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7/24/2019 Skripsi Risca

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EFEKTIVITAS SEDIAAN OBAT KUMUR MENGANDUNG

CENGKEH (Syzygium aromaticum) DALAM MENURUNKAN

KADAR VOLATILE SULFUR COMPOUNDS (VSC) KOMPONEN

CYSTEIN (H2S)

SKRIPSI

Diajukan K!a"a Uni#$%i&a% Ha%anu""in

Guna M'nui Saa %a&u S*a$a&

Un&uk M'!$+ Ga$ Sa$jana K"+k&$an Gi,i

DISUSUN OLEH:

RISCA LISAL

J111 11 133

BAGIAN ILMU KESEHATAN GIGI MASYARAKAT

FAKULTAS KEDOKTERAN GIGI

UNIVERSITAS HASANUDDIN

MAKASSAR

2014

LEMBAR PENGESAHAN


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Judul : E!"#$%$#&' S!d$&&( O) Ku*u+ C!(,"!-(Syzygium aromaticum)

D&l&* M!(u+u("&( K&d&+ Volatile Sulfur Compounds (VSC)

".*/.(!( C'#!$(H2S

Ol!- : R$'& L$'&l J 111 11 133

T!l&- D$/!+$"'& d&( D$'&-"&(

5&d& T&(,,&l 16 N.%!*)!+ 2014

Ol!- :

P'-i'-in,

P$+./ D$/ "$,/ Ra%'i"a$ Sa'a"0 MS

NIP/ 1345622 17456 2 551

M!(,!#&-u$7

Dkan Faku&a% K"+k&$an Gi,i

Uni#$%i&a% Ha%anu""in

P$+./ "$,/ H/ Man%ju$ Na%i$0 P/D

NIP/ 1365823 17659 1 551

PERNYATAAN

2


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S&& &(, )!+#&(d& #&(,&( d$)&8&- $($ :

N&*& : R$'& L$'&l

N$* : J 111 11 133

Ad&l&- *&-&'$'8& F&"ul#&' K!d."#!+&( G$,$ U($%!+'$#&' H&'&(udd$( M&"&''&+ &(,

#!l&- *!l&"u"&( /!(!l$#$&( d!(,&( 9udul EFEKTIVITAS SEDIAAN OBAT

KUMUR CENGKEH (Syzygium aromaticum) DALAM MENURUNKAN

KADAR VOLATILE SULFUR COMPOUNDS (VSC) KOMPONEN CYSTEIN

(H2S)d&l&* +&(,"& *!(!l!'&$"&( '#ud$ 5+.,+&* 5!(d$d$"&( S#+& Su

D!(,&( $($ *!(&"&( )&-8& d$d&l&* '"+$/'$ $($ #$d&" #!+d&/ "&+& &(,

/!+(&- d$&9u"&( u(#u" *!*/!+.l!- ,!l&+ "!'&+9&(&&( d$ 'uu 5!+,u+u&( T$(,,$7 d&(

'!/&(9&(, /!(,!#&-u&( '&& 9u,& #$d&" #!+d&/ "&+& &u /!(d&/ &(, /!+(&-

d$#ul$' &u d$#!+)$#"&( .l!- .+&(, l&$(7 "!u&l$ &(, '!&+& #!+#ul$' d$ &u d&l&*

(&'"&- $($ d&( d$'!)u#"&( d&l&* d&+ /u'#&"&

M&"&''&+7 2; N.%!*)!+ 2014

Nu+&!d& A 7SS.'

KATA PENGANTAR

3


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5u9$ d&( 'u"u+ /!(ul$' /&(9"&( "!/&d& Tu-&( &(, M&-& E'& "&+!(&

-&(& d!(,&( )!+" "!"u&(7 "&'$- d&( +&-*


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3 "$,/ Su$ijana Ma!!an,a$a0 S!/P$i+0 M/K% '!l&"u /!(&'!- &"&d!*$"

&(, '!(&(#$&'& *!*)!+$ du"u(,&(7 (&'$- *.#$%&'$ d&( '!*&(,

'!-$(,,& /!(ul$' )!+-&'$l *!(!l!'&$"&( 9!(9&(, /!+"ul$&-&( d!(,&( )&$"

