diskusi kelompok 3 inflamassi

7/23/2019 Diskusi Kelompok 3 Inflamassi

1/27

INFLAMASI AKUT DAN KRONIK

OLEH KELOMPOK 3ANGGOTA:

IZZATI HASAN 1110070110057

ERVA SEPTRINA 1110070110059MIRA NOVITA IRAWAN 1110070110061

ELSYA OKTAVIANTI 1110070110063MAIYANI LESTARI 1110070110065

USWATUN NISA 1110070110067TRINANDA AKASUMA 1110070110069FITRIA MANDASARI 1110070110071

MENOLA ASTRIGIONA 1110070110073


2/27


3/27

PENGERTIAN

Radang!"#"$" I%&&'($: infammation)"*"+"# ',$-.% *"'( $/"/ .'&"%($,

,'#"*"- -".&,% *"% "+,'"$( ,2"%($*"+" "'(%&"%4 !,'/-" '"%&2"("% ',"2$("%& ,'"*( -"*" ,-" "'(%&"% "%&,%&"+"( ,*,'"4 $,-,'( 2"',%"

,'!"2"'4 ""/ ,'(%,2$(8 R"*"%& ""/(%""$( "*"+"# $"/ *"'( ',$-.% /""$$, 2,2,!"+"% ,'#"*"- (%,2$( *"%('("$(8


4/27

Menurut Kamus KedokteranDorland:

R"*"%& ("+"# ',$-.% -'.,2( $,,-""%& *((!/+2"% .+,# ,*,'" ""/2,'/$"2"% "'(%&"%4 "%& !,'/%&$(,%"%/'2"%4 ,%&/'"%&(4 ""/

,%&/'/%& !"(2 "&,% -,%,*,'""/-/% "'(%&"% "%& ,*,'" (/8


5/27

Menurut Katzung (2002):R"*"%& ("+"# $/"/ -'.$,$ "%& *(%"($*"'( "'(%&"% #(*/- ""/ $,+ ,'#"*"-

$/"/ '"%&$"%& ""/ (%/' ,"$) "%&*(+"2/2"% ,'/"" .+,# -,!/+/# *"'"#"$2/+,') *"% "'(%&"% (2" .%%,(,($$/,)8


6/27

INFLAMASI AKUT

I%""$( "2/ "*"+"# ',$-.%$ $,&,'"*"% *(%( "%& !,'+"%&$/%& ',+"($(%&2" ,'#"*"- ,"$ "%& *('"%"%&

/%/2 ,%&('(2"% +,/2.$( 2, ,-","$4 ,2$/*"$( "('"% *"% -'.,(%-+"$"8


7/27

R,%,"% !,'(%&2" 2"$2"*,) 2,"*("% -"*"(%""$( "2/ *((%',&"$(2"% .+,# -,+,-"$"%

+.2"+ ,*(".' 2((";(8 Perubahan vaskulerdan rekutmen sel menetukan tiga darilima tanda local klasik infamasi akut:-"%"$ 2"+.')4 ,'"# '/!.')4 *"%

-,!,%&2"2"% /.')8.1 Perubahan Vaskuler

Perubahan Vaskuler yang dimaksud adalah

perubahan dalam kaliber pembuluh darah yang

mengakibatkan peningkatan aliran darah (vasodilatasi)dan perubahan struktur yang memungkinkan protein

plasma untuk meninggalkan sirkulasi (peningkatan

permeabilitas vaskuler)


8/27


9/27

Fase marginasi, "(/ +,/2.$(,'/"" %,/'.=+) /+"( 2,+/"' *"'("+('"% *"'"# *"% !,'"2//+"$( *(

$,-"%"%& -,'/2""% ,%*.,+-,!/+/# *"'"#8 K,/*("%,+,2"2"% *('( -"*" $,+ ,%*.,+4+,/2.$( ,%,+(%"- *( "%"'" $,+

,%*.,+ *"% !,'(&'"$( ,+,;"(*(%*(%& -,!/+/# *"'"# ,%//

"'(%&"% (%,'$($("+8


10/27

I%""$( "2/ ,%,!"!2"% 2,!..'"% $,+"-($,%*.,+ ,+"+/( $,/+"# "'" "%& !,'&"%/%& -"*",2"%($,4 .%$,4 */'"$(4 .+/,4 *"% 2"'"2,'($(2

