daftar isi potensi kunyit

7/25/2019 Daftar Isi Potensi Kunyit

1/16

Analisis Potensi Kunyit (Curcuma longaL.) sebagai Terapi

Kontrol Asma Bronkial yang Aman untuk Ibu Hamil

Disusun untuk mengikuti pemilihan MAWAPRES Fakultas Kedokteran UB

Oleh :

Hami Hunai! "ho!i Allu#a [0!0!00"#

$AK%LTA& K'"OKT'A

%I*'&ITA& BA+I,A-A

ALA/ 0122

1


2/16

AB&TAK&I

Asma $ronkial ter%adi aki$at adan&a hiperreakti'itas( edema dan spasme otot $ronkial

&ang kesemuan&a merupakan e)ek dari in)lamasi saluran napas* +n)lamasi terse$ut ter%adi

melalui $e$erapa %alur( &aitu akti'asi sel , helper( peningkatan akti'itas -F./B( dan

ter%adin&a stres oksidati)* Akti'asi sel , helper akan memerintahkan interleukin dan sitokin

untuk mem$uat sel.sel plasma memproduksi mediator.mediator in)lamasi* Enim.enim

proin)lamasi seperti 123 dan 423 $erperan sangat penting dalam produksi mediator

in)lamasi terse$ut* +nterleukin dan sitokin %uga mengakti'asi -F./B* -F./B ini selan%utn&a

memproduksi $an&ak produk.produk proin)lamasi* PPAR5 merupakan pengham$at langsung

dari akti'asi -F./B dan enim.enim proin)lamasi seperti 123 dan 423* Pada asma

$ronkial %uga ditemui peningkatan akti'itas R2S* Peningkatan R2S men&e$a$kan ter%adin&a

akti'asi sel , helper( akti'asi -F./B dan ter%adin&a stres oksidati)* 1ur6umin mampu

mengakti'asi ekspresi PPAR5 karena strukturn&a &ang merupakan agonis dan ligand dari

PPAR5 ( mengham$at 123.7 melalui pelepasan ikatan antigen dengan AP.!( dan

menetralisir R2S karena struktur $is.8.9.unsaturated 9.diketone &ang mampu merusak rantaioksidan* Dengan kemampuan inter'ensi terhadap %alur PPAR5 ( 123.7 dan R2S( 6ur6umin

mampu $erperan se$agai tatalaksana asma $ronkial* ,atalaksana asma pada i$u hamil saat ini

masih memiliki $an&ak e)ek samping( sedangkan 6ur6umin ter$ukti tidak menun%ukkan e)ek

samping dalam $e$erapa penelitian*

Kata kun3i: asma $ronkial( 6ur6umin( PPAR5( i$u hamil

2


3/16

AB&TA4T

Bron6hial asthma is 6aused $& $ron6hial hiperrea6ti'it&( oedema and mus6le spasm(

all o) :hi6h is the e))e6t o) air:a& in)lammation* +n)lammation o66urs through se'eral

path:a&s( :hi6h are; a6ti'ation o) T helper 6ells( in6reased a6ti'it& o) -F./B( and thedistur$an6e o) R2S* T helper 6ell a6ti'ation :ill lead 6&tokine and interleukin to make

plasma 6ells produ6e in)lammator& mediators* Pro.in)lammator& en&mes su6h as 123 and

423 are )undamental in the produ6tion o) these in)lammator& mediators* +nterleukins and

6&tokines also a6ti'ate -F./B* -F./B in turn( :ill produ6e man& other pro.in)lammator&

produ6ts* PPAR5 is a natural dire6t inhi$itor o) -F./B a6ti'ation and other pro.in)lammator&

en&mes su6h as 123 and 423* +n $ron6hial asthma( in6reased a6ti'ities o) R2S are also

