DAFTAR ISI

Halaman

KATA PENGANTAR .....................................................................................i

DAFTAR ISI....................................................................................................v

DAFTAR TABEL............................................................................................viii

DAFTAR GAMBAR........................................................................................ix

DAFTAR SINGKATAN..................................................................................x

DAFTAR LAMPIRAN ...................................................................................xi

ABSTRAK........................................................................................................xii

BAB 1 PENDAHULUAN................................................................................1

1.1 Latar Belakang................................................................................1

1.2 Rumusan Masalah...........................................................................3

1.3 Tujuan Penelitian............................................................................3

1.3.1 Tujuan Umum........................................................................3

1.3.2 Tujuan Khusus.......................................................................3

1.4 Manfaat Penelitian..........................................................................4

BAB 2 TINJAUAN PUSTAKA.......................................................................5

2.1 Duodenum.......................................................................................5

2.1.1 Anatomi Duodenum...............................................................5

2.1.2 Histologi Duodenum..............................................................6

2.1.3 Fisiologi Duodenum...............................................................8

2.1.4 Patologi Duodenum...............................................................10

2.1.4.1 Acute Duodenal Ulcer................................................10

2.2 Lidah Buaya....................................................................................16

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2.2.1 Uraian Tumbuhan..................................................................16

2.2.2 Ciri Morfologi Lidah Buaya..................................................16

2.2.3 Kandungan Zat Lidah Buaya.................................................17

2.2.4 Khasiat Lidah Buaya..............................................................18

2.3 Aspirin............................................................................................19

2.3.1 Uraian Umum........................................................................19

2.3.2 Dosis Aspirin.........................................................................20

2.3.3 Farmakokinetik Aspirin ........................................................20

2.3.4 Efek Samping Aspirin............................................................21

2.4 Penyembuhan Luka........................................................................23

2.4.1 Tahapan Penyembuhan Luka.................................................23

2.4.2 Faktor yang dapat Memperlambat Penyembuhan Luka........24

2.4.3 Penatalaksanaan Luka............................................................24

BAB 3 KERANGKA KONSEP DAN HIPOTESIS........................................26

3.1 Kerangka Konsep........................................................................26

3.2 Hipotesis......................................................................................27

BAB 4 METODE PENELITIAN.....................................................................28

4.1 Rancangan Penelitian......................................................................28

4.2 Tempat dan Waktu Penelitian.........................................................28

4.3 Populasi dan Sampel Penelitian......................................................28

4.3.1 Populasi Penelitian.................................................................28

4.3.2 Sampel Penelitian..................................................................28

4.3.3 Replikasi Penelitian...............................................................28

4.4 Karakteristik Sampel Penelitian.....................................................29

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4.5 Variabel Penelitian..........................................................................30

4.6 Definisi Operasional.......................................................................30

4.7 Alat dan Bahan Penelitian..............................................................30

4.8 Prosedur Penelitian.........................................................................32

4.9 Metode Analisis Data.....................................................................36

4.9.1 Uji Homogeneity of Variance dan Uji Normalitas.................36

4.9.2 Uji One Way ANOVA..........................................................36

4.9.3 Uji Tukey 5%..........................................................................37

4.9.4 Uji Korelasi dan Regresi........................................................37

4.10 Alur Penelitian..............................................................................38

BAB 5 HASIL PENELITIAN DAN ANALISA DATA..................................39

5.1 Gambaran Mikroskopis Kelompok Penelitian................................39

5.2 Tingkat Kedalaman Duodenal Ulcer..............................................41

5.3 Analisis Data...................................................................................43

5.3.1 Uji Homogenity of Variance dan Uji Normalitas..................43

5.3.2 Uji One Way ANOVA...........................................................44

5.3.3 Uji Tukey 5%..........................................................................45

5.3.4 Uji Korelasi dan Regresi........................................................46

BAB 6 PEMBAHASAN ..................................................................................49

BAB 7 KESIMPULAN DAN SARAN............................................................54

7.1 Kesimpulan.....................................................................................54

7.2 Saran ..............................................................................................54

DAFTAR PUSTAKA.......................................................................................55

LAMPIRAN.....................................................................................................59

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DAFTAR TABEL

Halaman

Tabel 2.1 Klasifikasi Ulcer Berdasarkan Kedalaman ..........................................11

Tabel 2.2 Zat yang Terkandung Dalam Lidah Luaya.......................................17

Tabel 2.3 Komposisi Kimia Lidah Buaya........................................................18

Tabel 5.1 Kedalaman Duodenal ulcer .............................................................41

Tabel 5.2 Tabel uji Homogenity of Variance...................................................44

Tabel 5.3 Tabel Uji Normalitas........................................................................44

Tabel 5.4 Tabel Uji One Way ANOVA............................................................45

Tabel 5.5 Tabel Uji Tukey 5% ......................................................................... 45

Tabel 5.6 Tabel Uji Korelasi............................................................................46

Tabel 5.7 Tabel Uji Regresi..............................................................................47

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DAFTAR GAMBAR

Halaman

Gambar 2.1 Anatomi Makroskopik Duodenum..............................................5

Gambar 2.2 Histologi Duodenum....................................................................8

Gambar 2.3 Mekanisme NSAID Terhadap Kerusakan Mukosa Duodenum...14

Gambar 2.4 Histopatologi Duodenal Ulcer......................................................15

Gambar 2.5 Tumbuhan Lidah Buaya................................................................17

Gambar 2.6 Rumus Struktur Aspirin................................................................20

Gambar 3.1 Kerangka Konsep........................................................................26

Gambar 4.1 Alur Penelitian.............................................................................37

Gambar 5.1 Kelompok Kontrol (-)...................................................................38

Gambar 5.2 Kelompok Kontrol (+)..................................................................38

Gambar 5.3 Kelompok Perlakuan 1..................................................................39

Gambar 5.4 Kelompok Perlakuan 2.................................................................40

Gambar 5.5 Kelompok Perlakuan 3..................................................................40

Gambar 5.6 Grafik Rerata Kedalaman Duodenal Ulcer...................................43

Gambar 5.7 Grafik Regresi...............................................................................48

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REVERSIBLE/ ADAPTASI SELEx :HiperplasiaHipertropia

REVERSIBLE/ ADAPTASI SELEx :HiperplasiaHipertropia

DAFTAR SINGKATAN

A. : Artery

CCK : Kolesistokinin

COX : Cyclo-oxygenase

HIV : Human Immunodeficiency Virus

M : Minggu

NSAID : Non Steroid Anti Inflamation Drug

PG : Prostaglandin

PGE2 : Prostaglandin E2

PGI2 : Prostaglandin I2

ppm : Parts per million

TOGA : Tanaman Obat Keluarga

TXA2 : Tromboxan A2

Vit : Vitamin

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DAFTAR LAMPIRAN

HalamanLampiran 1 Penelitian Pendahuluan ................................................................59

Lampiran 2 Hasil Penelitian .............................................................................63

Lampiran 3 Analisis Data ................................................................................70

Lampiran 4 Surat Keterangan Penelitian Histo Patologi Anatomi ..................76

Lampiran 5 Kartu Konsultasi Tugas Akhir.......................................................77

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