sintesis asam lemak (2)
DESCRIPTION
biokimiaTRANSCRIPT
Sintesis Asam Lemak
Oleh kelompok 4Mochammad Febry Pratama
Ninda Ramadani Herli NSifa Fauziah Dwidara
terjadi di sitoplasma khususnya pada bagian hepar dan kelenjar adiposa
Sintesis asam lemak terjadi apabila kelebihan Asetil-KoA
Reaksi dimulai dgn membawa asetil KoA keluar dari mitokondria ke sitoplasma melalui torak sitrat (citrate shuttle)
torak sitrat (citrate shuttle)
Citrate Shuttle (regeneration of pyruvate)
Oxaloacetate is converted back to pyruvate for re-entry into mitochondria
Step 1 Oxaloacetate + NADH + H+ 1048774 malate + NAD+ Reverse of the TA cycle reaction Catalyzed by cytosolic malate dehydrogenase
Step 2 Malate + NADP+ 1048774 pyruvate + CO2 + NADPH Catalyzed by malic enzyme
Pyruvate translocase transports pyruvate into mitochondria Pyruvate is converted to oxaloacetate by pyruvate carboxylase with
coupled hydrolysis of one ATP Pyruvate + ATP + CO2 + H2Orarroxaloacetate + ADP + Pi (reaction of gluconeogenesis)
Net Reaction NADP+ + NADH + H+ + ATP + H2O 1048774 NADPH + NAD+ + ADP + Pi
Thus transport of acetylCoA to cytosol requires expense of one ATP and conversion of one NADH to NADPH
Reaksi ini terjadi dalam 4 tahap dengan pemanjangan 2 atom karbon yaitundash Condensationndash Reductionndash Dehydrationndash reduction
bull Reaksi ini membutuhkan NADPH (Reaksi Enzim Malat HMP ShuntReaksi TCA)
digunakan untuk sintesis sebagai reduktor
ATP untuk membentuk ikatan tioester pada asetil KoA dan menggabungkan CO2 pada asetil KoA menjadi malonil KoA
CO2
Pembentukan Malonyl-CoA
Reaksi ini katalisis oleh enzim Acetyl CoA Carboxylase (mengandung gugus prostetik biotin)yang diaktifkan oleh sitrat dan Insulin
Pemanjangan rantai
Elongation of Palmitate to Stearoyl
Sintesis asam lemak tak jenuh
bull The double bonds of palmitoleate and oleate are introduced in vertebrates by fatty acyl-CoA desaturase together with cytochrome b5 and cytochrome b5 reductase
bull Two substrates fatty acyl-CoA and NADPH are oxidized simultaneously by O2 The desaturase is thus a mixed-function oxidase
Desaturation of fatty acids
Fatty acyl-CoA is desaturated (oxidized)
using O2 and NADPH(in smooth ER)
ER membrane
DIAGRAM OF SYNTHESIS
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
terjadi di sitoplasma khususnya pada bagian hepar dan kelenjar adiposa
Sintesis asam lemak terjadi apabila kelebihan Asetil-KoA
Reaksi dimulai dgn membawa asetil KoA keluar dari mitokondria ke sitoplasma melalui torak sitrat (citrate shuttle)
torak sitrat (citrate shuttle)
Citrate Shuttle (regeneration of pyruvate)
Oxaloacetate is converted back to pyruvate for re-entry into mitochondria
Step 1 Oxaloacetate + NADH + H+ 1048774 malate + NAD+ Reverse of the TA cycle reaction Catalyzed by cytosolic malate dehydrogenase
Step 2 Malate + NADP+ 1048774 pyruvate + CO2 + NADPH Catalyzed by malic enzyme
Pyruvate translocase transports pyruvate into mitochondria Pyruvate is converted to oxaloacetate by pyruvate carboxylase with
coupled hydrolysis of one ATP Pyruvate + ATP + CO2 + H2Orarroxaloacetate + ADP + Pi (reaction of gluconeogenesis)
Net Reaction NADP+ + NADH + H+ + ATP + H2O 1048774 NADPH + NAD+ + ADP + Pi
Thus transport of acetylCoA to cytosol requires expense of one ATP and conversion of one NADH to NADPH
Reaksi ini terjadi dalam 4 tahap dengan pemanjangan 2 atom karbon yaitundash Condensationndash Reductionndash Dehydrationndash reduction
