undang-undang republik indonesia no 19 tahun 2002...

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The 3rd International Seminar on Chemistry Innovations and Advances in Chemistry for the 21st Century Challenges

Jatinangor, 20-21 November 2014

UNDANG-UNDANG REPUBLIK INDONESIA

NO 19 TAHUN 2002 TENTANG HAK CIPTA

Pasal 72

KETENTUAN PIDANA

SANGSI PELANGGARAN

1. Barangsiapa dengan sengaja dan tanpa hak melakukan perbuatan

sebagaimana dimaksud dalam Pasal 2 ayat (1) atau Pasal 49 ayat (1)

dan ayat (2) dipidana dengan pidana penjara masing-masing paling

singkat 1 (satu) bulan dan/atau denda paling sedikit Rp 1.000.000,00

(satu juta rupiah), atau pidana penjara paling lama 7 (tujuh) tahun

dan/atau denda paling banyak Rp 5.000.000.000,00 (lima miliar

rupiah).

2. Barangsiapa dengan sengaja menyiarkan, memamerkan, mengedarkan,

atau menjual kepada umum suatu Ciptaan atau barang hasil

pelanggaran Hak Cipta atau Hak Terkait sebagaimana dimaksud pada

ayat (1) dipidana dengan pidana penjara paling lama 5 (lima) tahun

dan/atau denda paling banyak Rp 500.000.000,00 (lima ratus juta

rupiah).

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ISBN : 978-602-73435-0-4

PROCEEDING

The 3rd International Seminar on Chemistry 2014

Innovation and Advances in Chemistry for The 21st Century Challenges

Organized by: Department of Chemistry Faculty of Mathematics and Natural Sciences Padjadjaran University In cooperation with Indonesian Chemical Society

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Welcoming Address by the Organizing Committee

Honorable Rector of Universitas Padjadjaran Distinguished invited speakers, participants, ladies and gentlemen,

It is our great pleasure to welcome all the honorable guests, the distinguished guest and all the

participants to the 3rdtriennial International Seminar on Chemistry (ISC) 2014, here in Jatinangor, the small town you might never heard before. We are particularly happy that this

seminar has been organized to celebrate the 57th anniversary of Universitas Padjadjaran and as

a continuation of the previous ISC in 2008 and ISC 2011, we are organizing a seminar with invited speaker from various international scientific institutes. We believe that the 3rdISC 2014

meeting will be a place where the recent 21stcentury advances and innovations in chemistry can

be discussed and shared, not to mention issues emerged can be brought to light so all participants will be concerned and can contribute to solve the issues. We hope this seminar will

bring communication and cooperation in educational and research activities with the support

and collaboration of Indonesian Chemical Society, nongovernmental organizations, research institutions and scientific associations both in Indonesia and overseas.

This event will offer a comprehensive understanding on how to optimize the utilization of natural

resources through the knowledge of chemistry. It will cover topics, among others, not only associated with innovation in analytical methods, techniques and instrumentations, innovation

in material chemistry and nanotechnology, natural product chemistry and organic synthesis,

biomolecular sciences and biotechnology, information technology in chemical sciences and computational chemistry, environmental and green chemistry, and chemical education.

As a chairperson, we are very proud to report that today, the international seminar is attended by more than 300 participants, come from all overAustralia, Indonesia, Japan and Malaysia. We

invite 2 Indonesian invited speakers, and 7 foreign invited speakers come from Australia,

Germany, Japan, Malaysia, The Netherlands, and USA. There are 99 papers to be presented orally and 87 papers presented by poster covering wide-variety subjects of chemistry and its

application. We hope this event will open scientific discussions of the new findings particularly

toward “the role of chemistry in the utilization of natural resources” and followed by better understandings, formal and non-formal cooperation and also opportunities to explore further

collaboration among participants.

We would like to express our appreciation to all invited speakers, and contributed lecturer who are willing to share their knowledge, experiences, and advices in this event. We thank our

sponsor for their support to this event. Finally, we would also like to thank Rector of Universitas

Padjadjaran for his support to this seminar.

We hope you will enjoy a pleasant and valuable seminar at Universitas Padjadjaran.

