obat-gagal-jantung-materi-farmakoterapi-pada-gangguan-penyakit-kardiovaskuler
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OBAT GAGAL JANTUNG
Alfi Yasmina
Gagal Jantung
�Sindrom klinis dimana gangguan
struktur atau fungsi jantung
mengakibatkan ketidakmampuan
jantung memopa darah yang mencukupi
bagi jaringan
�Penyebab:
� Penyakit jantung iskemik, kardiomiopati, penyakit
jantung kongenital, penyakit katup jantung,
hipertensi
� Infeksi, aritmia, aktivitas fisik >>>, makan >>>,
cairan >>>, emosi, anemia, tirotoksikosis
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Terapi Gagal Jantung
� Nonfarmakologis
� Turunkan beban jantung: batasi aktivitas,
turunkan BB
� Batasi natrium
� Batasi cairan
Terapi Farmakologis Gagal Jantung
�� kontraktilitas
� Inotropik positif
�� beban jantung (preload & afterload)
� Vasodilator, Diuretika, Beta-bloker
�Perbaiki irama jantung
� Antiaritmia
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Terapi Gagal Jantung
� Inotropik positif
� Glikosida jantung: digitalis, digitoksin
� Simpatomimetik: dobutamin
� Inhibitor fosfodiesterase: amrinon, milrinon
� Vasodilator
� Vasodilator langsung: nitroprussid, hidralazin, ISDN
� α-bloker: prazosin
� ACEI, ARB
� Diuretika: tiazid, loop diuretics, diuretik hemat kalium
� Beta-bloker: metoprolol, bisoprolol, karvedilol
Digitalis
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Digoksin, Digitoksin
�Penghambat Na-K-ATPase (jantung, sel
lain)
�Agonis muskarinik
�� kontraktilitas tanpa � frekuensi
�Absorpsi digoksin <, tidak dimetabolisme
�Absorpsi digitoksin baik, waktu paruh
panjang, metabolisme ekstensif
�ES: SSP, saluran cerna, jantung
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Dopamin, Dobutamin
�Simpatomimetik
�Dopamin: � pelepasan NE
�Dobutamin: analog dopamin, agonis β1
�Waktu paruh pendek � infus kontinu
�Downregulasi reseptor
Dobutamin
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Amrinon, Milrinon
�Menghambat fosfodiesterase III
� Inotropik lemah
�Milrinon 20x lebih poten daripada amrinon
�ES: aritmia
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Terapi Gagal Jantung