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CoronavirusLiliani M Tjikoe

(20100310212)Dr. Pembimbing : dr. uliani!"#.$

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Coronavirusmeru#akan virus $s*rand #osi*i+ *erbesar.

Coronavirus *ersusun#ar*ikel berselubung!berukuran ,0-10 nm/ang mengandung

genom *ak bersegmen.ukleoka#sid eliksberdiame*er -11 nm.

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Corona virus memiliki

#ro*ein #en*ingdian*ara adala :

1. " (s#ike) #ro*ein(10k)

2. 4% #ro*ein (kD)3. M (membran)

#ro*ein

. % (envelo#e) #ro*ein(-12kD)! dan (nu5leo5a#sid)#ro*ein (0kD).

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Coronavirus #ada manusia #er*ama kali*eriden*i6kasi #ada #er*engaan *aun 10.*erda#a* jenis 5oronavirus /ang da#a*mengin+eksi manusia. 7ebera#a di an*aran/aadala :

1. Alpha coronaviruses 229E

2. Beta coronaviruses OC43,

3. SARS-CoV the coronavirus that causessevere acute respirator! s!n"ro#e, or SARS$

2%%3$4. Alpha coronaviruses &'(3 2%%4$

). Beta coronaviruses *+1 2%%)$ an"

(. &ovel coronavirus or ERS-CoV the

coronavirus that causes i""le East

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%PL'8$"'•

e#likasi dimulai darimasukn/a virus*ersebu* #ada membransi*o#lasma sel  meleka* #ada rese#*orsel ( amino#e#*idase)melalui gliko#ro*ein/ang *erle*ak #adamembran selubung

virus (melalui %2 a*au%3)  #ar*ikeldiin*ernalisasi  melalui endosi*osis

absor#*i+ 9liko#ro*ein%2  #en/a*uan

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  "e*ela #en/a*uan selubung sel  sin*esis#olimerase $ /ang bergan*ung #ada $s#esi6k virus  $ genomi5 men/andi sua*u

#oli#ro*ein  #ol/merase $ virus.  Molekul $ genomik /ang baru  berin*eraksi

dengan #ro*ein nukleoka#sid  memben*uknukleoka#sid eliks  berkembang melalui

sela#u* re*ikulum endo#lasmik kasar dana##ara*us 9olgi #ada daera /ang mengandunggliko#ro*ein virus  irus ma*ang   diba;adalam vesikel ke bagian *e#i sel  menungguingga sel ma*i un*uk dile#askan.

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  Corona virus diduga ber#engaru*erada# *erjadin/a 5ommon 5old sebesar#en/ebab 1=! dan berim#likasi *erada#*erjadin/a in+eksi saluran #erna+asanba;a! 5rou#! e>aserbasi asma!bron5ioli*is! dan #neumonia.

  "elain i*u #ada bebera#a #enili*ian5oronavirus da#a* men/ebabkan*erjadin/a en*eri*is a*au 5oli*is #ada ba/i

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  "elain #ada manusia! jenis 5oronavirusda#a* men/ebabkan #en/aki* *er*en*u

#ada e;an. enis *ersebu* dike*auiadala #or5ine 5oronavirus (*ransmissible gas*roen*eri*is 5oronavirus

! T9%) dan bovine 5oronavirus! dimana*ransmisi kedua jenis virus *ersebu*da#a* men/ebabkan *erjadin/a diare

#ada e;an.

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  'n+e5*ious bron5i*is virus ('7) 5auses avian in+e5*ious bron5i*is.

  Por5ine 5oronavirus (*ransmissible gas*roen*eri*is 5oronavirus  o+ #igs! T9%).

  7ovine 5oronavirus (7C)! res#onsible +or severe #ro+use en*eri*is in

o+ /oung 5alves.  &eline 5oronavirus (&Co) 5auses mild en*eri*is in 5a*s as ;ell as

severe &eline in+e5*ious #eri*oni*is  (o*er varian*s o+ *e same virus).

  *e *;o */#es o+ 5anine 5oronavirus (CCo) (one 5ausing en*eri*is!*e o*er +ound in res#ira*or/ diseases).

   Turke/ 5oronavirus (TC) 5auses en*eri*is in *urke/s.

  &erre* en*eri5 5oronavirus 5auses e#i@oo*i5 5a*arral en*eri*is in+erre*s.