4 O+&(, #u&"u7 Ni;+ Li%ad&( C$i%&ina Buain7 '!+#& '&ud&+&


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? Na$>a%&u (Kak F-*0 S$i&a0 Sa$i0 =&$*;ia0 =in"i0 Nia0 d&( Ran&i) '!+#&

Ha"ija&u d&( G$a;ia/ T!+$*& "&'$- &' "!-&d$+&(7 "!#ulu'&(7 d.&7 )&(#u&(7

'!*&(, *.#$%&'$7 /!+-$&(7 d&( &(d& #&8& &(, '!l&lu "&l$&( )!+$"&(

M!(,!(&l "&l$&( &d&l&- '&l&- 'u -&l &(, /&l$(, $(d&- d&l&* -$du/"u

6 T!*&( '!/!+9u&(,&( Nia Lian&+ d&( T$i%an&+%+ R?"* A%aui0 &(, #!l&-

'&*&


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5!(ul$' )!+-&+&/ "$+&(& Tu-&( )!+"!(&( *!*)&l&' '!,&l& "!)&$"&( d&+$ '!,&l&

/$-&" &(, #!l&- )!+'!d$& *!*)&(#u /!(ul$' A"-$+(& d!(,&( '!,!(&/ "!+!(d&-&(

-$7 /!(ul$' *!(,-&+&/"&( &,&+ "$+&(& #ul$'&( $($ d&/ *!(9&d$ '&l&- 'u )&-&(

/!*)!l&9&+&( d&( /!($(,"&( "u&l$#&' /!(d$d$"&( d$ F&"ul#&' K!d."#!+&( G$,$ "!

d!/&((&7 9u,& d&l&* u'&-& /!($(,"&( /!+)&$"&( "u&l$#&' "!'!-&( G$,$ d&(

Mulu# *&'&+&" A*$(

M&"&''&+7 23 N.%!*)!+ 2014

R$'& L$'&l

EFEKTIVITAS SEDIAAN OBAT KUMUR MENGANDUNG CENGKEH

(Syzygium aromaticum) DALAM MENURUNKAN KADAR VOLATILE

SULFUR COMPOUNDS (VSC) KOMPONEN CYSTEIN (H2S)

R$'& L$'&l

7


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ABSTRAK

B&u *ulu# &u )$&'& d$'!)u# d!(,&( halitosis &d&l&- (&&' #&" '!d&/ &(,

)!+&'&l d&+$ ud&+& &(, d$"!lu&+"&( .l!- '!'!.+&(, l!8 *ulu# d&( 60@(& )!+&'&l

d&+$ +.(,,& *ulu# &(, d$'!)&)"&( .l!- '!(&8& 'ulu+ &(, *ud&- *!(,u&/ &(,

d$'!)u# d!(,&( Volatile Sulfur Compound VSC T!l&- )!+!d&+ .) "u*u+ &(,

*!(,&(du(, !(,"!- "&+!(& .) "u*u+ !(,"!- *!(,&(du(, -&'$l $'.l&'$ d&+$

*$(&" !(,"!- Syzygium aromaticum) &$#u '!(&8& !u,!(.l &(, )!+/!+&(

'!)&,&$ &(#$)&"#!+$ &(, d&/ *!l&8&( )&"#!+$ +.(,,& *ulu# Tujuan !ni&ian$($

u(#u" *!(,!#&-u$ !!"#$%$#&' '!d$&&( .) "u*u+ &(, *!(,&(du(, !(,"!-Syzygium aromaticum d&l&* *!(u+u("&( "&d&+ Volatilesulfur compounds VSC

".*/.(!( -$d+.,!( 'ul$d&H2S 5!(!l$#$&( $($ d$l&"u"&( d$ "l$($" -&l$#.'$' RSGM

U($%!+'$#&' G&d9&- M&d& /&d& S!/#!*)!+


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ABSTRACT

M.u#- .d.+ .+ -&l$#.'$' $' .**.(l &ll!d )&d )+!- +.* #-! &$+ !/!ll!d ) &

/!+'.( #-+.u,- -$' *.u#-7 &(d 60@ &*! +.* #-! .+&l &%$# &u'!d ) %.l$l!

