tugas mandiri ilmu faal i.doc
TRANSCRIPT
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TUGAS MANDIRI ILMU FAAL I
PERAN KALSIUM TERHADAP KONTRAKSI OTOT
Oleh:
AUDINA THALIA
021511133066
ILMU FAAL I – DEPARTEMEN BIOLOGI ORAL
FAKULTAS KEDOKTERAN GIGI – UNIVERSITAS AIRLANGGA
Semester Gasal-20!"20#
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KATA PENGANTAR
Puji Syuku ke h!"i!# Tuh!# $!#% M!h! &'! !(!' li)*!h!# !h)!( "!#
hi"!y!h+Ny! 'ehi#%%! !khi#y! *e#uli' "!*!( )e#yele'!ik!# (u%!' )!#"ii il)u
,!!l II y!#% -eju"ul Pe#%!uh .!l'iu) Teh!"!* ./#(!k'i O(/( D!l!)
*e#uli'!# (u%!' )!#"ii i#i 'u"!h "iu'!h!k!# "e#%!# 'e)!k'i)!l )u#%ki# "!#
(e#(u#y! "e#%!# -!#(u!# -e-!%!i *ih!k 'ehi#%%! (u%!' )!#"ii i#i "!*!( 'ele'!i
"e#%!# l!#! U#(uk i(u *e#uli' )e#y!)*!ik!# (ei)! k!'ih ke*!"!:
1 D% A'! Sjuh!"! M.e' 'el!ku "/'e# *e)-i)-i#%
2 .elu!%! "!# (e)!#+(e)!# 'ej!4!( y!#% (el!h )e)-eik!# "uku#%!#
ke*!"! *e#uli' u#(uk )e#yele'!ik!# )!k!l!h i#i
D!l!) *e#uli'!# (u%!' )!#"ii i#i *e#uli' )/h/# )!!, jik! !"!
keku!#%!# "!i 'e%i (!(! -!h!'! )!u*u# 'e%i y!#% l!i# Oleh k!e#! i(u *e#uli'
"e#%!# (e-uk! )e#ei)! '!!# "!# ki(ik "!i *e)-!! Sehi#%%! *e#uli' "!*!(
)e)-e#!k!# ke'!l!h!# y!#% !"! "!# )e#j!"ik!# )!k!l!h (u%!' )!#"ii i#i
"e#%!# le-ih -!ik
Akhi#y! *e#uli' )e#%h!!*k!# !%! )!k!l!h i#i -e)!#,!!( )e)-ei
*e#%e(!hu!# "!# hik)!h -!%i *e)-!! Sehi%%! *e)-!! )e)!h!)i *e#%!uh
k!l'iu) (eh!"!* k/#(!k'i /(/(
Su!-!y! 31 De'e)-e 2015
Pe#uli'
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Da$tar Is%
.!(! Pe#%!#(!ii
D!,(! I'iiii
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D!,(! T!-el
A-'(!k i
A I P&NDAHULUAN
11 L!(! el!k!#%1
12 Tuju!# Pe#uli'!#2
13 M!#,!!(2
A II TIN7AUAN PUSTA.A
21 .!l'iu)3
211 De,i#i'i .!l'iu)3
212 Pe!# .!l'iu) "!l!) Tu-uh8
22 ./#(!k'i O(/(5
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222 F!k(/ Me)*e#%!uhi ./#(!k'i O(/(9
23 Pe!# .!l'iu) (eh!"!* ./#(!k'i O(/(
A III P&MAHASAN11
A I; P&NUTUP
81 Si)*ul!#18
DAFTAR PUSTA.A 15
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DAFTAR GAMAR
G!)-! 1 .e!"!!# el!k'!'i 'u!(u '!k/)e <
G!)-! 2 Mek!#i')e k/#(!k'i /(/( 9
G!)-!3 ./)-i#!'i =!>> "!# .!l)/"uli# 11
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ABSTRAK
.!l'iu) !"!l!h 'e-u!h ele)e# ki)i! "e#%!# 'i)-/l =! "!# #/)/ !(/)
20 .!l'iu) )eu*!k!# '!l!h '!(u l/%!) !lk!li (!#!h "!# )eu*!k!# )i#e!l
y!#% !)!( *e#(i#% -!%i )!#u'i! .!l'iu) !"!l!h #u(i'i *!li#% *e#(i#% y!#%
'!#%!( -e%u#! -!%i (u-uh Pe!# k!l'iu) "!l!) (u-uh le-ih k/)*lek' "!i
'eke"! )e#ye-!-k!# %i%i "!# (ul!#% )e#j!"i ku!( Fu#%'i u(!)! "!i k!l'iu) "i
"!l!) (u-uh !"!l!h k/#(!k'i /(/( .e(ik! /(/( )e#ei)! 'i#y!l k/#(!k'i i/#
k!l'iu) )e#%i#i'i!'i keku!(!# )e#!ik !#(!! ,il!)e# !k(i# "!# )i/'i# 'ehi#%%!