  &erre* s/s*emi5 5oronavirus 5auses &'P-like s/s*emi5 s/ndrome in+erre*s.A13B

  Pan*ro#i5 5anine 5oronavirus

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M%" (Middle %as*es#ira*or/ "/ndrome)

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M%"

Mos* #eo#le 5on6rmed *o ave M%"-Coin+e5*ion ave ad severe a5u*e res#ira*or/illness ;i* s/m#*oms o+:

  +ever

  5oug  sor*ness o+ brea*

  "ome #eo#le also ad gas*roin*es*inal s/m#*omsin5luding diarrea and nauseavomi*ing! bu*

"ome in+e5*ed #eo#le ad mild s/m#*oms (su5as 5old-like s/m#*oms) or no s/m#*oms a* all*e/ re5overed.

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M%"  &or man/ #eo#le ;i* M%"! more severe

5om#li5a*ions +ollo;ed! su5 as #neumonia andkidne/ +ailure. $bou* 3- ou* o+ ever/ 10 #eo#lere#or*ed ;i* M%" ave died. Mos* o+ *e

#eo#le ;o died ad an underl/ing medi5al5ondi*ion.

  7ased on ;a* resear5ers kno; so +ar! #eo#le;i* #re-e>is*ing medi5al 5ondi*ions (diabe*es

5an5er and 5roni5 lung! ear*! and kidne/disease. 'ndividuals ;i* ;eakened immunes/s*ems) ma/ be more likel/ *o be5ome in+e5*ed;i* M%"-Co! or ave a severe 5ase.

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"$"

  'ni*ial ou*break in "% $sia› 4ong 8ong and "inga#ore 6rs*

re#or*ed

›

Disease origina*ed in Cina› Eriginall/ *oug* *o be +rom ;ild

game marke*s Palm 5ive* 5a* - Paradoxurus

hermaphroditus

a55oon dog - Nyctereutes procyonoides

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"$" Pa*ogenesis  irus is *ransmi**ed b/ res#ira*or/ and +e5al rou*es

 

'n+e5*ion is media*ed b/ uman angio*ensin-5onver*ingen@/me 2 ($C%2) re5e#*or

› 4ig e>#ression

Lung alveolar e#i*elial 5ells

'n*es*inal en*ero5/*es

› Lo; e>#ression

7lood vessels (vir*uall/ all organs)

  Pneumonia

› Cause o+ dea* is lung +ailure

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Pulmonar/ 'nFamma*ion o+ "$"

Pa*ologi5 6ndings o+ lung *issue se5*ions. $: Pulmonar/ 5onges*ion and edema (4G% s*ain!original magni65a*ion >100). 7: $ mild degree o+ in*ers*i*ial l/m#o5/*i5 in6l*ra*ion. 'n*ra-alveolar organi@ing e>uda*ive lesion ;as o55asionall/ +ound. De*a5ed a*/#i5al #neumo5/*esindi5a*ed b/ arro; (4G% s*ain! original magni65a*ion >200). C: $*/#i5al mul*inu5lea*ed

#neumo5/*es ;ere o55asionall/ iden*i6ed. De6ni*e viral in5lusion ;as no* a##aren* (4G%s*ain! original magni65a*ion >00). D: &ibrin *rombi ;ere +reHuen*l/ no*ed in small #ulmonar/ar*eries and ar*erioles (4G% s*ain! ori inal ma ni65a*ion >200).

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"$" 

'n general! "$" begins ;i* : 4ig +ever (*em#era*ure grea*er *an

100.I& AJ3,.0ICB)

4eada5e! an overall +eeling o+dis5om+or*! and bod/ a5es

"ome #eo#le also ave mild res#ira*or/s/m#*oms a* *e ou*se*.

$bou* 10= - 20= #a*ien*s ave diarrea. $+*er 2 *o K da/s! "$" #a*ien*s ma/

develo# a dr/ 5oug. Mos* #a*ien*sdevelo# #neumonia.

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P%%T'E 

Curren*l/! *ere is no va55ine *o #reven* an/ o+ M%"-Co in+e5*ion or "$" in+e5*ion.

  CDC reven*ive a5*ions:

as /our ands o+*en ;i* soa# and ;a*er +or 20se5onds! and el# /oung 5ildren do *e same. '+

soa# and ;a*er are no* available! use an al5ool-based and sani*i@er.

Cover /our nose and mou* ;i* a *issue ;en /ou5oug or snee@e! *en *ro; *e *issue in *e *ras.

$void *ou5ing /our e/es! nose and mou* ;i*un;ased ands.

$void #ersonal 5on*a5*! su5 as kissing! or saring5u#s or ea*ing u*ensils! ;i* si5k #eo#le

Clean and disin+e5* +reHuen*l/ *ou5ed sur+a5es su5

as *o and doorknobs.