'ulu+ .*/.u(d' &ll!d %.l$l! 'ulu+ .*/.u(d VSC M.u#-8&'- #- .(#&$('

l.%! -&' )!!( $+ul!d (.8&d&'7 $# )!&u'! l.%!' &' & *.u#-8&'- .(#&$($(,

$'.l!d


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LEMBAR PENGESAHAN ///////////////////////////////////////////////////////////////////////// ii

PERNYATAAN //////////////////////////////////////////////////////////////////////////////////////////// iii

KATA PENGANTAR ///////////////////////////////////////////////////////////////////////////////// i#

ABSTRAK //////////////////////////////////////////////////////////////////////////////////////////////////// #iii

DAFTAR ISI/////////////////////////////////////////////////////////////////////////////////////////////////

DAFTAR TABEL////////////////////////////////////////////////////////////////////////////////////////// i#

DAFTAR GAMBAR///////////////////////////////////////////////////////////////////////////////////// #

BAB I PENDAHULUAN

11 LATAR BELAKANG 1

12 RUMUSAN MASALAH 2

13 TUJUAN 5ENELITIAN 3

131 Tu9u&( U*u* 3

132 Tu9u&( K-u'u' 3

14HI5OTESIS 5ENELITIAN 3

BAB II TINAUAN PUSTAKA

21 HALITOSIS 4

10


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211 E#$.l.,$ H&l$#.'$' 4

212 Kl&'$$"&'$ H&l$#.'$' =

213 M!"&($'*! H&l$#.'$' ?

22 CENGKEH 6

221 K&(du(,&( K$*$& 5&d& C!(,"!- 6

222 M&(& C!(,"!- 10

23 OBAT KUMUR 13

231 A"#$ D&l&* O) Ku*u+ 13

24 HUBUNGAN HALITOSIS DAN CENGKEH 1;

BAB III KERANGKA KONSEP

31 KERANGKA KONSE5 1

32 VARIABEL 5ENELITIAN 1?

33 KETERBATASAN 5ENELITIAN 1?

BAB IV METODE PENELITIAN

41 JENIS 5ENELITIAN 16

42 LOKASI 5ENELITIAN 16

11


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43 AKTU 5ENELITIAN 16

44 5O5ULASI SAM5EL 5ENELITIAN 16

4; METODE 5ENGAMBILAN SAM5EL 20

4= VARIABEL 5ENELITIAN 20

4 DEFINISI O5ERASIONAL 20

4? KRITERIA 5ENILAIAN 20

46 ALAT BAHAN 21

461 Al 21

462 B&-&( 21

410 5ROSEDUR 5ENELITIAN 21

4101 5!(,&*)$l&( S&*/!l 21

4102 5+.'!' 5!(,u9$&( D!(,&( O+&l-+.*& F$' I( 22

4103 K!l&$"&( E#$" 5!(!l$#$&( 22

411 DATA 23

412 ALUR 5ENELITIAN 24

BAB V HASIL PENELITIAN//////////////////////////////////////////////////////////////// 23

12


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BAB V1 PEMBAHASAN/////////////////////////////////////////////////////////////////////// 91

BAB VII PENUTUP

1 SIM5ULAN 3=

2 SARAN 3=

DAFTAR PUSTAKA//////// 94

DAFTAR TABEL

T&)!l ;1 D$'#+$)u'$ "&+&"#!+$'#$" '&*/!l /!(!l$#$&( 2;

T&)!l ;2 D$'#+$)u'$ "&d&+ +&


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"u*u+ !(,"!- )!+d&'&+"&( u'$& '&*/!l 2=

T&)!l ;3 5!+)!d&&( "&d&+ -$d+.,!( 'ul$d& H2S d&( *!#-$l*!+&/#&(

CH3SH '!)!lu* (pretest)d&( '!'ud&- $(#!+%!('$ (posttest)

)!+"u*u+ .) "u*u+ !(,"!- 26

T&)!l ;4 5!+)!d&&( "&d&+ Volatile Sulfur CompoundVSC '!)!lu*

(pretest)d&( '!'ud&- $(#!+%!('$ (posttest))!+"u*u+ .)

