skenario imunohematology

8/17/2019 skenario imunohematology

1/49

SGD 5 KELOMPOK 1

•CITRA AYU WAHYUNI

•DARA AZURA

•

DEA CHRISYANGGI MSH•DEWI PERTIWI

•DIANA SARI PASARIBU

•DIAN ASTARI


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ISTILAH KATA

•

Vaksin s!s"#nsi $ik%&&%'anis$# (i)#$a*kan a+a! (i $a+ikan ,an' (i-#%ikan !n+!k $#n.#'a* a+a!$#n'&-a+i "#n,aki+ $#n!)a%

• Pa%! &-s+%!k+i/ s!a+! "#n,!$-a+an$#n#+a" "a(a sa)!%an "#%na/asan ,an'(i s#-a-kan &)#* #$0s#$a a+a!

-%&nki+is k%&nis• I$!nisasi "%&s#(!% ,an' (i )ak!kan

!n+!k $#nin'ka+kan (#%aa+ i$!ni+as+!-!*


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IDENTIIKASI MASALAH

13 M#n'a"a (&k+#% $#n'an!%kan

i$!nisasi "a(a &s ,an' s!(a* -#%!sia)an!+ 4

23 A"a ,an' $#n,#-a-kan k#)!*ann,a

s#%in' ka$-!* 43 A"a *!-!n'ann,a i$!nisasi (#n'an

"#n.#'a*an +#%a(in,a in/#ksi "a(a &s4

63 Ba'ai$ana %#s"&n i$!n &s +#%*a(a""#n,aki+ ,an' (i (#%i+an,a 4

53 Ba'ai$ana "#$-#%ian i$!nisasi "a(a&%an' (#7asa 4


5/49

KLARIIKASI MASALAH

13 M#n'a"a (&k+#% $#n'an!%kan i$!nisasi"a(a &s ,an' s!(a* -#%!sia )an!+ 4

8a7a-

ka%#na s#$akin +!a !sia s#s#&%an'$aka %#sis+#nsi +!-!* +#%*a(a""#n,aki+ s#$akin +!%!n s#*in''a

$!(a* +#%s#%an' "#n,aki+9 &)#*ka%#na i+! (i an!%kan -a'i &%an',an' )an!+ !sia !n+!k (i i$!nisasi

a'a% sis+#$ i$!nn,a $#nin'ka+


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23 A"a ,an' $#n,#-a-kan k#)!*ann,as#%in' ka$-!* 4

a7a- ka%#na %#s"&n i$!n +!-!* &s +#)a*+!%!n +a"i +i(ak !'a (i -#%ikani$!nisasi !n+!k $#nin'ka+kan %#s"&ni$!n +!-!* &s 9 s#*in''a an+i-&(i ,an'(i*asi)kan +i(ak (a"a+ $#)a7anan+i'#n (#n'an -aik s#$#n+a%a $&

+#%!s $as!k k# +!-!* &s (#n'an"#%)a7anan (a%i an+i-&(i ,an' )#$a*&)#* ka%#na i+! k#)!*ann,a s#%in'ka$-!* s#-a'ai %#s"&n (a%i +!-!* &s


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3 A"a *!-!n'ann,a i$!nisasi (#n'an"#n.#'a*an +#%a(in,a in/#ksi "a(a &s 4

a7a- in/#ksi +#%a(i ka%#na a(an,a s#%an'an(a%i $& (an +!-!* &s +i(ak $a$"!$#)a7an s#%an'an +#%s#-!+ ka%#na%#s"&n i$!n ,an' (i$i)iki +!-!*n,a+#)a* $#n!%!n &)#* ka%#na i+! "#%)!(i-#%ikan i$!nisasi a'a% +#%a(i

"#nin'ka+an %#s"&n i$!n +!-!* &s 9s#*in''a (a"a+ $#%an'san'"#$-#n+!kan i$!ni+as +!-!* :an+i-&(i;(a%i sis+#$ i$!n (i(a)a$ +!-!*


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63 Ba'ai$ana %#s"&n i$!n &s +#%*a(a""#n,aki+ ,an' (i (#%i+an,a 4

a7a- k#+ika $& $as!k "#%+a*anan +!-!*n&ns"#si0k +!-!* &s +i(ak $a$"!