"('"% "%& *(#"$(+2"%4 $,!"&"( !,'(2/:

K.%'"2$( $,+ ,%*.,+ ,%(!/+2"% (%,'$,++/+"' &"--"*" ,%/+"8

>,"$ ,%*.,+ +"%&$/%& "2"% ,%&"2(!"2"%2,!..'"% "$2/+"% *,%&"% ,%,!"!2"% %,2'.$($*"% +,-"$%" $,+ ,%*.,+8

>,"$ ,%*.,+ "%& !,'&"%/%& +,/2.$( "2(!""2//+"$( +,/2.$( $,+"" ',$-.%$ (%""$(8

P,%(%&2""% '"%$(.$($ ,+"+/( "+/' ,$(/+"'(%'"$,+ ,%(%&2"2"% -,',"!(+("$,%/+"8

2,!..'"% *"'( -,!/+/# *"'"# !"'/8


11/27


12/27

Adhesi dan Transmigrasi

+,/2.$( 2"#('%" ,+,2" 2/" -"*"-,'/2""% ,%*.,+ "%& *($,!/ "*#,$(4$,!,+/ ,'""- *("%"'" $,+ $,+ ,%*.,+*"% ,+,;"( ,!'"%, !"$"+($ "$/2

2, '/"%& ,2$'""$2/+,' "& *($,!/*("-,*,$($8 "*#,$( 2/" (%( *(-,'"%"'"(.+,# .+,2/+ $/-,'"(+( (/%.&+.!(%-"*" $,+ ,%*.,+ "%& !,'(%,'"2$(*,%&"% (%,&'(% "%& /%/+ -"*"-,'/2""% $,+ +,/2.$(4 "(/ I@AM?1 *"%V@AM?1 *"% +"(%?+"(%8


13/27

Kemotaksis dan Aktivasi

E2$'"2"$"$( *"'( *"'"#4 +,/2.$(

!,'(&'"$( ,%// ,-" ,"$ ,%*,2"(&'"*(,% 2((";( -"*" $/"/ -'.$,$ "%&*($,!/ 2,."2$($8 2,*/" " ,2$.&,%*"% ,%*.&,% *"-" !,'$(" 2,."2(2,'#"*"- +,/2.$(4 ,+(-/(: 1) -'.*/2!"2,'( "%& *"-" +"'/42#/$/$%"-,-(*" *,%&"% N?.'(+,(.%(% ,'(%(

B) 2.-.%,% $($(, 2.-+,,%4,'/"" @5" 3) -'.*/2 ,"!.+($,"$" "'"2(*.%" AA) "+/' +(-.2$(&,%"$(8


14/27

F"&.$(.$($ *"% D,&'"%/+"$(

F"&.$(.$($ *"% ,+"!.'"$( ,%( *,&'"*"(,'/-"2"% """ /"" *"'( "*"%"+,/2.$( "%& *(',2'/ -"*" ,-"(%""$(8 F"&.$(.$($ ,'*('( ""$ (&"

+"%&2"# !,'!,*"4 ,"-( $"+(%& ,'2"(: (1!engenalan dan !erlekatan !artikel!ada leukosit "ang menelan# ($!enelanan, dengan !embentukan

vakuola %agositik selan&utn"a# dan ('!embunuhan dan degradasi material"ang ditelan


15/27

D,,2 -"*" F/%&$( L,/2.$(

D,,2 -"*" "*,$(8 -"*" *,,$(,%$( "*,$(+,/2.$( (-, I 4 ,%(!/+2"% &"%&&/"% "*,$( 4-,%,!"'"%4 "&.$(.$($4 -,!,2"'"%.2$(*"(8 D,=$(,%$( "*,$( +,/2.$( II*($,!"!2"% .+,# *,,2 %,+/'/# -"*","!.+($ /2.$" "%& %&"2(!"2"%#(+"%&%" $("+(+ C +,;($ C,-(.- .+(&.$"2"'(*"-"*" +,/2.$( "%& !,'(2""% *,%&"% $,+,2(%

-"*" ,%*.,+ "%& ,'"2("$( D,,2 -"*" (2'.!($(*"+

D,,2 -"*" -,!,%/2"% "&.+($.$.


