tugas biofarmasetika1.pptx

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TUGAS BIOFARMASETIKA 1

METABOLISME

NAMA : YULIANO MEDORA NO BP : 1201169

KELAS : REGULER

STIFARM PADANG

2013



METABOLISM

• The pup!"e !# $u% &e'()!*+"& +" "u,h 'h(' +'" ,!-.e"+!-+" e("+*/ e,e'e$ +$-e/ +- 'h+" ,("e &(+-% +' &!e

h/$!ph+*+,

• I- %e-e(* 'he $u% +" &e'()!*+4e$ )/ &+,!"!&(* e-4/&e"+- 'he e-$!p*("&+, e'+,u*u& !# *+.e ,e**" I- 'he p!,e"" !#&e'()!*+"& !# $u% &!*e,u*e" ,(- ,h(-%e 'he -('ue !#(&!-% !'he" )e,!&e &!e p!*( M!e p!*( &e'()!*+'e"'h(' )e,!&e +-"!*u)*e +- #(' "! e("+*/ e,e'e$ 'h!u%h 'he+$-e/" Du% &e'()!*+'e" ,(- )e &!e (,'+.e 'h(- 'he $u%!+%+- 5)+!('+.("+ -! ! *e"" (,'+.e 5)+!7$e'!+#+,('+!- !

+-(,'+.('+!- ! "+&+*( (,'+.+'+e"



• Du%" 'h(' h(.e )ee- ()"!)e$ )/ 'he +-'e"'+-e

+-'! 'he ,+,u*('+!- 8+** )e '(-"p!'e$ 'h!u%h'he p!'(* "/"'e& !# .e""e*" 5.e+-" p!'(e 8h+,h+" 'he &(+- )*!!$ "upp*/ !# 'he "'!&(,h7+-'e"'+-(* (e( '! 'he *+.e +'h "u)*+-%u(*

($&+-+"'('+!- '(-",u'(-e!u" p(e-'e(* !e,'(* 'he p!'(* "/"'e& (-$ 'he *+.e ,(- )e(.!+$e$



• I- 'he *+.e (-$ pe.+!u"*/ (*"! +- 'he

%("'!+-'e"'+-(* '(,' 'he 8h!*e ! p(' !# ( $u%'h(' ,he&+,(* ,h(-%e" +- e-4/&('+, (-$ +-%e-e(* e"u*'" peu)(h(---/( 5&e'()!*+'e" )e,!&e" &!e ! *e"" (,'+.e Th+" p!,e"" +" (*"!

,(**e$ $e'!+#+,('+!- ! )+!+-('+.("+ 5#+"' p(""e##e,' Thee (e (*"! $u%" 'h(' (,'u(**/"'e-%'he-e$ 'he+ ph(&(,!*!%+,(* p!pe'+e"5)+!7(,'+.('+!- Thee#!e 'he &e'()!*+,

e(,'+!-" +- 'he *+.e (-$ "!&e !'he !%(-"&!e (pp!p+('e*/ ,(**e$: )+!'(-"#!&('+!-



• E(&p*e" !# $u%" 'h(' )e,!&e &!e (,'+.e )/ )+!'(-"#!&('+!-:7 !'+"!-e (-$ pe$-+"!-e: ,!'+"!* (-$pe$-+"!*!-e7 Fe-("e'+- (-$ *!(h+$(': p((,e'(&!* (-$

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Factors affecting the rate of drug biotransforation

1!-,e-'('+!-B+!'(-"#!&('+!- "pee$ 8+** +-,e("e 8he- 'he,!-,e-'('+!- !# 'he $u% +-,e("e$Th+" +" 'ue up '! ( p!+-' 8hee 'he,!-,e-'('+!- )e,!&e" "! h+%h 'h('

(!u-$ 'he e-4/&e &!*e,u*e 'h(' &(e ,h(-%e",!-'+-u!u"*/ !,,up+e$ )/ $u% &!*e,u*e" (**!8" #! )+!'(-"#!&('+!-,!-"'(-' .e*!,+'/ +" e(,he$



2 *+.e #u-,'+!-

!- +&p(+e$ *+.e #u-,'+!- &e'()!*+"& &(/ )e#("'e ! "*!8e (**!8" #! 'he e##e,'" !# 'he $u% 8+** )e *3 (%e+- -e8)!-" (** *+.e e-4/&e" h(.e -!' #u**/

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; Ge-e'+, #(,'!": 'hee (e pe!p*e 8h! $! -!'h(.e ,e'(+- %e-e'+, #(,'!" e% E-4/&e" #!"u*#($+(4+-e (,e'/*('+!- ,!-"e<ue-'*/ e"hu##*e

'h+" $u% '! )e "*!8



= U"e !# !'he $u%"&(-/ *+p!ph+*+, $u%" 'h(' (e ()*e '! "'+&u*('e'he #!&('+!- (-$ (,'+.('+!- !# *+.e e-4/&e"Th+" +" ,(**e$ e-4/&e +-$u,'+!- (-$ 8h+,h+-h+)+'" 'he e-4/&e ,(**e$ e-4/&e +-h+)+'!"



