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KATA PENGANTAR
Dengan memanjatkan puji dan syukur kehadirat Allah SWT, yang telah
melimpahkan rahmat, hidayah dan inayahnya sehingga penelaah dapat menyelesaikan
pembuatan jurnal ini dengan judul The effect of hypoxemic resuscitation from
hemorrhagic shock on blood pressure restoration and on oxidative and inflammatory
responses ( Pengaruh resusitasi hypoxemic dari syok hemoragik pada tekanan darah
restorasi dan oksidatif dan tanggapan inflamasi ).
Adapun tujuan dari telaah jurnal ini adalah untuk memenuhi salah satu tugas mata
kuliahKegawatdaruratan.
Penelaah menyadari bahwa masih banyak kekurangan-kekurangan dalam
penyusunan jurnal ini, oleh karna itu penelaah mengharapkan kritik dan saran yang bersifat
membangun dari semua pihak.
Semoga segala upaya yang dilakukan penelaah maupun pihak yang bersangkutan
mendapat ridho Allah SWT, dan memberikan manfaat terutama kepada penelaah
khususnya, maupun pembaca pada umumnya.Amin.
Penelaah
Garut, November 2013
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DAFTAR ISI
KATA PENGANTAR i
DAFTAR ISI .. ii
Abstrak 1
Pendahuluan (Introduction) . 2
Metode (method)
C.1.Populasidansampel 4
C.2 DesainPenelitian 5
C.3 Pengukuranataupengumpulan data 7
C.4 Analisis data/uji statistic 9
D. HasilPenelitian
D.1.Alur penelitiandan data base line.. 9
D.2. HasilPenelitian ... 12
E. Diskus(Discuss) .. 12
F. Kesimpulan.... 17
DAFTAR PUSTAKA .................................................................................................... iii
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DAFTAR PUSTAKA
1. Kerner T, Ahlers O, Veit S, Riou B,Saunders M, Pison U for the European DCLHb
Trauma Study Group (2003) DCL-Hb for trauma patients with severe hemorrhagic
shock: the European On- Scene multicenter study. Intensive Care Med 29:378385
2. Bilkovski RN, Rivers EP, Horst HM (2004) Targeted resuscitation strategies after
injury. CurrOpinCrit Care 10:529538
3. Revell M, Greaves I, Porter K (2003) Endpoints for fluid resuscitation in hemorrhagic
shock. J Trauma 54:S63S67
4. Roberts I, Alderson P, Bunn F, Chinnock P, Ker K, Schierhout G (2004) Colloids versus
crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev
CD000567
5. Bickell WH, Wall MJ Jr, Pepe PE, Martin RR, Ginger VF, Allen MK, Mattox KL
(1994) Immediate versus delayed resuscitation for hypotensive patients with penetrating
torso injuries. N Engl J Med 331:11051109
6. Cavanaugh BP, Meyer LJ (2005) Normalizing physiological variables in acute illness:
five reasons for caution. Intensive Care Med 31:11611167
7. Roberts I, Evans P, Bunn F, Kwan I, Crowhurst E (2001) Is the normalization of blood
pressure in bleeding trauma patients harmful? Lancet 357:385387
8. Stern SA (2001) Low-volume fluid resuscitation for presumed hemorrhagic shock:
helpful or harmful? CurrOpinCrit Care 7:422430
9. Shafi S, Kauder D (2004) Fluid resuscitation and blood transfusion in patients with
polytrauma. ClinOrthop422:3742
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10. Li C, Jackson RM (2002) Reactive species mechanisms of cellular hypoxia
reoxygenation injury. Am J Physiol Cell Physiol 282:C227C241
11. Granger DN, Korthious RJ (1995) Physiologic mechanisms of postischemic tissue
injury. Annu Rev Physiol57:311332
12. Droge W (2002) Free radicals in the physiological control of cell function. Physiol Rev
82:4795
13.Therade-Matharan E, Laemmel E, Duranteau J, Vicaut E (2004) Reactive oxygen
species production by mitochondria in endothelial cells exposed reoxygenation after
hypoxia and glucose depletion is mediated by ceramide. Am J PhysiolRegulIntegr
Comp Physiol 287:R1037R1043
14. Tamion F, Richard V, BonmarchandG, Leroy J,Hiron M, Daveau M, Thuillez C,
Lebreton JP (2000) Reduced synthesis of inflammatory cytokines by a free radical
scavenger after hemorrhagic shock in rats. CritCare Med 28:25222527
15. Perry MA, Wadhwa SS (1988) Gradual reintroduction of oxygen reduces reperfusion
injury in cat stomach. Am J Physiol 254:G366G372
16. Douzinas EE, Livaditi O, Xiarchos AG, Giamarellos-Bourboulis EJ, Villiotou V,
Liappas IA, Evangelou E, Rapidis AD, Roussos C (2006) The effect of hypoxemic
resuscitation of hemorrhagic shock on hemodynamic stabilization and inflammatory
response: a pilot study in a rat experimental model. J Trauma 61:918923
17. Victor VM, De La Fuente M (2003) Several Functions of immune cells in mice
changed by oxidative stress caused by endotoxin. Physiol Res 52:789796
18. Agarwal R, Chase SD (2002) Rapid, fluorimetric-liquid chromatographic
determination of malondialdehydein biological samples. J
ChromatogrBAnalytTechnol Biomed Life Sci775:121126
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19. Douzinas EE, Livaditi O, Tasoulis M-K, Pelekanou A, Giamarellos- Bourboulis EJ
(2007) Stimulation of monocytes is a pathway involved in systemic inflammatory
response following haemorrhagic shock resuscitation: the effect of hypoxaemic
resuscitation. ClinExpImmunol (in press)
20. McGillMW, Rowan AN (1989) Biological effects of blood loss: implications from
sampling volumes and techniques. ILAR News 31:520
21. Escobar GA, Cheng AM, Moore EE, Johnson JL, Tannahill C, Baker HV, Moldawer
LL, Banerjee A (2007) Stored packed red blood cell transfusion up-regulates
inflammatory gene expression in circulating leukocytes. Ann Surg 246:129134
22. Flom-Halvorsen HI, Ovrum E, Oystese R, Brosstad F (2003) Quality of intraoperative
autologus blood withdrawal used for retransfusion after cardiopulmonary bypass. Ann
ThoracSurg 76:744748
23. Lenfant C, Aucutt C (1965) Oxygen uptake and change in carbon dioxide tension in
human blood stored at 37 C. J ApplPhysiol 20:503508
24. Powers KA, Woo J, Khadaroo RG, Papia G, Kapus A, Rotstein OD (2003) Hypertonic
resuscitation of hemorrhagic shock upregulates the anti-inflammatory response by
alveolar macrophages. Surgery 134:312318
25. Haase E, Bigam DL, Nakonechny QB, Jewell LD, Korbutt G, Cheung PY (2004)
Resuscitation with 100% oxygen causes intestinal glutathione oxidation andreoxygenation injury in asphyxiated newborn piglets. Ann Surg240:364373
26. Douzinas EE, Pitaridis MT, Patsouris E, Kollias S, Boursinos V, Karmpaliotis DI,
Gratsias Y, Evangelou E, Papalois A, Konstantinidou AE, Roussos C (2003)
Myocardial ischemia in intestinalpostischemic shock: the effect of hypoxemic
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