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Genom DENV terdiri dari11.644 nukleotida dantersusun dari 3 protein

struktural yaitu core protein(C), memran (!), dan

en"elope (E) serta # protein

nonstruktural

!emiliki 4 serotipe "irus(Den$1, Den$%, Den$3, Den$

4)

  VIRUS DENGUE

Den&ue "irus merupakan&enus 'la"i"irus dan amily

'la"i"iridae

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PenempelanVirus

Fusi

Virus

Translasi

Replikasi

1

2

3

4

7

6

5

Rilisirus

!a"urasi

#u$$in%

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!ani&es"asi 'linis

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aoratory Dia&nosis

• Complete *lood Counts

• +ematocrit

• latelet Count• -erum -G/, -G/

• 0mmunolo&ical /ests (0&!

0&G 2nti Den&ue, Ns1)

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atopysiolo&y

 /ransmitted y teite o 2edesmosuito (2edesae&ypti)

0ncuation 3$14days

2cute illness and

"iremia 3$# days

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Den&ue "irus enters and replicates 5itinmonocytes, mast cells, rolasts

0nnate and adapti"e immune response

Cytokine release7 /N'$a, 0$%, 0$6, 0$8

Compliment acti"ation

2ntiody dependent enancement (2DE)tou&t to contriute to se"ere inections

 /$cell acti"ation7 CD4 and CD8 cellscytokine production

 

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No specic terapy

*ed rest

-upporti"e measures7

  adeuate ydration

antipiretic (i needed)

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  Close monitorin& oypotension9sock

  :y&en administration

  0V. 0nusion o crystalloids9colloids

  latelet transusion

  Clottin& actors replacement

  Case atality is ;< in &ood centers

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