Dr. rer.nat. Iwan Hastiawan

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Remarks by Head of Indonesian Chemical Society

Distinguished guests, all invited speakers, participants, ladies and gentlemen,

It is a great pleasure for me on behalf of the Indonesian Chemical Society to welcome you at

the 3rd International Seminar on Chemistry 2014 this morning here at the Auditorium of the Center for Japanese Language Study, Jatinangor Campus, Padjadjaran University. Chemistry as

a science discipline is rapidly growing and embracing other sciences. This means that chemists

should always update their recent chemical knowledge and information they acquired. Therefore, this International Seminar on Chemistry has a special importance for us, particularly

for Indonesian chemical society, primarily as it shows our endeavour in chemical research and

development, appropriate for our unique demands, and secondly as it provides means to

exchange information and experiences, particularly with regard to the chemistry progress and other related matters including international cooperation.

Distinguished guests, ladies and gentlemen, I hope that you will gain a lot of benefits from the fruitful discussion during the seminar. I would

like to express my expression to the Organizing Committee of the seminar. I am indeed

delighted and thank you for all your effort and hard working for making this seminar happened.

To all distinguished guests from abroad and from other cities in Indonesia, enjoy your stay in

Jatinangor and have a nice time.

Head, Indonesian Chemical Society

Dr. Muhamad Abdulkadir Martoprawiro

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Opening remarks by Rector of Universitas Padjadjaran

Honorable invited speakers, and all participants of the 3rd International Seminar on Chemistry

2014.

First of all, on behalf of Universitas Padjadjaran, please allow me to extend my warmest

welcome. I am much honored to be the host of this event which is organized as one of activities

in celebrating the 57th anniversary of Universitas Padjadjaran.

This seminar will cover topic “Innovations and Advances In Chemistry for The 21st Century

Challenges”. As we all aware, chemistry is the science that studies atoms and molecules along with their properties. All matter is composed of atoms and molecules, so chemistry is all

encompassing and is referred to as the central science because all other scientific fields use its

discoveries.

We all know that investigating materials and devices at the nanoscale level has become the

topic of discussion in our daily life even at the dinner table. The behavior of nanoscale materials

is close to atomic behavior rather than that of bulk materials. This leads to vivid properties and well-defined concepts, even though the description of these properties can be understood in

terms of quantum mechanics, which provides only a fuzzy picture.

On the other hand medicinal chemistry has evolved from the chemistry of bioactive compounds

in early days to works at the interface of chemistry and biology nowadays. Medicinal chemistry

of bioactive natural products spans a wide range of fields, including isolation and characterization of bioactive compounds from natural sources, structure modification for

optimization of their activity and other physical properties, and total and semi-synthesis for a

thorough scrutiny of structure activity relationship. In addition, synthesis of natural products also provides a powerful means in solving supply problems in clinical trails and marketing of the

drug, for obtaining natural products in bulk amounts is often very difficult.

Knowing that committee has selected outstanding speakers from various prestigious institutions, I believe that all participants will enjoy the discussion of the issues covered by the

topic of this seminar. I hope this meeting will serve as an excellent opportunity for all of us to

discuss views, trends, exchange knowledge, establish links and lead us to the right direction while stepping in the next future with green chemistry.

I would like to express my appreciation to all invited speakers and participants, and last but not least my deep thanks to the organizing committee for their efforts to make this seminar

happened which will enrich Basic Scientific Pattern of Universitas Padjadjaran i.e. “Nurturing

Law and Environment”.

I wish all of you have a nice stay and inspiring meeting in our university.