$#)a7an (#n'an "#%+a*anan +!-!*n&s"#si0k $& $#%an'san'"#%+a*anan +!-!* s"#si0k $#n'*asi)kan an+i-&(i "#%+a*anan+!-!* &s )#$a* an+i-&(i +i(ak$a$"! $#)a7an $& ,an' $#na(i"#n,#-a- "#n,aki+ &s3


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53 Ba'ai$ana "#$-#%ian i$!nisasi"a(a &%an' (#7asa 4

a7a-

"#$-#%ian i$!nisasi "a(a &%an'(#7asa -#%!"a s!n+ikan (a"a+

-#%!"a in+%a$!s.!)a% $a!"!ns!-.!+an +#%'an+!n' #nis


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PETA KONSEP

Dis#%an'&)#* $&

Ti$-!)'#a)a

Lan!+!sia

N&ns"#si0

k

S"#si0k

B!a+an

R#s"&ni$!n+!-!*

A- ka)a*$#)a7a

n A'

A)a$ia*

Ak+i/

P#$-#%ian

Vaksin

Pasi/

Di-#%ikan

i$!nisasi

OS


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LEARNING OB8ECTIVE

• Ma*asis7a=I $a$"! $#n#)askan

> (#/#nisi i$!nisasi9 $an/aa+n,a

> #nis>#nis i$!nisasi

> $#kanis$# k#%a i$!nisasi> an+i'#n9 an+i-&(i9 $*. (an %#aksian+a%a an+i-&(i (an an+i'#n

> %#s"&n i$!n +!-!* +#%*a(a"i$!nisasi

> "#$-#%ian


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D#/#nisi i$!nisasi

I$!nisasi a(a)a* s!a+! .a%a !n+!k$#nin'ka+kan k#k#-a)an s#s#&%an'

s#.a%a ak+i/ +#%*a(a" s!a+! an+i'#n9s#*in''a -i)a k#)ak ia +#%"aan "a(aan+i'#n ,an' s#%!"a9 +i(ak +#%a(i

"#n,aki+3


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Di)i*a+ (a%i .a%a +i$-!)n,a +#%(a"a+ 2

#nis k#k#-a)an 13K#k#-a)an "asi/

K#k#-a)an ,an' (i"#%&)#* (a%i )!a%

+!-!*9 -!kan (i-!a+ &)#* in(i


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Man/aa+ i$!nisasi•

M#n.#'a* +#%a(in,a "#n,aki+ +#%+#n+!"a(a s#s#&%an'

• M#nin'ka+kan i$!ni+as +!-!*

• Un+!k $#n'!%an'i an'ka "#n(#%i+a s!a+!"#n,aki+ ,an' san'a+ $#$-a*a,akan

• M#n.#'a* "#n(#%i+aan ,an' (is#-a-kan"#n,aki+ $#n!)a% ,an' s#%in' -#%an'ki+

•

Bia,a )#-i* $!%a*• P%&(!k+i0+as k#%a +#+a" +#%a'a


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8#nis ? 8#nis Vaksin

• O%an' (#7asa *a%!s $#$#n!*i (&sis"%i$#% +#+an!s9 +#%!+a$a s#+#)a*$#n'a)a$i .#(#%a a"a"!n ,an'-#%*!-!n'an (#n'an +#+an!s9 s#"#%+i)!ka ,an' (is#-a-kan &)#* ka%a+3

• Wani+a ,an' *a$i) !'a -isa$#n(a"a+kan


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• Vaksinasi HPV (i%#k&$#n(asikan !n+!ks#$!a 7ani+a -#%!sia (i -a7a* 2@ +a*!n

• Wani+a ,an' $asi* ak+i/ s#.a%a s#ks!a) !'a *a%!s (i


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• P#n,aki+ ,an' (is#-a-kan


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• S#$!a &%an' (#7asa +an"a -!k+ik#k#-a)an +#%*a(a"


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• P#n,aki+ ,an' (is#-a-kan


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• Vaksinasi "n#!$&nia "a(a !sia )an!+

.!k!" #/#k+i/ !n+!k $#)in(!n'i !sia)an!+ s#*a+ +#%*a(a" "#n,aki+in"a%! k%&nis+#%$as!k as$a3

• Vaksin "&)isaka%i(a "n#!$&k&k(a"a+ $#nin'ka+kan an+i-&(i (#n'an#/#k+i/

@3 Vaksin "n#!$&.&..a)"&),sa..*a%i(#


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(ian!%kan "a(a &%an'

(#7asa&sia dan golongan 4aksin yang

diberikan%eterangan

16 ? 1@ +a*!n MMR :$#as)#s9$!$"s9 %!-#))a;

