Apo

ptos

is (

% o

f co

ntro

l)

0

50

100

150

200

EPN

LBH 589 + - + + ZOL - + + + NAC - - - +

ba

LBH589 - + - + +

NAC - - - - +

ZOL - - + + +

Uncleaved PARP

Cleaved PARP

-Tubulin

Cleaved caspase 3

KMS12BM

cKMS12BM

Rel

ativ

e M

ean

Flu

ores

cenc

e In

tens

ity

0,0000

0,0005

0,0010

0,0015

0,0020

0,0025CTR panobinostat ZOL COMB

pHSP27/HSP27

d

LBH589 - + - + ZOL - - + +

p-p38-MAPK

P38-MAPK

KMS12BM

Supplementary Figure S2

1.0 1.12 1.44 1.16

GAPDH