5.2. glukoneogenesis dan metabolisme glikogen
Post on 20-Feb-2018
238 Views
Preview:
TRANSCRIPT
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
1/35
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
2/35
GLUCONEOGENESIS
Biosynthesis of glucose3 4 carbon noncarbohydrate recursors
En!y"es located in the cytosol
Gluconeogenic organsLiver
Kidney cortex
#atesCatabolism by nervous tissue
Utilization by skeletal muscles
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
3/35
GLUCONEOGENESIS
SUBS$%&$ES
GLUCOGENIC AMINO ACI!
LAC"A"EGL#CE$OL
%$O%IONA"E
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
4/35
'%ECU%SO%SGLUCOSE
#ructose ()* + bishoshate
,ihydro-yacetonehoshate
Glyceraldehyde 3 + hoshate
GL.CE%OL
'.%U/&$E
Glycerol 3 + hoshate 'hoshoenolyru0ate
O-aloacetate
&L&NINE
L&C$&$E
Other
a"ino acids
'%O'ION&$E
SUCCIN.L+
Co&
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
5/35
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
6/35
CO%I C.CLES1ELE$&L 2USCLE LI/E%BLOO,
GLUCOSE
'.%U/&$E
L&C$&$E
GLUCOSE
'.%U/&$E
L&C$&$E
* &$'&$'
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
7/35
()3 Bishoshoglycerate
3 + 'hoshoglycerate
+ 'hoshoglycerate
Glyceraldehyde 3 + hoshate
'hoshoenolyru0ate
GLUCOSE
,&'
#ructose ()* + bishoshate
'.%U/&$E
O5&LO&CE$&$E
'E'
'.%U/&$E
L&C$&$E
O&&
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
8/35
GLUCOSE + &L&NINE C.CLES1ELE$&L 2USCLE LI/E%BLOO,
GLUCOSE
'.%U/&$E
&L&NINE
GLUCOSE
'.%U/&$E
&L&NINE
* &$'&$'
N N
U%E&
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
9/35
O-aloacetate
Glucose * + hoshate
GLUCOSE
'.%U/&$E
#ructose * + hoshate
#ructose ()* + bishoshate
'hoshoenolyru0ate
&$'
&$'
&$'
&$'
G$'
&$'
&$'
N&,N&,
(
O
O 3
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
10/35
B.'&SS %E&C$IONS
'.%U/&$E to 'OS'OENOL'.%U/&$E%#$U&A"E CA$'O(#LA!E
Generates O5&LO&CE$&$E
Mitoc)ondrial matrixA"% * e+endent
'IO"IN * de+endent
&CE$.L Co&* +ositive allosteric activator
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
11/35
B.'&SS %E&C$IONS
'.%U/&$E to 'OS'OENOL'.%U/&$E%,O!%,OENOL%#$U&A"E
CA$'O(#KINA!E
ecarboxylation and +)os+)orylationCytosol
$eversible
G"% * e+endent
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
12/35
'E' C&%BO5.1IN&SE
C
C O
C O
O
C
C O
C O
OP
CO
O5&LO&CE$&$E
C O
O
'E'
C&%BO5.1IN&SE
'OS'OENOL'.%U/&$E
PP
G
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
13/35
B.'&SS %E&C$IONS
#%UC$OSE ()* BIS'OS'&$E to
#%UC$OSE * + 'OS'&$E
#%UC$OSE ()* + BIS'OS'&$&SE
LI&E$
KINE#
!KELE"AL MU!CLE
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
14/35
B.'&SS %E&C$IONS
GLUCOSE * 'OS'&$E to GLUCOSEGLUCOSE * + 'OS'&$&SE
Irreversible
,ydrolysis
Endo+lasmic reticulum o- t)e liver
Absent in t)e brain and skeletal muscle
$e.uires M/0
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
15/35
SU22&%. of %E&C$IONS%E&C$&N$S '%O,UC$S
'yru0ate 6 CO6 &$' 6O O-aloacetate 6 &,' 6 'iO-aloacetate 6 G$' 'hoshoenolyru0ate 6 G,'
'hoshoenolyru0ate hoshoglycerate
hoshoglycerate 3 + hoshoglycerate
