biofarmasetika-2
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RUTE PERORAL(lanjut)RUTE PERORAL(lanjut)
Biof Biof--S1S1--0505
FENOMENA DUA PUNCAK
Dapat disebabkan variabilitas dalam:- pengosongan lambung- motilitas usus
- adanya makanan- kegagalan sediaan tablet - siklus enterohepatik
Sebagian besar obat , absorpsi terjadi di usus- pengosongan lambung sebagian --- puncak I- pengosongan lambung yang tertunda--- puncak II
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Rowland & Tozer, Clinical
Pharmacokinetics, 1995
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RUTE PERORAL(lanjut)RUTE PERORAL(lanjut)
Biof Biof--S1S1--0505
FENOMENA DUA PUNCAK (lanjut)
Ranitidin PeroralIntravena
siklus enterohepatik
Obat dari sirkulasi sistemik
Terkonsentrasi dalam kantung empedu
Kontraksi kantung empedu empedu mengandung obat
Usus reabsorpsi kembali -- resirkulasi
PUNCAK GANDA
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Effect of varyingEffect of varying
volumes of watervolumes of water
on oral drugon oral drug
absorptionabsorption
From: Shargel L, Yu ABC.From: Shargel L, Yu ABC.
Applied Biopharmaceutics Applied Biopharmaceutics
and Pharmacokineticsand Pharmacokinetics, 4, 4thth
edition, 1999, p. 119.edition, 1999, p. 119.
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