DPT :(i"*+*#%ia9+#+an!s (an a.#))!)a%

"#%+!ssis;

T#+an!s (#7asa: s#)an!+n,a s#+ia"

1 +a*!n s#ka)i;

Da%i 15>@5 +a*!n+#+an!s (an "&)i& &%a)s#+ia" 1 +a*!n


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1 ? 66 +a*!n MMR Ba'i $#%#ka ,an'-#%#sik&

Wani+a F 2 +a*!n HVP :*!$an"a"i))&$a


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ANTIGEN9 ANTIBODI9 DANMHC


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An+i'#n

S!a+! a+ ,an' -i)a (i-#%ikan s#.a%a "a%#n+#%a) k#(a)a$ +!-!* akan $#%an'san' "#$-#n+!kanan+i-&(i ,an' akan -#%#aksi s#.a%a k*as (an (a"a+

(ia$a+i3


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• Si/a+>si/a+ an+i'#n13 Si/a+ asin' *an,a an+i'#n ,an' -#%si/a+ asin' +#%*a(a"

s!a+! in(i#ni$ a%in'an *an,a a+>a+,an' (i$#+a-&)isasikan (an "#ka +#%*a(a" k#%a #ni$>#ni$ a%in'an akan -#%)ak! s#-a'ai an+i'#n3

53 K#k*asan an+i'#n

@3 K#k*asan s"#si#s

3 Is&s"#si0si+as

3 A!+& s"#si0+as

3 S"#si0+as &%'an

13S"#si0+as *#+#%&'#nik :*#+#%&0);

A +i- (i


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An+i-&(i >i$!n&')&-!)in

• S!a+! a+ .ai% ,an' (i-!a+ s#-a'ai%#s"&ns +#%*a(a" %an'san'an an+i'#n (an(i'!nakan &)#* sis+#$ k#k#-a)an +!-!*!n+!k $#n'i(#n+i0kasi (an

$#n#+%a)isasikan -#n(a asin'9 s#"#%+i-ak+#%i (an si/a+ an+i-&(i

13 M#%!"akan s!a+! "%&+#in23 T#%-#n+!k s#-a'ai %#s"&ns +#%*a(a"

%an'san'an an+i'#n

3 B#%#aksi k*as (#n'an an+i'#n ,an' .&.&k

(#n'ann,a3


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• I$!n&')&-!)ina(a)a* ')&-!)in ,an' -#k#%a s#-a'ai an+i-&(i

• S+%!k+!% i$!n&')&-!)inI$!n&')&-!)in ia)a* ')ik&"%&+#in9 +ia" $&)#k!)n,a

$#$"!n,ai (!a "asan' %an+ai "&)i"#"+i(a ,an'

!k!%ann,a -#%-#(a +#%ika+ &)#* ika+an (is!)0(a3Ran+ai "#n(#k (is#-!+ %an+ai %in'an:)i'*+L;(an %an+ai "anan' (is#-!+ %an+ai-#%a+:*#a


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• K#)as>k#)as i$!n&')&-!)in

13 I'G –

M#%!"akan -a'ian +#%-#sa% i$!n&')&-!)in3 BM 153(a)+&n3 Wak+! "a%!*n,a 2 *a%i3 B#n+!kn,a s#%!"a

k!$"a%an (an "anan'n,a 25> A (an )#-a%n,a 6A3

– K&ns#n+%asin,a (i(a)a$ s#%!$ n&%$a) ia)a* 5>1@ $'=$)

– I'G (a"a+ $#)#7a+i ")as#n+a (an $#$-#%ikan k#k#-a)an

"asi/ a)a$ia* k#"a(a -a,i>-a,i ,an' -a%! )a*i%23 I'A

– B#%a+ $&)#k!)n,a 1@3 (a)+&n97ak+! "a%!*n,a @>*a%i

– Ka(a% n&%$a)n,a (i(a)a$ s#%!$ ia)a* 9@>692 $'=$)3

–I'A +i(ak (a"a+ $#)#7a+i ")as#n+a

– T#%(a"a+ (a)a$ k&ns#n+%asi +in''i (a)a$ sa)!%an na/as9ai% $a+a9 .ai%an #$"#(!9 ai% )i!% sa)!%an "#n.#%naan9 ASI9(an k#%in'a+3


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3 I'M – B#%a+ $&)#k!)n,a 3>13 (a)+&n9 ka(a%

n&%$a)n,a (i(a)a$ s#%!$ 95>2 $'=$)9 7ak+! "a%!*n,a1 *a%i +i(ak (a"a+ $#n#$-!s ")as#n+a3