ke"u! ,il!)e# (e'e-u( -e%e'e '!(u '!)! l!i# "!# )e#%h!'ilk!# */'e'
k/#(!k'i Se(el!h i(u i/# k!l'iu) !k!# "i*/)*! ke)-!li ke "!l!) e(iulu)
'!)*!i */(e#'i!l !k'i /(/( y!#% -!u "!(!#% l!%i I/# k!l'iu) '!#%!( "i*eluk!#
u#(uk )e#j!%! k/#(!k'i /(/( !%! (i"!k (ehe#(i
.!(! ku#i: .!l'iu) k/#(!k'i /(/( ,il!)e# !k(i# )i/'i# */(e#'i!l !k'i
Calcium is a chemical element with the symbol Ca and atomic number 20.
Calcium is one of the alkaline earth metal and a mineral that is essential for humans. Calcium is the most important nutrient which is very useful for the body.
The role of calcium in the body is more complex than just cause teeth and bones
strong. The main function of calcium in the body is contraction of muscle. When
the muscles receiving signals contraction calcium ions initiate attractive force
between the filamens of actin and miosin filamens so that both are shifted to one
another and produce a contraction process. !fter that the calcium ions are
pumped back into the reticulum until the new action potential of muscle came
back again. "ons of calcium is needed to maintain muscle contraction that does
not stop.
#eywords$ calcium contraction of muscle filamens of actin and miosin
action potential
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BAB I
PENDAHULUAN
& Latar Bela'a()
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Tuju!# "!i *e#uli'!# )!k!l!h i#i !"!l!h :
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y!#% -euu(!# 'e"iki( '!li#% (u)*!#% (i#"ih '!(u '!)! l!i# Se-!lik#y! *!"!
ke!"!!# k/#(!k'i ,il!)e# !k(i# i#i (e(!ik ke "!l!) "i!#(!! ,il!)e# )i/'i#
'ehi#%%! uju#%+uju#%#y! 'ek!!#% '!li#% (u)*!#% (i#"ih '!(u '!)! li# "e#%!#
*e)!#j!#%!# y!#% )!k'i)!l Le)*e#% ju%! "i(!ik /leh ,il!)e# !k(i# '!)*!i
ke uju#% ,il!)e# )i/'i# 7!"i k/#(!k'i /(/( (ej!"i "e#%!# !"!#y! mekanisme
pergeseran filamen. ?Guy(/# !#" H!ll 2013
Mek!#i')e kej! /(/( *!"! "!'!#y! )eli-!(k!# 'u!(u *eu-!h!# "!l!)