bull Reaksi ini membutuhkan NADPH (Reaksi Enzim Malat HMP ShuntReaksi TCA)
digunakan untuk sintesis sebagai reduktor
ATP untuk membentuk ikatan tioester pada asetil KoA dan menggabungkan CO2 pada asetil KoA menjadi malonil KoA
CO2
Pembentukan Malonyl-CoA
Reaksi ini katalisis oleh enzim Acetyl CoA Carboxylase (mengandung gugus prostetik biotin)yang diaktifkan oleh sitrat dan Insulin
Pemanjangan rantai
Elongation of Palmitate to Stearoyl
Sintesis asam lemak tak jenuh
bull The double bonds of palmitoleate and oleate are introduced in vertebrates by fatty acyl-CoA desaturase together with cytochrome b5 and cytochrome b5 reductase
bull Two substrates fatty acyl-CoA and NADPH are oxidized simultaneously by O2 The desaturase is thus a mixed-function oxidase
Desaturation of fatty acids
Fatty acyl-CoA is desaturated (oxidized)
using O2 and NADPH(in smooth ER)
ER membrane
DIAGRAM OF SYNTHESIS
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
torak sitrat (citrate shuttle)
Citrate Shuttle (regeneration of pyruvate)
Oxaloacetate is converted back to pyruvate for re-entry into mitochondria
Step 1 Oxaloacetate + NADH + H+ 1048774 malate + NAD+ Reverse of the TA cycle reaction Catalyzed by cytosolic malate dehydrogenase
Step 2 Malate + NADP+ 1048774 pyruvate + CO2 + NADPH Catalyzed by malic enzyme
Pyruvate translocase transports pyruvate into mitochondria Pyruvate is converted to oxaloacetate by pyruvate carboxylase with
coupled hydrolysis of one ATP Pyruvate + ATP + CO2 + H2Orarroxaloacetate + ADP + Pi (reaction of gluconeogenesis)
Net Reaction NADP+ + NADH + H+ + ATP + H2O 1048774 NADPH + NAD+ + ADP + Pi
Thus transport of acetylCoA to cytosol requires expense of one ATP and conversion of one NADH to NADPH
Reaksi ini terjadi dalam 4 tahap dengan pemanjangan 2 atom karbon yaitundash Condensationndash Reductionndash Dehydrationndash reduction
bull Reaksi ini membutuhkan NADPH (Reaksi Enzim Malat HMP ShuntReaksi TCA)
digunakan untuk sintesis sebagai reduktor
ATP untuk membentuk ikatan tioester pada asetil KoA dan menggabungkan CO2 pada asetil KoA menjadi malonil KoA
CO2
Pembentukan Malonyl-CoA
Reaksi ini katalisis oleh enzim Acetyl CoA Carboxylase (mengandung gugus prostetik biotin)yang diaktifkan oleh sitrat dan Insulin
Pemanjangan rantai
Elongation of Palmitate to Stearoyl
Sintesis asam lemak tak jenuh
bull The double bonds of palmitoleate and oleate are introduced in vertebrates by fatty acyl-CoA desaturase together with cytochrome b5 and cytochrome b5 reductase
bull Two substrates fatty acyl-CoA and NADPH are oxidized simultaneously by O2 The desaturase is thus a mixed-function oxidase
Desaturation of fatty acids
Fatty acyl-CoA is desaturated (oxidized)
using O2 and NADPH(in smooth ER)
ER membrane
DIAGRAM OF SYNTHESIS
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Citrate Shuttle (regeneration of pyruvate)
Oxaloacetate is converted back to pyruvate for re-entry into mitochondria
Step 1 Oxaloacetate + NADH + H+ 1048774 malate + NAD+ Reverse of the TA cycle reaction Catalyzed by cytosolic malate dehydrogenase
Step 2 Malate + NADP+ 1048774 pyruvate + CO2 + NADPH Catalyzed by malic enzyme
Pyruvate translocase transports pyruvate into mitochondria Pyruvate is converted to oxaloacetate by pyruvate carboxylase with
coupled hydrolysis of one ATP Pyruvate + ATP + CO2 + H2Orarroxaloacetate + ADP + Pi (reaction of gluconeogenesis)
Net Reaction NADP+ + NADH + H+ + ATP + H2O 1048774 NADPH + NAD+ + ADP + Pi