16/27

M,*(".' K((";( I%""$(

P'(%$(- // ,*(".'4 $,!"&"( !,'(2/:

M,*(".' *"-" !,'$(2/+"$( *( *"+" -+"$"2#/$/$%" $(%,$($ .+,# #"()4 ""/ *"-"*(#"$(+2"% $,"'" +.2"+ .+,# $,+ *( ,-",'"*(%" (%""$(8 M,*(".' "%& !,'"$"+*"'( -+"$" 2.-+,,%4 2(%(%4 "2.'2."&/+"$() !,',*"' *"+" $('2/+"$( $,!"&"(-',2/'$.' (%"2(4 "%& #"'/$ ,%&"+"(-,,"#"% -'.,.+((2 /%/2 ,%*"-"2"%!"#"% !(.+.&($%"8 M($"+%": #($"(%,*"+" $,+ "$


17/27

S,!"&("% !,$"' ,*(".' ,%&(%*/2$(

,,2%" *,%&"% !,'(2""% -"*" ',$,-.'$-,$(=2 -"*" $,+ "'&,8 ($"+%": -'.,"$,+($.$.

M,*(".' *"-" ,'"%&$"%& $,+ "'&,

/%/2 ,+,-"$2"% .+/2,+ ,,2.'$,2/%*,'8

M,*(".' #"%" *"-" !,2,'" -"*" $"/""/ $"%&" ,-/%"( $,*(2( "'&,4 ""/

*"-" ,-/%"( "2(("$ +/"$ !($",'*"-" -,'!,*""% #"$(+ "%& $"%&"!,$"' !,'&"%/%& -"*" ,%($ $,+ "%&*(-,%&"'/#(8


18/27

F/%&$( ,*(".' //%" *("/' $,"'"2,"8 S,2"+( ,'"2("$( *"% *(+,-"$2"% *"'($,+ 4 $,!"#"&("% !,$"' ,*(".' ,-"'/$"2 #(+"%& ($"+%" ,"!.+( AA )4 *((%"2("$( .+,# ,%(% ($"+%"4 2(%(%"$, "%&,%&(%"2("$( !'"*(2(%(% )4 *( ,+((%"$( ($"+%"4 "%(.2$(*"% /%&/ ,"!.+(.2&(&,% "%& .2$(2 )4 ""/ *((%#(!($( -'.,(%-,%"!" .-+,,% )8

"+"$"% /"" #,2 "%* !"+"%, "*"+"#!"#;" $,!"#"&("% !,$"' ,*(" .' ,(+(2(-.,%$( /%/2 ,%,!"!2"% ,,2 "%&!,'!"#""


19/27


20/27

A2(!" I%""$( A2/

R,$.+/$(-'.$,$ (%( ,+(-/( %,'"+($"$( ""/

-,!/"%&"% !,'!"&"( ,*(".' 2((";( 4%.'"+($"$( -,',"!(+("$ "$2/+,'4 **"%

-,%,%("% ,(&'"$( +,/2.$( *((2/( 2,"("% +,;" "-"-.$($ ) %,'.=+ "%& ,%&"+"(,2$'""$"$( 8

P,!,%/2"% "'(%&"% -"'/ $"''(%& )

=!'.$($ (%( ,'"*( $,,+"# *,2$'/2$( "'(%&"%"%& $/! $"%$("+ ""/ 2,(2" ,'"*( (%""$(-"*" "'(%&"% "%& (*"2 !,',&,%,'"$(8

K,"/"% 2,"'"# (%""$( 2'.%(2 !($" ,'"*(

$,,+"# (%""$( "2/4 ;"+"/-/% "%*" (%""$(2'.%(2 *"-" /%/+ -"*" ";"+ ,"$ 8


21/27

INFLAMASI KRONIK

I%""$( K'.%(2 "*"+"# ',%$-.%$ "%&!,'+"%&$/%& ',+"( +"" *"% *("%*"(

*,%&"% (%/2$ +(.$( *"% "2'."&*($,'"( *,%&"% -'.+(,'"$( -,!/+/#*"'"# *"% -,!,%/2"% "'(%&"%-"'/8