ke!"!!# y!#% el!(i, "!i ,il!)e#+,il!)e# !k(i# "!# )i/'i# Sel!)! k/#(!k'i /(/(
,il!)e#+,il!)e# (i*i' !k(i# (eik!( *!"! "u! %!i' y!#% -e%e!k ke Pi(! A
)e'ki*u# ,il!)e# (e'e-u( (i"!k -e(!)-!h -!#y!k N!)u# %e!k!# *e%e'e!#
i(u )e#%!ki-!(k!# *eu-!h!# "!l!) *e#!)*il!# '!k/)e y!i(u *e#%h!*u'!#
'e-!%i!# !(!u 'eluuh#y! %!i' H Sel!i# i(u ,il!)e# )i/'i# le(!k#y! )e#j!"i
'!#%!( "ek!( "e#%!# %!i'+%!i' "!# *i(!+*i(! A 'e(! le-! '!k/)e )e#j!"i
6
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-eku!#% 'ehi#%%! k/#(!k'i (ej!"i ./#(!k'i -el!#%'u#% *!"! i#(e!k'i !#(!!
!k(i# )i/'i# u#(uk )e)-e#(uk k/)*lek !k(i#+)i/'i#
?4/"-i/l/%y4/"*e''/)
Gam/ar 2 Mek!#i')e ./#(!k'i O(/(
?Su)-e : h((*:BB4444/"-i/l/%y4/"*e''/)Bk/#(!k'i+/(/(B
$!#% )e#ye-!-k!# ,il!)e#+,il!)e# !k(i# -e%e'e ke"!l!) "i! !#(!!
,il!)e#+,il!)e# )i/'i# !"!l!h keku!(!# y!#% "i-e#(uk /leh i#(e!k'i je)-!(!#
'il!#% "!# ,il!)e# )i/'i# "e#%!# ,il!)e# !k(i# P!"! ke!"!!# i'(i!h!( keku!(!#
i#i (i"!k !k(i, (e(!*i -il! 'e-u!h */(e#'i!l !k'i -ej!l!# "i 'e*!#j!#% )e)-!#e
'e!-u( /(/( h!l i#i !k!# )e#ye-!-k!# e(ikulu) '!k/*l!')! )ele*!'k!# i/#
k!l'iu) "!l!) ju)l!h -e'! y!#% "e#%!# e*!( )e#%elili#%i )i/,i-il I/#+i/#
k!l'iu) i#i ke)u"i!# )e#%!k(i,k!# keku!(!# "i !#!(!! ,il!)e# !k(i# "!# )i/'i#
"!# )ul!i (ej!"i k/#(!k'i Te(!*i e#e%i ju%! "i*eluk!# u#(uk -el!#%'u#%#y!
*/'e' k/#(!k'i e%i i#i -e!'!l "!i ik!(!# -ee#e%i (i#%%i *!"! )/lekul ATP
7
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y!#% "iu!ik!# )e#j!"i !"e#/'i#e "i,/',!( ?ADP u#(uk )e)-e-!'k!# e#e%i
?Guy(/# !#" H!ll 2013
2&2&2 Fa't1r mem3e()ar*% '1(tra's% Ot1t
A"! ,!k(/+,!k(/ y!#% )e)*e#%!uhi keku!(!# k/#(!k'i /(/( ./#(!k'i
/(/( !k!# le-ih ku!( -il! 'e"!#% e%!#% "!# -il! 'uhu#y! uku* *!#!' .el!l!h!#
"!# "i#%i# )e)*ele)!h keku!(!# k/#(!k'i eiku( ,!(/ y!#% )e)*e#%!uhi
k/#(!k'i /(/(:
1 Te**e !(!u '(!i!'e e,,e( y!i(u )e#i#%k!(#y! keku!(!# k/#(!k'i
-eul!#% k!li *!"! 'u!(u 'e!-u( /(/( k!e#! '(i)ul!'i -euu(!# -e'eli#%