"u*u+ !(,"!- 30

DAFTAR GAMBAR

G&*)&+ 41 Alu+ 5!(!l$#$&( 24

G&*)&+ ;1 5+.'!' /!(,&*)$l&( '&*/!l d."u*!(#&'$

/+$)&d$ 2=

14


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G&*)&+ ;2 5+.'!' )!+"u*u+ .) "u*u+ !(,"!- d."u*!(#&'$

/+$)&d$ 2

G&*)&+ ;3 I(9!"'$ '&*/!l "! $(l!# oralchromad."u*!(#&'$

/+$)&d$ 26

BAB I

PENDAHULUAN

1/1/ LATAR BELAKANG

B&u *ulu# &u )$&'& d$'!)u# d!(,&( halitosis &d&l&- (&&' #&" '!d&/ &(,

)!+&'&l d&+$ ud&+& &(, d$"!lu&+"&( .l!- '!'!.+&(, l!8 *ulu# d&( *!(u+u# '#ud$

d&+$ /&+& &-l$ d$ A*!+$"& S!+$" 60@(& )!+&'&l d&+$ +.(,,& *ulu# &(,

d$'!)&)"&( .l!- '!(&8& 'ulu+ &(, *ud&- *!(,u&/ &(, d$'!)u# d!(,&( Volatile

Sulfur Compound VSC Volatile sulfur compounds &d&l&- -&'$l /+.du"'$ d&+$

&"#$$#&' )&"#!+$ &(&!+.) d$ d&l&* *ulu# &(, *!(,-&'$l"&( '!(&8& )!+u/& 'ulu+

&(, *ud&- *!(,u&/ d&( )!+)&u #$d&" !(&" 5+.'!' #!+9&d$(& VSC &d&l&- d$&8&l$

d!(,&( /!*!&-&( 'u)'#+ /+.#!$( d&+$ '$'& *&"&(&( .l!- )&"#!+$ ,+&* (!,$ &(,

)!+'$ /+.#!.l$#$" *!(9&d$ +&(#&$ /!/#$d& d&( &'&* &*$(. '!/!+#$ *!#-$.($(7

'#!$(! d&( '#$(!1K!*ud$&( &'&* &*$(. #!+'!)u# &"&( d$+!du"'$ *!(9&d$ *!#-$l

*!+&/#&(7 -$d+.,!( 'ul$d& d&(

d$*!#-$l 'ul$d& revotella intermedia7 revotella nigrescens d&( !reponema

denticola )!+".+!l&'$ d!(,&( "&d&+ -$d+.,!( 'ul$d& orphyromonas gingivalis7

.intermedia7 d&( !annerella forsythensis)!+".+!l&'$ d!(,&( "&d&+ *!#$l *!+"&/#&(

S!l&(9u#(&7 *!#$l *!+"&/#&( *!+u/&"&( /!(!)&) u#&*& -&l$#.'$' d$)&(d$(,"&(

15


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-$d+.,!( 'ul$d& d&( d$*!#$l'ul$d& d$*&(& *!#$l *!+"&/#&( d&( -$d+.,!( 'ul$d&

)!+&'&l d&+$ $(#+&.+&l7 '!d&(,"&( d$*!#$l'ul$d& d$du,& )!+&'&l d&+$ !"'#+&.+&l2

B&-&( &(#$*$"+.)& &(, '!+$(, d$,u(&"&( d&l&* "!-$du/&( '!-&+$


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2 A/&"&- '!d$&&( .) "u*u+ &(, *!(,&(du(, !(,"!- Syzygium

Aromaticum d&/ *!(u+u("&( "&d&+ Volatilesulfur compounds VSC

".*/.(!( *!#-$.($( CH3SH

1/9/ TUUAN PENELITIAN

1/1/1/ Tujuan U'u'

U(#u" *!(,!#&-u$ !!"#$%$#&' '!d$&&( .) "u*u+ &(, *!(,&(du(,

!(,"!- Syzygium Aromaticum d&l&* *!(u+u("&( "&d&+ Volatile

sulfur compounds VSC

1/1/2/ Tujuan Ku%u%

1 U(#u" *!(,!#&-u$ !!"#$%$#&' '!d$&&( .) "u*u+ &(,

*!(,&(du(, !(,"!- Syzygium Aromaticum d&l&* *!(u+u("&(

"&d&+ Volatilesulfur compounds VSC ".*/.(!( '#!$(! H2S

2 U(#u" *!(,!#&-u$ !!"#$%$#&' '!d$&&( .) "u*u+ &(,

*!(,&(du(, !(,"!- Syzygium Aromaticum d&l&* *!(u+u("&(

"&d&+ Volatilesulfur compounds VSC ".*/.(!( *!#-$.($(!

