lbh 589 + - + +
DESCRIPTION
a. b. LBH589 - + - + +. KMS12BM. ZOL - - + + +. NAC - - - - +. Uncleaved PARP. Cleaved PARP. Cleaved caspase 3. g -Tubulin. - PowerPoint PPT PresentationTRANSCRIPT
Apo
ptos
is (
% o
f co
ntro
l)
0
50
100
150
200
EPN
LBH 589 + - + + ZOL - + + + NAC - - - +
ba
LBH589 - + - + +
NAC - - - - +
ZOL - - + + +
Uncleaved PARP
Cleaved PARP
-Tubulin
Cleaved caspase 3
KMS12BM
cKMS12BM
Rel
ativ
e M
ean
Flu
ores
cenc
e In
tens
ity
0,0000
0,0005
0,0010
0,0015
0,0020
0,0025CTR panobinostat ZOL COMB
pHSP27/HSP27
d
LBH589 - + - + ZOL - - + +
p-p38-MAPK
P38-MAPK
KMS12BM
Supplementary Figure S2
1.0 1.12 1.44 1.16
GAPDH