)ound* +n6reased R2S a6ti'ities :ill lead to a6ti'ation o) T helper6ells( -F./B a6ti'ation and

o


4/16

KATA P'/ATA

Pu%i s&ukur kepada ,uhan ?ang Maha Esa karena atas rahmat.-&a penulis dapat

men&elesaikan kar&a tulis &ang $er%udul @Analisis Potensi Kun&it =Curcuma longa4*>

se$agai ,erapi Kontrol Asma Bronkial &ang Aman untuk +$u amil*

Penulis mengu6apkan terima kasih kepada;

!* Kedua orang tua penulis &ang senantiasa mem$erikan dukungan moral(

material dan doCa(

7* amal( saha$at penulis &ang telah $an&ak mem$erikan $antuan

kepada penulis untuk men&elesaikan kar&a tulis ini(

* Dan semua pihak &ang telah ikut $erperan akti) demi terselesaikann&a

penulisan proposal penelitian ini*

Penulis $erharap agar kar&a tulis ini dapat diman)aatkan se$agai dasar penelitian selan%utn&a

untuk mengu%i potensi Kun&it =Curcuma longa4*> se$agai terapi kontrol Asma Bronkial &ang

aman untuk +$u hamil( e)ekti)( alamiah( dan relati) ter%angkau*

Penulis men&adari $ah:a kar&a tulis ini $elumlah sempurna dan masih $an&ak kesalahan

&ang ter%adi* Penulis mengharapkan saran dan masukan dari para pem$a6a demi

pen&empurnaan kar&a tulis ini selan%utn&a*

Malang( 0 April 70!!

Penulis

4


5/16

"A$TA I&I

,uul

Abstraksi

Abstra3t

Kata Pengantar

"a!tar Isi

"a!tar Tabel

"a!tar /ambar

"a!tar &kema

Bab 2. P'"AH%L%A

!*!* 4atar Belakang

!*7* Rumusan masalah

!** ,u%uan Penulisan

!** Man)aat Penulisan

Bab 0. TI,A%A P%&TAKA

7*!* Asma Bronkial

7*!*! De)inisi( Etiologi dan Klasi)ikasi Asma Bronkial

7*!*7 Patogenesis Asma Bronkial

7*!* Proses +n)lamasi dan Alergik Molekuler pada Asma Bronkial

7*!* Peranan R2S dalam Patogenesis Asma Bronkial

7*!*G ,atalaksana Asma Bronkial

7*7* Asma Bronkial pada +$u amil

7*7*! Pengo$atan Asma Bronkial pada +$u amil

7*7*7 E)ek Samping dan Resiko Pengo$atan Asma Bronkial pada +$u

amil

7* PPAR5

7* R2S

7*G 1ur6umin

7*" Curcuma longa L.

Bab 6. 'TO"' P'%LI&A

*!* Si)at Penulisan

*7* Metode Perumusan Masalah

** Kerangka Berpikir

i

ii

iii

i7

7

7ii

7iii

i8

2

9

9

9

;

;!G.70*

77* Wang HH( Ro6ht6hina E( ,an A( 1umming R( 4eeder SR( Mit6hell P =April

700>* Use o) inhaled and oral 6orti6osteroids and the long.term risk o) 6atara6t*

Ophthalmolog-!!" =>; "G7

7* Dahl R =August 700">* S&stemi6 side e))e6ts o) inhaled 6orti6osteroids in patients

:ith asthma*%espir #ed!00 =L>; !0!7* D:idedi et al. Anti.in)lammator& status modulation $& using +ndian her$

,urmeri6 in osteoarthritis ; a 6lini6al degenerati'e disorder* 70!0

7G* Anonim* *!*!*! Selective beta* agonists side e!!ects5. British 6ational

Formular-=G ed*>* 4ondon; BMH Pu$lishing roup 4td and Ro&al

Pharma6euti6al So6iet& Pu$lishing* Mar6h 700L*

7"* 1armi6hael S4( Sha: M( Ma 1( Werler MM( Rasmussen SA( 4ammer EH*

#aternal corticosteroid use and oro!acial cle!ts* Am H 2$stet &ne6ol

700J!=">;GLG e!.J dis6ussion "L.( e!.7* Se6kl HR et al* HAMA 7;!0.( !