3 hoshoglycerate 6 &$' ()3 bishoshoglycerate
()3 bishoshoglycerate 6 N&, Glyceraldehyde 3 'O4
Glyceraldehyde 3 'O4 ,ihydro-yacetone 'O4
G3+' 6 ,&' #ructose ()* bishoshate#ructose ()* bishoshate #ructose * hoshate
#ructose * hoshate Glucose * hoshate
Glucose * hoshate GLUCOSE
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
16/35
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
17/35
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
18/35
O
HOCH2
O
HOCH2
O
O
HOCH2
O
O
HOCH2
O
O
HOCH2
O
O
HOCH2
O
O
HOCH2
O
O
HOCH2
O
HOCH2
O
O
(4/lycosidic bond
7(*8glycosidicbond
GL.COGEN
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
19/35
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
20/35
GL.COGEN S.N$ESIS
GL.COGENESIS
'hoshorylation of glucose
%e9uires acti0ated glucose
U,' Glucose
U% * Glu +yro+)os+)orylase
GL.COGENIN
112 amino acids
!el-3/lucosylatin/ enzymeGlyco/en +rimer
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
21/35
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
22/35
GL.COGEN S.N$&SE %eactionGL.COGEN
S.N$&SE
O
O
CO
(4
O
O
O
O O
O
CO
(4
O
O
O
O
CO
(4
O
O
O
O
CO
(4
O
O
O
''
U
O
GL.COGENINGL.COGEN 6 (
GL.COGEN
S.N$&SE
O
O
CO
(4
O
O
O ''
U
O
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
23/35
GL.COGEN S.N$ESIS
U,' + GLUCOSE
Glucose ( + 'O4
GLUCOSE * 'O4
GLUCOSE
&$'
&,'
U$'
''i
GL.COGEN
7Glucose8n
7Glucose8n 6(
E5O1IN&SE
U,'+Glc '.%O'OS'O%.L&SE
'OS'OGLUCO2U$&SE
GL.COGEN S.N$&SE
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
24/35
() * glycosidic bond
Branching en!y"e
amylo 456457trans/lycosylase
$ransfers ter"inal residues
* +: residues
B%&NC #or"ation
OOOO
O
O
O O O O
B%&NCING
EN;.2EO(4
O
OOO
OOO
O
O
O
O
OO
O
O
O
O
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
25/35
GL.COGEN S.N$ESIS
O
O
O
O
O
O
OOOO
O
O
O O O O
O(4
O
OOO
OOO
O
O
O
O
O
O
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
26/35
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
27/35
GL.COGEN ,EG%&,&$ION
GL.COGENOL.SIS
%)os+)orolysis
$e.uires inor/anic +)os+)ate
45 6* /lycosidic bond
Glucose 4 3 +)os+)ate
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
28/35
O O
O
CO
(4
O
O
O
O
CO
(4
O
O
O
O
CO
(4
O
O
OO
GL.COGENGL.COGEN + (
GL.COGEN
'OS'O%.L&SE
O
O
CO
(4
O
O
GL.COGEN 'OS'O%.L&SE
''O4
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
29/35
&"ylo ( *Glucosidase
,EB%&NCING EN;.2E
O(4
O
O
O
O
O
O
O
GLUC&N
$%&NS#E%&SE
O
O
O
O
O
OO
O O
O
O
O
O
O
O
O
GL.COGEN
'OS'O%.L&SE
O
O
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
30/35
GL.COGENOL.SIS
'OS'O%.L&SE
GLUC&N
$%&NS#E%&SE
()* GLUCOSI,&SE'
'
'
O
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
31/35
GL#COGEN ME"A'OLI!M
Glycogen brea
S.N$ESISand ,EG%&,&$IONare
%ECI'%OC&LL. %EGUL&$E,>
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
32/35
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
33/35
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
34/35
-
7/24/2019 5.2. Glukoneogenesis Dan Metabolisme Glikogen
35/35
top related