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    i

    KATA PENGANTAR

    Dengan memanjatkan puji dan syukur kehadirat Allah SWT, yang telah

    melimpahkan rahmat, hidayah dan inayahnya sehingga penelaah dapat menyelesaikan

    pembuatan jurnal ini dengan judul The effect of hypoxemic resuscitation from

    hemorrhagic shock on blood pressure restoration and on oxidative and inflammatory

    responses ( Pengaruh resusitasi hypoxemic dari syok hemoragik pada tekanan darah

    restorasi dan oksidatif dan tanggapan inflamasi ).

    Adapun tujuan dari telaah jurnal ini adalah untuk memenuhi salah satu tugas mata

    kuliahKegawatdaruratan.

    Penelaah menyadari bahwa masih banyak kekurangan-kekurangan dalam

    penyusunan jurnal ini, oleh karna itu penelaah mengharapkan kritik dan saran yang bersifat

    membangun dari semua pihak.

    Semoga segala upaya yang dilakukan penelaah maupun pihak yang bersangkutan

    mendapat ridho Allah SWT, dan memberikan manfaat terutama kepada penelaah

    khususnya, maupun pembaca pada umumnya.Amin.

    Penelaah

    Garut, November 2013

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    DAFTAR ISI

    KATA PENGANTAR i

    DAFTAR ISI .. ii

    Abstrak 1

    Pendahuluan (Introduction) . 2

    Metode (method)

    C.1.Populasidansampel 4

    C.2 DesainPenelitian 5

    C.3 Pengukuranataupengumpulan data 7

    C.4 Analisis data/uji statistic 9

    D. HasilPenelitian

    D.1.Alur penelitiandan data base line.. 9

    D.2. HasilPenelitian ... 12

    E. Diskus(Discuss) .. 12

    F. Kesimpulan.... 17

    DAFTAR PUSTAKA .................................................................................................... iii

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    DAFTAR PUSTAKA

    1. Kerner T, Ahlers O, Veit S, Riou B,Saunders M, Pison U for the European DCLHb

    Trauma Study Group (2003) DCL-Hb for trauma patients with severe hemorrhagic

    shock: the European On- Scene multicenter study. Intensive Care Med 29:378385

    2. Bilkovski RN, Rivers EP, Horst HM (2004) Targeted resuscitation strategies after

    injury. CurrOpinCrit Care 10:529538

    3. Revell M, Greaves I, Porter K (2003) Endpoints for fluid resuscitation in hemorrhagic

    shock. J Trauma 54:S63S67

    4. Roberts I, Alderson P, Bunn F, Chinnock P, Ker K, Schierhout G (2004) Colloids versus

    crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev

    CD000567

    5. Bickell WH, Wall MJ Jr, Pepe PE, Martin RR, Ginger VF, Allen MK, Mattox KL

    (1994) Immediate versus delayed resuscitation for hypotensive patients with penetrating

    torso injuries. N Engl J Med 331:11051109

    6. Cavanaugh BP, Meyer LJ (2005) Normalizing physiological variables in acute illness:

    five reasons for caution. Intensive Care Med 31:11611167

    7. Roberts I, Evans P, Bunn F, Kwan I, Crowhurst E (2001) Is the normalization of blood

    pressure in bleeding trauma patients harmful? Lancet 357:385387

    8. Stern SA (2001) Low-volume fluid resuscitation for presumed hemorrhagic shock:

    helpful or harmful? CurrOpinCrit Care 7:422430

    9. Shafi S, Kauder D (2004) Fluid resuscitation and blood transfusion in patients with

    polytrauma. ClinOrthop422:3742

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    10. Li C, Jackson RM (2002) Reactive species mechanisms of cellular hypoxia

    reoxygenation injury. Am J Physiol Cell Physiol 282:C227C241

    11. Granger DN, Korthious RJ (1995) Physiologic mechanisms of postischemic tissue

    injury. Annu Rev Physiol57:311332

    12. Droge W (2002) Free radicals in the physiological control of cell function. Physiol Rev

    82:4795

    13.Therade-Matharan E, Laemmel E, Duranteau J, Vicaut E (2004) Reactive oxygen

    species production by mitochondria in endothelial cells exposed reoxygenation after

    hypoxia and glucose depletion is mediated by ceramide. Am J PhysiolRegulIntegr

    Comp Physiol 287:R1037R1043

    14. Tamion F, Richard V, BonmarchandG, Leroy J,Hiron M, Daveau M, Thuillez C,

    Lebreton JP (2000) Reduced synthesis of inflammatory cytokines by a free radical

    scavenger after hemorrhagic shock in rats. CritCare Med 28:25222527

    15. Perry MA, Wadhwa SS (1988) Gradual reintroduction of oxygen reduces reperfusion

    injury in cat stomach. Am J Physiol 254:G366G372

    16. Douzinas EE, Livaditi O, Xiarchos AG, Giamarellos-Bourboulis EJ, Villiotou V,

    Liappas IA, Evangelou E, Rapidis AD, Roussos C (2006) The effect of hypoxemic

    resuscitation of hemorrhagic shock on hemodynamic stabilization and inflammatory

    response: a pilot study in a rat experimental model. J Trauma 61:918923

    17. Victor VM, De La Fuente M (2003) Several Functions of immune cells in mice

    changed by oxidative stress caused by endotoxin. Physiol Res 52:789796

    18. Agarwal R, Chase SD (2002) Rapid, fluorimetric-liquid chromatographic

    determination of malondialdehydein biological samples. J

    ChromatogrBAnalytTechnol Biomed Life Sci775:121126

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    19. Douzinas EE, Livaditi O, Tasoulis M-K, Pelekanou A, Giamarellos- Bourboulis EJ

    (2007) Stimulation of monocytes is a pathway involved in systemic inflammatory

    response following haemorrhagic shock resuscitation: the effect of hypoxaemic

    resuscitation. ClinExpImmunol (in press)

    20. McGillMW, Rowan AN (1989) Biological effects of blood loss: implications from

    sampling volumes and techniques. ILAR News 31:520

    21. Escobar GA, Cheng AM, Moore EE, Johnson JL, Tannahill C, Baker HV, Moldawer

    LL, Banerjee A (2007) Stored packed red blood cell transfusion up-regulates

    inflammatory gene expression in circulating leukocytes. Ann Surg 246:129134

    22. Flom-Halvorsen HI, Ovrum E, Oystese R, Brosstad F (2003) Quality of intraoperative

    autologus blood withdrawal used for retransfusion after cardiopulmonary bypass. Ann

    ThoracSurg 76:744748

    23. Lenfant C, Aucutt C (1965) Oxygen uptake and change in carbon dioxide tension in

    human blood stored at 37 C. J ApplPhysiol 20:503508

    24. Powers KA, Woo J, Khadaroo RG, Papia G, Kapus A, Rotstein OD (2003) Hypertonic

    resuscitation of hemorrhagic shock upregulates the anti-inflammatory response by

    alveolar macrophages. Surgery 134:312318

    25. Haase E, Bigam DL, Nakonechny QB, Jewell LD, Korbutt G, Cheung PY (2004)

    Resuscitation with 100% oxygen causes intestinal glutathione oxidation andreoxygenation injury in asphyxiated newborn piglets. Ann Surg240:364373

    26. Douzinas EE, Pitaridis MT, Patsouris E, Kollias S, Boursinos V, Karmpaliotis DI,

    Gratsias Y, Evangelou E, Papalois A, Konstantinidou AE, Roussos C (2003)

    Myocardial ischemia in intestinalpostischemic shock: the effect of hypoxemic

    reperfusion. Crit Care Med 31:21832189

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