-e-e!*! "e(ik Pe#%!uh i#i "i'e-!-k!# k!e#! k/#'e#(!'i i/# =!2> "i"!l!) 'e!-u( /(/( y!#% )e#i#%k!(k!# !k(ii(!' )i/,i-il
2 Su))!'i -e-e"! "e#%!# (e**e *!"! 'u))!'i (i!* /(/( -ek/#(!k'i
"e#%!# keku!(!# -e-e"! y!#% )eu*!k!# h!'il *e#ju)l!h!# k/#(!k'i
"u! j!l!# ?'u))!'i u#i( )/(/ -e%!#"! "!# 'u))!'i -e%el/)-!#%
3 F!(iue !"!l!h )e#uu##y! k!*!'i(!' -ekej! k!e#! *ekej!!# i(u 'e#"ii
8 Te(!#i !"!l!h *e#i#%k!(!# ,ekue#'i '(i)ul!'i "e#%!# e*!( 'ehi#%%! (i"!k
!"! *e#i#%k!(!# (e%!#%!# k/#(!k'i
5 Ri%/ (ej!"i -il! 'e-!%i!# (e-e'! ATP "!l!) /(/( (el!h "ih!-i'k!#
'ehi#%%! k!l'iu) (i"!k l!%i "!*!( "ike)-!lik!# ke RS )el!lui )ek!#i')e
*e)/)*!!# ?4/"-i/l/%y4/"*e''/)
Me(/"e *e%e'e!# ,il!)e# "ijel!'k!# )el!lui )ek!#i')e k/#(!k'i
*e#!)*u!# !k(i# "!# )i/'i# )e)-e#(uk k/)*lek' !k(/+)i/'i# y!#%
"i*e#%!uhi /leh ATP Mi/'i# )eu*!k!# */"uk "!# */'e' (e'e-u( )e)*u#y!i
ik!(!# "e#%!# ATP Sel!#ju(#y! ATP y!#% (eik!( "e#%!# )i/'i# (ehi"/li'i'
)e)-e#(uk k/)*lek' )i/'i# ADP+Pi "!# !k!# -eik!(!# "e#%!# !k(i#
Sel!#ju(#y! (!h!* el!k'!'i k/#,/)!'i/#!l k/)*lek' !k(i# )i/'i# ADP+*i
'e!! -e(!h!* )ele*!'k!# ik!(!# "e#%!# Pi "!# ADP */'e' (ek!i( "!#
(ele*!'#y! !k(i# )e#%h!'ilk!# %!y! ,ek(/i!l ?&ely# = 200
2&, Pera( Kals%*m tera.a3 1t1t
8
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Se*e(i y!#% (ej!"i "i /(/( *!"! u)u)#y! '(i)ulu' y!#% )e)iu
'e-!%!i!# -e'! k/#(!k'i /(/( !"!l!h !"!#y! *e#i#%k!(!# i/# k!l'iu) i#(!'elul!
Pe#i#%k!(!# i#i "!*!( "i(i)-ulk!# *!"! je#i' /(/( */l/' y!#% -e-e"! /leh
*e!#%'!#%!# '!!, *!"! 'e!-u( /(/( '(i)ul!'i h/)/#e e%!#%!# 'e!-u( !(!u
*eu-!h!# *!" !li#%ku#%!# ki)i!4i 'e!-u( ?Guy(/# !#" H!ll 2013
I/# k!l'iu) )e#%i#i'i!'i keku!(!# )ek!#ik !#(!! ,il!)e# !k(i# "!#
)i/'i# y!#% )e#ye-!-k!# ke"u! ,il!)e# (e'e-u( -e%e'e '!(u '!)! l!i#
'ehi#%%! )e#%h!'ilk!# */'e' k/#(!k'i Se(el!h ku!#% "!i '!(u "e(ik )!k! i/#
k!l'iu) "i*/)*! ke)-!li ke "!l!) e(ikulu) '!k/*l!')! /leh */)*!