– An+i-&(i (a)a$ %#s"&ns i$!n "%i$#% – P%#(&$inan (i"%&(!ksi /#+!s3

63 I'D – K&ns#n+%asin,a (i(a)a$ s#%!$ ia)a* 9 $'=$) – S#-a'ian -#sa% -#%a(a (i in+%as#) a%in'an :+#%!+a$a

s#) $as+; "a(a s"#si#s ,an'a sa$a3 – Ti(ak (a"a+ $#)#7a+i ")as#n+a a+a! $#n'ika+ k&$")#$#n – Pa(a k#a(aan a+&"i ss#"#%+i as$a9%ini+is a)#%'i9 (an

(#%$a+i+isa+&"i a+a! #ksi$ ka(a%n,a akan $#nin'ka+9(#$ikian "!)a "a(a anak>anak ,an' $#n'i(a" in/#ksi.a.in'3


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Ma&% *is+&.&$"a+i-i)i+,.&$")#J:MHC;

Sis+#$ i$!n $#$"!n,ai /!n'si (a)a$ "#%+a*anan +!-!*3 Un+!k$ana)ankan /!n'si +#%s#-!+9 sis+#$ i$!n *a%!s (a"a+ $#n'#na)$&)#k!)>$&)#k!) asin' a'a% (a"a+ (i-#(akan (a%i $&)#k!) i+!s#n(i%i3 Han,a $&)#k!) ,an' $#$i)iki #"i+&" ,an' akan (ik#na)

s#) sis+#$ i$!n ,ai+! s#) B (an s#) T3 M&)#k!) ,an' ak*i%9-#%sa$a "%&+#in )ainn,a (isan(i &)#* '#n ,an' +#%)#+ak (i%#'i&,an' )!as (a)a$ k%&$&s&$ @ ,an' (is#-!+ MHC


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• K&n+%&) '#n#+ikPa(a "#n(#%i+a ,an' +#)a* $#n(a"a+ +%ans/!si

(a%a* -#%!)an' ka)i (i+#$!kan an+i-&(i ,an'(a"a+ $#n''!$"a)kan )#!k&si+3 O)#* ka%#nai+! +i$-!) is+i)a* HLA:H!$an L#!.&.,+#An+i'#n;3 HLA a(a)a* MHC "a(a $an!sia,an' $#%!"akan %#'i& '#n#+ik )!as ,an'

$#n,an(i $&)#k!) MHC>I9 MHC>II (an "%&+#in)ain3

D#7asa ini (ik#+a*!i k&$")#ks HLA,an' +#%(i%ia+as )&k!s HLA>A9 HLA>B9 HLA>C9 HLA>D9 :HLA>DR DAN HLA>D9 HLA>DP;3 T#%n,a+a s#+ia")&k!s i+! "&)i$&%/ (an $asi* +#%(i%i a+as-#-#%a"a *a")&+i"3 Dian+a%a )&k!s HLA>B (anHLA>DR (a)a$ k%&$&s&$ @ (i+#$!kan )&k!s)ain ,ai+! MHC>III ,an' $#n#n+!kan (an$#n'#n(a)ikan sin+#sis s#!$)a* $&)#k!)3


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• P#$-a'ian k&$")#ks*is+&k&$"a+i-i)i+as $a,&%

M&)#k!) MHC>I (an MHC>II -#%"#%an "a(a"#n'#na)an i$!n9 ,ai+! "a(a "%#s#n+asi

/%a'$#n an+i'#n k#"a(a s#) T3B#%(asa%kan %!$!s -an'!nann,a9 $&)#k!) MHC

(a"a+ (i-a'i $#na(i '&)&n'an9 ,ai+!