Rector,

Prof. Ganjar Kurnia

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Committees

Steering Committee Prof. Dr. Ganjar Kurnia (Rector of Universitas Padjadjaran)

Prof. Dr. Engkus Kuswarno (Vice Rector for Academic Affairs)

Prof. Dr. Rina Indiastuti (Vice Rector for Finance Affairs) Dr. dr. med. Setiawan (Vice Rector for Cooperation Affairs)

Prof. Dr. Ir. Roni Kastaman (Vice Rector for Infrastructure)

Prof. Dr. Budi Nurani R. (Dean of Faculty of Mathematics and Natural Sciences) Dr. Muhammad A. Martoprawiro (Head of Indonesian Chemical Society)

Scientific Committee

Prof. Dr. Husein H. Bahti Prof. Dr. Ukun M.S. Soedjanaatmadja

Prof. Dr. Toto Subroto

Prof. Dr. Unang Supratman Prof. Dr. Soetijoso Soemitro

Prof. Dr. Roekmi-ati Tjokronegoro

Prof. Dr. O. Suprijana Prof. Dr. Rustam E. Siregar

Prof. Dr. J. J. Beintema (University of Groningen - The Netherlands)

Prof. Dr. Hideo Hayashi (Osaka Prefecture University - Japan)

Organizing Committee

Chairperson : Dr. rer.nat. Iwan Hastiawan

Vice chairperson : Juliandri, Ph.D Secretary : Dr. Diana Rakhmawaty Eddy

Dr. Tri Mayanti

Dr. Shabarni Gaffar Titin Sofyatin, M. S.

Kiki Maesaroh, A. Md.

Registration : Dr. Yeni Wahyuni H Haryono, M.T

Shanty Wyantuti, M.Si

Satriadi, S.T Treasurer : Drs. Agus Safari, M.Si

Dr. Desi Harneti PH

Dr. Rani Maharani Yusi Deawati, M.Si

Ida Nurfarida, S.Si

Ai Rohayati

Publication : Dr. Rustaman Dr. Atiek Rostika Noviyanti,M.Si

Allyn P. M.T.

Uji Pratomo, M.Si Program : Dr. Tati Herlina

Dr. Euis Julaeha

Dr. Anni Anggraeni Dr. Iman Permana Maksum

Dr. Iman Rahayu

Dr. A. Muthalib Dr. Khomaini Hasan

Logistics : Dr. Dikdik Kurnia

Dr. Solihudin

Dr. Dadan Sumiarsa Nenden H., M.S

Hendi Asikin

Ajat Exhibition : Christi L. Natanael, M.S

Diana Hendrati, M.S

Ika Wiani, M.S Dr. Rubiyanto

Rukiah, M.T

Sponshorship : Dr. Darwati

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Ace Tatang Hidayat, M.Si

Dr. A. Zainudin

Dr. E. Ernawaty

Food and Beverages : Sadiah Djajasoepena, M.Si Saadah Diana R., M.S

Yati B. Yuliyati, M.S

Nurlelasari, M.Si Supporting team : Chemistry Student Association

(HIMAKA Universitas Padjadjaran)

Editor : Uji Pratomo, M.Si

Dr. Tati Herlina

Dr. Atiek Rostika

Cover Design : Uji Pratomo, M.Si

Layout : Uji Pratomo, M.Si

viii



TABLE OF CONTENT

Welcoming Address by the Organizing Committee .............................Error! Bookmark not defined.

Remarks by Head of Indonesian Chemical Society ..............................Error! Bookmark not defined.

Opening remarks by Rector of Universitas Padjadjaran ......................Error! Bookmark not defined.

Committees .........................................................................................Error! Bookmark not defined.

Table Of Content .................................................................................Error! Bookmark not defined.

Invited Speaker ...................................................................................Error! Bookmark not defined.

From Donor-Acceptor Complexes to Gallium Nitride Nanorods ......Error! Bookmark not defined.

Henry F Schaefer

Roles of TMEPAI/PMEPA1 in Cancer Progression ............................Error! Bookmark not defined.

Mitsuyasu Kato, Yukihide Watanabe, Thanh Thao Vo Nguyen, Riezki Amalia

Selective tumour-targeting with biomolecule–chemotherapeutics conjugates... Error! Bookmark

not defined.

Stefan Richter, Wilma Neumann, Menyhárt B. Sárosi, Imola Sárosi, Verena Ahrens, David

Böhme, Annette G. Beck-Sickinger, Evamarie Hey-Hawkins

Transaminases as tools for the synthesis of chiral amines ...............Error! Bookmark not defined.

A.C. Terwisscha van Scheltinga, C.C. van Oosterwijk& B.W. Dijkstra

Strategies in Bacterial Production of Recombinant Human Thrombinfor Its Use as a Fibrin

Sealant Component..........................................................................Error! Bookmark not defined.