)e)-!#e =!>> "!# i/# i#i (e(!* "i'i)*!# "!l!) e(ikulu) '!)*!i */(e#'i!l !k'i
/(/( y!#% -!u "!(!#% l!%i *e#%elu!!# i/# k!l'iu) "!i )i/,i-il !k!#)e#ye-!-k!# k/#(!k'i /(/( (ehe#(i ?Guy(/# !#" H!ll 2013
P!"! /(/( */l/' k/#(!k'i /(/( "i!k(i,k!# /leh 'u!(u )ek!#i')e y!#%
'eluuh#y! -e-e"! y!i(u *e#%%!#(i (/*/#i# 'el+'el /(/( */l/' )e#%!#"u#%
'eju)l!h -e'! */(ei# *e#%!(u l!i# y!#% "i'e-u( k!l)/"uli# ?G!)-! 2
@!l!u*u# */(ei# k!l)/"uli# 'eu*! "e#%!# (/*/#i# k!l)/"uli# )e)*u#y!i
!! y!#% -e-e"! "!l!) )e)iu k/#(!k'i .!l)/"uli# )el!kuk!# k/#(!k'i
/(/( "e#%!# )e#%!k(i,k!# je)-!(!# 'il!#% )i/'i# P/'e' !k(i!'i /(/( */l/'
"i!4!li "e#%!# i/# k!l'iu) -eik!(!# "e#%!# k!l)/"uli# ?Guy(/# !#" H!ll
2013
9
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Gam/ar , ./)-i#!'i =!>> "!# .!l)/"uli#
?'u)-e : Guy(/# !#" H!ll 2013 H!l 9
./#'e#(!'i i/# k!l'iu) ?=!>> i#(!'elul! )e#i#%k!( ke(ik! =!>>
)e)!'uki 'el )el!lui k!#!l k!l'iu) *!"! )e)-!#e 'el !(!u e(ikulu)
'!k/*l!')! ?SR =!>> -eik!(!# "e#%!# k!l)/"uli# )e)-e#(uk k/)*lek' =!>> +
.!l)/"uli# y!#% ke)u"i!# )e#%!k(i!'i !#(!i i#%!# )i/'i# ki#!'e ?)i/'i#
li%h( h!i# ki#!'eB ML=. ML=. )e),/',/il!'i !#(!i i#%!# )i/'i# ?ML=
)e#ye-!-k!# k/#(!k'i /(/( */l/' .e(ik! k/#'e#(!'i =!>> )e#uu# k!e#!
*e)/)*!!# =!>> kelu! 'el */'e' )e#j!"i (e-!lik "!# )i/'i# ,/',!(!'e
)ele*!'k!# ,/',!( "!i ML= )e#ye-!-k!# k/#(!k'i ?Guy(/# !#" H!ll 2013
10
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BAB III
PEMBAHASAN
.!l'iu) )eu*!k!# ele)e# y!#% *!li#% *e#(i#% y!#% "i-u(uhk!# /leh
(u-uh "!l!) ju)l!h -!#y!k .!e#! Se)-il!# *uluh Se)-il!# *e'e# k!l'iu)
(e"!*!( *!"! (ul!#% y!#% u)u#y! -e,u#%'i 'e-!%!i *e#y!#%%! (u-uh Te(!*i
k!l'iu) (i"!k h!#y! u#(uk (ul!#% S!l!h '!(u "!i -e-e!*! )!#,!!( k!l'iu)
!"!l!h u#(uk k/#(!k'i /(/(
&)*!( *uluh *e'e# "!i 'eluuh (u-uh (e"ii !(!' /(/( !#%k! "!#
)u#%ki# 'e*uluh *e'e# l!i##y! -eu*! /(/( */l/' "!# j!#(u#% Pi#'i* "!'! y!#%
'!)! )e#%e#!i k/#(!k'i "!*!( "i(e!*k!# *!"! ke(i%! je#i' /(/( y!#% -e-e"!