13 M&)#k!) MHC>I

23 M&)#k!) MHC>II3 M&)#k!) MHC>III


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• M&)#k!) MHC>I

MHC>I +#%(i%i a+as 2 "&)i"#"+i(a %an+ai -#%a+"&)i$&%0k (an %an+ai %in'an n&n>"&)i$&%0k ,an'(is#-!+ $ik%&')&-!)in -#+a 23 MHC>I +#%(i%i a+asHLA>A9 HLA>B9 HLA>C ,an' (a"a+ (ik#na) s#)

CTL=T.9 "#%+a$a ka)i (ik#+a*!i -#%"#%an "a(a"#n&)akan +an(!%3 M&)#k!) MHC>I (is#-!+ !'aan+i'#n +%ans")an+asi3

L&k!s MHC>I $#n#n+!kan #ks"%#si a+a! an+i'#n

"#%$!kaan "a(a $#$-%an "#%$!kaan s#$!a s#)+!-!* ,an' $#$i)iki n!k)#!s (an +%&$-&si+s#*in''a s#) T. akan $!(a* $#n'#na) s#) ,an'+#%in/#ksi


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• M&)#k!) MHC>II

K&$")#ks MHC>II ,an' +#%(i%i a+as HLA>D :DP9D (an DR; $#n#n+!kan #ks"%#si a+a!an+i'#n "#%$!kaan s#)>s#) i$!n&k&$"#+#n+#%+#n+! s#"#%+i s#) B9 $&n&si+9 $ak%&/a'9(an APC !n+!k $#n'ak+i/kan s#) T3

M&)#k!) MHC>II $#n'ika+ $&)#k!) "#"+i(a ,an's!(a* (i"%&s#s s#) APC $#na(i k&$")#ks,an' k#$!(ian (i an'k!+ k# "#%$!kaan s#)s#*in''a (a"a+ (ik#na) &)#* s#) CD63

P%#s#n+asi an+i'#n (a)a$ ika+an k&$")#ks(#n'an $&)#k!) :MHC>II; &)#* APC k# s#) TCD6 +#%s#-!+ $#%!"akan "#%$!)aan%#aksi i$!n ,an' s#)an!+n,a $#n#n+!kan

#nis %#s"&ns ,an' akan +#%a(i3


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• M&)#k!) MHC>III

P#$-#n+!kan k&$"&n#n -#-#%a"asi+&kin (an $&)#k!) )ain (i+#n+!kan&)#* $&)#k!) MHC>III3


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IMUNISASI DEWASA

• RESPON IMUN PADA VAKSINASI

k&$"&n#n "#n+in' (a)a$ $#ni$-!)kan


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R#s#"+&% i$!n&')&-!)in "a(a)i$/&si+ B -#%/!n'si

!n+!k -#%"#%an (an -#%in+#%aksi(#n'an an+i'#n

23RESPON SELULER

(i)ak!kan &)#* )i$/&si+ T ,an'-#%/!n'si

s#-a'ai s#) an+a%a ,an' (iak+i/kan$#)a)!i "#)#"asan si+&kin3


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• VAKSIN

B#%"#%an "#n+in' s#-a'ai$#n'in(!ksi $#$&%i i$!n&)&'ik"a(a s#) T9s#) B9(an APC3

• A8UAN

$#%!"akan -a*an ,an'

(i"#%)!kan s#-a'ai +a$-a*an "#)a%!+an+i'#n a+a! "#%an'san' "%&(!ksian+i'#n3


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8#nis>#nis


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3 %#k&$-inan


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• KEAMANAN

*a) ,an' ("a+ +#%a(i "a(a"#n''!naan


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• Vaksin ,an'(i $a+ikan

>k&n+a$inasi>%#aksi a)#%'i

>"%&s#s $#$a+ikan -ak+#%i k!%an'$#$a(ai3

• Vaksin ")as$i( DNA

>$#ni$-!)kan +&)#%ansi a+a! a!+&i$!n

NBVaksin s+a-i) s#)a$a 1 +a*!n "a(as!*! 6C s#(an'kan "a(a s!*! C*an,a -#%+a*an 2> *a%i


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• 8a(7a) i$!nisasi "a(a &%an' (#7asa

TETANUS TOKSOIDVaksinasi )#n'ka" (&sis "%i$#% (%(i/+#%i (an +&ks&i( +#+an!s9(#n'an(&sis (i-#%ikan a%ak 6 $in''! (an

(&sis k# (i-#%i @ *in''a 12 -!)an3Ma.a$


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INLUENZADi -#%ikan s#+ia" +a*!n F5& +a*!nMa.a$


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HEPAITITS A

D#n'an (&sis a%ak @>12 -!)an "a(a

in(i


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RABIES

Ma.a$


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Y#))&7 /#


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REERENSI

7773i$!nisasi3n#+

Ka%n#n G3 Ba%a+7i(aa3 2@3I$!n&)&'iDasa%3 8aka%+a3 K UI 3

Sa+is* G!"+#9Mik%&-i&)&'& Dasa%9 #(isi
http://www.imunisasi.net/http://www.imunisasi.net/

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