Toto Subroto, Iman Permana Maksum, Saronom Silaban, Khomaini Hasan,Shabarni-Gaffar,

Sutarya Enus, Soetijoso Soemitro

Deproteinized Natural Rubber (DPNR) ProductionFrom The Latex Of Hevea brasiliensis MUELL

ARG With Enzymatic Method ...........................................................Error! Bookmark not defined.

R. Ukun MS Soedjanaatmadja, Dewi Astrid, Inky Febrianty, Ade Sholeh Hidayat, Ace Tatang

Hidayat, Iman Permana Maksum, Iman Rahayu, Saadah Diana Rachman, Safri Ishmayana

The Utilization of Unlimited Sunlight Energy to Sustain Our Better and Safe Environment by the

Hybridization of Artificial Photosynthesis of Ti-oxide Based Photocatalysts and Photosynthesis of

Green Vegetables in the Plant Factory ............................................Error! Bookmark not defined.

Masakazu ANPO

Novel and Bioactive Chemicals from Malaysian Plants ....................Error! Bookmark not defined.

Khalijah Awang

Small molecule fluorine chemistry: applications in organic synthesis, specialised materials and

medicinal chemistry .........................................................................Error! Bookmark not defined.

Roger W. Read

ix



Contributed Paper .............................................................................. Error! Bookmark not defined.

Modification of Natural Silica with PEG 4000 as The Stationary Phase for The Analysis Of

Caffeine by HPLC .............................................................................. Error! Bookmark not defined.

Budhi Oktavia, Desy Kurniawati, Edi Nasra, Mayora Primanelide

Chitin Extraction From Shrimp Shells By Deproteinization Using Papain ....... Error! Bookmark not

defined.9

Yuli Rohyami, Reni Banowati Istiningrum, Ida Sulistyaningrum, Nur Isnaini

Uncertainty Measurement in the Analysis of Wastewater Chemical Oxygen Demand at

Integrated Laboratory of Islamic University of Indonesia ................ Error! Bookmark not defined.

Thorikul Huda, Septian Andriwibowo, Ida Ayu Sulistya

Preparation of Composite Apatite La9.33Si6O26 (LSO) - Zr0.85Y0.15O1.925 (YSZ) .... Error! Bookmark not

defined.

Ferli S. Irwansyah, Sahrul Hidayat, Dani Gustaman Syarif, and Atiek Rostika Noviyanti

Characterization of Nickel(II) Coordination Polymers with 2,4,5-triphenyl-1H-imidazole Ligand

......................................................................................................... Error! Bookmark not defined.

Fawait Afnani, Fahimah Martak

Kinetics of Dehydrochlorination Process Reaction Between Dichloropropanol and Sodium

Hydroxide ......................................................................................... Error! Bookmark not defined.

Herliati, Robiah Yunus,, Lubena, Yeti Widyawati

Study for Corrosion Inhibition of Mild Steel in Acid Media by Carboxymethyl Chitosan/Amylose

Fraction Composite .......................................................................... Error! Bookmark not defined.

Maria Erna, Jimmi Copriady and Herdini

Synthesis Mg3,1Al0,45Fe0,25Ce0,3 Hydrotalcite Doped with Hydrothermal and Coprecipitation

method : Different calcination temperature .................................... Error! Bookmark not defined.

Mochamad Zen, Dadan Sumiarsa, Roekmi-ati Tjokronegoro, Rustam E. Siregar

Chemical Soil Characteristics Affected By Incubation Time Of Organic Hydrogel In Ultisols .. Error!

Bookmark not defined.

Mulyani, O, Suriadikusumah, A, Salim, .H.E

Synthesis and Characterization Of Nio Nanoparticles By Sol-Gel And Sonochemical Methods

......................................................................................................... Error! Bookmark not defined.

Sherly Kasuma Warda Ningsih

Investigation of Surfactant Anionic Effect on Morphology and Performance of Cellulose acetate-

Polystyrene Nanofiltration Membrane for Desalination .................. Error! Bookmark not defined.