O(/( 'kele( (e"ii "!i -e-e!*! ik!( )u'le ,i-e' Mu'le ,i-e
)eu*!k!# 'el 'ili#"e y!#% *!#j!#% y!#% (e"ii "!i -e-e!*! #uleu' O(/( !k!#
)el!kuk!# k/#(!k'i "!# el!k'!'i k!e#! )e#"!*!( 'i#y!l "!i 'i'(e) '!!,
S!!, 'e#'/ik )e)-!4! i)*ul' "!i (u-uh ke /(!k -!%i!# )/(/ik -e!khi *!"!
)u'le ,i-e S!(u )u'le ,i-e (e"ii "!i )y/,i-il S!(u )y/,i-il (e"ii "!i
-e-e!*! '!k/)e S!(u '!k/)e (e"ii "!i (hik !#" (hi# ,il!)e# Thik ,il!)e# !"!l!h )i/'i# "!# (e#%!h#y! "i'e-u M+li#e M/lekul )i/'i# (e"ii !(!'
e#!) !#(!i */li*e(i"!+"u! rantai berat )!'i#%+)!'i#% "e#%!# -e!( )/lekul
ki!+ki! 200000 "!# e)*!( rantai ringan "e#%!# -e!( )/lekul )!'i#%+)!'i#%
'eki(! 20000 Du! !#(!i -e!( '!li#% )elili( '!(u '!)! l!i# u#(uk )e)-e#(uk
helik' %!#"! y!#% "i'e-u( 'e-!%!i ekor )/lekul )i/'i# S!l!h '!(u uju#% "!i
!#(!i i#i )eli*!( 'e!! -il!(e!l ke "!l!) 'u!(u '(uk(u */li*e*(i"! %l/-ul!
y!#% "i'e-u( kepala miosin 7!"i (e"!*!( "u! ke*!l! -e-!' *!"! )/lekul )i/'i#
helik' %!#"! &)*!( !#(!i i#%!# ju%! -!%i!# "!i ke*!l! )i/'i# y!i(u "u! 'e(i!*
ke*!l! R!#(!i+!#(!i i#%!# i#i )e)-!#(u )e#%!(u ,u#%'i ke*!l! 'el!)!
k/#(!k'i /(/(
Se-u!h ,il!)e#( !k(i# )u#i (!#*! !"!#y! k/)*lek' (/*/#i#+(/*/)i/'i#
!k!# -eik!(!# 'e!! e*!( "!# ku!( "e#%!# ke*!l! )/lekul )i/'i# L!lu jik!
k/)*lek' (/*/#i#+(/*/)i/'i# "i(!)-!hk!# *!"! ,il!)e#( !k(i# ik!(!# !#(!!
!k(i# "!# )i/'i# i#i (i"!k !k!# (e-e#(uk Oleh k!e#! i(u "i"u%! -!h4! -!%i!#
!k(i, *!"! ,il!)e#( !k(i# #/)!l "!i /(/( y!#% 'e"!#% el!k'!'i !k!# "ih!)-!(
11
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!(!u 'e!! ,i'ik "i(u(u*i /leh k/)*lek' (/*/#i#+(/*/)i/'i# Aki-!(#y! (e)*!(
i#i (i"!k "!*!( )elek!( *!"! ke*!l! ,il!)e#( )i/'i# u#(uk )e#i)-ulk!#
k/#(!k'i Se-elu) (ej!"i k/#(!k'i e,ek *e#%h!)-!(!# k/)*lek' (/*/#i#+
