TUGAS PENELUSURAN EBM

Nama: Gemia Clarisa Fathi

NPM: 1102014114

Kelompok: A-15

FAKULTAS KEDOKTERAN

UNIVERSITAS YARSI

JL. LET. JEND. SUPRAPTO, CEMPAKA PUTIH

JAKARTA PUSAT 10510

2014

1. SKENARIO

Seorang pasien berusia 60 tahun datang ke sebuah klinik dengan keluhan sering merasa pusing. Pasien mengaku bahwa dia sebelumnya telah berobat, ia didiagnosis terkena penyakit hipertensi dan diberikan obat amlodipine. Setelah dokter memeriksanya lagi, ternyata tekanan darahnya tak kunjung menurun, akhirnya dokter memberikan resep obat amlodipine yang dikombinasikan dengan losartan.

2. PERTANYAAN KLINIS

Mana yang lebih efektif antara pemberian obat amlodipine saja dengan obat amlodipine yang dikombinasikan dengan losartan?

3. KOMPONEN PICO

P: Pasien penderita hipertensi

I: Amlodipine yang dikombinasikan dengan losartan

C: Amlodipine

O: Efektivitas

4. KATA KUNCI

Hypertension AND Amlodipine AND Combination amlodipine and losartan

5. PEMILIHAN SITUS

www.ebscohost.com / MEDLINE complete

6. PEMBATASAN

Last 5 years, full article, abstract available

7. HASIL PENCARIAN: 18 artikel

Park CG., Youn HJ., Chae SC., et al. (2012). Evaluation of the dose-response relationship of amlodipine and losartan combination in patients with essential hypertension: an 8-week, randomized, double-blind, factorial, phase II, multicenter study. American Journal Of Cardiovascular Drugs: Drugs, Devices, And Other Interventions [Am J Cardiovasc Drugs]. Vol. 12 (1), pp. 35-47

Suh SY., Ahn T., Bae JH., et al/ (2014). Efficacy and Tolerability of Amlodipine Camsylate/Losartan 5/100-mg Versus Losartan/Hydrochlorothiazide 100/12.5-mg Fixed-Dose Combination in Hypertensive Patients Nonresponsive to Losartan 100-mg Monotherapy. Clinical Therapeutics [Clin Ther]. Vol. 36 (10), pp. 1402-11.

Wright RF., Duprez D., Purkayastha D., et al. (2011). Combination angiotensin-receptor blocker (ARB)/calcium channel blocker with HCTZ vs the maximal recommended dose of an ARB with HCTZ in patients with stage 2 hypertension: the exforge as compared to losartan treatment in stage 2 systolic hypertension (EXALT) study. Journal Of Clinical Hypertension (Greenwich, Conn.) [J Clin Hypertens (Greenwich)]. Vol. 13 (8), pp. 588-97.

Unniachan S., Wu D., Rajagopalan S., et al. (2014). Evaluation of blood pressure reduction response and responder characteristics to fixed-dose combination treatment of amlodipine and losartan: a post hoc analysis of pooled clinical trials. Journal Of Clinical Hypertension (Greenwich, Conn.) [J Clin Hypertens (Greenwich)]. Vol. 16 (9), pp. 671-7.

Nishiwaki M., Hosoai H., Ikewaki K., et al. (2013). Efficacy and effects on lipid metabolism of 48-week prospective, multicenter, randomized, open-label trial. Clinical Therapeutics [Clin Ther]. Vol. 35 (4), pp. 461-73

Hong BK., Park CG., Kim KS., et al. ()Comparison of the efficacy and safety of fixed-dose amlodipine/losartan and losartan in hypertensive patients inadequately controlled with losartan: a randomized, double-blind, multicenter study. American Journal Of Cardiovascular Drugs: Drugs, Devices, And Other Interventions [Am J Cardiovasc Drugs].

