%s". I$'n a;aan %+e#l'!an 'n"'!$enga!"%f!an s%s"e$ %$'n a+a"an (3% e3e#sa)

S%s". %$'n a;aan


17/28

&"N$I S%' IM"N:A;AAN

Se aga% AP4 (An"%gen P#esen"%ng 4ell) "*:Sel

en #%"%! an Ma!#ofaga (MH4 I an MH4 II)

El%$%nas% (Efe!"o#) Sel en #%"%! $a!#ofaga N64ell


18/28

AP!

S2t21ah m2n62na1i suatuanti62n, AP! akanmasuk k2 sa1uran1im9atik dan t2r5a8a k2arah nodus3nodus 1im92t2rd2kat untuk52rt2mu

danm2n6akti


19/28


20/28

'ellular


21/28

Gerd-Rudiger Burmester and Antonio Pezzutto (2003) : Color Atlas of Immunology !"ieme #tuttgart $

'ellular Adaptive Immunity

)

ellular

Innate Immunity

> l i ti +


22/28

>ocal in _tion+ p .... trationof

epit4elium

of tis .....>ocal in ection Ad4erence toAeplth.llum Aa

+ - ...@.% FF 9- 9 - . -c- --. _

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N c e lls&cti)at ion o macropha e s

endritic cells mi rate tolymph nodes to initiate

Eound he alin induc ed&ntimi cro" ial p r ote ins

and Normal lora In ec

>ocal chemical actorsPha ocytes

?es pecially in lun <

peptides + pha ocytes + and anti"ocomplement destroy macr

in)adin m icroor an isms&cti)ation o #H3D= cells 9

anadap ti)e immunityBlood clottin helps limit

spread o In ectioni7u r e 2 -= Immuno iolo7y @ led . ? eJ Scie nce (%%; +


23/28

Sel B

Sel B yang telah dibentuk oleh sumsum tulang belakang

belum aktif . Saat ada patogen, sel B diaktifkan melalui 2cara yaitu T cell dependent activation dan T cellindependent activation

Sel Th yang aktif akan merangsang sel Bberproliferasi dan berdiferensiasi menjadi sel plasmayang mensekresi antibodi


24/28

Imunoglo"ulin

Sel

Sel mem antu proliferasi sel O untu< menJadi selplasma se4in77a di4asil


25/28

Bestru


26/28

Sel t regulator


27/28

R%SPON T%RHA#AP IN&%0SIA;A'

,eco nition

K

prl ormad+

non H.

dfic and "roadl+specific

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Inna teImmunity

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H

0-" 4ours)

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,eco nitionof

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f i7u r e 2 -%Immuno iolo7y@Ced . ( Da r land


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pertemuan_3_sistem imun seluler.pptx

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