(/*/)i/'i# i(u h!u' "ih!)-!( .e!"!!# (e'e-u( )e)-!4! ki(! ke*!"! *e!#
i/# k!l'iu) De#%!# !"!#y! i/# k!l'iu) "!l!) ju)l!h -e'! e,ek *e#%h!)-!(!#
(/*/#i#+(/*/)i/'i# (eh!"!* ,il!)e#( !k(i# i(u 'e#"ii "ih!)-!( il! i/#
k!l'iu) -e%!-u#% "e#%!# (/*/#i# = "!# 'e(i!* )/lekul (/*/#i# = "!*!(
-eik!(!# 'e!! ku!( "e#%!# e)*!( i/# k!l'iu) k/)*lek' (/*/#i# !k!#
)e#%!l!)i *eu-!h!# -e#(uk y!#% )e#!ik )/lekul (/*/)i/'i# "!#
)e)i#"!hk!##y! le-ih "!l!) kelekukk!# !#(!! "u! u#(!i !k(i# .e!"!!# i#i
E)e)-uk! -!%i!# !k(i, "!i !k(i# 'ehi#%%! )e)u#%ki#k!# k/)*lek' i#i
)e#!ik ke*!l! je)-!(!# 'il!#% )i/'i# "!# )e#ye-!-k!# (ej!"i#y! k/#(!k'i
il! 'e-u!h /(/( -ek/#(!k'i (i)-ul 'u!(u kej! y!#% )e)-u(uhk!#
e#e%i Seju)l!h -e'! ATP "i*e!h )e)-e#(uk ADP 'el!)! */'e' k/#(!k'i
'e)!ki# -e'! ju)l!h kej! y!#% "il!kuk!# /leh /(/( 'e)!ki# -e'! ju)l!h ATP
y!#% "i*e!hk!# y!#% "i'e-u( efek %enn Se-elu) k/#(!k'i (ej!"i ke*!l!
je)-!(!# 'il!#% -eik!(!# "e#%!# ATP Ak(ii(!' ATP!'e "!i ke*!l! )i/'i# 'e%e!
)e)!h ATP (e(!*i )e#i#%%!l!k!# h!'il *e)e!h!##y! y!i(u ADP "!# i/# ,/',!(
y!#% !k!# (eik!( *!"! ke*!l! ./)*l/k (/*/#i#+(/*/)i/'i# -eik!(!# "e#%!#
i/# k!l'iu) )!k! -!%i!# !k(i, *!"! ,il!)e# )e#j!"i (e-uk! "!# ke*!l! )i/'i#
ke)u"i!# -eik!(!# "e#%!# -!%i!# i#i
Ik!(!# !#(!! ke*!l! je)-!(!# 'il!#% "!# -!%i!# !k(i, ,il!)e# !k(i#
)e#ye-!-k!# *eu-!h!# -e#(uk ke*!l! )e#ye-!-k!# ke*!l! )e#ekuk ke! !h
le#%!# je)-!(!# 'il! .e"u"uk!# i#i )e)-eik!# power stroke u#(uk )e#!ik
,il!)e# !k(i# e%i y!#% e)#%!k(i,k!# !"!l!h e#e%i y!#% "i'i)*!# /leh
*eu-!h!# -e#(uk y!#% (ej!"i *!"! ke*!l! '!!( )/lekul ATP (el!h "i*e!hk!#
e%i(u ke*!l! je)-!(!# 'il!#% )e#ekuk )!k! ATP "!# i/# ,/',!( (ele*!' "!i
ke*!l! Se(el!h ke*!l! (e*i'!h "!i !k(i# )/lekul ATP y!#% -!u "i*e!h u#(uk
)e)ul!i 'iklu' -!u y!#% )e#i)-ulk!# 'u!(u */4e '(/ke y!#% -!u il!
