Hubungan antara Anemia Defisiensi Besi dan Kejang demam: Sebuah Tinjauan sistematis dan Meta-Analisis

Oleh:Fartwa Maratus S , S.kedGita Dewita, S.kedM. Patrio Gondo S, S.kedSeulanga Rachmani M.H, S.ked

KEPANITERAAN KLINIK ILMU PENYAKIT ANAKFAKULTAS KEDOKTERAN UNIVERSIITAS LAMPUNGRUMAH SAKIT UMUM AHMAD YANIMETRO

Perbandingan Ceftriaxon dan Kloramfenikol sebagai Terapi Demam Tifoid AkutABSTRAKPENDAHULUANSymptomsNumber (%)Chloramphenicol treated patientsNo. = 27Ceftriaxone treated patientsNo. = 25TotalNo. = 52Fever27 (100)25 (100)52 (100)Abdominal discomfort22 (81)18 (72)40 (77)Headache21 (72)19 (76)40 (77)Epistaxsis13 (48)14 (56)27 (52)Cough16 (59)16 (64)32 (62)Vomiting12 (44)11 (44)23 (44)Diarrhea9 (33)8 (32)17 (33)SignsFever27 (100)25 (100)52 (100)Toxic look21 (78)22 (88)43 (83)Abdominal tenderness23 (85)21 (81)44 (85)Splenomegaly22 (81)18 (72)40 (77)Abdominal distension20 (74)19 (76)39 (75)Hepatomegaly10 (37)10 (40)20 (38)Jaundice01 (4)1 (2)Table (1) Clinical picture of (52) acute typhoid fever patientsComplete blood pictureRangeMeanHaemoglobin5.5-14.8 gm%11 1.8Total white blood cell count2.3 - 11.4X 10 / cmm5 2.3Platelet count46-458 x 10/ cmm185 87.4Widal agglutination titerChloramphenicol treated

patients (27) No. (%)Ceftriaxone treatedpatients (25) No. (%)Total patients (52) No. (%)Anti-O = 1/80 - Anti-H = 1/801 (4) - 2 (7)1 (4) - 2 (8)2 (4%) - 4 (8%)Anti-O = 1/160 - Anti-H = 1/1607 (26) - 5 (19)5 (20) - 5 (20)12 (23%) - 10 (19%)Anti-O = 1/320 - Anti-H = 1/3206 (22) - 9 (33)5 (20) - 6 (24)11 (21%) - 15 (29%)Anti-O = 1/640 - Anti-H = 1/6408 (30) - 8 (30)7 (28) - 7 (28)15 (29%) - 15 (29%)Anti-O 1/160 - Anti-H 1/16021 (78) - 22 (81)17 ( 68) - 18 (72)38 (73%) - 40 (77%)Table (2) Haematological profile and Widal agglutination titer of (52) acute typhoid fever patientsTable (3) Antimicrobial susceptibility pattern of 52 S.typhi isolates Susceptibility patternNumber of isolates%Any resistance

ChloramphenicolTMP-SMX Ampicillin Ciprofloxacin Ceftriaxone421

1800840

3500Multidrug resistance (MDR) to

chloramphenicol,TMP- SMX and

Ampicillin24Isolates with no resistance to any

of the five tested drugs713Kesimpulan Ceftriaxon memiliki waktu yang lebih singkat untuk penurunan suhu badan sampai normal sehingga menjadikan obat pilihan utama pengobatan demam typhoid.Peningkatan kembali sensitifitas isolat terhadap kloramfenikol, sehingga dijadikan salah satu obat pilihan demam typhoid.Ampicilin dan TMF-SMX tidak dijadikan obat lini pertama pengobatan demam typhoid.TERIMA KASIH