Sri Mulijani

Isolation and Characterization of Triterpenoid Compoundfrom Indonesian Sarang-Semut Plant

Tubers (Myrmecodia pendans Merr. & L.M. Perry) ......................... Error! Bookmark not defined.

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Hilmana Radhia Putera, Dikdik Kurnia, Dadan Sumiarsa

The Study on The Effect of Phytochemical Properties in Aloe vera Extract To Oral Candida in

Cancer Survivor ................................................................................Error! Bookmark not defined.

Indah Suasani Wahyuni, Elizabeth Fitriana Sari, Trinugroho Heri Fadjari

Antioxidant Activity And Bioactive Component Of Ethanolic Extract Of Basil (Ocimumbasilicum

L.) Seed After Fractionation .........................................................................................................80

Dede Sukandar, Sandra Hermanto, Adawiyah, Eka Rizki Amelia and Chitta Putri Noviani

Evaluation of fucoidan bioactivity asanti-gastriculcers in mice ........Error! Bookmark not defined.

Ellya Sinurat, Rosmawaty P

Fracture Pattern of Controlled Groundwater Flow in the Volcanic System Case Study in

Ciherang, West Java, Indonesia ....................................................................................................89

Cipta Endyana, Hendarmawan, Emi Sukiyah, Irwan Ari Dharmawan, Faisal Helmi

Coolant Wastewater Treatment From Rest of Milling Aluminium Production at Indonesian

Aerospace Ltd. With Electrocoagulasi Method ................................Error! Bookmark not defined.

Saptadi Fadjatmiko

The Effectivenees of Laboratory Experiment Method to Increase Activity and Student’s

Achievement on Teaching Salt Hydrolysis ........................................Error! Bookmark not defined.

Ramlan Silaban, Agustina ML Tobing , Irving Josafat Alexander

Application Method Of Inquiry In Improving Student Learning Chemistry Class XI SMA Sains In

Jayapura City ....................................................................................Error! Bookmark not defined.

Tiurlina Siregar

Effect of Dehydration in Making Time Permanent Supply Aedes aegypti Larvae . Error! Bookmark

not defined.

Anita Oktari, Yati Supriatin, Ridha Robbi Amanati

Separation Of Alkaloid Compounds From Fruit Of Mahkota Dewa (Phaleria macrocarpa Boerl.)

Using Liquid Chromatography ..........................................................Error! Bookmark not defined.

Diana Hendrati

Determination Of Chrom Hexavalent (Cr(VI)) from Electroplating Waste Using

Spectrophotometry ..........................................................................Error! Bookmark not defined.

Euis Yuliani, Suryatmana Tanuwijaya, Yusuf Akhyar Bahtiar

Myristicin Isolation Of Nutmeg (Myristica Fragrans Hout) With Hexane Extraction Method Error!

Bookmark not defined.

Korry Novitriani and Tanendri Arrizqiyani

Adsorption of Carbon Black Using Chitosan in Deinking Process .....Error! Bookmark not defined.

Muryeti, Estuti Budi Mulyani, Elya Sinurat

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Synthesis of Mg/Al Hydrotalcite by Sol-Gel and Coprecipitation Methods .... Error! Bookmark not

defined.

Puji Kurniawati, Tri Esti Purbaningtias, Bayu Wiyantoko, Is Fatimah

The Chitosan Synthesis And Characterization Of Tutut Shell (Bellamya Javanica van den Bush) as

Anti Microbial .................................................................................. Error! Bookmark not defined.

Meti Kusmiati, Korry Novitriani, Ummy Mardiana

Antibacterial Potency of AC Kuningan’s Sweet Potato (Ipomea batatas) on Eescherichia coli

Bacteria ............................................................................................ Error! Bookmark not defined.

Abdul Muis, Ilah Nurlaelah

Application of Trunk of Heart-leaved Moonseed Extract as an Intercalating Agent of DNA

Visualization ..................................................................................... Error! Bookmark not defined.

Adhitya Sukma Trijaya, Tri Aminingsih, Ade Heri Mulyati

Comparison Study of Three Different Polymerase Amplifying Breast Cancer HER-2 Gen For PCR-

Based Diagnostic Applications Purpose ........................................... Error! Bookmark not defined.