ke*!l! y!#% (ek/k!#% ?"i'e(!i "e#%!# e#e%i 'i)*!#!##y! y!#% -e!'!l "!i
*e)e!h!# ATP -eik!!(!# "e#%!# -!%i!# !k(i, y!#% -!u *!"! ,il!)e# !k(i#
ke*!l! )e#j!"i (i"!k (ek/k!#% "!# !khi#y! (ej!"i power stroke l!%i
12
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./#(!k'i /(/( y!#% (ej!"i k!e#! '!!, 'e#'/ik )e)-!4! i)*ul' "!i
(u-uh ke /(!k -!%i!# )/(/ik -e!khi *!"! )u'le ,i-e Mek!#i')e kej! /(/(
"i)ul!i "!i i)*ul' y!#% -ej!l!# "!i /(!k '!)*!i (e)i#!l -u((/# )e#ye-!-k!#
i/# =! )!'uk )e#%!k(i,k!# k!l)/"uli# .!l)/"uli# )e#%!k(i,k!# e#Ci) */(ei#
ki#!'e 'ehi#%%! *i#(u =! (e-uk! "!# I/# =! )!'uk I/# =! y!#% )!'uk
)ele-uk!# e'ikel e-e!*! Ae(yh/li#e "ih!#uk!# /leh e#Ci)
!(ylhl/i#e'(e!'e "i #eu/)u'ul! ju#(i/# "!# -e-e!*! "i(!#%k!* e'e*(/
Ae(yh/li#e y!#% "i(!#%k!* )e#%!k(i,k!# '!/*l!')i" e(iulu) )ele*!'k!#
=! y!#% !"! "!l!) /(/( =! (e'e-u( )e#e)*el *!"! */(/#i# )e#%!ki-!(k!#
-i#"i#% 'i(e (elih!( i#"i#% 'i(e -e(e)u "e#%!# )i/'i# he!" )e)-e#(uk /''
-i"%e "!# /''-i"%e )el!kuk!# */4e '(/ke )e#%!ki-!(k!# !(i# )e#"ek!(
"e#%!# )i/'i# S!k/)e )e)e#"ek 'ehi#%%! /(/( -i'! "i%e!kk!#
13
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BAB IV
PENUTUP
4& S%m3*la(.!l'iu) )eu*!k!# )i#e!l y!#% '!#%!( *e#(i#% -!%i )!#u'i! S!l!h '!(u
,u#%'i "!i k!l'iu) y!i(u i/# k!l'iu) )e)*u#y!i *e!#!# *e#(i#% *!"! k/#(!k'i
/(/( $!#% (ej!"i *!"! /(/( !#%k! y!i(u '(i)ulu' y!#% )e)iu 'e-!%i!# -e'!
k/#(!k'i /(/( */l/' !"!l!h !"!#y! *e#i#%k!(!# i/# k!l'iu) i#(!'elule
Pe#i#%k!(!# i#i "!*!( "i(i)-ulk!# *!"! je#i' /(/( */l/' y!#% -e-e"! I/#
k!l'iu) !k!# -eik!(!# "e#%!# k!l)/"uli# ke)u"i!# -e%!-u#% "e#%!# "!#
'ek!li%u' )e#%!k(i,k!# kinase rantai ringan miosin &miosin light chain kinase'
y!i(u e#Ci) ,/',/il!'i R!#(!i i#%!# "!i 'e(i!* ke*!l! )i/'i# y!#% "i'e-u( !#(!i
*e#%!(u !k!# )e#%!l!)i ,/',/il!'i 'e-!%!i e'*/# (eh!"!* )i/'i# ki#!'e
R!#(!i *e#%!(u y!#% )e#%!l!)i ,/',/il!'i ke*!l! )e)iliki ke)!)*u!# u#(uk
-eik!(!# 'e!! -eul!#% "e#%!# ,il!)e# !k(i# "!# -ekej! )el!lui 'eluuh */'e'
'iklu' E(!ik!# -ek!l! '!)! 'e*e(i y!#% (ej!"i *!"! /(/( !#%k!( 'ehi#%%!
)e#%h!'ilk!# k/#(!k'i /(/(
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DAFTAR PUSTAKA
Al)!('ie S 2005 Pi#'i* D!'! Il)u GiCi j!k!(! : PT G!)e"i! Pu'(!k!
U(!)! H 230+28<
ei"%e M7: S)//(h )u'le ell !liu) !(i!(i/# )eh!#i')' 7 Phy'i/l
596:508