Download - yteee
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NSAID
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Pendahuluan
• NSAID (Non Steroidal Anti Inflammatory Drugs) adalah suatu kelompok obat yang berfungsi sebagai anti inflamasi, analgetik, dan atipiretik
• Mekanisme kerja -> menghambat enzim COX
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• Farmakokinetik:OAINS dengan cepat diserap oleh lambung
dan usus kecil bagian atas selanjutnya obat akan melalui hati dan diubah menjadi metabolit yang larut dalam air, kemudian disebarkan ke seluruh tubuh melalui darah.
T ½ = 1-2 jam
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Mekanisme Kerja
(Cyclooxygenase)
TRAUMA
Kerusakan Membran Sel
Fosfolipid
Asam Arakidonat
Endoperoksida
TromboxanTXA2
ProstacyclinPgl2
ProstaglandinPgE2/F2
COX1
COX2
STEROID
NSAID
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• Farmakodinamik
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Penggunaan NSAID
Komplikasi
Kardiovaskuler
Pencernaan
Ginjal
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Sistem Kardiovaskuler
• Infark Miokard• Gagal Jantung• Stroke
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Sistem Pencernaan
• Mual dan Dispepsia• Gastritis• Ulkus Peptikum dan Perforasi
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NSAID COX-1 dihambat
Prostaglandin Berkurang
Kerusakan Mukosa
Lambung
Perdarahan
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Perdarahan
Darah Tercampur Asam Lambung
MelenaAnemia
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Ginjal
• Nefritis interstisial• Sindrom nefrotik• Gagal ginjal akut• Nekrosis tubular akut
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Prostaglandin Terhambat
Vasokontriksi Arteriol Aferen
Glomerulus
Tekanan Perfusi Ginjal Turun
Kerusakan Ginjal
Gagal Ginjal Akut