7L* Ameri6an 1ollege o) 2$stetri6ians and &ne6ologists =A12>*#anagement o!

preterm labor* Washington =D1>; 700 Ma&* p* =A12 pra6ti6e $ulletinJ no* >

7* Ale


12/16

"* Singh S( Aggar:al BB*Activation o! transcription !actor 6F"appaB is suppressed

b- curcumin 3di!erulo-lmethane4 * 0 -o'em$er 700!; !L!!LG

G* De1aterina( R and Basta( * n Fatt- acids and the in!lammator- response

biological bac"ground* European eart Hournal Supplements * Hune 700!; Suppl

D; D7D

"* Uni'ersit& o) Kansas Medi6al 1enter =700>* +icosanoids and n!lammation*

http;II6lasses*kum6*eduIsomI$io6L0!IsmallTgroupIei6osanoidsIei6osanoids.700*

* So$erman( Ro& H* and 1hristmas( Peter* The organi1ation and conseuences o!

eicosanoid signaling*700. Clin. nvest!!! =L>; !!0!!!

L* Bald:in( A* S*( Hr* The 6F"appa B and "appa B proteins2 ne, discoveries and

insights. Annu Re' +mmunol* !"; !;".L* 4em$erger( ,*J Des'ergne( B*J Wahli( W*JAnnu %ev Cell Dev Biol ( !"? &*(

G0* B* M* Forman( H* 1hen( and R* M* E'ans( @The pero0isome proli!eratoractivated

receptors2 ligands and activators( Annals o) the -e: ?ork A6adem& o) S6ien6es(

'ol* L0( no* !( pp* 7""7G( !"

G!* 2:en S( Pearson D( Suare.Mende N( 2CDris6oll R( Wood6o6k A*+vidence o!

!reeradical activit- in asthma* - Engl H Med !!J7G; GL".

G7* Pr&or WA( 1hur6h DF*Aldeh-des/ h-drogen pero0ide/ and organic radicals as

mediators o! o1one to0icit-* Free Radi6 Biol Med !!J!!;!."

12
http://www.brit-thoracic.org.uk/Portals/0/Clinical%20Information/Asthma/Guidelines/sign101%20revised%20June%2009.pdfhttp://www.brit-thoracic.org.uk/Portals/0/Clinical%20Information/Asthma/Guidelines/sign101%20revised%20June%2009.pdfhttp://classes.kumc.edu/som/bioc801/small_group/eicosanoids/eicosanoids-2004http://classes.kumc.edu/som/bioc801/small_group/eicosanoids/eicosanoids-2004http://www.brit-thoracic.org.uk/Portals/0/Clinical%20Information/Asthma/Guidelines/sign101%20revised%20June%2009.pdfhttp://www.brit-thoracic.org.uk/Portals/0/Clinical%20Information/Asthma/Guidelines/sign101%20revised%20June%2009.pdf


13/16

G* 1alhoun WH( Reed E( Moest DR( Ste'ens 1A*+nhanced supero0ide production

b- alveolar macrophages and airspace cells/ air,a- in!lammation/ and alveolar

macrophage densit- changes a!ter segmental antigen bronchoprovocation in

allergic subects* Am Re' Respir Dis !7J !G;!.7G

G* Sanders SP( :eier H4( arrison SH( ,rush MA( Rem$ish SH( 4iu M1*

Spontaneous o0-gen radical production at sites o! antigen challenge in allergic

subects* Am H Respir 1rit 1are Med !GJ!G!;!7G.

GG* Barnes PH*Air pollution and asthma2 molecular mechanisms* Mol Med ,oda&

!GJ!;!.GG

G"* +6hinose M( Sugiura ( ?amagata S( Koarai A( Shirato K*ncrease in reactive

nitrogen species production in chronic obstructive pulmonar- disease air,a-s* Am

H Respir 1rit 1are Med 7000J!"7;0!."