Thus transport of acetylCoA to cytosol requires expense of one ATP and conversion of one NADH to NADPH
Reaksi ini terjadi dalam 4 tahap dengan pemanjangan 2 atom karbon yaitundash Condensationndash Reductionndash Dehydrationndash reduction
bull Reaksi ini membutuhkan NADPH (Reaksi Enzim Malat HMP ShuntReaksi TCA)
digunakan untuk sintesis sebagai reduktor
ATP untuk membentuk ikatan tioester pada asetil KoA dan menggabungkan CO2 pada asetil KoA menjadi malonil KoA
CO2
Pembentukan Malonyl-CoA
Reaksi ini katalisis oleh enzim Acetyl CoA Carboxylase (mengandung gugus prostetik biotin)yang diaktifkan oleh sitrat dan Insulin
Pemanjangan rantai
Elongation of Palmitate to Stearoyl
Sintesis asam lemak tak jenuh
bull The double bonds of palmitoleate and oleate are introduced in vertebrates by fatty acyl-CoA desaturase together with cytochrome b5 and cytochrome b5 reductase
bull Two substrates fatty acyl-CoA and NADPH are oxidized simultaneously by O2 The desaturase is thus a mixed-function oxidase
Desaturation of fatty acids
Fatty acyl-CoA is desaturated (oxidized)
using O2 and NADPH(in smooth ER)
ER membrane
DIAGRAM OF SYNTHESIS
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Reaksi ini terjadi dalam 4 tahap dengan pemanjangan 2 atom karbon yaitundash Condensationndash Reductionndash Dehydrationndash reduction
bull Reaksi ini membutuhkan NADPH (Reaksi Enzim Malat HMP ShuntReaksi TCA)
digunakan untuk sintesis sebagai reduktor
ATP untuk membentuk ikatan tioester pada asetil KoA dan menggabungkan CO2 pada asetil KoA menjadi malonil KoA
CO2
Pembentukan Malonyl-CoA
Reaksi ini katalisis oleh enzim Acetyl CoA Carboxylase (mengandung gugus prostetik biotin)yang diaktifkan oleh sitrat dan Insulin
Pemanjangan rantai
Elongation of Palmitate to Stearoyl
Sintesis asam lemak tak jenuh
bull The double bonds of palmitoleate and oleate are introduced in vertebrates by fatty acyl-CoA desaturase together with cytochrome b5 and cytochrome b5 reductase
bull Two substrates fatty acyl-CoA and NADPH are oxidized simultaneously by O2 The desaturase is thus a mixed-function oxidase
Desaturation of fatty acids
Fatty acyl-CoA is desaturated (oxidized)
using O2 and NADPH(in smooth ER)
ER membrane
DIAGRAM OF SYNTHESIS
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Pembentukan Malonyl-CoA
Reaksi ini katalisis oleh enzim Acetyl CoA Carboxylase (mengandung gugus prostetik biotin)yang diaktifkan oleh sitrat dan Insulin
Pemanjangan rantai
Elongation of Palmitate to Stearoyl
Sintesis asam lemak tak jenuh
bull The double bonds of palmitoleate and oleate are introduced in vertebrates by fatty acyl-CoA desaturase together with cytochrome b5 and cytochrome b5 reductase
bull Two substrates fatty acyl-CoA and NADPH are oxidized simultaneously by O2 The desaturase is thus a mixed-function oxidase
Desaturation of fatty acids
Fatty acyl-CoA is desaturated (oxidized)
using O2 and NADPH(in smooth ER)
ER membrane
DIAGRAM OF SYNTHESIS
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Pemanjangan rantai
Elongation of Palmitate to Stearoyl
Sintesis asam lemak tak jenuh
bull The double bonds of palmitoleate and oleate are introduced in vertebrates by fatty acyl-CoA desaturase together with cytochrome b5 and cytochrome b5 reductase
bull Two substrates fatty acyl-CoA and NADPH are oxidized simultaneously by O2 The desaturase is thus a mixed-function oxidase
Desaturation of fatty acids
Fatty acyl-CoA is desaturated (oxidized)
using O2 and NADPH(in smooth ER)
ER membrane
DIAGRAM OF SYNTHESIS