CH3SH

1/6/ HIPOTESIS PENELITIAN

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1 S!d$&&( .) "u*u+ &(, *!(,&(du(, !(,"!- Syzygium Aromaticum

d&/ *!(u+u("&( "&d&+ Volatile sulfur compounds VSC ".*/.(!(

'#!$(! H2S

2 S!d$&&( .) "u*u+ &(, *!(,&(du(, !(,"!- Syzygium Aromaticum

d&/ *!(u+u("&( "&d&+ Volatile sulfur compounds VSC ".*/.(!(

*!#-$.($(! CH3SH

BAB II

TINAUAN PUSTAKA

2/1/ HALITOSIS

H&l$#.'$' &d&l&- )&u (&&' #&" '!d&/ &(, "!lu&+ d&+$ +.(,,& *ulu# S&*/&$ '&

$($7 -&l$#.'$' *!+u/&"&( '&l&- 'u *&'&l&- "!'!-&( *ulu# &(, )&(&" d$"!lu-"&(

*&'&+&" '!#!l&- "&+$!' d&( /!(&"$# /!+$.d.(#&l4

2/1/1/ E&i++,i Hai&+%i%

H&l$#.'$' d&/ d$'!)&)"&( .l!- )!)!+&/& &"#.+7 &(#&+& l&$( :

& F$'$.l.,$'

5!(u+u(&( &l$+&( '&l$%& '& #$du+ *!+u/&"&( '&l&- 'u /!(!)&)

-&l$#.'$'

Fu(,'$ u#&*& d&+$ '&l$%& &d&l&- '!)&,&$ &(#$)&"#!+$7 *!(,&(,"u# ."'$,!( "!

d&l&* +.(,,& *ulu#7 #+&('/.+# !($* '!/!+#$ &*l&'! d&( u(#u" *!('#&)$l"&(

4


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/H d&l&* *ulu#;

) 5.l.,$'

1 5!(!)&) I(#+&.+&l

& G$,$

D$'!)&)"&( .l!- ,$,$ ,!l$,$ "&+!(& &d&(& l!'$ "&+$!' &(,

d&l&* d!(,&( $*/&"'$ *&"&(&(7 lu"& !"'#+&"'$ d!(,&(

,u*/&l&( d&+&- G$,$ /&l'u &"+$l$"7 #!+u#&*& "!#$"& d$/&"&$

'& #$du+ d&( #$d&" #!+u+ d$)!+'$-"&(7 9u,& d&/

*!(,-&'$l"&( )&u *ulu# &(, d$'!)&)"&( .l!- &(d$d$&'$'=

) I(!"'$ 5!+$.d.(#&l

B!+d&'&+"&( )!)!+&/& /!(!l$#$&( *!(u(9u""&( )&-8&

/!(&"$# /!+$.d.(#&l *!(!)&)"&( )&u #$d&" '!d&/ K.('#+&'$

VSC &(, #$(,,$ d$d&/"&( /&d& /!(d!+$#& /!(&"$#

/!+$.d.(#&l T.(!(#$-= *!(u9u""&( )&-8& ".('#+&'$ d&+$

VSC /&d& (&&' d&+$ *ulu# *!($(," d!(,&( &d&(& /."!#

d&l&*7 VSC d$#!*u"&( l!)$- )&(&" /&d& /&'$!( d!(,&(

/+.)$(, '!)!'&+ 4 ** &u l!)$- d&+$/&d& /&'$!( d!(,&(

"!d&l&*&( /."!# "u+&(, d&+$ 4 **=

M$"+.l.+&

B&"#!+$ &(, *!(!)&)"&( )&u *ulu#7 &d&l&-

Fuso#acterium nucleatum$ revotella intermedia$ d&(

!annerella forsythensis B&"#!+$ l&$( &(, #!l&- #!+l$) d&l&*

5


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/+.du"'$ '!(&8& 'ulu+ %.l$l #!+*&'u" rophyromonas

gingivalis$ orphyromonas endodontalis$ !reponema

denticola$ Aggregati#acter actinomycetemcomitans$

Atopo#ium parvulum$ Campylo#acter rectus$ %esulfovi#rio

spesies$ "i&enella corrodens$ "u#acterium sulci$ Spesies

Fuso#acterium dan eptostreptococcus micros B&"#!+$

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