Fi!trasi g!oeru!us

• T! %*!&eu*( #+*'('+!- 'he "!*u)+*+'/ p!pe'+e" !#'he $u% h($ -! e##e,' #('7"!*u)*e ,!&p!u-$" $+#*'("+

(" 8e** (" 8('e7"!*u)*e ,!&p!u-$" O-*/ $u%" 'h('u-$e%! #+*'('+!-

• Du%" (-$ 'he+ &e'()!*+'e" 8h+,h $+""!*.e$ +- 'he

p*("&( (,!"" 'he 8(**" !# 'he u*'(#+*'('e p(""+.e*/%*!&eu*+ Du+-% 'he #+*'('e 8(" ,!-,e-'('e$ +-'u)u*e" *+p!ph+*+, "u)"'(-,e" $+##u"e" )(, p(""+.e*/'h!u%h 'he ,e** &e&)(-e +-'! 'he )*!!$ (-$ 'hu"

(.!+$ e,e'+!-



• h/$!ph+*+, "u)"'(-,e" (*&!"' +&&e$+('e*/$+$+#u"+ )(, (-$ e&!.e$ 'h!u%h 'he u+-e

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#+*'('+!- +- <u+e' ,!-$+'+!-"7The e$u,'+!- $ue '! e$u,e$ p*("&( p!'e+- )+-$+-% p!'e+-'he $u% "u)"'(-,e



Reabsor"si tubu!us

• 'u)u*( e()"!p'+!- #! &!"' !# 'he +-%e$+e-'" 8+** )e e()"!)e$ 'h!u%h p(""+.e $+##u"+!-

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)e ()"!)e$ )/ 'he +-'e"'+-e +' +" $+##+,u*' '!

$+##u"e 'h!u%h 'he 'u)u*e"



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• The $!"e +" '!! h+%h ! '!! #eue- ,(- ,(u"e'!+, e##e,'" 8hee(" 'he $!"e +" '!! *!8 ! '!!"e*$!& p!$u,e" -! e##e,' e.e- +-,he&!'he(peu'+, e"+"'(-,e ,(- ,(u"e %e&"



• Du%" 8+'h ( *!-% h(*#7*+#e !.e 2; h!u" +"%e-e(**/ %+.e- e-!u%h $!"e" 5&(+-'e-(-,e!-,e $(+*/ $! -!' -ee$ '! )e up '! 273 '+&e" ($(/ #! e(&p*e $+%!+-• !-.e"e*/ ( $u% 'h(' +" &e'()!*+4e$ <u+,*/(-$ '1 ? 2 !# he "h!' "h!u*$ )e %+.e- up '! 376'+&e" ( $(/ "! 'h(' p*("&( *e.e*" e&(+- h+%h



• e,e'+!- !# ( $u% (-$ +'" &e'()!*+'e":,!-,e-'('+!-" ,(u"+-% ( $e,e("e +- 'he )!$/ !#-u'+'+!u" +-%e$+e-'"• e,e'+!- ,(- !,,u $epe-$ !-:ph/"+,!,he&+,(* p!pe'+e": &!*e,u*( 8e+%h'pK ( "!*u)+*+'/ .(p! pe""ue



• e,e'+!- ,(- '(e p*(,e 'h!u%h:7 S+-: ,!-,ue-' 8+'h "8e(' e% p((*$eh/$e )!&+$e7 A'+!-: $u% (-$ +'" &e'()!*+'e" (e e,e'e$ &**

('+!- +-'e,h(-%e()*e (-$ +-'e,h(-%e()*e h(&'he )()/ p$ 5p!+"!-+-% #! e(&p*e@ "*eep+-%p+**" -+,!'+-e pe-+,+**+- ,h*!(&phe-+,!* IN>e%!'(&+-e7 K+$-e/ 5u+-e7 B+*e (-$ %u' 5#e,e"7 Lu-% 58+'h ep+('!/ (+



E!iination through the #idne$s

• K+$-e/ +" (- +&p!'(-' !%(- !# e,e'+!-• M!"' $u%" (e e,e'e$ 'h!u%h 'he u+-e (-$

'he pe.(*e-,e !# e(,h $u% +- 'he #!& !#&e'()!*+'e" e,e'e$ (-$ !-*/ ( "&(** p(' +-'he !+%+-(* "'('e

• ('2 +- (- +!- 8h+,h +" e("+*/ "!*u)*e +- u+-ee,e'e$



• Su)"'(-,e" 'h(' *+p!ph+*+, (-$ u-+!-+4e$"*!8e e,e'+!- '! +&p!.e 'he p!pe'+e" !#h+$!#+*-/( 'he- 'he )+!'(-"#!&('+!- +-,*u$e$

%!up7O> !7OO> (-$ +-'! 'he &!*e,u*e



• The "pee$ (-$ &(%-+'u$e !# e,e'+!- 'h!u%h'he +$-e/ +" $e'e&+-e$ )/:7 G*!&eu*( #+*'('+!-7 Tu)u*( e()"!p'+!-7 Tu)u*( "e,e'+!-

tugas biofarmasetika1.pptx

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