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Elongation of Palmitate to Stearoyl
Sintesis asam lemak tak jenuh
bull The double bonds of palmitoleate and oleate are introduced in vertebrates by fatty acyl-CoA desaturase together with cytochrome b5 and cytochrome b5 reductase
bull Two substrates fatty acyl-CoA and NADPH are oxidized simultaneously by O2 The desaturase is thus a mixed-function oxidase
Desaturation of fatty acids
Fatty acyl-CoA is desaturated (oxidized)
using O2 and NADPH(in smooth ER)
ER membrane
DIAGRAM OF SYNTHESIS
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Sintesis asam lemak tak jenuh
bull The double bonds of palmitoleate and oleate are introduced in vertebrates by fatty acyl-CoA desaturase together with cytochrome b5 and cytochrome b5 reductase
bull Two substrates fatty acyl-CoA and NADPH are oxidized simultaneously by O2 The desaturase is thus a mixed-function oxidase
Desaturation of fatty acids
Fatty acyl-CoA is desaturated (oxidized)
using O2 and NADPH(in smooth ER)
ER membrane
DIAGRAM OF SYNTHESIS
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
bull The double bonds of palmitoleate and oleate are introduced in vertebrates by fatty acyl-CoA desaturase together with cytochrome b5 and cytochrome b5 reductase
bull Two substrates fatty acyl-CoA and NADPH are oxidized simultaneously by O2 The desaturase is thus a mixed-function oxidase
Desaturation of fatty acids
Fatty acyl-CoA is desaturated (oxidized)
using O2 and NADPH(in smooth ER)
ER membrane
DIAGRAM OF SYNTHESIS
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Fatty acyl-CoA is desaturated (oxidized)
using O2 and NADPH(in smooth ER)
ER membrane
DIAGRAM OF SYNTHESIS
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
DIAGRAM OF SYNTHESIS
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Asam lemak essensial
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Asam Lemak essensialAsam lemak essensial tidak dapat
dihasilkan sendiri oleh tubuh karena tidak mempunyai enzim yang dapat menyisipkan ikatan ganda diluar posisi 9 di asam lemak jenuh
Asam lemak yang essensial bagi mamalia adalah asam lemak linoleat dan α-linolenat
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Sintesis asam lemak esensial
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Sintesis omega 3
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Fatty acid elongation and desaturase(s) systems act jointly in generation of long- and very-long-chain unsaturared fatty acids Starting from C16 and C18 elongation specific desaturases generate cis-monounsaturated palmitoleic acid (Δ9 C161) and oleic acid (Δ9 C181 Fig 1) Both palmitoleic and oleic acid are then used for the synthesis of a variety of other long-chain unsaturated fatty acids
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-
Animasihttpwwwwileycomcollegefobquizquiz1919-22htmlhttpwwwwileycomcollegepratt0471393878studentanimationsfatty_acidindexhtmlhttpbio-animationsblogspotcom200804biochemistry-fatty-acid-metabolismhtml
- Sintesis Asam Lemak
- Slide 2
- torak sitrat (citrate shuttle)
- Citrate Shuttle (regeneration of pyruvate)
- Slide 5
- Pembentukan Malonyl-CoA
- Slide 7
- Slide 8
- Slide 9
- Pemanjangan rantai
- Slide 11
- Slide 12
- Elongation of Palmitate to Stearoyl
- Sintesis asam lemak tak jenuh
- Slide 15
- Slide 16
- Slide 17
- Slide 18
- Slide 19
- Asam lemak essensial
- Asam Lemak essensial
- Slide 22
- Slide 23
- Slide 24
- Slide 25
-