Download - Kolesterol
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Dewi Wulan SariIfat Uzlifat
Ivon NovindaSri Rahayu
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1.BAHAN PEMBENTUK HORMON STEROID SPT ESTROGEN, PROGESTERON, TESTOSTERON
2.MEMBANTU MEMBENTUK PRO VIT D3.MEMBENTUK MEMBRAN SEL
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Fungsi Lemak• Sumber energi terbesar• Pelindung organ penting, spt organ perut,
pantat• Pengangkut vitamin: A, D, E dan K• Nutrisi esensial: As linoleat dan linolenat• Jenis yg ditimbun di bawah kulit:Trigliserid• Waktu muda langsing, sekarang langsung• Dulu bau parfum, sekarang bau ….
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Jenis Lemak• Fatty acids
– Saturated– Unsaturated– Triglycerides
• Sterols– Cholesterol– Testosterone– Estradiol
• Phospholipids– Lecithin
• Sphingolipids– Cerebrosides
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BAHAYA KOLESTEROL• ATHEROSKLEROSIS• TROMBUS• PENYEMPITAN PEMBULUH DARAH:
– STROKE (3S)– PENYAKIT JANTUNG KORONER– GANGREN KAKI
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Proses Atherogenesis
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Atherothrombotic : Spectrum of Disease
Cerebro Vascular Diseases
Cardio Vascular Diseases
Peripheral Vascular DiseasesImpotensi-baru takut?
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Animasi angioplasti-Stent
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Balon
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Kolesterol exogen dan endogen, kurus kol tinggi—rugi doubel porsi
Pabrik pembuat kolesterol, tempat menyimpan
4. Menyimpan:Feritin, glikogen, vit ADEK, bahkan …
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Obat-obatan :
Antibiotik, Analgesik-antipiretik, OAT
Penggunaan Narkoba dan Alkohol yang berlebihan
Infeksi mikroorganisme
patologis :
Virus Hepatitis, Aflatoxin dll.
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Profil Lemak yang penting• LDL (bad) cholesterol• Total Cholesterol • HDL (good) cholesterol• Triglycerides
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KOLESTEROL MAKANAN
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Buah dan Sayuran
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Kasus Kolesterol• Banyak makan lemak, kolesterol tinggi-
wajar.• Sudah kurus, tidak banyak makan yg
enak berlemak, tetapi kolesterol tinggi, rugi double porsi ini terjadi karena sumber kolesterol tidak hanya exogen tetapi juga endogen di hati.
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Biosynthesis summary
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Lipoprotein Subclasses
5 10 20 40 60 80 1000
Diameter (nm)
1.20
1.10
1.06
1.02
1.006
0.95
Den
sity
(g/m
l)
HDL2
HDL3
ChylomicronRemnants
VLDL
IDL
Chylo-microns
Lp(a)
LDL
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Lipoprotein class
Density (g/mL)
Diameter (nm)
Protein % of dry wt
Phospholipid %
Triacylglycerol % of dry wt
HDL 1.063-1.21 5 – 15 33 29 8
LDL 1.019 – 1.063
18 – 28 25 21 4
IDL 1.006-1.019 25 - 50 18 22 31
VLDL 0.95 – 1.006
30 - 80 10 18 50
chylomicrons < 0.95 100 - 500 1 - 2 7 84
Composition and properties of human lipoproteins
most proteins have densities of about 1.3 – 1.4 g/mL and lipid aggregates usuallyhave densities of about 0.8 g/mL
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KOMPOSISI PROTEIN dan LEMAK pada HDL dan LDL
• HDL: Lebih banyak Protein• LDL: Lebih banyak Lemak
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HDL dan LDL
• HDL: Lemak yang baik hati (Friendly lipid)• LDL: Lemak yang jahat
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HDL
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LDL molecule
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Fungsi HDL vs LDL
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Intestine
Excretion
Dietary intake
LiverBiliary
Excretion
Exogenous pathway
Endogenous pathway
Reverse Cholesterol Transport
Extra-hepatictissues
Rifai, Handbook of Lipoprotein Testing, 1997
An Overview of Cholesterol Metabolism
Large Intestine
Small Intestine LDL-C
HDL-C Extra-hepatictissues
Extra-hepatictissues
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Fungsi HDL vs LDLIlustrasi
• HDL: -Mengangkut butir lemak dari arteri perifer spt arteri koroner dan arteri di otak ke tempat penyimpanannya di hepar
-Ibarat pasukan pembersih sampah• LDL: -Mengangkut butir lemak dari hepar ke arteri perifer spt arteri koroner dan arteri di otak
-Ibarat pasukan provokator
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Diharapkan: HDL tinggi, LDL rendah
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Blood Lipids (Fats)Normal Artery
Source: Pfizer, Inc.
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Blood Lipids (Fats)Occluded (clogged) Artery
Source: Pfizer, Inc.
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Profil Lipid yang diharapkan• HDL tinggi • LDL rendah• Trigliserida normal atau rendah• Kolesterol total rendah atau normal saja
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TERIMA KASIH
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TERIMA KASIH
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TERIMA KASIH
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TERIMA KASIH
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TERIMA KASIH