Desriani

Peat Water Purification By Absorption With Baggase Charcoal ....... Error! Bookmark not defined.

Halida Sophia, Akmal Mukhtar, Patricia Lucky Yoseva

Limonoids from the seed of Chisocheton macrophyllus (Meliaceae) ……………………………………..170

Nulelasari, Desi Harneti, Moelyono Moekti Wardoyo, Unang Supratman, and Khalijah Awang

Authors Index .................................................................................. Error! Bookmark not defined.76

70



71



Limonoids from the seed of Chisocheton macrophyllus (Meliaceae)

Nulelasari1, Desi Harneti

1, Moelyono Moekti Wardoyo

2,

Unang Supratman1*

, and Khalijah Awang3

1Department of Chemistry, Faculty of Mathematics and Natural Sciences,

Padjadjaran University, Jatinangor 45363, Indonesia 2Faculty of Pharmacy, Padjadjaran University, Jatinangor 45363, Indonesia

3Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 59100, Malaysia

Abstract

The Chisocheton genus, a member of the Meliaceae family, contains approximately 50 species that are mainly distributed in India, Thailand, Malaysia and Indonesia. Chisocheton macrophyllus is a higher plant and found growing in the rain

forest in northern part of Sulawesi Island, Indonesia. In this communication, we describe the isolation and structure

elucidation of a new limonoid dysobinol (1), with known limonoid, dysobinin (2) from the seed of the Chisocheton

macrophyllus (Meliaceae). Their structures were elucidated by extensive spectroscopic methods including 1D- (1H, 13C and DEPT) and 2D-NMR (1H-1H COSY, HMQC and HMBC) experiments as well as HR-ESI-TOFMS analysis.

Keywords: Dysobinol, Dysobinin, limonoid, Chisocheton macrophyllus, Meliaceae

1. Introduction

The Chisocheton genus, a member of the Meliaceae family, contains approximately 50 species that are

mainly distributed in India, Thailand, Malaysia and Indonesia [1,2]. The genus Chisocheton is a subtropical

and tropical plant family widely known for its insecticidal limonoid constituents [3]. Previous phytochemical

studies on Chisocheton species have yielded a number of interesting compounds, including limonoids [4,5],

antifungal meliacin-type compound [6], dammarane triterpenoids [7], and spermidine alkaloids [8]. As part

of our studies on novel compounds from Indonesia Meliaceae plants [9,10], we carried out a study on

Chisocheton macrophyllus. C. macrophyllus is a higher plant and found growing in the rain forest in

northern part of Sulawesi Island, Indonesia [2,11].

The plant is known as a Ma-aa in Indonesia, and the seed oil from this plant is used in

Indonesian for lighting [12]. Its leaves have been reported to yield dammarane

triterpenoids [7], but the seeds of this plant has never been phytochemically investigated.

In this communication, we describe the isolation and structure elucidation of one new

limonoid (1) along with known limonoid (2) from the seed of C. macrophyllus. Their

structures were elucidated by extensive spectroscopic methods including 1D- (1H,

13C and

DEPT) and 2D-NMR (1H-

1H COSY, HMQC and HMBC) experiments as well as HR-ESI-

TOFMS analysis. 2. Materials and Methods

2.1. General experimental procedures

Melting points were measured on a Fisher-John micro melting point apparatus and are

uncorrected. Optical rotations were recorded on a ATAGO AP-300 automatic polarimeter.

The IR spectra were recorded on a Perkin-Elmer spectrum-100 FT-IR in KBr. Mass spectra

were obtained with a JEOL JMS-700 and a SynaptG2 mass spectrometer instruments. 1H-

and 13

C-NMR spectra were obtained with a JEOL JNM A-500 spectrometer using TMS as

internal standard. Chromatographic separations were carried out on silica gel 60 (Merck).

PTLC glass plates were precoated with silica gel GF254 (Merck, 0.25 mm). TLC plates

were precoated with silica gel GF254 (Merck, 0.25 mm) and detection was achieved under

undang-undang republik indonesia no 19 tahun 2002...

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