Yamamoto K., Ozaki H., Takayasu K., et al. (2011). The effect of losartan and amlodipine on left ventricular diastolic function and atherosclerosis in Japanese patients with mild-to-moderate hypertension (J-ELAN) study. Hypertension Research: Official Journal Of The Japanese Society Of Hypertension [Hypertens Res]. Vol. 34 (3), pp. 325-30.

Kim SH., Ryu KH., Lee NH., et al. (2011). Efficacy of fixed-dose amlodipine and losartan combination compared with amlodipine monotherapy in stage 2 hypertension: a randomized, double blind, multicenter study. BMC Research Notes [BMC Res Notes]. Vol. 4, pp. 461.

Fukutomi M., Hoshide S., Eguchi K., et al. (2013). Low-grade inflammation and ambulatory blood pressure response to antihypertensive treatment: the ALPHABET study. American Journal Of Hypertension [Am J Hypertens]. Vol. 26 (6), pp. 784-92.

Lee JH., Chae MR., Park JK., et al. (2012). The effects of the combined use of a PDE5 inhibitor and medications for hypertension, lower urinary tract symptoms and dyslipidemia on corporal tissue tone. International Journal Of Impotence Research [Int J Impot Res]. Vol. 24 (6), pp. 221-7.

Ram CV., Vasey J., Panjabi S., et al. (2012). Comparative effectiveness analysis of amlodipine/renin-angiotensin system blocker combinations. Journal Of Clinical Hypertension (Greenwich, Conn.) [J Clin Hypertens (Greenwich)]. Vol. 14 (9), pp. 601-10.

Kawano Y., Horio T., Kamide K., et al. (2010). Blood pressure and medication during long-term antihypertensive therapy based on morning home SBP in hypertensive patients: Hypertension Control Based on Home Systolic Pressure (HOSP) substudy. Clinical And Experimental Hypertension (New York, N.Y.: 1993) [Clin Exp Hypertens]. Vol. 32 (4), pp. 239-43.

Wald DS., Morris JK., Wald NJ. (2012). Randomized Polypill crossover trial in people aged 50 and over. Plos One [PLoS One]. Vol. 7 (7), pp. e41297.

Hoshide S., Fukutomi M., Eguchi K., et al. (2012). Change in high-sensitive cardiac troponin T on hypertensive treatment. Clinical And Experimental Hypertension (New York, N.Y.: 1993) [Clin Exp Hypertens]. Vol. 35 (1), pp. 40-4.

Arias SC., Valente CP., Machado FG., et al. (2013). Regression of albuminuria and hypertension and arrest of severe renal injury by a losartan-hydrochlorothiazide association in a model of very advanced nephropathy. Plos One [PLoS One]. Vol. 8 (2), pp. e56215.

Duggan ST., Chwieduk CM., Curran MP. (2010). Aliskiren: a review of its use as monotherapy and as combination therapy in the management of hypertension. Drugs [Drugs]. Vol. 70 (15), pp. 2011-49.

Spinar J., Vitovec J., Soucek M. (2014). Biomedical Papers Of The Medical Faculty Of The University Palack, Olomouc, Czechoslovakia [Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub]. Vol. 158 (3), pp. 412-21.

Braun LA., Rosenfeldt F. (2013). Pharmaco-nutrient interactions - a systematic review of zinc and antihypertensive therapy. International Journal Of Clinical Practice [Int J Clin Pract]. Vol. 67 (8), pp. 717-25.

8. ARTIKEL YANG DIPILIH

Unniachan S., Wu D., Rajagopalan S., et al. (2014). Evaluation of blood pressure reduction response and responder characteristics to fixed-dose combination treatment of amlodipine and losartan: a post hoc analysis of pooled clinical trials. Journal Of Clinical Hypertension (Greenwich, Conn.) [J Clin Hypertens (Greenwich)]. Vol. 16 (9), pp. 671-7.

9. TYPE OF QUESTION

Therapy/Treatment

10. TYPE OF STUDY/METHODOLOGY

Randomized, double-blind, clinical trials.