G* ulsmann AR( Raatgeep R( den.ollander H1( Sti%nen ,( Sa


14/16

""* ,ippets B uil$ert ,W* #anaging Asthma in Children/ Part *2 Achieving and

#aintaining Control* 1onsultant )or Pediatri6ians L* 700

"* Fanta 1 =Mar6h 700>* Asthma* - Engl H Med "0 =!0>; !007!

"L* oppelt.Strue$e M( Wolter D( Res6h K =De6em$er !L>* Glucocorticoids inhibit

prostaglandin s-nthesis not onl- at the level o! phospholipase A* but also at the

level o! c-cloo0-genasePG+ isomerase* Br* H* Pharma6ol* L =>; !7LG

"* ennari 1 =Ma& !>* Di))erential e))e6t o) glu6o6orti6oids on 6al6ium

a$sorption and $one mass* Br* H* Rheumatol* 7 Suppl 7; !!

0* Demissie K( Bre6kenridge MB( Rhoads *n!ant and maternal outcomes in the

pregnancies o! asthmatic ,omen* Am H Respir 1rit 1are Med !LJ !GL; !0!

!0G

!* Demissie K( Mar6ella SW( Bre6kenridge MB( Rhoads *#aternal asthma and

transient tach-pnea o! the ne,born* Pediatri6s !LJ !07; L07* Murph& et al*Asthma during pregnanc-2 mechanisms and treatment implications.

ERS Hournals* 700G

* Ma:hinner& ( Spe6tor S4* Optimum management o! asthma in pregnanc-*Drugs

!L"; 7;!L.!L

* S6hat M*Asthma during pregnanc-2 A prospective stud- in pregnancies* Thora0

!LLJ ; !7.!L

G* 1hien SH( Mint S*Asthma in pregnanc- in menses. n2 #S/ ed. Bronchial

asthma2 #echanisms and Therapeutic* Boston( Mass* 4ittle Bro:n 1o*( !

"* Walker BE* Teratolog-;.7( !!* Reinis6h HM et al S6ien6e* 707;".L( !

L* Warrell DW and ,a&lor R* 4an6et !;!!.L( !"L

* B* M* Forman( H* 1hen( and R* M* E'ans( @The pero0isome proli!eratoractivated

receptors2 ligands and activatorsAnnals o! the 6e, ?or" Academ- o! Sciences(

'ol* L0( no* !( pp* 7""7G( !"

L0* 1lark RB* The role o! PPA%s in in!lammation and immunit-* H 4euko6 Biol

7007J!=>;LL00

L!* Da&nes RA( Hones D1*+merging roles o! PPA%s in in!lammation and immunit-*

-at Re' +mmunol 7007J7=!0>;LGL7* Adeline et al. &HDeo0-delta &*/&>prostaglandin 9* inhibits glucocorticoid

binding and signalling in macrophages through a pero0isome proli!erator

activated receptor gammaindependent process.PPAR alphaI$etaIgamma and

in)lammation* Paris* 700G

L* o)seth 4H( ?ing 4*denti!-ing and de!using ,eapons o! mass in!lammation in

carcinogenesis* Bio6him Bioph&s A6ta* 700"J!"G;L* Epu$ 700G

L* Aggar:al BB*6uclear !actor"appaB2 the enem- ,ithin* 1an6er 1ell

700J"=>;70L*

14


15/16

LG* Shishodia S( Aggar:al BB*6uclear !actor"appaB2 a !riend or a !oe in cancer;

Bio6hem Pharma6ol 700J"L=">;!0!L0

L"* De'asaga&am( ,PAJ ,ilak H1( Boloor KK( Sane Ketaki S( haskad$i Saro% S( 4ele

RD * Free %adicals and Antio0idants in @uman @ealth2 Current Status and

Future Prospects* Hournal o) Asso6iation o) Ph&si6ians o) +ndia =HAP+>* 700J G7;

"

L* Rada B( 4eto ,4* O0idative innate immune de!enses b- 6o0Duo0 !amil- 6ADP@

o0idases* 1ontri$ Mi6ro$iol !G* 700L; !"L

LL* Arau%o et al. Biological Activities o! Curcuma longa L.Brail* 700!*

L* AraV%o( 1*A*1*( 4eon( 4*4*J Mem* +nst* 2s:aldo 1ru( Rio de Haneiro( 700!( "=G>(

