DAFTAR ISI

HALAMAN JUDUL................................................................................................i LEMBAR PENGESAHAN....................................................................................iiDAFTAR ISI...........................................................................................................iiiBAB IPENDAHULUAN.......................................................................................11.1. Latar Belakang..................................................................................11.2. Rumusan Permasalahan.....................................................................21.3. Tujuan Penelitian...............................................................................21.4. Manfaat Penelitian.............................................................................2BAB II TINJAUAN PUSTAKA............................................................................3 2.1Tinjauan Tentang Parasetamol............................................3 2.2Tinjauan Tentang Ko-Kristal (Rekayasa Materi)....................5 2.3Tinjauan Tentang Sediaan Larutan Drop.......................6 2.4Tinjauan Tentang Eksipien. ...................................................7 2.5Persyaratan Mutu .............................................................................9BAB III METODE PENELITIAN................................................................ 123.1. Alat dan Bahan Skala Lab..........................................................123.2. Alat dan Bahan Skala Industri133.3. Perhitungan Dosis .133.4. Perhitungan Jumlah Pelarut.153.5. Acceptable Daily Intake (ADI) .163.6. Rancangan Formula Larutan Drop 15 ml ..183.7. Scalling Up.193.8. Spesifikasi Sediaan 19BAB IV KERANGKA KERJA..........................................................214.1. Kerangka Konseptual..................................................................214.2. Kerangka Operasional......................................................................244.3. Rancangan Evaluasi Sediaan .27BAB V PEMBAHASAN .32BAB V KESIMPULAN.......................................................................................... 365.1. Kesimpulan........................................................................................ 365.2. Saran.................................................................................................. 36LAMPIRAN.37DAFTAR PUSTAKA............................................................................................... 40

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