KULIAH PENGANTAR BLOK KULITAMBAR MUDIGDO

BAHAN PRAKTIKUMPAPILOMAKARSINOMA EPIDERMOID DENGAN KORNIFIKASIKARSINOMA EPIDERMOID NON KORNIFIKASIKARSINOMA SEL BASALNAEVUS PIGMENTOSUSMELANOMA MALIGNA

PAPILOMABentuk neoplasma jinak yang menonjoldaripermukaan kulit atau mukosa,tonjolanpapiler dan berbentuk seperti jari.

PAPILOMAKlinistumbuh diberbagai tempat

2.Morfologia. Makroskopis b. Mikroskopis

Sinonim: - Epidermoid carcinoma - Prickle cell carcinoma - Squamous cell carcinoma - Carcinoma planocellulare Karsinoma epidermoid KornifikasiKARSINOMA EPIDERMOID DENGAN KORNIFIKASI

Klinis: - ulserasi atau bunga kol - 40-60 th - limfogen - tungkai bawah,bibir anus, vulva,dsb3. Morfologi - Makroskopis - Mikroskopis

KARSINOMA EPIDERMOID DENGAN KORNIFIKASI Sinonim :- Epidermoid carcinoma- Prickle carcinoma- Squamous cell carcinoma- Carcinoma p;anocellulare

b. Klinis : - ulserasi yg tidak sembuh - bentuknya seperti bunga kol - pria, usia 40-60 th - menyebar secara limfogen - lokasi : tungkai bawah , bibir, anus, dll - faktor predisposisi : sinar matahari, dll

c. Morfologi : a. Makroskopis : benjolan bunga kolmudah berdarah. b. Mikroskopis :- epidermis menebal, polarisasi jelek- epitel tumbuh ke dalam/ keluar- terdapat mutiara tanduk- tampak sel-sel tumor bentuk poligonal - di Stroma terdapat sel-sel radang

CARCINOMA EPIDERMOID NON KORNIFIKASI Morfologi Mikroskopis :Epidermis menebal tidak teratus, polarisasi jelekSel-sel tumor poligonal banyak mitosis patologis.Tidak ditemukan mutiara tanduk.

KASINOMA SEL BASAL Sinonim :- Basalioma - Ulcus Rodent- Epitelioma sel basal - Basal cell carcinoma

B. Klinis : - terjadi pada semua umur - lokasi pada muka bagian atas. - faktor predisposisi : sinar matahari, arsen, ulkus, sikatriks.

C. Morfologi a. Makroskopis : benjolan kulit, ulseratifrapuh b. Mikroskopis : - kelompok sel tumor, batas tegas, inti hiperkromasi, mitosis patologis. - tipe solid - tipe kistik - tipe adenoid

NAEVUS PIGMENTOSUSKlinis merupakan tumor jinak yg timbul dari sel-sel nevus.Morfologi - Makroskopis :biasanya berupa andeng-andeng, konsistensi kenyal.- Mikroskopis : epidermis agak hiperplastik

MELANOMA MALIGNAKlinis :- tumor sangat ganas.- lokasi : kulit, mukosa, mata dan selaputotak.- perkembangan naevus tipe intradermal- sering ditemukan pada usia diatas 40 th- faktor predisposisi : trauma, infeksi virus, faktor herediter.

B. Morfologi a. Makroskopis : - warna coklat kehitaman, permukaan tidak rata, ulseratif, konsistensi kenyal. b. Mikroskopis : - pada kulit epidermis menebal sebagian ulseratif - poligonal, spindel, hiperkromasi - bulat poligonal, spindel, besar, polimorf inti hiperkromasi

DEFINITION OF MACROSCOPIC TERMSMacule circumscribe lesion of up to 5 mm in diameter characterized by flateness and usually distinguised from surrounding skin by its coloration.Patch circumscribe lesion of up to 5 mm in diameter characterized by flateness and usually distinguised from surrounding skin by its coloration.

Papule elevated dome-shaped or flat-topped lesion 5 mm or less across.Nodule elevated with spherical contour greater than 5 mm across.Plaque elevated flat-topped lesion usually greater than 5 mm across(may be caused by coalescent papules)Vesicle fluid-filled raised lesion greater than 5 mm across. Bulla fluid-filled raised lesion greater than 5 mm across.

Blister Common term used for vesicle or bullaPustule Discrete pus-filled raised lesionWheal Itchy transient elevated lesion with variable blanching and erythema formed as the result of dermal edema.Scale Dry, horny, platelike excrescence, usually the resultcornificationLichenification Thickened and rough skin characterized by prominent skin markings, usually the result of repeated rubbing in susceptible persons.

Excoriation Traumatic lesion characterized by breakageof the epidermis , cauing a raw linear area , often self induced.

DEFINITION OF MICROSCOPIC TERMSHyperkeratosis Thickening of the stratum corneum often associated with a qualitative abnormality of the keratin.Parakeratosis Modes of keratinization characterized by the retention of the nucleiin the stratum corneum .Acanthosis Diffuse epidermal hyperplasiaPapilomatosis surface elevation caused by hyperplasia and enlargement of continous dermal papilae.

Dyskeratosis Abnormal keratinization accuring prematurelyAcantholysis Loss of intercelluler connections resulting in loss of cohesion between keratinocytes.Spoiosis Intercellular edema of epidermis Hydropic swelling intra cellular of keratinocytes.Exocytosis infiltrations of the epidermis by inflammatory ErosionDiscontinuity of the skin exhibiting in complete loss of the epidermisUlcerationVacuolization Lentiginous