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Lampiran 1 Penghitungan dosis flufenazin dekanoat

Setiap 1 ampul berisi 25 mg Flufenazin dekanoat, dilarutkan menggunakan

sesame oil 10 ml yang telah disterilkan. Penghitungan dosis menggunakan

rumus:

𝑑𝑜𝑠𝑖𝑠 𝑦𝑎𝑛𝑔 𝑑𝑖𝑖𝑛𝑔𝑖𝑛𝑘𝑎𝑛 (𝑚𝑔)

𝑑𝑜𝑠𝑖𝑠 1 𝑎𝑚𝑝𝑢𝑙 (𝑚𝑔) 𝑋 10 𝑚𝑙 𝑋 𝑏𝑒𝑟𝑎𝑡 𝑡𝑖𝑘𝑢𝑠 (𝑘𝑔)

Penghitungan dosis Flufenazin dekanoat 2 mg/kgBB

2

25𝑋 10 𝑋 … . (𝑘𝑔)

Berat tikus (kg) Dosis 2 mg/kgBB

0,19 0,152

0,20 0,16

0,21 0,168

0,22 0,176

0,23 0,184

0,24 0,192

0,25 0,2

0,26 0,208

0,27 0,216

0,28 0,224

0,29 0,232

0,30 0,240

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Lampiran 2 Penghitungan dosis ekstrak kulit manggis

Setiap 1 kaplet berisi 500 mg ekstrak kulit manggis, dilarutkan menggunakan

etanol 1 %.

Dosis yang digunakan adalah 600 mg/kgBB.13

Berat badan tikus ± 200 mg = 0,2 kg

Dosis ekstrak kulit manggis untuk tikus adalah adalah

𝐷𝑜𝑠𝑖𝑠 𝑒𝑘𝑠𝑡𝑟𝑎𝑘 𝑘𝑢𝑙𝑖𝑡 𝑚𝑎𝑛𝑔𝑔𝑖𝑠 (𝑚𝑔

𝑘𝑔𝐵𝐵) × 𝑏𝑒𝑟𝑎𝑡 𝑏𝑎𝑑𝑎𝑛 𝑡𝑖𝑘𝑢𝑠 (𝑘𝑔)

= 600𝑚𝑔

𝑘𝑔𝐵𝐵× 0,2 𝑘𝑔

= 120 𝑚𝑔

Dilarutkan dengan 30 ml etanol 1% disesuaikan dengan kapasitas minum tikus.

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Lampiran 3 Ethical clearance

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Lampiran 4 Surat Ijin Penelitian

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Lampiran 5 Analisis data

Descriptives

kelompok Statistic Std. Error

katalase

k0

Mean 2,5500 ,33912

95% Confidence Interval for Mean Lower Bound 1,6085

Upper Bound 3,4915

5% Trimmed Mean 2,5556

Median 2,5000

Variance ,575

Std. Deviation ,75829

Minimum 1,50

Maximum 3,50

Range 2,00

Interquartile Range 1,38

Skewness -,226 ,913

Kurtosis -,139 2,000

p1

Mean 5,8200 ,76560


Upper Bound 7,9457


Median 5,2500

Variance 2,931

Std. Deviation 1,71194

Minimum 3,60

Maximum 8,00

Range 4,40


Skewness ,057 ,913


p2

Mean 8,3000 1,54394


Upper Bound 12,5867


Median 8,0000

Variance 11,919

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Minimum 5,00

Maximum 13,25

Range 8,25


Skewness ,626 ,913


k1

Mean 10,1700 ,89521


Upper Bound 12,6555


Median 10,6000

Variance 4,007


Minimum 6,75

Maximum 12,00

Range 5,25


Skewness -1,724 ,913

Kurtosis 3,564 2,000

Tests of Normality

kelompok Kolmogorov-Smirnova Shapiro-Wilk

Statistic df Sig. Statistic df Sig.

katalase

k0 ,146 5 ,200* ,992 5 ,985

p1 ,230 5 ,200* ,955 5 ,776

p2 ,212 5 ,200* ,922 5 ,543

k1 ,365 5 ,028 ,813 5 ,103

*. This is a lower bound of the true significance.

a. Lilliefors Significance Correction

Test of Homogeneity of Variances

katalase

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Levene Statistic df1 df2 Sig.

2,703 3 16 ,080

ANOVA

katalase

Sum of Squares df Mean Square F Sig.

Between Groups 162,987 3 54,329 11,184 ,000

Within Groups 77,726 16 4,858

Total 240,713 19

Multiple Comparisons

Dependent Variable: katalase

Bonferroni

(I) kelompok (J) kelompok Mean

Difference (I-J)

Std. Error Sig. 95% Confidence Interval

Lower Bound Upper Bound

k0

p1 -3,27000 1,39397 ,193 -7,4635 ,9235

p2 -5,75000* 1,39397 ,005 -9,9435 -1,5565

k1 -7,62000* 1,39397 ,000 -11,8135 -3,4265

p1

k0 3,27000 1,39397 ,193 -,9235 7,4635

p2 -2,48000 1,39397 ,565 -6,6735 1,7135

k1 -4,35000* 1,39397 ,040 -8,5435 -,1565

p2

k0 5,75000* 1,39397 ,005 1,5565 9,9435

p1 2,48000 1,39397 ,565 -1,7135 6,6735

k1 -1,87000 1,39397 1,000 -6,0635 2,3235

k1

k0 7,62000* 1,39397 ,000 3,4265 11,8135

p1 4,35000* 1,39397 ,040 ,1565 8,5435

p2 1,87000 1,39397 1,000 -2,3235 6,0635

*. The mean difference is significant at the 0.05 level.

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Lampiran 6 Dokumentasi

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Lampiran 7 Biodata mahasiswa

Identitas

Nama : Miranti Anggun Sari

NIM : 22010112130164

Tempat/tanggal lahir : Semarang, 25 Agustus 1994

Jenis Kelamin : Perempuan

Nomor HP : 089679094604

e-mail : [email protected]

Riwayat Pendidikan Formal

1. SD : SD Hj Isriati Baiturrahman Semarang Lulus tahun: 2006

2. SMP : SMP N 8 Semarang Lulus tahun: 2009

3. SMA : SMA N 1 Semarang Lulus tahun: 2012

4. FK UNDIP : Masuk tahun : 2012

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