7.7L

0* Mukhopadh&a& A( Basu -( hatak -( et al*Antiin!lammator- and irritant

activities o! curcumin analogues in rats* Agents A6tions !L7J!7;G0L.G!G!* Arora R( Basu -( Kapoor N( et al*Antiin!lammator- studies on Curcuma longa

3turmeric4* +ndian H Med Res !!JG;!7L.!7G

7* Sri'asta'a R*nhibition o! neutrophil response b- curcumin* Agents A6tions

!LJ7L;7L.0

* Singh( S* and Aggar:al( B* B*(9*Biol* Chem*( !G( *:E( 7G7G000

* Bierhous( A* et al*J Thromb*@aematostasis( !( ::( 7L7

G* Surh( ?* H*( 1hun( K* S*( 1ha( * *( an( S* S*( Keum( ?* S*( Park( K* K* and 4ee(

S* S*(#utat*%es*( 0112( >(E>(&( 77"L

"* R* A* Sharma( A* H* es6her( and W* P* Ste:ard( @Curcumin2 the stor- so !ar(

+uropean 9ournal o! Cancer( 'ol* !( no* !( pp* !GG!"L( 700G

* S* N* Ho'ano'i6( 1* W* Boone( S* Steenken( M* ,rinoga( and R* B* Kaske&( @@o,

curcumin ,or"s pre!erentiall- ,ith ,ater soluble antio0idants( Hournal o) the

Ameri6an 1hemi6al So6iet&( 'ol* !7( no* !( pp* 0"0"L( 700!

L* 4in( H*K*( Pan( M**( 4in.Shiau( S*?*JBioFactors( 7000( &( !G.!GL

* Hoe( B* and 4okesh( B* R*(Biochim*Bioph-s*Acta( !( &**>/ 7GG7"

!00* Do$elis +-( ed* Magi6 and Medi6ine o) Plants* Pleasant'ille( -?; ReaderCs

Digest Asso6iation( +n6* !L"

!0!* ,oda S( Mi&ase ,( Ari6h ( et al*6atural antio0idants. Antio0idativecompounds isolated !rom rhi1ome o! Curcuma longa L* 1hem Pharma6ol Bull

!LGJ;!7G.!7L

!07* Akram et al* C8%C8#A LO6GA A6D C8%C8#62 A %++7 A%TCL+.

70!0

!0* Ammon P,( Wahl MA !!*Pharmacolog- o! Curcuma longa* Planta Med

G; !.

!0* iroshi +nano et al. Potent Preventive Action o! Curcumin on %adiation

nduced nitiation o! #ammar- Tumorigenesis in %ats. 7000

15


16/16

!0G* E'erett P1( Me&ers HA( Makkin%e A( Ra$$i M( 4erner A* Pre6lini6al

assessment o) 6ur6umin as a potential therap& )or B144* Am H ematol 700J

L7=!>; 7.0

!0"* E'erett P1( Me&ers HA( Makkin%e A( Ra$$i M( 4erner A* Pre6lini6al

assessment o) 6ur6umin as a potential therap& )or B144* Am H ematol 700J

L7=!>; 7.0

!0* 3u H( Fu ?( and 1hen A.Activation o! pero0isome proli!eratoractivated

receptorI contributes to the inhibitor- e!!ects o! curcumin on rat hepatic stellate

cell gro,th*Am 9 Ph-siol Gastrointest Liver Ph-siol 7LG; 70 0( 700

!0L* heng S and 1hen A*Activation o! PPA%gamma is reuired !or curcumin to

induce apoptosis and to inhibit the e0pression o! e0tracellular matri0 genes in

hepatic stellate cells in vitro* Bio6hem H L; !!G( 700

!0* Fan hang et al. 1ar6inogenesis 'ol*70 no* pp*GG!( !

16

daftar isi potensi kunyit

Documents