22/27

(%""$( 2'.%(2 *("%*"( *,%&"% #"+?#"+!,'(2/ :

(%=+'"$( $,+ .%.%/+,"' '"*"%&2'.%(2) "%& ,%"2/- "2'."&4

+(.$(4 *"% $,+ -+"$" *,2$'/2$( "'(%&"%4 $,!"#"&("% !,$"'

*("/' .+,# $,+ '"*"%&

',-"(' -,'!"(2"% ) ,+(!"2"%2+.'(,'"$( -,!/+/# *"'"# !"'/ "%&(.&,%,$($ ) *"% =!'.$


23/27

IK ,'"*( -"*" $"" $,!"&"( !,'(2/ : in%eksi virus

intraksi intrasel a!a!un secara kusus memerlukanlim%osit ( dan makro%ag untuk mengidenti)kasi danmengeradikasi sel "ang terin%eksi

*n%eksi mikroba !ersisten

Adan"a serangkaian mikro organisme ter!ilih, termasuk

mikrobakterium, Tre!onema !allidium, dan %ungustertentu +rganisme ini memiliki !athogenesis langsung"ang lemah, teta!i secara khusus da!at menimbulkanres!os imun "ang disebut hi!ersentivitas lambat

Pe&anan "ang lama terhada! agen "ang ber!otensi toksik

Pen"akit autoimuneseorang "ang mengalami res!ons imun terhada!

antigen dan &aringan tubuhn"a sendiri Karena antigen"ang bertanggung &a-ab sebagian besar di!erbaharuisecara konstan, ter&adi reaksi imun terhada! dirin"a

sendiri "ang berlangsung terus.menerus


24/27

S,+ *"% M,*(".' I%""$(K'.%(2

M"2'."&

L(.$(

S,+ -+"$" E.$(%.=+

S,+ "$


25/27

E,2 S($,(2 I%""$(

S,("- .'"%& "%& ,%*,'(" -,%"2(('/$ !,'" ,+"# ,%&"+"( ,,2 $($,(2(%""$( 4 "%& $,"'" !,'$""?$""

*($,!/ ',"2$( "$, "2/8 D," #"%"$"+"# $"/ *"'( !,'!"&"( ,,2 $($,(2(%""$( "%& +,!(# %"" : ,,2 +"(%%"4"(/ -,%(%&2""% $.%.+,% 4 "+"($, 4

"%.',2$("4 *,&'"*"$( -'.,(% .. $2,+,"%& *(-,',-" 4 #(-.,%$(4 $(%,$($#,-"( !,'!"&"( -'.,(%4 *"% -,'/!"#"%-..+ $,+ *"'"# -/(# *"+" $('2/+"$(


26/27

S,!"&("% !,$"' (%,2$( !"2,'( ,%&(%*/2$( (%,2$(!"2,'( ,%&(%*/2$( -,%(%&2""% $,+-.+(.'.%/2+,"' %,/'.=+(") "%& ',+"(, $,+,2(4

$,,%"'" (%,2$( -"'"$( *"% /&" ',$-.%$ "+,'&()$,"'" 2#/$/$ "2"% ,%&(%*/2$( ,.$(%.=+("8 V('/$,',%/4 $,-,'( .%.%/+,.$($ (%,2$(.$"4&.%*.%&"% /-$)4 *"% '/!,++"4 ,%(!/+2"%-,%(%&2""% $,+,2( -"*" +(.$( +(.$(.$($)8

N"/% *,(2("% $,!"&("% !,$"' ('/$4 '(2,$("4-'..."4 $,'" ,%($ (%,2$( !"2,'( ,',%/*," (.(*)4 *($,'"( *,%&"% -,%/'/%"% /+"#$,+ *"'"# -/(# *"+" $('2/+"$( +,/2.-,%()8

L,/2.-,%( /&" *(,/2"% -"*" (%,2$( "%& $"%&"!"%"2 ,'*"-" -"*" -"$(,% "%& (*"2 !,'*"""2(!"?($"+%" 2"%2,' "%& ,%,!"'8


27/27

TU

diskusi kelompok 3 inflamassi

Documents