TINJAUAN PUSTAKA

PATOGENESIS DAN PENATALAKSANAAN ITP

Oleh :

YULYANI WERDININGSIH

BAGIAN / SMF ILMU PENYAKIT DALAM FAKULTAS KEDOKTERAN

UNIVERSITAS SEBELAS MARET / RUMAH SAKIT UMUM DAERAH

DOKTER MOEWARDI SURAKARTA

2010

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LEMBAR PENGESAHAN

PATOGENESIS DAN PENATALAKSANAAN ITP

Telah dipresentasikan dan disahkan

sebagai salah satu persyaratan stase ICU

Pada Hari/tgl :.........................................

Pembimbing :

dr. Purwoko, SpAn-KAKV

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DAFTAR ISI

Halaman Judul ...................................................................................................... i

Lembar Pengesahan ..............................................................................................ii

Daftar Isi ...............................................................................................................iii

Daftar Gambar dan Tabel .............................................................................. iv

Daftar singkatan .................................................................................................. v

BAB 1 PENDAHULUAN .................................................................................. 1

BAB 2 TROMBOSIT ......................................................................................... 3

2.1.Struktur Trombosit ................................................................... 3

2.2.Trombopoesis ............................................................................... 7

BAB 3 PATOGENESIS DAN DIAGNOSIS ITP ......................................... 11

3.1 Patogenesis ................................................................................ 11

3.2 Diagnosis .................................................................................... 14

BAB 4 PENATALAKSANAAN ITP .............................................................. 18

4.1. Prinsip Terapi ITP ..................................................................... 18

4.2. Terapi ITP ................................................................................. 20

BAB 5 KESIMPULAN .............................................................................. 25

DAFTAR PUSTAKA .............................................................................. 26

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DAFTAR GAMBAR DAN TABEL

Gambar 2.1.Anatomi dan Jalur Signaling Trombosit ........................................... 5

Gambar 2.2.Mekanisme Terbentuknya Sumbat Trombosit ................................. 7

Gambar 2.3.Hematopoesis ................................................................................... 8

Gambar 2.4.Mekanisme Aktifasi TPO-R oleh TPO ............................................ 9

Gambar 2.5.Mekanisme Umpan Balik Trombopoetin ........................................ 10

Gambar 3.1.Patofisiologi ITP .............................................................................. 12

Gambar 3.2.Patogenesis Penyebaran Epitop pada ITP ...................................... 13

Gambar 4.1.Mekanisme Kerja Terapi ITP ......................................................... 19

Gambar 4.2.Bagan Pengelolaan Penderita ITP .................................................. 24

Tabel 3.1. Guideline ASH untuk ITP ................................................................. 16

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DAFTAR SINGKATAN

ITP : Idhiopathic Thrombocytopenic Purpura atau Immune

Thrombocytopenic Purpura

ASH : American Society of Haematology

IVIG : Intra Venous Immuno Globulin

BCSH : British Committe for Standart in Haematology

GP : Glikoprotein

DNA : Deoxy Nucleic Acid

vWF : Von Willebrand Factor

PGG2 : Prostaglandin G2

PGH2 : Prostaglandin H2

TxA2 : Tromboksan A2

PG12 : Prostasiklin

PF4 : Platelet Factor 4

βTG : Beta Trombo Globulin

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